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The map label for this gene is hdc [H]

Identifier: 37521788

GI number: 37521788

Start: 2374383

End: 2375531

Strand: Reverse

Name: hdc [H]

Synonym: gll2219

Alternate gene names: 37521788

Gene position: 2375531-2374383 (Counterclockwise)

Preceding gene: 37521789

Following gene: 37521787

Centisome position: 50.99

GC content: 59.01

Gene sequence:

>1149_bases
ATGAGTACGGCCGGTATTCGCGCGAGTGTTGCAGATGAATTAGTGACCTACGGTCTTTCCCTGGATATCCACAAGCGCAA
CCACCTCGGGTACCCTTTCTGTCTGAAGTACGACCATGCCGAACAGCTAGCCGAGACAATCCAGGACCAGCGCTACACCC
TCATCAACATCGGTGATCCATTCAGTTCGCCCATATACCAGATCAGCAGCCTTGAGTACGAGCGGCAGGTGCTGGGCTTC
TTTGCCGAACTCTTCGGGCTCGACCGGCAGCCGCGGCCCTGGTGGGGATACATTGGCAGTTGTGGGACCGAGGGCAACCT
ATACGGACTGCTGCTGGGCCGCCTCGCCCAGCCCGAAGGGATCTTATACTTCTCCGAGGCCGCCCACTACTCGGTCGGAA
AAGCTGCCCGCATGTTCCGCATGCCCTACCGCAAGGTCCGTTCCCAGGCAAGCGGCGAAATGGACTATGCTCACCTGGCC
GAGATCGTCGAGTCGGGGCAGCCCGTCATCATCAACTTGACCCTGGGGACGACGTTTACCGGTGCGGTGGACGAGATTGG
CCGCACTGTTGAGGCCCTGACTGGTAGGGGCATTGGCCTCGATCAGGTTTATATCCATGTCGACGCTGCCCTCGGCGGGA
TGATCGCCTGCTACATCAGGCCCGAACTGATTAGTTTCGACTGGCCGATCGGTTCGCTCGCCATCTCCGGGCACAAGTTT
ATCGGCTGTCCTCACCCCTGCGGTGTGGTGCTCACCTACAAAGAGACGGCCGACCGGTTCAGCTCTGAGATCAGCGCCGA
GGTTGAATACATCGGCTCGACGGATCTGACGATCATGGGCTCCCGAAATGGCCATACGCCTCTGTACCTGTGGGCAGAAA
TCCAGCGCCGAAAAAGCACCTTCCACCTTGAAGCTGAAGCGATAGTCGATAAGGCTCGGTTCCTGCACCAGAAGCTAAGT
GACCAAGGGCTCCCGGCGCTGCTCAATCCTCTTTCGAGCACGGTCGTTTTCCCGCGTCCCCCGCAGCCGGTCATCGCGAA
ATATCAACTTGCCGTCCAGGTGGACCAGGCTCACGCGGTGATCATGCAACAGCACAGCTACGAGCTTCTAGAAGAGTTCG
CCGGGGTGCTGGGCACTTGCCTAGGTTGA

Upstream 100 bases:

>100_bases
CTGCCGAATGGCATTCTCGGCGATTCGCAGGAATTCCCGTTGCTCCTGCGCGCGAAGGCGGGAGACATCAGAGATTTCAC
TTCATCACGGAGGATAAGCT

Downstream 100 bases:

>100_bases
CTCGCCGCAGGCAAGGGAGCCGAGGTTCGCTCAGGCGTCTTTCTCGTACCATCCGGCAACCCGCTCGTAGGTGTGGGCAA
CCTAGAAGAGCCCGCTCTCT

Product: histidine decarboxylase

Products: NA

Alternate protein names: HDC [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MSTAGIRASVADELVTYGLSLDIHKRNHLGYPFCLKYDHAEQLAETIQDQRYTLINIGDPFSSPIYQISSLEYERQVLGF
FAELFGLDRQPRPWWGYIGSCGTEGNLYGLLLGRLAQPEGILYFSEAAHYSVGKAARMFRMPYRKVRSQASGEMDYAHLA
EIVESGQPVIINLTLGTTFTGAVDEIGRTVEALTGRGIGLDQVYIHVDAALGGMIACYIRPELISFDWPIGSLAISGHKF
IGCPHPCGVVLTYKETADRFSSEISAEVEYIGSTDLTIMGSRNGHTPLYLWAEIQRRKSTFHLEAEAIVDKARFLHQKLS
DQGLPALLNPLSSTVVFPRPPQPVIAKYQLAVQVDQAHAVIMQQHSYELLEEFAGVLGTCLG

Sequences:

