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The map label for this gene is aacA4 [H]

Identifier: 37521985

GI number: 37521985

Start: 2572897

End: 2573418

Strand: Direct

Name: aacA4 [H]

Synonym: glr2416

Alternate gene names: 37521985

Gene position: 2572897-2573418 (Clockwise)

Preceding gene: 37521984

Following gene: 37521994

Centisome position: 55.22

GC content: 64.18

Gene sequence:

>522_bases
ATGTCGGGCTTAATTTCGATGACCTTCCGTCCGCTCGCACTGGCTGACCTGGTCTTGCTTCACGAGTGGCTGGCCCGTCC
GCATGTAGCCCAGTGGTGGGGACCGCCGCCCTCCGGTGCCGAAGTCGAGGAAGAGTATGGGCCGCTCCTTGACGGGACGG
GGCCGCATCGCGCTTACATCGCCCTTCAGGCGGGTATGCCCATCGGCTTTATCCAATCGTACACACCAGTGGCATGTCAT
GGGGAGGGGTGGTGGCTGGAGGAGCACGACGCAGGTGTACGCGGCATCGACCAGTTCCTCGCCCCTGCCGACCAGCTTGG
CCGGGGACTCGGTACCGCCATGGTCCTGGCCTTCGTGTCTGAGCTTCTGGCGGATCCGGGCGTCACGCGCATCCAGACCG
ACCCCTCCCCACAGAACCGCCGGGCCATTCGGTGCTACGAAAAAGCCGGCTTTCGGGCGGTCCGGGAGATCGACACGCCC
GACGGATGTGCCCTCCTGATGTACTACGATCGTCAAGTTTGA

Upstream 100 bases:

>100_bases
CCTCGACCTGGCCGTCGATGCGACGGATCTGGATACCTTCCGCTGCGCCGCGCAGTTTTGAGCAAACGGGTCTAAAAAAT
TGTACTCACTTCAGGCACGA

Downstream 100 bases:

>100_bases
CAAGGGTCCGCTAGTCCATGTTTGTTGCTCGACGAGCGTCTGCAGTTGTTCATGGCGCAAGCGAATGGGAGGGTGCGCAT
TTGCGCTACAGGATATTCCG

Product: aminoglycoside N6'-acetyltransferase

Products: NA

Alternate protein names: AAC(6'); Amikacin resistance protein [H]

Number of amino acids: Translated: 173; Mature: 172

Protein sequence:

>173_residues
MSGLISMTFRPLALADLVLLHEWLARPHVAQWWGPPPSGAEVEEEYGPLLDGTGPHRAYIALQAGMPIGFIQSYTPVACH
GEGWWLEEHDAGVRGIDQFLAPADQLGRGLGTAMVLAFVSELLADPGVTRIQTDPSPQNRRAIRCYEKAGFRAVREIDTP
DGCALLMYYDRQV

Sequences:

>Translated_173_residues
MSGLISMTFRPLALADLVLLHEWLARPHVAQWWGPPPSGAEVEEEYGPLLDGTGPHRAYIALQAGMPIGFIQSYTPVACH
GEGWWLEEHDAGVRGIDQFLAPADQLGRGLGTAMVLAFVSELLADPGVTRIQTDPSPQNRRAIRCYEKAGFRAVREIDTP
DGCALLMYYDRQV
>Mature_172_residues
SGLISMTFRPLALADLVLLHEWLARPHVAQWWGPPPSGAEVEEEYGPLLDGTGPHRAYIALQAGMPIGFIQSYTPVACHG
EGWWLEEHDAGVRGIDQFLAPADQLGRGLGTAMVLAFVSELLADPGVTRIQTDPSPQNRRAIRCYEKAGFRAVREIDTPD
GCALLMYYDRQV

Specific function: Resistance to antibiotics containing the purpurosamine ring including gentamicin, kanamycin, tobramycin, and neomycin [H]

COG id: COG1670

COG function: function code J; Acetyltransferases, including N-acetylases of ribosomal proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 N-acetyltransferase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000182
- InterPro:   IPR016181
- InterPro:   IPR019432 [H]

Pfam domain/function: PF00583 Acetyltransf_1; PF10331 AlcB [H]

EC number: =2.3.1.82 [H]

Molecular weight: Translated: 19042; Mature: 18911

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLISMTFRPLALADLVLLHEWLARPHVAQWWGPPPSGAEVEEEYGPLLDGTGPHRAYI
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCHHHCCCCCCCCCCCEEEE
ALQAGMPIGFIQSYTPVACHGEGWWLEEHDAGVRGIDQFLAPADQLGRGLGTAMVLAFVS
EEECCCCCHHHCCCCCEEECCCCCEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHH
ELLADPGVTRIQTDPSPQNRRAIRCYEKAGFRAVREIDTPDGCALLMYYDRQV
HHHCCCCCEEEECCCCCCCCHHHHHHHHHCHHHHHHCCCCCCEEEEEEECCCC
>Mature Secondary Structure 
SGLISMTFRPLALADLVLLHEWLARPHVAQWWGPPPSGAEVEEEYGPLLDGTGPHRAYI
CCCHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCHHHCCCCCCCCCCCEEEE
ALQAGMPIGFIQSYTPVACHGEGWWLEEHDAGVRGIDQFLAPADQLGRGLGTAMVLAFVS
EEECCCCCHHHCCCCCEEECCCCCEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHH
ELLADPGVTRIQTDPSPQNRRAIRCYEKAGFRAVREIDTPDGCALLMYYDRQV
HHHCCCCCEEEECCCCCCCCHHHHHHHHHCHHHHHHCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2841303; 1963948 [H]