Click here to switch to the map view.

The map label for this gene is qor [C]

Identifier: 37521829

GI number: 37521829

Start: 2422095

End: 2423108

Strand: Reverse

Name: qor [C]

Synonym: gll2260

Alternate gene names: 37521829

Gene position: 2423108-2422095 (Counterclockwise)

Preceding gene: 37521831

Following gene: 37521828

Centisome position: 52.01

GC content: 65.09

Gene sequence:

>1014_bases
ATGAAAGCCGTGGGCTACAGACAGCCGCTGCCGGTGGACGACCCGAACGCGCTGCTCGATGTCGATTTGCCGGAACCGGC
AGTGGCCGGGCGCGATCTGCTCGTCGAGGTCAAGGCTATCTCCGTCAATCCGGTGGATACGAAGGTGCGCCGCGGCACCG
CGCCGCCGGAGGGCCAGATCAAGGTGCTCGGTTGGGATGCGAGCGGCGTCGTGCGCGCGGTGGGGCCCGAGGTGAGTTTG
TTTCGACCGGGCGATGCGGTATGGTATGCGGGCTCGATCGTCCGCCCCGGCACCAACAGCGAACTGCACACCGTCGATGA
GCGCATCGTGGGCCGCAAGCCTGCGAGCCTCGATTTTGCCCGGGCCGCCGCTTTGCCGCTCACGACGATCACCGCCTGGG
AGTTGCTGTTCGATCGCCTGCAAGTGGCCCGGGACAGGACCGGGCGGGGCGAGACGCTGCTCATTGTCGGGGCTGCCGGG
GGGGTAGGTTCGATCCTCACCCAACTGGCGCGGCAGTTGACCGGGATCACGGTGATCGGCACCGCCTCGCGGCCCGAAAC
CCGAAAGTGGGTCCAGGATCTGGGTGCCCACCACGTCATCGACCACTCCAGACCCCTGGTTGAACAACTGCAGCGCCTCG
GCATCCCGCAAGTGTCCTATGTGGCGAGCCTGACGCAGACCGACACGCACTACGCCCAGCTGGTCGAAGCGCTCGCGCCC
CAGGGCAGGCTCGCTCTTATCGACGATCCCGGGCCGCTCGATGTGACGCTGCTCAAGCGCAAGAGCCTGTCGCTGCACTG
GGAATTGATGTTCACCCGCTCACTTTTCACGACCGCCGACCTCATCGAACAGCACCGTCTGTTGGACGAGGTGGCCCAAA
TGGTGGAGGCCGGGGTGATCCAGACCACCGTGGGCGAGCATTTCGGACGGATTTGCGCTGAAAACCTGCGCAAGGCCCAT
GCCCTGATCGAGAGCGGTCAGGCCAAAGGCAAGATCGTTTTGGAAGGATTTTGA

Upstream 100 bases:

>100_bases
TGAGCGTGGAGCCGTTGGCTTCGAATTATCGATCATCTGTAGTGCGATCGGTGCTTCCGTCAAAATCGATCAGTGACCAC
AATTTTTTGAGGAGTTGTTT

Downstream 100 bases:

>100_bases
GCGACGGCGCGGGGCTCACGCTCCAAACTTTGGGCCGATGGACGGAGCGCATTGGGTAACATAAACTACCGAAGTTACCC
ATAGGGTTTTGGCCCCCGGT

Product: oxidoreductase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MKAVGYRQPLPVDDPNALLDVDLPEPAVAGRDLLVEVKAISVNPVDTKVRRGTAPPEGQIKVLGWDASGVVRAVGPEVSL
FRPGDAVWYAGSIVRPGTNSELHTVDERIVGRKPASLDFARAAALPLTTITAWELLFDRLQVARDRTGRGETLLIVGAAG
GVGSILTQLARQLTGITVIGTASRPETRKWVQDLGAHHVIDHSRPLVEQLQRLGIPQVSYVASLTQTDTHYAQLVEALAP
QGRLALIDDPGPLDVTLLKRKSLSLHWELMFTRSLFTTADLIEQHRLLDEVAQMVEAGVIQTTVGEHFGRICAENLRKAH
ALIESGQAKGKIVLEGF

Sequences:

>Translated_337_residues
MKAVGYRQPLPVDDPNALLDVDLPEPAVAGRDLLVEVKAISVNPVDTKVRRGTAPPEGQIKVLGWDASGVVRAVGPEVSL
FRPGDAVWYAGSIVRPGTNSELHTVDERIVGRKPASLDFARAAALPLTTITAWELLFDRLQVARDRTGRGETLLIVGAAG
GVGSILTQLARQLTGITVIGTASRPETRKWVQDLGAHHVIDHSRPLVEQLQRLGIPQVSYVASLTQTDTHYAQLVEALAP
QGRLALIDDPGPLDVTLLKRKSLSLHWELMFTRSLFTTADLIEQHRLLDEVAQMVEAGVIQTTVGEHFGRICAENLRKAH
ALIESGQAKGKIVLEGF
>Mature_337_residues
MKAVGYRQPLPVDDPNALLDVDLPEPAVAGRDLLVEVKAISVNPVDTKVRRGTAPPEGQIKVLGWDASGVVRAVGPEVSL
FRPGDAVWYAGSIVRPGTNSELHTVDERIVGRKPASLDFARAAALPLTTITAWELLFDRLQVARDRTGRGETLLIVGAAG
GVGSILTQLARQLTGITVIGTASRPETRKWVQDLGAHHVIDHSRPLVEQLQRLGIPQVSYVASLTQTDTHYAQLVEALAP
QGRLALIDDPGPLDVTLLKRKSLSLHWELMFTRSLFTTADLIEQHRLLDEVAQMVEAGVIQTTVGEHFGRICAENLRKAH
ALIESGQAKGKIVLEGF

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=335, Percent_Identity=29.5522388059701, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI194239674, Length=320, Percent_Identity=25.9375, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI13236495, Length=320, Percent_Identity=25.9375, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI194239676, Length=185, Percent_Identity=34.5945945945946, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI24308257, Length=308, Percent_Identity=26.9480519480519, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI18379349, Length=217, Percent_Identity=32.258064516129, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1790485, Length=337, Percent_Identity=29.3768545994065, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17507255, Length=244, Percent_Identity=31.5573770491803, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71987554, Length=184, Percent_Identity=32.0652173913043, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319520, Length=324, Percent_Identity=26.8518518518519, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36534; Mature: 36534

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVGYRQPLPVDDPNALLDVDLPEPAVAGRDLLVEVKAISVNPVDTKVRRGTAPPEGQI
CCCCCCCCCCCCCCCCCEEECCCCCCCCCCCEEEEEEEEEEECCCCHHHHCCCCCCCCCE
KVLGWDASGVVRAVGPEVSLFRPGDAVWYAGSIVRPGTNSELHTVDERIVGRKPASLDFA
EEEEECCCCEEEECCCCEEEECCCCEEEEECEEECCCCCCHHHHHHHHHHCCCCCCCHHH
RAAALPLTTITAWELLFDRLQVARDRTGRGETLLIVGAAGGVGSILTQLARQLTGITVIG
HHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEE
TASRPETRKWVQDLGAHHVIDHSRPLVEQLQRLGIPQVSYVASLTQTDTHYAQLVEALAP
CCCCCHHHHHHHHCCCHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHCC
QGRLALIDDPGPLDVTLLKRKSLSLHWELMFTRSLFTTADLIEQHRLLDEVAQMVEAGVI
CCCEEEECCCCCCEEEEEECCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
QTTVGEHFGRICAENLRKAHALIESGQAKGKIVLEGF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
>Mature Secondary Structure
MKAVGYRQPLPVDDPNALLDVDLPEPAVAGRDLLVEVKAISVNPVDTKVRRGTAPPEGQI
CCCCCCCCCCCCCCCCCEEECCCCCCCCCCCEEEEEEEEEEECCCCHHHHCCCCCCCCCE
KVLGWDASGVVRAVGPEVSLFRPGDAVWYAGSIVRPGTNSELHTVDERIVGRKPASLDFA
EEEEECCCCEEEECCCCEEEECCCCEEEEECEEECCCCCCHHHHHHHHHHCCCCCCCHHH
RAAALPLTTITAWELLFDRLQVARDRTGRGETLLIVGAAGGVGSILTQLARQLTGITVIG
HHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEE
TASRPETRKWVQDLGAHHVIDHSRPLVEQLQRLGIPQVSYVASLTQTDTHYAQLVEALAP
CCCCCHHHHHHHHCCCHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHCC
QGRLALIDDPGPLDVTLLKRKSLSLHWELMFTRSLFTTADLIEQHRLLDEVAQMVEAGVI
CCCEEEECCCCCCEEEEEECCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
QTTVGEHFGRICAENLRKAHALIESGQAKGKIVLEGF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]