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The map label for this gene is hofD [H]

Identifier: 37522002

GI number: 37522002

Start: 2589477

End: 2590286

Strand: Direct

Name: hofD [H]

Synonym: glr2433

Alternate gene names: 37522002

Gene position: 2589477-2590286 (Clockwise)

Preceding gene: 37522001

Following gene: 37522003

Centisome position: 55.58

GC content: 63.83

Gene sequence:

>810_bases
GTGTTCGCCATCGGGTTTTGGGCAATCGTCGGGGCGGCGGTGGGCAGTTGCATCAACGTCGTCGCCCACCGTTTGCCCCA
GGGCATTTCGCTGTGGTGGCCACCTTCGCGCTGCCCCGGCTGCCTGACCCCGCTCGGGCCGCTGGAGAACGTACCGGTAC
TGGGTTGGTTGTGGTTGGGGGGTAAATGTCGTCACTGCCGGATGGCAATTCCGGTGCGCTATGCGCTGGTGGAACTGGGG
ACGGCGGGGTTATCCGGTGTGCTCGCCTGGCATTTTCAGGCGGCCTTTACCTCCACAAGCCTGGTGGAGGTGGCCTGCTG
GGGATTTTTTGTGGCGGTGCTGTTGGCGCTGAGCCTGATCGATCTCGACACGCTCGAACTGCCGGGGGAACTGACCGCCG
CCGGGATCGTCGGGGGGTTGGTGTTCCGTACGTTTTTTCCAGTCTGGGCAAGCGGCGCCTGGGCGAGCGGCCCGCCCGGT
CTGGTGGACGCGCTGTACGGACTGCTGGTAGGTATCGGGCTATTCGATGTGATTAGCTACGTCGGCGAGAAGGCGATGGG
CAAAGAGGCGATGGGGGGCGGCGATGCGACCCTGGCGGGGCTCATCGGCGTCTGGCTGGGGTGGAAGTTGCTTCTGGTTT
CGCTCGCTTTTGGCTTTGGTCTAGGAGCGGTTTTCGGTCTGGCGGGCATCGCCGCCGGACGGCTCAAGCGCGAAGAGCCG
CTGCCCTTTGGCCCGTTTCTGGCCCTCGGTGCGCTGGGCGGGCTATTGTTTGGGGAAAGCTGGATAACGAGTTACATGAC
GCTGTTTTAA

Upstream 100 bases:

>100_bases
GGGTGTCTGGCGGCTGATTGCGTCGTGCCCGGGTTTTGTGCAGCCAGTTCAGGGAGGTTGGACGTTAGGCTAGAACCGTT
CAGACGGCAGGAGGCCCCGG

Downstream 100 bases:

>100_bases
TCCGATGACCCTCGATGTACAGGTGACGAACGTAACGAGCGCACTGGCCGCCTTGTTGGGCCTCAAAAGCGGCATGGGTG
TCGAAATCGCCCCCGAGCAA

Product: type 4 prepilin peptidase

Products: NA

Alternate protein names: Leader peptidase; Prepilin peptidase; N-methyltransferase [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MFAIGFWAIVGAAVGSCINVVAHRLPQGISLWWPPSRCPGCLTPLGPLENVPVLGWLWLGGKCRHCRMAIPVRYALVELG
TAGLSGVLAWHFQAAFTSTSLVEVACWGFFVAVLLALSLIDLDTLELPGELTAAGIVGGLVFRTFFPVWASGAWASGPPG
LVDALYGLLVGIGLFDVISYVGEKAMGKEAMGGGDATLAGLIGVWLGWKLLLVSLAFGFGLGAVFGLAGIAAGRLKREEP
LPFGPFLALGALGGLLFGESWITSYMTLF

Sequences:

>Translated_269_residues
MFAIGFWAIVGAAVGSCINVVAHRLPQGISLWWPPSRCPGCLTPLGPLENVPVLGWLWLGGKCRHCRMAIPVRYALVELG
TAGLSGVLAWHFQAAFTSTSLVEVACWGFFVAVLLALSLIDLDTLELPGELTAAGIVGGLVFRTFFPVWASGAWASGPPG
LVDALYGLLVGIGLFDVISYVGEKAMGKEAMGGGDATLAGLIGVWLGWKLLLVSLAFGFGLGAVFGLAGIAAGRLKREEP
LPFGPFLALGALGGLLFGESWITSYMTLF
>Mature_269_residues
MFAIGFWAIVGAAVGSCINVVAHRLPQGISLWWPPSRCPGCLTPLGPLENVPVLGWLWLGGKCRHCRMAIPVRYALVELG
TAGLSGVLAWHFQAAFTSTSLVEVACWGFFVAVLLALSLIDLDTLELPGELTAAGIVGGLVFRTFFPVWASGAWASGPPG
LVDALYGLLVGIGLFDVISYVGEKAMGKEAMGGGDATLAGLIGVWLGWKLLLVSLAFGFGLGAVFGLAGIAAGRLKREEP
LPFGPFLALGALGGLLFGESWITSYMTLF

Specific function: Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue [H]

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A24 family [H]

Homologues:

Organism=Escherichia coli, GI87082194, Length=265, Percent_Identity=32.8301886792453, Blast_Score=88, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010627
- InterPro:   IPR014032
- InterPro:   IPR000045 [H]

Pfam domain/function: PF06750 DiS_P_DiS; PF01478 Peptidase_A24 [H]

EC number: =3.4.23.43 [H]

Molecular weight: Translated: 28152; Mature: 28152

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAIGFWAIVGAAVGSCINVVAHRLPQGISLWWPPSRCPGCLTPLGPLENVPVLGWLWLG
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEEECC
GKCRHCRMAIPVRYALVELGTAGLSGVLAWHFQAAFTSTSLVEVACWGFFVAVLLALSLI
CCCCCCEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLDTLELPGELTAAGIVGGLVFRTFFPVWASGAWASGPPGLVDALYGLLVGIGLFDVISY
CCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VGEKAMGKEAMGGGDATLAGLIGVWLGWKLLLVSLAFGFGLGAVFGLAGIAAGRLKREEP
HHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LPFGPFLALGALGGLLFGESWITSYMTLF
CCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFAIGFWAIVGAAVGSCINVVAHRLPQGISLWWPPSRCPGCLTPLGPLENVPVLGWLWLG
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEEECC
GKCRHCRMAIPVRYALVELGTAGLSGVLAWHFQAAFTSTSLVEVACWGFFVAVLLALSLI
CCCCCCEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLDTLELPGELTAAGIVGGLVFRTFFPVWASGAWASGPPGLVDALYGLLVGIGLFDVISY
CCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VGEKAMGKEAMGGGDATLAGLIGVWLGWKLLLVSLAFGFGLGAVFGLAGIAAGRLKREEP
HHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LPFGPFLALGALGGLLFGESWITSYMTLF
CCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]