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The map label for this gene is todF [H]

Identifier: 37521904

GI number: 37521904

Start: 2497813

End: 2498679

Strand: Reverse

Name: todF [H]

Synonym: gll2335

Alternate gene names: 37521904

Gene position: 2498679-2497813 (Counterclockwise)

Preceding gene: 37521906

Following gene: 37521901

Centisome position: 53.63

GC content: 62.4

Gene sequence:

>867_bases
ATGGCAACATCTTTGGCGAGCACCAGTAAAAGATGGACCTGGCGCGGCTGGCAGGTTCACTACGTCGAAGCCGGCACCGA
CCGACCCGGAGTGCCTCTGCTGTTGGTGCATGGCTTCGGAGCCTCCACCGACCACTGGCGCAAGAACATCGGGCCGCTCA
GTGAGCACCATCCGGTCTGGGCTGTCGATCTATTGGGGTTTGGCCGCACCCAAAAGCCCAACATCGCCTACAGCGGCGAG
TTGTGGCGCGATCAACTGCGCGATTTTACAAGCGAGATTATCGGCCGGCCGCCGGTGGTGGCGGGCAATTCCCTGGGCGG
CTACGCGGCCCTGGTGCTGGCCGCGGACCACCCGGAATGGGTAAAGGGCCTGGTGCTCATCAATGGTGCGGGGCCGTTTT
CGGGAGCCCCCCAGCCGAATGCGTTTCAGAAATTGACCGGCGAGGTGGCCAAGGGCTTTTTCTCCCAGAGTTGGGCAAGC
TGGCTGCTGTTTCAGTATTTTCGCCAACCCTCGAACATCCGGCGAGTGCTGGGCCAGGTCTACCACGACCAGGGTGCGGT
GACAGACGAGCTGGTCGCCGACATTTATCGCCCTTCGTGCGATCCGGGGGCGGCGGTAGTGTTTGCCTCGGTCTTCCAGA
CTCCCCAGGGCCGCTACGTCGACGAATTGCTGGGAAGCCTCCGGCGACCGCTGTTGTTGCTGTGGGGCGAGAGCGATCCC
TGGATGAACGTCGATCGGGCAAAGCGCTTTCTCGAGGCGTACCCGAGCGGTCAATTGCAGTTGATTCCAGCGGGCCATTG
CCCCCACGACGAGCGGCCCGAACTGGTCAACGCTTACTTGAGCGAGTGGGCCGAGCAAATTTCCTAG

Upstream 100 bases:

>100_bases
CACGCCGGCTCATGCAGCAAGTCCTCTCGCACAACGATTCCACGATGGCATAGGCAAACTGCCGTTTCCTCTGTCCGGCG
GTCCGCTAAAATGTTAAGTA

Downstream 100 bases:

>100_bases
CCCCGAATGGCCCTGGGTGGTTGAAGGCGTTTTCACTCAGCGCCTGGAAAATACCAGTTCGAGAGTCTCCCCGGGAGCCG
GGTGCAAAAACCGGCTGGCA

Product: hypothetical protein

Products: NA

Alternate protein names: HOHH [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MATSLASTSKRWTWRGWQVHYVEAGTDRPGVPLLLVHGFGASTDHWRKNIGPLSEHHPVWAVDLLGFGRTQKPNIAYSGE
LWRDQLRDFTSEIIGRPPVVAGNSLGGYAALVLAADHPEWVKGLVLINGAGPFSGAPQPNAFQKLTGEVAKGFFSQSWAS
WLLFQYFRQPSNIRRVLGQVYHDQGAVTDELVADIYRPSCDPGAAVVFASVFQTPQGRYVDELLGSLRRPLLLLWGESDP
WMNVDRAKRFLEAYPSGQLQLIPAGHCPHDERPELVNAYLSEWAEQIS

Sequences:

>Translated_288_residues
MATSLASTSKRWTWRGWQVHYVEAGTDRPGVPLLLVHGFGASTDHWRKNIGPLSEHHPVWAVDLLGFGRTQKPNIAYSGE
LWRDQLRDFTSEIIGRPPVVAGNSLGGYAALVLAADHPEWVKGLVLINGAGPFSGAPQPNAFQKLTGEVAKGFFSQSWAS
WLLFQYFRQPSNIRRVLGQVYHDQGAVTDELVADIYRPSCDPGAAVVFASVFQTPQGRYVDELLGSLRRPLLLLWGESDP
WMNVDRAKRFLEAYPSGQLQLIPAGHCPHDERPELVNAYLSEWAEQIS
>Mature_287_residues
ATSLASTSKRWTWRGWQVHYVEAGTDRPGVPLLLVHGFGASTDHWRKNIGPLSEHHPVWAVDLLGFGRTQKPNIAYSGEL
WRDQLRDFTSEIIGRPPVVAGNSLGGYAALVLAADHPEWVKGLVLINGAGPFSGAPQPNAFQKLTGEVAKGFFSQSWASW
LLFQYFRQPSNIRRVLGQVYHDQGAVTDELVADIYRPSCDPGAAVVFASVFQTPQGRYVDELLGSLRRPLLLLWGESDPW
MNVDRAKRFLEAYPSGQLQLIPAGHCPHDERPELVNAYLSEWAEQIS

Specific function: Not Clear. Seems To Be Implicated In The Early Steps Of Biotin Biosynthesis. [C]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dmpD/todF/xylF esterase family [H]

Homologues:

Organism=Homo sapiens, GI218777837, Length=287, Percent_Identity=27.1777003484321, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24586387, Length=111, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24586391, Length=111, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24586389, Length=111, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24586385, Length=111, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: NA

Molecular weight: Translated: 32041; Mature: 31909

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATSLASTSKRWTWRGWQVHYVEAGTDRPGVPLLLVHGFGASTDHWRKNIGPLSEHHPVW
CCCCCCCCCCCEEECCCEEEEEECCCCCCCCCEEEEECCCCCCHHHHHCCCCCCCCCCEE
AVDLLGFGRTQKPNIAYSGELWRDQLRDFTSEIIGRPPVVAGNSLGGYAALVLAADHPEW
EEEECCCCCCCCCCEEECCHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEEECCCHHH
VKGLVLINGAGPFSGAPQPNAFQKLTGEVAKGFFSQSWASWLLFQYFRQPSNIRRVLGQV
EEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
YHDQGAVTDELVADIYRPSCDPGAAVVFASVFQTPQGRYVDELLGSLRRPLLLLWGESDP
HHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEECCCCC
WMNVDRAKRFLEAYPSGQLQLIPAGHCPHDERPELVNAYLSEWAEQIS
CCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ATSLASTSKRWTWRGWQVHYVEAGTDRPGVPLLLVHGFGASTDHWRKNIGPLSEHHPVW
CCCCCCCCCCEEECCCEEEEEECCCCCCCCCEEEEECCCCCCHHHHHCCCCCCCCCCEE
AVDLLGFGRTQKPNIAYSGELWRDQLRDFTSEIIGRPPVVAGNSLGGYAALVLAADHPEW
EEEECCCCCCCCCCEEECCHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEEECCCHHH
VKGLVLINGAGPFSGAPQPNAFQKLTGEVAKGFFSQSWASWLLFQYFRQPSNIRRVLGQV
EEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
YHDQGAVTDELVADIYRPSCDPGAAVVFASVFQTPQGRYVDELLGSLRRPLLLLWGESDP
HHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEECCCCC
WMNVDRAKRFLEAYPSGQLQLIPAGHCPHDERPELVNAYLSEWAEQIS
CCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1916282; 2670929 [H]