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The map label for this gene is ddc [H]

Identifier: 37521791

GI number: 37521791

Start: 2377254

End: 2378852

Strand: Reverse

Name: ddc [H]

Synonym: gll2222

Alternate gene names: 37521791

Gene position: 2378852-2377254 (Counterclockwise)

Preceding gene: 37521792

Following gene: 37521790

Centisome position: 51.06

GC content: 64.04

Gene sequence:

>1599_bases
ATGCAGTCCATGCAGCCACCCGAATTACAAGCACCGCTCCAGACTCAAGAATCGCGCTGCCCACAGCCGCCCTTTGAGCA
TCTGTTTCTATCTGGGGCTGAGGCGGGCACTGCTGCCTACCGGCAGGCAGTCTCGACTGCCACCGATATCCTCGTGCGCT
TCGCTCTCCAGCCGCAGCCGTACCGGGGGGCTAGCCCTCAGGAACTGGCAGCAGTTCTGGCAGGCGACCCCTGTCCGGAA
GCGGGCCTGCCGACTCGCGAAGTCCTCGAACGGGTCGAGGAACTGGTCGTACAGCACTCGGTCAAGGTGACCCATCCTGA
CTGCATCGCCCACCTGCACTGTCCGCCGTTGATCCCGGCCCTCGCAGCGGAGATGGTGGTGAGCGCTACCAATCAGTCCC
TCGACTCCTGGGACCAGAGCCCGGCAGCGACGATCGTCGAGCAGCAAATCGTACAGTGGCTCTGCCGGTTGTACTTCGCC
CAGGCGGGCGACGGTACCTTCACGAGTGGAGGTACTCAGTCCAACTTCATGGGCCTGCTCCTGGCCAGGGACCACTATGC
ACTCACACACCTGGACTGGAACTGCGAGGAACGGGGCCTGCCGCCGGGGGCGGAGCGTCTGCGCATTCTCTGTTCGCAGG
CGGCCCACTTCACCGTGCAGAAGTCCGCAGGACTTTTGGGCCTGGGCCGCGCCTCCGTCGTCCCTGTCGGGCCGGACTCG
GACTACCGCCTCCGCGGCGTTGCCGTCGAGCGGGCCATTGCCGACTTGCGGCGCGACGGGCTCTCGCCCATCGCCCTGGT
AGCTACCGCTGGGACCACCGACCTCGGCAGCATCGACGCCATGGCAGAACTGGCGATAGTCGCCCGTACCCACGGCCTCT
GGCTGCATGCCGACGCCGCGGTCGGCGGGGCACTCGCCTTGAGCGAGCACCACCGCGGTCTCCTCGCGGGTATCGAGGCT
GCCGACTCCATCACCGTGGACTTCCATAAACTGTTCTACCAGCCCATCAGTTGTGGGGCATTTCTAGTTCGCAACCGGCG
GGCTTTCGAGGTTCTAAGGCTCCACGCCGACTGCCTCAACCCCGAAGGCACCGAGGAAGCGGGCATCCCTGACCTTGTCA
TCAAGTCTGTCCTGACCACCCGCCGCTTCGACGCTCTCAAACTCTACATCTGCCTCCAGGCGCTTGGTCGGCGCGAGTTC
GCCCGCCTTGTCGAGTCGACGATGGAACTGGCCCGGGCGACTGCAACCATCATCGAGCACGACCCGGAACTGGAACTGGC
CTGCTACCCGGCTATCAATGCCGTGGTCTTCCGCTACGCTCCAGAGGGGCTATCTGCCTTTGAACTCGATTCGATCAATA
AAACCGTCCAGGCGACCCTGCTGCGAAGGGGAAGGGCCGTCGTTGCCCGGACCCGGCTCAAAGACCGGGTCCAGCTGAAG
TTCACCTTGCTCAACCCCCTGACCACGGTCGACCATATCCGCGGTCTGCTTCAGGAAATCAAGGCCATCGGCAGGGCAGA
GGCTGCCCGGGGCGTAGCAGCGGACCCGGCGAGCACTGTATCTTGTCTAGCGCCAAATAGCCCAATGCTGAATCTCTAA

Upstream 100 bases:

>100_bases
ATCGTCGAAGTGGGCGGGCGCGACGGCAGCGTCGTGCGCTTCCTGCCGCCGCTCATCGTCACCGACAGCCAGATAGACAC
AATAGCCGAGGTATTCCACG

Downstream 100 bases:

>100_bases
TTTCAGAGAGTACCTGGCCTTCAGGTCTTTCTATGCATGTTCAGCTAAAGATTGACCGCCTGAGTTGGATGTTGTTTATA
CAAGGAAATCATGACGTCAA

Product: L-2,4-diaminobutyrate decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MQSMQPPELQAPLQTQESRCPQPPFEHLFLSGAEAGTAAYRQAVSTATDILVRFALQPQPYRGASPQELAAVLAGDPCPE
AGLPTREVLERVEELVVQHSVKVTHPDCIAHLHCPPLIPALAAEMVVSATNQSLDSWDQSPAATIVEQQIVQWLCRLYFA
QAGDGTFTSGGTQSNFMGLLLARDHYALTHLDWNCEERGLPPGAERLRILCSQAAHFTVQKSAGLLGLGRASVVPVGPDS
DYRLRGVAVERAIADLRRDGLSPIALVATAGTTDLGSIDAMAELAIVARTHGLWLHADAAVGGALALSEHHRGLLAGIEA
ADSITVDFHKLFYQPISCGAFLVRNRRAFEVLRLHADCLNPEGTEEAGIPDLVIKSVLTTRRFDALKLYICLQALGRREF
ARLVESTMELARATATIIEHDPELELACYPAINAVVFRYAPEGLSAFELDSINKTVQATLLRRGRAVVARTRLKDRVQLK
FTLLNPLTTVDHIRGLLQEIKAIGRAEAARGVAADPASTVSCLAPNSPMLNL

Sequences:

>Translated_532_residues
MQSMQPPELQAPLQTQESRCPQPPFEHLFLSGAEAGTAAYRQAVSTATDILVRFALQPQPYRGASPQELAAVLAGDPCPE
AGLPTREVLERVEELVVQHSVKVTHPDCIAHLHCPPLIPALAAEMVVSATNQSLDSWDQSPAATIVEQQIVQWLCRLYFA
QAGDGTFTSGGTQSNFMGLLLARDHYALTHLDWNCEERGLPPGAERLRILCSQAAHFTVQKSAGLLGLGRASVVPVGPDS
DYRLRGVAVERAIADLRRDGLSPIALVATAGTTDLGSIDAMAELAIVARTHGLWLHADAAVGGALALSEHHRGLLAGIEA
ADSITVDFHKLFYQPISCGAFLVRNRRAFEVLRLHADCLNPEGTEEAGIPDLVIKSVLTTRRFDALKLYICLQALGRREF
ARLVESTMELARATATIIEHDPELELACYPAINAVVFRYAPEGLSAFELDSINKTVQATLLRRGRAVVARTRLKDRVQLK
FTLLNPLTTVDHIRGLLQEIKAIGRAEAARGVAADPASTVSCLAPNSPMLNL
>Mature_532_residues
MQSMQPPELQAPLQTQESRCPQPPFEHLFLSGAEAGTAAYRQAVSTATDILVRFALQPQPYRGASPQELAAVLAGDPCPE
AGLPTREVLERVEELVVQHSVKVTHPDCIAHLHCPPLIPALAAEMVVSATNQSLDSWDQSPAATIVEQQIVQWLCRLYFA
QAGDGTFTSGGTQSNFMGLLLARDHYALTHLDWNCEERGLPPGAERLRILCSQAAHFTVQKSAGLLGLGRASVVPVGPDS
DYRLRGVAVERAIADLRRDGLSPIALVATAGTTDLGSIDAMAELAIVARTHGLWLHADAAVGGALALSEHHRGLLAGIEA
ADSITVDFHKLFYQPISCGAFLVRNRRAFEVLRLHADCLNPEGTEEAGIPDLVIKSVLTTRRFDALKLYICLQALGRREF
ARLVESTMELARATATIIEHDPELELACYPAINAVVFRYAPEGLSAFELDSINKTVQATLLRRGRAVVARTRLKDRVQLK
FTLLNPLTTVDHIRGLLQEIKAIGRAEAARGVAADPASTVSCLAPNSPMLNL

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI197383062, Length=437, Percent_Identity=27.6887871853547, Blast_Score=182, Evalue=9e-46,
Organism=Homo sapiens, GI197276620, Length=431, Percent_Identity=27.1461716937355, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI4503875, Length=431, Percent_Identity=27.1461716937355, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI194294551, Length=456, Percent_Identity=29.3859649122807, Blast_Score=169, Evalue=8e-42,
Organism=Homo sapiens, GI92110055, Length=474, Percent_Identity=27.6371308016878, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI58331246, Length=441, Percent_Identity=25.8503401360544, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI4503281, Length=430, Percent_Identity=25.3488372093023, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI132814448, Length=430, Percent_Identity=25.3488372093023, Blast_Score=132, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI71993062, Length=439, Percent_Identity=25.7403189066059, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17555682, Length=428, Percent_Identity=25.7009345794392, Blast_Score=151, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI71993058, Length=357, Percent_Identity=26.890756302521, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17534817, Length=462, Percent_Identity=25.7575757575758, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17534819, Length=462, Percent_Identity=25.7575757575758, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI133931025, Length=464, Percent_Identity=25.2155172413793, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71981211, Length=388, Percent_Identity=23.1958762886598, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71981217, Length=397, Percent_Identity=22.6700251889169, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21356415, Length=374, Percent_Identity=31.283422459893, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI17136594, Length=436, Percent_Identity=26.8348623853211, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24652373, Length=488, Percent_Identity=27.4590163934426, Blast_Score=139, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24585139, Length=448, Percent_Identity=26.5625, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI221476190, Length=448, Percent_Identity=26.5625, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24585143, Length=448, Percent_Identity=26.5625, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24657193, Length=415, Percent_Identity=24.8192771084337, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24657185, Length=415, Percent_Identity=24.8192771084337, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24657188, Length=415, Percent_Identity=24.8192771084337, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17136190, Length=466, Percent_Identity=26.3948497854077, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24585135, Length=466, Percent_Identity=26.3948497854077, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24586044, Length=414, Percent_Identity=25.1207729468599, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI28573972, Length=458, Percent_Identity=25.1091703056769, Blast_Score=105, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 57552; Mature: 57552

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSMQPPELQAPLQTQESRCPQPPFEHLFLSGAEAGTAAYRQAVSTATDILVRFALQPQP
CCCCCCCCCCCCCHHHHHCCCCCCHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
YRGASPQELAAVLAGDPCPEAGLPTREVLERVEELVVQHSVKVTHPDCIAHLHCPPLIPA
CCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCEECCHHHHHCCCCCCHHHH
LAAEMVVSATNQSLDSWDQSPAATIVEQQIVQWLCRLYFAQAGDGTFTSGGTQSNFMGLL
HHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEE
LARDHYALTHLDWNCEERGLPPGAERLRILCSQAAHFTVQKSAGLLGLGRASVVPVGPDS
EECCCEEEEEECCCCHHCCCCCCHHHHHHHHHHHHHEEEECCCCEEEECCCCEEECCCCC
DYRLRGVAVERAIADLRRDGLSPIALVATAGTTDLGSIDAMAELAIVARTHGLWLHADAA
CCEEEHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCEEEEECCC
VGGALALSEHHRGLLAGIEAADSITVDFHKLFYQPISCGAFLVRNRRAFEVLRLHADCLN
CCCHHHHHHHCCHHHHHCCCCCCEEHHHHHHHHCHHCCCHHHHCCCHHHHHHHHHHHHCC
PEGTEEAGIPDLVIKSVLTTRRFDALKLYICLQALGRREFARLVESTMELARATATIIEH
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCC
DPELELACYPAINAVVFRYAPEGLSAFELDSINKTVQATLLRRGRAVVARTRLKDRVQLK
CCCCEEEEECHHHHEEEEECCCCCCEEEHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEE
FTLLNPLTTVDHIRGLLQEIKAIGRAEAARGVAADPASTVSCLAPNSPMLNL
EEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCC
>Mature Secondary Structure
MQSMQPPELQAPLQTQESRCPQPPFEHLFLSGAEAGTAAYRQAVSTATDILVRFALQPQP
CCCCCCCCCCCCCHHHHHCCCCCCHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
YRGASPQELAAVLAGDPCPEAGLPTREVLERVEELVVQHSVKVTHPDCIAHLHCPPLIPA
CCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCEECCHHHHHCCCCCCHHHH
LAAEMVVSATNQSLDSWDQSPAATIVEQQIVQWLCRLYFAQAGDGTFTSGGTQSNFMGLL
HHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEE
LARDHYALTHLDWNCEERGLPPGAERLRILCSQAAHFTVQKSAGLLGLGRASVVPVGPDS
EECCCEEEEEECCCCHHCCCCCCHHHHHHHHHHHHHEEEECCCCEEEECCCCEEECCCCC
DYRLRGVAVERAIADLRRDGLSPIALVATAGTTDLGSIDAMAELAIVARTHGLWLHADAA
CCEEEHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCEEEEECCC
VGGALALSEHHRGLLAGIEAADSITVDFHKLFYQPISCGAFLVRNRRAFEVLRLHADCLN
CCCHHHHHHHCCHHHHHCCCCCCEEHHHHHHHHCHHCCCHHHHCCCHHHHHHHHHHHHCC
PEGTEEAGIPDLVIKSVLTTRRFDALKLYICLQALGRREFARLVESTMELARATATIIEH
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCC
DPELELACYPAINAVVFRYAPEGLSAFELDSINKTVQATLLRRGRAVVARTRLKDRVQLK
CCCCEEEEECHHHHEEEEECCCCCCEEEHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEE
FTLLNPLTTVDHIRGLLQEIKAIGRAEAARGVAADPASTVSCLAPNSPMLNL
EEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614 [H]