Click here to switch to the map view.

The map label for this gene is hisC [H]

Identifier: 37522044

GI number: 37522044

Start: 2633496

End: 2634728

Strand: Reverse

Name: hisC [H]

Synonym: gvip341

Alternate gene names: 37522044

Gene position: 2634728-2633496 (Counterclockwise)

Preceding gene: 37522046

Following gene: 37522043

Centisome position: 56.55

GC content: 67.72

Gene sequence:

>1233_bases
GTGTTAAGAAGGAGCATCGGTTTGTACAGGAGTGTCCCGGTGGAAATTTCGCGCCGCGCCGCGTTGCAGGGGTTGAGTTG
GTGGGCTGGTGTAGCGGCGGTTGCCCCCCCGGCACTGTGGGCCGCCGAGGTGCGCCGGGTCTCCTCGGTGCAGGGCGTGG
GCGTCCCGGCCGGCACGGTGCGCTTGCTCTACAACGAAAATCCCCTCGGGCCTTCGCCTCTGGCGCTCAAAGCGGCTTCA
GAGGCGCTGGACGGCTGCAACCGCTACCCGATGGCGACGGTTTTCTCGCTGCTTGAGGGGATCTGCGCGCTCCACGGCCT
GAGTCTTGCTTCGCCCGGCAGTGCCGCGGATCTCGGTGCGCTGTTTGAGGCTTTTGAAGCGAGTTCGGTATTGCTCGGGG
CCGGTTCTTCGGAGATCCTGCAGGCGGTGGCCCTGGCCTGGGGCCTCGATGGGGGCGAATTTGTCGAAGCGTCCCCCGGT
TACGGCGCGGTGGGCTCCGCCGCCCAGAGCATGTTGGGCGAGCGGGTCCGGCGGGTGGCTGTACCGCTCACGCCCGAGTA
CCGCCACGACGTGGAGGCGATGGCGGGAGCCGTGACCCCCAGGACCCGGGTGGTCGTCATCACCAACCCCAACAATCCCA
CCGGCACCGCCCTTACCCTGGCCGAGATCACCCGCCTGGCCGACCGCCTCGATCCAAAGACCCTGCTGGTGGTCGACGAA
GCCTACATCGACTTTGCCGAGTCGCCCGGGGTGATGAGCGCCATGGGCCTTGCCGCGAGCCGGCCCAACGTGCTGGTCAC
CCGCACCTTCTCCAAAATCCACGGCCTGGCGGGGCTCAGGCTCGGTTACGCGGTCGCATCCCAACCGGTGCGCGAGCGGT
TGCGCCCTTACCTGCTCAACATGCTGGGGGTGAACACCGCCGTTGTGGCCGCCGCCGCCGCTTCCCTCGCCGACGCCGAC
TACCTGATGCGCTCACGCCAGGTCGCTGTGGCCGCCCGTACCCAACTGCTGGCCAAACTGCCCGAATTCGGCCTGAAGCC
CGTGCCCGGCGACGCGCCCTTTGTCTGGGCCAAAGTCCAAGGCGACTGCGGCCCGCTGGTTCAGAAACTGGCCCGCGCCG
ATGTACTGATTGCAGGCGGCCAGCGCTGGCAGCTACCCGGCTATGTGCGCATCTCCACGGGTCTACCGGCGGAGATGGAC
ATGCTCTTTGCCACCCTCGGAGCGAAGGCGTAG

Upstream 100 bases:

>100_bases
GGTTGCAACAACGCCAAGCCGAAAGCGATGTATTTATTGTAGGCGGAAAGCATCGAGTCCCCTGGTAGTAGCGATCTCCA
CAATCGCCACAGTCTAAATC

Downstream 100 bases:

>100_bases
CACCCATTAATGCATAGACAAGCGGTACTGTTCTGCGCGCTGGTCGGCGTGCATCTGTTGGGATCGATCCTACTGGAGCA
AGCGATGGCGGCGGAGCCGG

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MLRRSIGLYRSVPVEISRRAALQGLSWWAGVAAVAPPALWAAEVRRVSSVQGVGVPAGTVRLLYNENPLGPSPLALKAAS
EALDGCNRYPMATVFSLLEGICALHGLSLASPGSAADLGALFEAFEASSVLLGAGSSEILQAVALAWGLDGGEFVEASPG
YGAVGSAAQSMLGERVRRVAVPLTPEYRHDVEAMAGAVTPRTRVVVITNPNNPTGTALTLAEITRLADRLDPKTLLVVDE
AYIDFAESPGVMSAMGLAASRPNVLVTRTFSKIHGLAGLRLGYAVASQPVRERLRPYLLNMLGVNTAVVAAAAASLADAD
YLMRSRQVAVAARTQLLAKLPEFGLKPVPGDAPFVWAKVQGDCGPLVQKLARADVLIAGGQRWQLPGYVRISTGLPAEMD
MLFATLGAKA