>Translated_382_residues
MSTAGIRASVADELVTYGLSLDIHKRNHLGYPFCLKYDHAEQLAETIQDQRYTLINIGDPFSSPIYQISSLEYERQVLGF
FAELFGLDRQPRPWWGYIGSCGTEGNLYGLLLGRLAQPEGILYFSEAAHYSVGKAARMFRMPYRKVRSQASGEMDYAHLA
EIVESGQPVIINLTLGTTFTGAVDEIGRTVEALTGRGIGLDQVYIHVDAALGGMIACYIRPELISFDWPIGSLAISGHKF
IGCPHPCGVVLTYKETADRFSSEISAEVEYIGSTDLTIMGSRNGHTPLYLWAEIQRRKSTFHLEAEAIVDKARFLHQKLS
DQGLPALLNPLSSTVVFPRPPQPVIAKYQLAVQVDQAHAVIMQQHSYELLEEFAGVLGTCLG
>Mature_381_residues
STAGIRASVADELVTYGLSLDIHKRNHLGYPFCLKYDHAEQLAETIQDQRYTLINIGDPFSSPIYQISSLEYERQVLGFF
AELFGLDRQPRPWWGYIGSCGTEGNLYGLLLGRLAQPEGILYFSEAAHYSVGKAARMFRMPYRKVRSQASGEMDYAHLAE
IVESGQPVIINLTLGTTFTGAVDEIGRTVEALTGRGIGLDQVYIHVDAALGGMIACYIRPELISFDWPIGSLAISGHKFI
GCPHPCGVVLTYKETADRFSSEISAEVEYIGSTDLTIMGSRNGHTPLYLWAEIQRRKSTFHLEAEAIVDKARFLHQKLSD
QGLPALLNPLSSTVVFPRPPQPVIAKYQLAVQVDQAHAVIMQQHSYELLEEFAGVLGTCLG

Specific function: Catalyzes The Production Of Gaba. [C]

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

None

Paralogues:

None

Copy number: 3820 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.22 [H]

Molecular weight: Translated: 42276; Mature: 42145

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTAGIRASVADELVTYGLSLDIHKRNHLGYPFCLKYDHAEQLAETIQDQRYTLINIGDP
CCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCEEEEECHHHHHHHHHHCCCEEEEEECCC
FSSPIYQISSLEYERQVLGFFAELFGLDRQPRPWWGYIGSCGTEGNLYGLLLGRLAQPEG
CCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCC
ILYFSEAAHYSVGKAARMFRMPYRKVRSQASGEMDYAHLAEIVESGQPVIINLTLGTTFT
EEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEECCCCC
GAVDEIGRTVEALTGRGIGLDQVYIHVDAALGGMIACYIRPELISFDWPIGSLAISGHKF
CHHHHHHHHHHHHCCCCCCCEEEEEEEEEHHCCEEEEEECCCCEEECCCCCCEEECCCEE
IGCPHPCGVVLTYKETADRFSSEISAEVEYIGSTDLTIMGSRNGHTPLYLWAEIQRRKST
ECCCCCCCEEEEEHHHHHHHHHHHCCEEEEECCCCEEEEECCCCCCCEEEEEEHHHCCCE
FHLEAEAIVDKARFLHQKLSDQGLPALLNPLSSTVVFPRPPQPVIAKYQLAVQVDQAHAV
EEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEECCCCCCCHHEEEEEEEEECCHHHH
IMQQHSYELLEEFAGVLGTCLG
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STAGIRASVADELVTYGLSLDIHKRNHLGYPFCLKYDHAEQLAETIQDQRYTLINIGDP
CCCCCHHHHHHHHHHHCCEEEEECCCCCCCCEEEEECHHHHHHHHHHCCCEEEEEECCC
FSSPIYQISSLEYERQVLGFFAELFGLDRQPRPWWGYIGSCGTEGNLYGLLLGRLAQPEG
CCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCC
ILYFSEAAHYSVGKAARMFRMPYRKVRSQASGEMDYAHLAEIVESGQPVIINLTLGTTFT
EEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEECCCCC
GAVDEIGRTVEALTGRGIGLDQVYIHVDAALGGMIACYIRPELISFDWPIGSLAISGHKF
CHHHHHHHHHHHHCCCCCCCEEEEEEEEEHHCCEEEEEECCCCEEECCCCCCEEECCCEE
IGCPHPCGVVLTYKETADRFSSEISAEVEYIGSTDLTIMGSRNGHTPLYLWAEIQRRKST
ECCCCCCCEEEEEHHHHHHHHHHHCCEEEEECCCCEEEEECCCCCCCEEEEEEHHHCCCE
FHLEAEAIVDKARFLHQKLSDQGLPALLNPLSSTVVFPRPPQPVIAKYQLAVQVDQAHAV
EEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEECCCCCCCHHEEEEEEEEECCHHHH
IMQQHSYELLEEFAGVLGTCLG
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA