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The map label for this gene is lepB [H]

Identifier: 37522050

GI number: 37522050

Start: 2638970

End: 2639563

Strand: Direct

Name: lepB [H]

Synonym: glr2481

Alternate gene names: 37522050

Gene position: 2638970-2639563 (Clockwise)

Preceding gene: 37522049

Following gene: 37522054

Centisome position: 56.64

GC content: 59.6

Gene sequence:

>594_bases
GTGTCACCGTCCTACCGGCATTGCTTCATGAGTTCACCGCCCAACCCCCAACCCGAGGAAAATAAGCTCTGGTCCTTTCT
CAAAAGCCAGCGCGAGAATATTCAGTCCATCGCTGTGGCGCTGGTGTTGACCTTCACCATCCAGACCTTTGCCGCCCAGG
CGTTTTATATCCCCTCGGGCTCGATGGAGCCGACGCTGCTCATCAACGATCGCCTGATGGTCGAGAAGATCACCTACGAC
TTCTCTACCCCCGAGCGCGGTCAGATCATCGTTTTCACCCCGCCCAAGAACCACTTCAACAGCAACGACCAGCCCTTCAT
CAAGCGGGTGATCGGGCTGCCGGGCGATACGGTGGAAGTCAAAGCGGGCAAGGTGTTCATCAACGGCAAAGCGCTCGACG
AAAAATACATTGCCGAGCCGCCCGCCTACGTCATGCCCCCGGTCAAGGTGCCCGCCGACCAGTTTTTCGTCATGGGCGAC
AACCGCAACAACAGCTTCGACTCGCACATCTGGGGCTTCCTGCCGCGCCAAAACGTGATCGGCCGGGCCATCTTCCGCTT
CTGGCCCCTCGACCGGCTCGGCCCGCTCGGGTAA

Upstream 100 bases:

>100_bases
AGAAGCTCGAAGGGTTGCCGGGCCTGCAGGTGGAGCTTAAAGAGTAGTGTCCGGCGGCAGGGCAGTCCGGGCAGGAGCCG
CCGATGGTCTATGATCATCG

Downstream 100 bases:

>100_bases
TTTGGGGCTAGCGGTCCACCGCCCGCTCCCCGCCCCAGCGCGCCACGATCTGATCGTCGTACTCGTCGGCGCTGAAAGCA
ACCGCACCCACAGCCGCTTT

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 197; Mature: 196

Protein sequence:

>197_residues
MSPSYRHCFMSSPPNPQPEENKLWSFLKSQRENIQSIAVALVLTFTIQTFAAQAFYIPSGSMEPTLLINDRLMVEKITYD
FSTPERGQIIVFTPPKNHFNSNDQPFIKRVIGLPGDTVEVKAGKVFINGKALDEKYIAEPPAYVMPPVKVPADQFFVMGD
NRNNSFDSHIWGFLPRQNVIGRAIFRFWPLDRLGPLG

Sequences:

>Translated_197_residues
MSPSYRHCFMSSPPNPQPEENKLWSFLKSQRENIQSIAVALVLTFTIQTFAAQAFYIPSGSMEPTLLINDRLMVEKITYD
FSTPERGQIIVFTPPKNHFNSNDQPFIKRVIGLPGDTVEVKAGKVFINGKALDEKYIAEPPAYVMPPVKVPADQFFVMGD
NRNNSFDSHIWGFLPRQNVIGRAIFRFWPLDRLGPLG
>Mature_196_residues
SPSYRHCFMSSPPNPQPEENKLWSFLKSQRENIQSIAVALVLTFTIQTFAAQAFYIPSGSMEPTLLINDRLMVEKITYDF
STPERGQIIVFTPPKNHFNSNDQPFIKRVIGLPGDTVEVKAGKVFINGKALDEKYIAEPPAYVMPPVKVPADQFFVMGDN
RNNSFDSHIWGFLPRQNVIGRAIFRFWPLDRLGPLG

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=99, Percent_Identity=37.3737373737374, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 22363; Mature: 22232

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPSYRHCFMSSPPNPQPEENKLWSFLKSQRENIQSIAVALVLTFTIQTFAAQAFYIPSG
CCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCC
SMEPTLLINDRLMVEKITYDFSTPERGQIIVFTPPKNHFNSNDQPFIKRVIGLPGDTVEV
CCCCEEEECCCEEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHCCCCCEEEE
KAGKVFINGKALDEKYIAEPPAYVMPPVKVPADQFFVMGDNRNNSFDSHIWGFLPRQNVI
EECEEEECCCCCCHHHHCCCCCEECCCCCCCCCEEEEEECCCCCCCCCHHHCCCCCHHHH
GRAIFRFWPLDRLGPLG
HHHHHHHCCHHHCCCCC
>Mature Secondary Structure 
SPSYRHCFMSSPPNPQPEENKLWSFLKSQRENIQSIAVALVLTFTIQTFAAQAFYIPSG
CCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCC
SMEPTLLINDRLMVEKITYDFSTPERGQIIVFTPPKNHFNSNDQPFIKRVIGLPGDTVEV
CCCCEEEECCCEEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHCCCCCEEEE
KAGKVFINGKALDEKYIAEPPAYVMPPVKVPADQFFVMGDNRNNSFDSHIWGFLPRQNVI
EECEEEECCCCCCHHHHCCCCCEECCCCCCCCCEEEEEECCCCCCCCCHHHCCCCCHHHH
GRAIFRFWPLDRLGPLG
HHHHHHHCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7865790 [H]