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The map label for this gene is 37522060

Identifier: 37522060

GI number: 37522060

Start: 2648954

End: 2649598

Strand: Reverse

Name: 37522060

Synonym: gll2491

Alternate gene names: NA

Gene position: 2649598-2648954 (Counterclockwise)

Preceding gene: 37522063

Following gene: 37522053

Centisome position: 56.87

GC content: 64.81

Gene sequence:

>645_bases
ATGCGAGTACATCACCCTTACCACGAAATACCTGTGGAAACACTGAATGTAGATTTTTTTAATCTTTCGCCTTTATCGGT
AGCGCGTCGGTTGATCGGGTGCGCGGTAGTGCGCGTCCTGGCAGGCGAGCGCCTGAGCGGCCGGATTGTCGAGACTGAAG
CCTACGGCGGCCTGCGCGATCCTTCCTGCTATGTCGTGCGGCGCGACGAGCGCATCTGGTCTTTGCTGTCGGGACCGCCC
GGAGTCCTCTATTTGCACCGCGCCTATCGGCATTGGCTATTAAACATCACCTGCGACGCGGTAGGCGAACCGGCCTGCGT
GCTTATCCGCGCCCTGGAGCCCACCGGCGGCGAGGAGCGCATGCGGCAGCTGCGCCGGGGCGCGCGGGATCTGACCAACG
GTCCGGCCCGCCTGGTGGAGGCTCTGGCCATCGATTCCGCCTGGGAGGCGAGCGCCCTGCCGCGAGCGGAATTCTGGCTG
GAGGCGGGCGAGCCGGTGCCCGAGGAGCAGGTGCTCAACACGGTGCGCATTGGTCTGACCCGCGGCAAGGACTTGCCCTG
GCGCTTCGCTGTGCGGGATAGCCCCTGGGTGTCCCGGTCGGTGGAAGCGGTACTCTCTGAAGCATCGCTCTCTGCCGGTC
TCTAG

Upstream 100 bases:

>100_bases
TCGTTCTGGTACCACTTGACGATCAGGTCGTTGTTTTTGCGGATAAATTGCTGGAGTTGCCTGTCTTGGCTGGGCGAGGG
TATCATGGCGGCCCTTTCGC

Downstream 100 bases:

>100_bases
CGTGTTGATTGCGCCACCGGTAAGCGCTCCAGTTCGCGGCGATCCCACTGGGCCAGATCGGCGGCAGCCTCGTAGGTGCT
CTGCAAGAAAGCAAGAAGCG

Product: N-methylpurine-DNA glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MRVHHPYHEIPVETLNVDFFNLSPLSVARRLIGCAVVRVLAGERLSGRIVETEAYGGLRDPSCYVVRRDERIWSLLSGPP
GVLYLHRAYRHWLLNITCDAVGEPACVLIRALEPTGGEERMRQLRRGARDLTNGPARLVEALAIDSAWEASALPRAEFWL
EAGEPVPEEQVLNTVRIGLTRGKDLPWRFAVRDSPWVSRSVEAVLSEASLSAGL

Sequences:

>Translated_214_residues
MRVHHPYHEIPVETLNVDFFNLSPLSVARRLIGCAVVRVLAGERLSGRIVETEAYGGLRDPSCYVVRRDERIWSLLSGPP
GVLYLHRAYRHWLLNITCDAVGEPACVLIRALEPTGGEERMRQLRRGARDLTNGPARLVEALAIDSAWEASALPRAEFWL
EAGEPVPEEQVLNTVRIGLTRGKDLPWRFAVRDSPWVSRSVEAVLSEASLSAGL
>Mature_214_residues
MRVHHPYHEIPVETLNVDFFNLSPLSVARRLIGCAVVRVLAGERLSGRIVETEAYGGLRDPSCYVVRRDERIWSLLSGPP
GVLYLHRAYRHWLLNITCDAVGEPACVLIRALEPTGGEERMRQLRRGARDLTNGPARLVEALAIDSAWEASALPRAEFWL
EAGEPVPEEQVLNTVRIGLTRGKDLPWRFAVRDSPWVSRSVEAVLSEASLSAGL

Specific function: Unknown

COG id: COG2094

COG function: function code L; 3-methyladenine DNA glycosylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA glycosylase MPG family

Homologues:

Organism=Homo sapiens, GI62632769, Length=204, Percent_Identity=37.2549019607843, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI62632765, Length=204, Percent_Identity=37.2549019607843, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI62632771, Length=204, Percent_Identity=37.2549019607843, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): 3MGH_GLOVI (Q7NHP4)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925437.1
- ProteinModelPortal:   Q7NHP4
- SMR:   Q7NHP4
- GeneID:   2600892
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:gll2491
- NMPDR:   fig|251221.1.peg.2491
- HOGENOM:   HBG664239
- OMA:   EHISSQY
- BioCyc:   GVIO251221:GLL2491-MONOMER
- HAMAP:   MF_00527
- InterPro:   IPR011034
- InterPro:   IPR003180
- Gene3D:   G3DSA:3.10.300.10
- PANTHER:   PTHR10429
- TIGRFAMs:   TIGR00567

Pfam domain/function: PF02245 Pur_DNA_glyco; SSF50486 FMT_C_like

EC number: 3.2.2.-

Molecular weight: Translated: 23869; Mature: 23869

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVHHPYHEIPVETLNVDFFNLSPLSVARRLIGCAVVRVLAGERLSGRIVETEAYGGLRD
CCCCCCHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCC
PSCYVVRRDERIWSLLSGPPGVLYLHRAYRHWLLNITCDAVGEPACVLIRALEPTGGEER
CCEEEEECCHHHHHHHCCCCCEEHHHHHHHHHEEEEEECCCCCCCEEEEEECCCCCCHHH
MRQLRRGARDLTNGPARLVEALAIDSAWEASALPRAEFWLEAGEPVPEEQVLNTVRIGLT
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHC
RGKDLPWRFAVRDSPWVSRSVEAVLSEASLSAGL
CCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRVHHPYHEIPVETLNVDFFNLSPLSVARRLIGCAVVRVLAGERLSGRIVETEAYGGLRD
CCCCCCHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCC
PSCYVVRRDERIWSLLSGPPGVLYLHRAYRHWLLNITCDAVGEPACVLIRALEPTGGEER
CCEEEEECCHHHHHHHCCCCCEEHHHHHHHHHEEEEEECCCCCCCEEEEEECCCCCCHHH
MRQLRRGARDLTNGPARLVEALAIDSAWEASALPRAEFWLEAGEPVPEEQVLNTVRIGLT
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHC
RGKDLPWRFAVRDSPWVSRSVEAVLSEASLSAGL
CCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292