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The map label for this gene is def

Identifier: 37521797

GI number: 37521797

Start: 2388063

End: 2388626

Strand: Reverse

Name: def

Synonym: gll2228

Alternate gene names: 37521797

Gene position: 2388626-2388063 (Counterclockwise)

Preceding gene: 37521798

Following gene: 37521795

Centisome position: 51.27

GC content: 63.3

Gene sequence:

>564_bases
ATGGCGAACCAACTGCAGGTGCCCAAGCAAAAGCTGGCCAAGCCGCCCCTGGCGATTCACACCCTCGGGGACCGGGTCTT
GCGCCAGGGCAGCAAACAAATCTCGGGCATCAACGACGAAGTGCGCAAGCTCGCCCAGCAGATGCTCCAGACGATGTACA
GCGCCGACGGTATCGGCCTTGCCGCCCCCCAGGTAGGCGTCAACAAGCGGATGATCGTCGTCGACATCGACCCGGAGAAC
GCCGCCCGGCCGCCGCTGGTGCTCATCAACCCGCTGATCAAGCAATTCAGCAGCGATCTGGCCGTCGATCAAGAAGGCTG
CCTGAGCGTGCCCAGCATTTACGCCGATGTGCGCCGTCCCGAGCGCGTCGTGGCTACCTACCGCGACTTGAACGGTCGGC
CGGTCACCCTCGAAGCGACCGGCCTGCTCGCCCGCTGCATCCAGCATGAGATCGATCACCTTGATGGTGTGCTGTTCGTC
GATCGCGTCGAGAACCAGATTGCCCTCGCTCCCCAACTGGTCGAAAAAGGATTTGCCGTCCGGGACGTACAGGTGCGCGC
CTGA

Upstream 100 bases:

>100_bases
GTACTGAGCGCTCAGGCACTGGCGGTCTGAAGGCCGATCCCAGCCGCCGTCGGGAGATCAAGGGTGCCATAATGGACCTA
TCGAGCTTTTCGGCGTATCT

Downstream 100 bases:

>100_bases
GCAAATTTGGGCCATTGCAGATATAAAAAACCAGGCTTCGAGCCTGGTTTTTTATGGGATGGGATATGGGCTGAGGTGCT
ACTGCAACTCGGCGGTCTCT

Product: peptide deformylase

Products: NA

Alternate protein names: PDF 2; Polypeptide deformylase 2

Number of amino acids: Translated: 187; Mature: 186

Protein sequence:

>187_residues
MANQLQVPKQKLAKPPLAIHTLGDRVLRQGSKQISGINDEVRKLAQQMLQTMYSADGIGLAAPQVGVNKRMIVVDIDPEN
AARPPLVLINPLIKQFSSDLAVDQEGCLSVPSIYADVRRPERVVATYRDLNGRPVTLEATGLLARCIQHEIDHLDGVLFV
DRVENQIALAPQLVEKGFAVRDVQVRA

Sequences:

>Translated_187_residues
MANQLQVPKQKLAKPPLAIHTLGDRVLRQGSKQISGINDEVRKLAQQMLQTMYSADGIGLAAPQVGVNKRMIVVDIDPEN
AARPPLVLINPLIKQFSSDLAVDQEGCLSVPSIYADVRRPERVVATYRDLNGRPVTLEATGLLARCIQHEIDHLDGVLFV
DRVENQIALAPQLVEKGFAVRDVQVRA
>Mature_186_residues
ANQLQVPKQKLAKPPLAIHTLGDRVLRQGSKQISGINDEVRKLAQQMLQTMYSADGIGLAAPQVGVNKRMIVVDIDPENA
ARPPLVLINPLIKQFSSDLAVDQEGCLSVPSIYADVRRPERVVATYRDLNGRPVTLEATGLLARCIQHEIDHLDGVLFVD
RVENQIALAPQLVEKGFAVRDVQVRA

Specific function: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions

COG id: COG0242

COG function: function code J; N-formylmethionyl-tRNA deformylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the polypeptide deformylase family

Homologues:

Organism=Homo sapiens, GI11641243, Length=174, Percent_Identity=33.9080459770115, Blast_Score=86, Evalue=2e-17,
Organism=Escherichia coli, GI1789682, Length=138, Percent_Identity=45.6521739130435, Blast_Score=119, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24645728, Length=171, Percent_Identity=32.7485380116959, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24645726, Length=168, Percent_Identity=31.547619047619, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DEF2_GLOVI (Q7NIF5)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925174.1
- ProteinModelPortal:   Q7NIF5
- SMR:   Q7NIF5
- GeneID:   2600630
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:gll2228
- NMPDR:   fig|251221.1.peg.2228
- HOGENOM:   HBG665227
- OMA:   MVIKKFT
- ProtClustDB:   PRK00150
- BioCyc:   GVIO251221:GLL2228-MONOMER
- BRENDA:   3.5.1.88
- GO:   GO:0006412
- HAMAP:   MF_00163
- InterPro:   IPR000181
- Gene3D:   G3DSA:3.90.45.10
- PANTHER:   PTHR10458
- PIRSF:   PIRSF004749
- PRINTS:   PR01576
- TIGRFAMs:   TIGR00079

Pfam domain/function: PF01327 Pep_deformylase; SSF56420 Fmet_deformylase

EC number: =3.5.1.88

Molecular weight: Translated: 20557; Mature: 20426

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: NA

Important sites: ACT_SITE 150-150

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANQLQVPKQKLAKPPLAIHTLGDRVLRQGSKQISGINDEVRKLAQQMLQTMYSADGIGL
CCCCCCCCHHHHCCCCEEEHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCC
AAPQVGVNKRMIVVDIDPENAARPPLVLINPLIKQFSSDLAVDQEGCLSVPSIYADVRRP
CCCCCCCCCEEEEEEECCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCH
ERVVATYRDLNGRPVTLEATGLLARCIQHEIDHLDGVLFVDRVENQIALAPQLVEKGFAV
HHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCEEEEEHHCCHHHHHHHHHHCCCCE
RDVQVRA
EEEEECC
>Mature Secondary Structure 
ANQLQVPKQKLAKPPLAIHTLGDRVLRQGSKQISGINDEVRKLAQQMLQTMYSADGIGL
CCCCCCCHHHHCCCCEEEHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCC
AAPQVGVNKRMIVVDIDPENAARPPLVLINPLIKQFSSDLAVDQEGCLSVPSIYADVRRP
CCCCCCCCCEEEEEEECCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCH
ERVVATYRDLNGRPVTLEATGLLARCIQHEIDHLDGVLFVDRVENQIALAPQLVEKGFAV
HHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCEEEEEHHCCHHHHHHHHHHCCCCE
RDVQVRA
EEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292