Sequences:

>Translated_410_residues
MLRRSIGLYRSVPVEISRRAALQGLSWWAGVAAVAPPALWAAEVRRVSSVQGVGVPAGTVRLLYNENPLGPSPLALKAAS
EALDGCNRYPMATVFSLLEGICALHGLSLASPGSAADLGALFEAFEASSVLLGAGSSEILQAVALAWGLDGGEFVEASPG
YGAVGSAAQSMLGERVRRVAVPLTPEYRHDVEAMAGAVTPRTRVVVITNPNNPTGTALTLAEITRLADRLDPKTLLVVDE
AYIDFAESPGVMSAMGLAASRPNVLVTRTFSKIHGLAGLRLGYAVASQPVRERLRPYLLNMLGVNTAVVAAAAASLADAD
YLMRSRQVAVAARTQLLAKLPEFGLKPVPGDAPFVWAKVQGDCGPLVQKLARADVLIAGGQRWQLPGYVRISTGLPAEMD
MLFATLGAKA
>Mature_410_residues
MLRRSIGLYRSVPVEISRRAALQGLSWWAGVAAVAPPALWAAEVRRVSSVQGVGVPAGTVRLLYNENPLGPSPLALKAAS
EALDGCNRYPMATVFSLLEGICALHGLSLASPGSAADLGALFEAFEASSVLLGAGSSEILQAVALAWGLDGGEFVEASPG
YGAVGSAAQSMLGERVRRVAVPLTPEYRHDVEAMAGAVTPRTRVVVITNPNNPTGTALTLAEITRLADRLDPKTLLVVDE
AYIDFAESPGVMSAMGLAASRPNVLVTRTFSKIHGLAGLRLGYAVASQPVRERLRPYLLNMLGVNTAVVAAAAASLADAD
YLMRSRQVAVAARTQLLAKLPEFGLKPVPGDAPFVWAKVQGDCGPLVQKLARADVLIAGGQRWQLPGYVRISTGLPAEMD
MLFATLGAKA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=332, Percent_Identity=25.3012048192771, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786816, Length=278, Percent_Identity=28.0575539568345, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322075, Length=353, Percent_Identity=26.0623229461756, Blast_Score=77, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 42925; Mature: 42925

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRRSIGLYRSVPVEISRRAALQGLSWWAGVAAVAPPALWAAEVRRVSSVQGVGVPAGTV
CCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEE
RLLYNENPLGPSPLALKAASEALDGCNRYPMATVFSLLEGICALHGLSLASPGSAADLGA
EEEECCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
LFEAFEASSVLLGAGSSEILQAVALAWGLDGGEFVEASPGYGAVGSAAQSMLGERVRRVA
HHHHHCCCCEEEECCHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHC
VPLTPEYRHDVEAMAGAVTPRTRVVVITNPNNPTGTALTLAEITRLADRLDPKTLLVVDE
CCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEH
AYIDFAESPGVMSAMGLAASRPNVLVTRTFSKIHGLAGLRLGYAVASQPVRERLRPYLLN
HHHHHCCCCCHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLGVNTAVVAAAAASLADADYLMRSRQVAVAARTQLLAKLPEFGLKPVPGDAPFVWAKVQ
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEC
GDCGPLVQKLARADVLIAGGQRWQLPGYVRISTGLPAEMDMLFATLGAKA
CCHHHHHHHHHHCCEEEECCCEECCCCEEEECCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MLRRSIGLYRSVPVEISRRAALQGLSWWAGVAAVAPPALWAAEVRRVSSVQGVGVPAGTV
CCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCEE
RLLYNENPLGPSPLALKAASEALDGCNRYPMATVFSLLEGICALHGLSLASPGSAADLGA
EEEECCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
LFEAFEASSVLLGAGSSEILQAVALAWGLDGGEFVEASPGYGAVGSAAQSMLGERVRRVA
HHHHHCCCCEEEECCHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHC
VPLTPEYRHDVEAMAGAVTPRTRVVVITNPNNPTGTALTLAEITRLADRLDPKTLLVVDE
CCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEH
AYIDFAESPGVMSAMGLAASRPNVLVTRTFSKIHGLAGLRLGYAVASQPVRERLRPYLLN
HHHHHCCCCCHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLGVNTAVVAAAAASLADADYLMRSRQVAVAARTQLLAKLPEFGLKPVPGDAPFVWAKVQ
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEC
GDCGPLVQKLARADVLIAGGQRWQLPGYVRISTGLPAEMDMLFATLGAKA
CCHHHHHHHHHHCCEEEECCCEECCCCEEEECCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA