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The map label for this gene is lhgO [H]

Identifier: 37521776

GI number: 37521776

Start: 2361018

End: 2362238

Strand: Reverse

Name: lhgO [H]

Synonym: gll2207

Alternate gene names: 37521776

Gene position: 2362238-2361018 (Counterclockwise)

Preceding gene: 37521777

Following gene: 37521775

Centisome position: 50.7

GC content: 66.5

Gene sequence:

>1221_bases
ATGAGCGCATTCGATTTTGCCATTGTCGGCGGCGGCATCGTCGGGCTCTCGGTGGGCATGGCCCTCACCGAGCGCTACCC
CGGCGCCCGCCTGCTGGTGCTCGAAAAAGAATCGTCCTGGGCCGGCCACCAGACCGGCCACAACAGCGGCGTCATCCATT
CGGGAGTCTACTACAAACCCGGCAGCCTCAAAGCCCGCTTCGCCACCGCCGGCCGCCGCGCGGTGGTCGAGTTTTGCCAG
AAGCACGGCATCGAGTACGACATCTGCGGCAAGGTGATTGTCGCTACCGAATCGCGGGAACTCCCGCAGCTGGAGAACTT
GCTGGCGCGCGGCCTGGCCAACGGTATTCCCGTCGAGCGCATCGGTGCTGAGCAGCTGCGCGCGATCGAGCCGCACGTGC
GGGGGCTTGCCGCCATCCGCGTGCCGACCGCGGGCATCGTCAATTATGCCCAGGTGGCCGCCGCCTACGCGCGCATCGTC
GCTGAGCGCGGCGGCGAGGTGCGGCTGGGCACGCGCGTGGTGAATTTGGCCGCCGCCGCCGACGGCATCACCCTGGAGAC
CGACCGGGGCAGCTTCTTTACCCGCTACTTCATCAACTGCGCGGGGCTTTTTTGCGATCGGGTAGCCGAGTTGTGCGGCC
TGGCGACCGAGGCGAAGATTGTGCCCTTTCGCGGCGAGTACTACGAACTGGTTCCCGAGAAGCGCCACCTGTGCAGGCAC
CTGATCTACCCGGTGCCCAACCCGGACTTTCCGTTTCTGGGGGTGCACTTCACGCGCATGATCGACGGCACCGTCCACGC
GGGCCCCAATGCGGTGCTGGCGCTGGCGCGGGAGGGCTACTCCTGGGGTGAGATAAACCTGGGCGACACCGCCGAGGTCT
TGGCCTACGGCGGTTTCTGGAAACTTGCCGCCCGCCACGCGGGCGAAGGATTCAAAGAAATCGTCCGCTCGCTTTCGAAA
GCCGCCTTCGTGCGCTCCTTGCAACAGCTCATCCCGGAGGTGCAGCCCGAGGATGTCGTGCCGGCGGGCAGCGGCGTCAG
AGCCCAGGCGCTCACCCGCCAAGGCAAGCTGGTGGACGACTTTTTGTTCGCCACGGGCAACCACTCTCTGCACGTACTCA
ACGCGCCCTCCCCGGCGGCCACCGCCTCGATTCCGATCGGCAAAGCCGTGGTCGAGCGCATTCCCGGGTCGGTGACCAGC
CGGCTGACCCTGACACGATAG

Upstream 100 bases:

>100_bases
CGTCACGACGGCTTCTGGCAACCGATGGACACCCTGCGCGACAAGCGGTTGCTCGAAGATCTGTGGAATTCCGGCAAAGC
GCCGTGGAAGGTGTGGTGAG

Downstream 100 bases:

>100_bases
GAACCCACCTACCCATGAAAATTCTTGCAACCGGTACCGAAGGGTACATCGGCACCCTGCTCGGCGGCGTGCTGCTCGAG
CGCGGGCACGAGGTCACAGG

Product: hydroxyglutarate oxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MSAFDFAIVGGGIVGLSVGMALTERYPGARLLVLEKESSWAGHQTGHNSGVIHSGVYYKPGSLKARFATAGRRAVVEFCQ
KHGIEYDICGKVIVATESRELPQLENLLARGLANGIPVERIGAEQLRAIEPHVRGLAAIRVPTAGIVNYAQVAAAYARIV
AERGGEVRLGTRVVNLAAAADGITLETDRGSFFTRYFINCAGLFCDRVAELCGLATEAKIVPFRGEYYELVPEKRHLCRH
LIYPVPNPDFPFLGVHFTRMIDGTVHAGPNAVLALAREGYSWGEINLGDTAEVLAYGGFWKLAARHAGEGFKEIVRSLSK
AAFVRSLQQLIPEVQPEDVVPAGSGVRAQALTRQGKLVDDFLFATGNHSLHVLNAPSPAATASIPIGKAVVERIPGSVTS
RLTLTR

