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The map label for this gene is dfrA [H]

Identifier: 37522019

GI number: 37522019

Start: 2605990

End: 2607003

Strand: Direct

Name: dfrA [H]

Synonym: glr2450

Alternate gene names: 37522019

Gene position: 2605990-2607003 (Clockwise)

Preceding gene: 37522018

Following gene: 37522020

Centisome position: 55.93

GC content: 65.19

Gene sequence:

>1014_bases
GTGGTGCTGTGTGACCGCCGACACCTGAGCGGTTATGGTGGCTGCATGCGGAGCTTGATTACCGGTGCTTCGGGATTTAT
CGGCAAACGGCTCGCGCTTCGCCTGCTGGGCGAAGGACGCGGGGTGATCTACCTGGGCCGCCGTCCCGTCGCTGAACTCG
ACCGGCAGGGTGCCAAGTTTGTGCAGGGCGATATTGCCGACAAAGCCGCCGTCGATAGGGCAATGACCGGGGTGCAACGG
GTGTTTCACCTGGCGGCCTGGTTTGAATTCGGCATCGACGACCCTGAGAAGATGGAGCGCATCAACGTCGGGGGCACGCG
CAACGTGCTGGTATCCGCCCTGGAGCATGGTATGGAGCGGGTGGTGTATTCAAGCACCACGGGTATATACCACCCGACCC
AAGGGGTCGTCGATGAACGCTCGCCTGTGAGCGCTGCACCCGTCACCCATTACACCCGCACCAAGGTGGCGGCCCACGCT
GCGGCGGTCGAGTTATATTCTCGGGGTTGTCCGGTGGTGGTTGCCCTGCCGGGTTATGTCTATGGCCCCGACAGCGACGG
TCCCTTCGGCGGCAGCCTCCGGCAACTTCTGGCCGGCCAGATCCCGGCTCTGGTGGGGGCCGAGCAGCGCTCCAGCTACG
TCCACGTCGACGACGTGGTCGAAGGACTGTTGCTTGCCGAGCAACACGGCACCCTCGGGGAGACGTATATCCTGGCGGGC
GAGGTGATGAGCTTTCGCGAGTGGTACCGCCTGGTGGCCGAGGTGAGCGGCACGCCGGTCCCGAGCCTGGAACTGCCGCC
CTGGCTGCTCTACCCGGTGGCGGCGGTCTCGGAGTGGCTGGGCAAACTGGGTGGGCGGCCTTCGATCGTCTCGCGCGAGG
TGCTCGATTATCTGCAGGGCGACATGACCGCCTCGGGAGCCAGGGCCGCAAAAGAACTGGGCTGGCAATCGCGGCCTTTG
CGTCCGGCGATAGCCGAAACCATCCGCTGGTACCAGGAGCACCCGGCGGGATGA

Upstream 100 bases:

>100_bases
GCATGATGATCTTCGAGGCCGATTCGCTGGAGGAAGCCCGGGCAATCGTGGCGGGCGACCCGCTGGTGCGCGACGGCTGC
GTCGAATTCGAGTTGCACCA

Downstream 100 bases:

>100_bases
ATCTGCGCGATGCTGTCGAGCACTGGCTCGATCATCTGATTGCCGCACGTTCCCTGGCGGGCAACACCCTCAAAGCCTAC
CAGCGCGATCTCGAAGAGTT

Product: hypothetical protein

Products: NA

Alternate protein names: DFR; Dihydrokaempferol 4-reductase [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MVLCDRRHLSGYGGCMRSLITGASGFIGKRLALRLLGEGRGVIYLGRRPVAELDRQGAKFVQGDIADKAAVDRAMTGVQR
VFHLAAWFEFGIDDPEKMERINVGGTRNVLVSALEHGMERVVYSSTTGIYHPTQGVVDERSPVSAAPVTHYTRTKVAAHA
AAVELYSRGCPVVVALPGYVYGPDSDGPFGGSLRQLLAGQIPALVGAEQRSSYVHVDDVVEGLLLAEQHGTLGETYILAG
EVMSFREWYRLVAEVSGTPVPSLELPPWLLYPVAAVSEWLGKLGGRPSIVSREVLDYLQGDMTASGARAAKELGWQSRPL
RPAIAETIRWYQEHPAG

Sequences:

>Translated_337_residues
MVLCDRRHLSGYGGCMRSLITGASGFIGKRLALRLLGEGRGVIYLGRRPVAELDRQGAKFVQGDIADKAAVDRAMTGVQR
VFHLAAWFEFGIDDPEKMERINVGGTRNVLVSALEHGMERVVYSSTTGIYHPTQGVVDERSPVSAAPVTHYTRTKVAAHA
AAVELYSRGCPVVVALPGYVYGPDSDGPFGGSLRQLLAGQIPALVGAEQRSSYVHVDDVVEGLLLAEQHGTLGETYILAG
EVMSFREWYRLVAEVSGTPVPSLELPPWLLYPVAAVSEWLGKLGGRPSIVSREVLDYLQGDMTASGARAAKELGWQSRPL
RPAIAETIRWYQEHPAG
>Mature_337_residues
MVLCDRRHLSGYGGCMRSLITGASGFIGKRLALRLLGEGRGVIYLGRRPVAELDRQGAKFVQGDIADKAAVDRAMTGVQR
VFHLAAWFEFGIDDPEKMERINVGGTRNVLVSALEHGMERVVYSSTTGIYHPTQGVVDERSPVSAAPVTHYTRTKVAAHA
AAVELYSRGCPVVVALPGYVYGPDSDGPFGGSLRQLLAGQIPALVGAEQRSSYVHVDDVVEGLLLAEQHGTLGETYILAG
EVMSFREWYRLVAEVSGTPVPSLELPPWLLYPVAAVSEWLGKLGGRPSIVSREVLDYLQGDMTASGARAAKELGWQSRPL
RPAIAETIRWYQEHPAG

Specific function: INVOLVED IN THE SYNTHESIS OF ENTEROBACTERIAL COMMON ANTIGEN (ECA) AND REQUIRED FOR SYNTHESIS OF LIPOPOLYSACCHARIDE O-SIDE CHAINS. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroflavonol-4-reductase family [H]

Homologues:

Organism=Homo sapiens, GI116268111, Length=353, Percent_Identity=29.7450424929178, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI239745448, Length=346, Percent_Identity=29.7687861271676, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI310132178, Length=346, Percent_Identity=29.4797687861272, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI310113012, Length=346, Percent_Identity=29.4797687861272, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI193211614, Length=264, Percent_Identity=22.3484848484848, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI8393516, Length=264, Percent_Identity=22.3484848484848, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17570557, Length=343, Percent_Identity=23.6151603498542, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR017829
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =1.1.1.219 [H]

Molecular weight: Translated: 36522; Mature: 36522

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLCDRRHLSGYGGCMRSLITGASGFIGKRLALRLLGEGRGVIYLGRRPVAELDRQGAKF
CCEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHCCHHH
VQGDIADKAAVDRAMTGVQRVFHLAAWFEFGIDDPEKMERINVGGTRNVLVSALEHGMER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHH
VVYSSTTGIYHPTQGVVDERSPVSAAPVTHYTRTKVAAHAAAVELYSRGCPVVVALPGYV
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCEE
YGPDSDGPFGGSLRQLLAGQIPALVGAEQRSSYVHVDDVVEGLLLAEQHGTLGETYILAG
ECCCCCCCCCHHHHHHHHHCCHHHHCHHHHCCEEEHHHHHHHHHHHHCCCCCCCHHHHHH
EVMSFREWYRLVAEVSGTPVPSLELPPWLLYPVAAVSEWLGKLGGRPSIVSREVLDYLQG
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
DMTASGARAAKELGWQSRPLRPAIAETIRWYQEHPAG
CCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVLCDRRHLSGYGGCMRSLITGASGFIGKRLALRLLGEGRGVIYLGRRPVAELDRQGAKF
CCEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHCCHHH
VQGDIADKAAVDRAMTGVQRVFHLAAWFEFGIDDPEKMERINVGGTRNVLVSALEHGMER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHH
VVYSSTTGIYHPTQGVVDERSPVSAAPVTHYTRTKVAAHAAAVELYSRGCPVVVALPGYV
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCEE
YGPDSDGPFGGSLRQLLAGQIPALVGAEQRSSYVHVDDVVEGLLLAEQHGTLGETYILAG
ECCCCCCCCCHHHHHHHHHCCHHHHCHHHHCCEEEHHHHHHHHHHHHCCCCCCCHHHHHH
EVMSFREWYRLVAEVSGTPVPSLELPPWLLYPVAAVSEWLGKLGGRPSIVSREVLDYLQG
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
DMTASGARAAKELGWQSRPLRPAIAETIRWYQEHPAG
CCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]