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The map label for this gene is luxQ [H]

Identifier: 37521827

GI number: 37521827

Start: 2419843

End: 2421054

Strand: Direct

Name: luxQ [H]

Synonym: glr2258

Alternate gene names: 37521827

Gene position: 2419843-2421054 (Clockwise)

Preceding gene: 37521826

Following gene: 37521830

Centisome position: 51.94

GC content: 62.05

Gene sequence:

>1212_bases
ATGGACTTCAGCAAACTACTTGCAGACCGGAGCGATGCGATCATCGAGCAGTGGATCGCGGCCGTCCGCTCCGACCGCCG
GATCAGCAGCGACGACGGACTGCCCTACTCCGCCGTGCGCAACAGTTTGCCCGATGTGCTCAGGGCAATGGTCACCGTCC
TTTCCCAGACGGAGAAGAGCGACACCGGACTGCTGGTGAGCAAAAGCCTGGTGCACGGTTCCCTGCGGGCCAGCCAGGGT
TTCAACCCCGCTGAAATTGCCCAGGAGTATCGGTTGCTGCGCCGGGTGATCTTCACGGTCCTGGATGGGGAAATGACGCG
CGGTTCAATAACCGGGGTGGTGCGGGCCGTCCATCTGATCAACGAGGTGGTGGACGAGGCGATCGCTTCTTGCTTCCAAA
GCTACGTGGATGAGCGCCTGCGCGAACTGGCGCAACTGCAAAGCCAGTTGTTGCTCACCAATCAAGAACTTGGCCGGTTG
GTGCGCGCCCACCAGGACAATCTCTCGGTGCTGGCCCACGAGTTGAAGACTCCCCTCAATTCGATCATCGGCTATGCAAA
TCTCTTTTTGCGCACCGGCCGTACCCGCACGGACATCGGGGACACCCTGCCCGACTTCGAACACATCGAGCGGGTGGTGC
GCAACGGCACCCGGCTGCTGCACCTGATCAACGATGCGCTGGAGTTTTCGCGCTCGGAGGCCGGGCAGACCCGGTTGCAC
CTGGAGGCGGTCGCGCTGCGCCCGACAGTCGAAGAAGTGGTCGAGACGATCCGGCCGCTGGCCGCAGCGCAGGGTTTGGA
AGTTTCGCTCGATTGCGGGTTGGCCCCCCAGACCGTAGCGAGCGACAGCATGCGCCTGCAACAAATCCTCACCAACCTGC
TCAGCAATGCCGTGCGCTACACCCCGAGCGGTTCTGTACGGGTGGAGTGCAAGGCTGTGGACGACAGACACTGGTCGGTC
GCCGTGAGCGACACTGGTCTGGGCATCGCCCCCGAAGATCAACCCCACATCTTCGAGCCCTACTCGCGTTTCAGCTGCAA
CGAGCGCAGCCGGACCGAAGGCACCGGGCTCGGGCTTGCGATCGTCTCCCAACTGGTGAACCTGCTGCAGGGCAAAATCG
CGCTGGTCTCTGAACCCGGTGTCGGCTCGACATTCACTGTGACCTTCCCTGTGCAAGTCCAATCTCTCACAGCCCAGAAC
ACACCGATTTGA

Upstream 100 bases:

>100_bases
CCTCTACAATCGTGAGCATTCACGGGTGCTTGGAAGGTGCTGGGGGCGGAAGTGATTCGTCGGAACCGGTTCCTTCCACT
CCACTATTGACTCGCCAGCC

Downstream 100 bases:

>100_bases
GCATAGGTAGCTGAGCTGCAGCAGCCAGCCGAACTGTCCGGCGCAGGAAAACCCACTCACTTCAGAGCATGAAGTGAGCG
GATATCCTTGCGCCGGTCGG

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MDFSKLLADRSDAIIEQWIAAVRSDRRISSDDGLPYSAVRNSLPDVLRAMVTVLSQTEKSDTGLLVSKSLVHGSLRASQG
FNPAEIAQEYRLLRRVIFTVLDGEMTRGSITGVVRAVHLINEVVDEAIASCFQSYVDERLRELAQLQSQLLLTNQELGRL
VRAHQDNLSVLAHELKTPLNSIIGYANLFLRTGRTRTDIGDTLPDFEHIERVVRNGTRLLHLINDALEFSRSEAGQTRLH
LEAVALRPTVEEVVETIRPLAAAQGLEVSLDCGLAPQTVASDSMRLQQILTNLLSNAVRYTPSGSVRVECKAVDDRHWSV
AVSDTGLGIAPEDQPHIFEPYSRFSCNERSRTEGTGLGLAIVSQLVNLLQGKIALVSEPGVGSTFTVTFPVQVQSLTAQN
TPI

Sequences:

>Translated_403_residues
MDFSKLLADRSDAIIEQWIAAVRSDRRISSDDGLPYSAVRNSLPDVLRAMVTVLSQTEKSDTGLLVSKSLVHGSLRASQG
FNPAEIAQEYRLLRRVIFTVLDGEMTRGSITGVVRAVHLINEVVDEAIASCFQSYVDERLRELAQLQSQLLLTNQELGRL
VRAHQDNLSVLAHELKTPLNSIIGYANLFLRTGRTRTDIGDTLPDFEHIERVVRNGTRLLHLINDALEFSRSEAGQTRLH
LEAVALRPTVEEVVETIRPLAAAQGLEVSLDCGLAPQTVASDSMRLQQILTNLLSNAVRYTPSGSVRVECKAVDDRHWSV
AVSDTGLGIAPEDQPHIFEPYSRFSCNERSRTEGTGLGLAIVSQLVNLLQGKIALVSEPGVGSTFTVTFPVQVQSLTAQN
TPI
>Mature_403_residues
MDFSKLLADRSDAIIEQWIAAVRSDRRISSDDGLPYSAVRNSLPDVLRAMVTVLSQTEKSDTGLLVSKSLVHGSLRASQG
FNPAEIAQEYRLLRRVIFTVLDGEMTRGSITGVVRAVHLINEVVDEAIASCFQSYVDERLRELAQLQSQLLLTNQELGRL
VRAHQDNLSVLAHELKTPLNSIIGYANLFLRTGRTRTDIGDTLPDFEHIERVVRNGTRLLHLINDALEFSRSEAGQTRLH
LEAVALRPTVEEVVETIRPLAAAQGLEVSLDCGLAPQTVASDSMRLQQILTNLLSNAVRYTPSGSVRVECKAVDDRHWSV
AVSDTGLGIAPEDQPHIFEPYSRFSCNERSRTEGTGLGLAIVSQLVNLLQGKIALVSEPGVGSTFTVTFPVQVQSLTAQN
TPI

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=266, Percent_Identity=34.9624060150376, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI145693157, Length=263, Percent_Identity=31.9391634980989, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1788713, Length=236, Percent_Identity=31.3559322033898, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI87081816, Length=330, Percent_Identity=28.7878787878788, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1786783, Length=250, Percent_Identity=31.6, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI48994928, Length=235, Percent_Identity=31.9148936170213, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788549, Length=230, Percent_Identity=30, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790346, Length=241, Percent_Identity=28.6307053941909, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI87082128, Length=251, Percent_Identity=29.8804780876494, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1790436, Length=223, Percent_Identity=29.1479820627803, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1786912, Length=227, Percent_Identity=29.5154185022026, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787894, Length=222, Percent_Identity=30.1801801801802, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786600, Length=271, Percent_Identity=28.7822878228782, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788393, Length=293, Percent_Identity=26.6211604095563, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788279, Length=222, Percent_Identity=25.6756756756757, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789808, Length=137, Percent_Identity=33.5766423357664, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790861, Length=217, Percent_Identity=32.258064516129, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790551, Length=205, Percent_Identity=29.7560975609756, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 44254; Mature: 44254

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFSKLLADRSDAIIEQWIAAVRSDRRISSDDGLPYSAVRNSLPDVLRAMVTVLSQTEKS
CCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
DTGLLVSKSLVHGSLRASQGFNPAEIAQEYRLLRRVIFTVLDGEMTRGSITGVVRAVHLI
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
NEVVDEAIASCFQSYVDERLRELAQLQSQLLLTNQELGRLVRAHQDNLSVLAHELKTPLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
SIIGYANLFLRTGRTRTDIGDTLPDFEHIERVVRNGTRLLHLINDALEFSRSEAGQTRLH
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHEE
LEAVALRPTVEEVVETIRPLAAAQGLEVSLDCGLAPQTVASDSMRLQQILTNLLSNAVRY
HHHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEE
TPSGSVRVECKAVDDRHWSVAVSDTGLGIAPEDQPHIFEPYSRFSCNERSRTEGTGLGLA
CCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCHHHH
IVSQLVNLLQGKIALVSEPGVGSTFTVTFPVQVQSLTAQNTPI
HHHHHHHHHCCCEEEEECCCCCCEEEEEEEEEEEECCCCCCCC
>Mature Secondary Structure
MDFSKLLADRSDAIIEQWIAAVRSDRRISSDDGLPYSAVRNSLPDVLRAMVTVLSQTEKS
CCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
DTGLLVSKSLVHGSLRASQGFNPAEIAQEYRLLRRVIFTVLDGEMTRGSITGVVRAVHLI
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
NEVVDEAIASCFQSYVDERLRELAQLQSQLLLTNQELGRLVRAHQDNLSVLAHELKTPLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
SIIGYANLFLRTGRTRTDIGDTLPDFEHIERVVRNGTRLLHLINDALEFSRSEAGQTRLH
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHEE
LEAVALRPTVEEVVETIRPLAAAQGLEVSLDCGLAPQTVASDSMRLQQILTNLLSNAVRY
HHHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEE
TPSGSVRVECKAVDDRHWSVAVSDTGLGIAPEDQPHIFEPYSRFSCNERSRTEGTGLGLA
CCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCHHHH
IVSQLVNLLQGKIALVSEPGVGSTFTVTFPVQVQSLTAQNTPI
HHHHHHHHHCCCEEEEECCCCCCEEEEEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]