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The map label for this gene is pcp

Identifier: 37521978

GI number: 37521978

Start: 2567565

End: 2568182

Strand: Direct

Name: pcp

Synonym: glr2409

Alternate gene names: 37521978

Gene position: 2567565-2568182 (Clockwise)

Preceding gene: 37521977

Following gene: 37521982

Centisome position: 55.11

GC content: 65.7

Gene sequence:

>618_bases
ATGCGGGTTCTGCTGACCGGCTTCGAGCCTTTCGCGGGGGAGCTTGTCAATCCCTCCTGGGAAGTGGCAAGCCGACTGGC
GGAGCGGCGAATTTCCGGTTGCACCGTGGCGGCGGAGCGGTTGCCGACCGTTTTCGGCGCCTCGATTGCCTGTCTGCGCA
CGGCCCTTGAGCGCCACCGCCCGCAGGCGGTGGTTTGTCTCGGCGAAGCCGGGGGACGCGCGGCCATCTCGATCGAGCGG
GTCGCCCTCAACCTCGATGAGGCACGCATCCCCGACAACAAGGGTCAGCAGCCGGTCGAGATTCCCGTCGAGCCCGGCGC
TCCGGCAGCTTACTTCGCGACATTGCCGGTGCGGGCGATCGTGGCAAAGCTACTGGCGGCGGGCATCCCGGCGGAAATTT
CGCGCACGGCCGGGGGGTTTGTCTGCAACCACACGTTCTACGGCCTGATGCACCATCTCGGGCAAGCCACCCCCGTGCGC
GCCGGGTTCATCCACATTCCCTATCTGCCGGAGCAGGCCGTTCGCTATCCCGGCAAAGCGAGCATGGAACTGGCGACCAC
CCTGCGCGGTATCGAAATGGTCCTGGAAGTGCTCAGATCAGAACAGAACGTCCTGTAG

Upstream 100 bases:

>100_bases
CAACCCGAGCCGCGACGCGGGCAGCCCCAAGTGGCTCGCCTGGCAGGATATCCAGCAGGTGCGCGCCAAGTACGACGAAC
TTGTGGTGCCCCGGTAGCCC

Downstream 100 bases:

>100_bases
ATTCAGGCGTGCCCCCGGCAGGACGTCTTCGCCGTCGAGCACCTGCGGAGACTGGAGTACTTCTGCATCCCGGCCCGGCC
GATAAATTTCGACCCGTTGG

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase; Pyroglutamyl-peptidase I; PGP-I; Pyrase

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MRVLLTGFEPFAGELVNPSWEVASRLAERRISGCTVAAERLPTVFGASIACLRTALERHRPQAVVCLGEAGGRAAISIER
VALNLDEARIPDNKGQQPVEIPVEPGAPAAYFATLPVRAIVAKLLAAGIPAEISRTAGGFVCNHTFYGLMHHLGQATPVR
AGFIHIPYLPEQAVRYPGKASMELATTLRGIEMVLEVLRSEQNVL

Sequences:

>Translated_205_residues
MRVLLTGFEPFAGELVNPSWEVASRLAERRISGCTVAAERLPTVFGASIACLRTALERHRPQAVVCLGEAGGRAAISIER
VALNLDEARIPDNKGQQPVEIPVEPGAPAAYFATLPVRAIVAKLLAAGIPAEISRTAGGFVCNHTFYGLMHHLGQATPVR
AGFIHIPYLPEQAVRYPGKASMELATTLRGIEMVLEVLRSEQNVL
>Mature_205_residues
MRVLLTGFEPFAGELVNPSWEVASRLAERRISGCTVAAERLPTVFGASIACLRTALERHRPQAVVCLGEAGGRAAISIER
VALNLDEARIPDNKGQQPVEIPVEPGAPAAYFATLPVRAIVAKLLAAGIPAEISRTAGGFVCNHTFYGLMHHLGQATPVR
AGFIHIPYLPEQAVRYPGKASMELATTLRGIEMVLEVLRSEQNVL

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PCP_GLOVI (Q7NHX6)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925355.1
- ProteinModelPortal:   Q7NHX6
- SMR:   Q7NHX6
- MEROPS:   C15.001
- GeneID:   2600810
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:glr2409
- NMPDR:   fig|251221.1.peg.2409
- HOGENOM:   HBG360405
- OMA:   NTAGTYV
- BioCyc:   GVIO251221:GLR2409-MONOMER
- BRENDA:   3.4.19.3
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00417
- InterPro:   IPR000816
- InterPro:   IPR016125
- Gene3D:   G3DSA:3.40.630.20
- PANTHER:   PTHR23402
- PIRSF:   PIRSF015592
- PRINTS:   PR00706
- TIGRFAMs:   TIGR00504

Pfam domain/function: PF01470 Peptidase_C15; SSF53182 Peptidase_C15-like

EC number: =3.4.19.3

Molecular weight: Translated: 22029; Mature: 22029

Theoretical pI: Translated: 7.98; Mature: 7.98

Prosite motif: PS01334 PYRASE_CYS; PS01333 PYRASE_GLU

Important sites: ACT_SITE 79-79 ACT_SITE 142-142 ACT_SITE 165-165

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLLTGFEPFAGELVNPSWEVASRLAERRISGCTVAAERLPTVFGASIACLRTALERHR
CEEEEECCCCHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
PQAVVCLGEAGGRAAISIERVALNLDEARIPDNKGQQPVEIPVEPGAPAAYFATLPVRAI
CCEEEEEECCCCEEEEEEEHHEECCCHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHH
VAKLLAAGIPAEISRTAGGFVCNHTFYGLMHHLGQATPVRAGFIHIPYLPEQAVRYPGKA
HHHHHHCCCCHHHHHCCCCEEHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHCCCCCC
SMELATTLRGIEMVLEVLRSEQNVL
HHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRVLLTGFEPFAGELVNPSWEVASRLAERRISGCTVAAERLPTVFGASIACLRTALERHR
CEEEEECCCCHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
PQAVVCLGEAGGRAAISIERVALNLDEARIPDNKGQQPVEIPVEPGAPAAYFATLPVRAI
CCEEEEEECCCCEEEEEEEHHEECCCHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHH
VAKLLAAGIPAEISRTAGGFVCNHTFYGLMHHLGQATPVRAGFIHIPYLPEQAVRYPGKA
HHHHHHCCCCHHHHHCCCCEEHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHCCCCCC
SMELATTLRGIEMVLEVLRSEQNVL
HHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292