Sequences:

>Translated_406_residues
MSAFDFAIVGGGIVGLSVGMALTERYPGARLLVLEKESSWAGHQTGHNSGVIHSGVYYKPGSLKARFATAGRRAVVEFCQ
KHGIEYDICGKVIVATESRELPQLENLLARGLANGIPVERIGAEQLRAIEPHVRGLAAIRVPTAGIVNYAQVAAAYARIV
AERGGEVRLGTRVVNLAAAADGITLETDRGSFFTRYFINCAGLFCDRVAELCGLATEAKIVPFRGEYYELVPEKRHLCRH
LIYPVPNPDFPFLGVHFTRMIDGTVHAGPNAVLALAREGYSWGEINLGDTAEVLAYGGFWKLAARHAGEGFKEIVRSLSK
AAFVRSLQQLIPEVQPEDVVPAGSGVRAQALTRQGKLVDDFLFATGNHSLHVLNAPSPAATASIPIGKAVVERIPGSVTS
RLTLTR
>Mature_405_residues
SAFDFAIVGGGIVGLSVGMALTERYPGARLLVLEKESSWAGHQTGHNSGVIHSGVYYKPGSLKARFATAGRRAVVEFCQK
HGIEYDICGKVIVATESRELPQLENLLARGLANGIPVERIGAEQLRAIEPHVRGLAAIRVPTAGIVNYAQVAAAYARIVA
ERGGEVRLGTRVVNLAAAADGITLETDRGSFFTRYFINCAGLFCDRVAELCGLATEAKIVPFRGEYYELVPEKRHLCRHL
IYPVPNPDFPFLGVHFTRMIDGTVHAGPNAVLALAREGYSWGEINLGDTAEVLAYGGFWKLAARHAGEGFKEIVRSLSKA
AFVRSLQQLIPEVQPEDVVPAGSGVRAQALTRQGKLVDDFLFATGNHSLHVLNAPSPAATASIPIGKAVVERIPGSVTSR
LTLTR

Specific function: Oxidizes L-2-hydroxyglutarate, probably to recover alpha-ketoglutarate mistakenly reduced by other enzymes or formed during growth on propionate [H]

COG id: COG0579

COG function: function code R; Predicted dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the L2HGDH family [H]

Homologues:

Organism=Homo sapiens, GI13376331, Length=411, Percent_Identity=45.4987834549878, Blast_Score=330, Evalue=1e-90,
Organism=Escherichia coli, GI87082148, Length=392, Percent_Identity=48.2142857142857, Blast_Score=371, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17565764, Length=402, Percent_Identity=45.0248756218905, Blast_Score=336, Evalue=1e-92,
Organism=Drosophila melanogaster, GI24585081, Length=384, Percent_Identity=41.9270833333333, Blast_Score=310, Evalue=1e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015657
- InterPro:   IPR006076 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.1.3.15 [H]

Molecular weight: Translated: 43630; Mature: 43498

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAFDFAIVGGGIVGLSVGMALTERYPGARLLVLEKESSWAGHQTGHNSGVIHSGVYYKP
CCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCEECC
GSLKARFATAGRRAVVEFCQKHGIEYDICGKVIVATESRELPQLENLLARGLANGIPVER
CCCEEHHHHHHHHHHHHHHHHCCCCEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCHHH
IGAEQLRAIEPHVRGLAAIRVPTAGIVNYAQVAAAYARIVAERGGEVRLGTRVVNLAAAA
CCHHHHHHHCHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEECHHEEEHHHHC
DGITLETDRGSFFTRYFINCAGLFCDRVAELCGLATEAKIVPFRGEYYELVPEKRHLCRH
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHCCHHHHHHHH
LIYPVPNPDFPFLGVHFTRMIDGTVHAGPNAVLALAREGYSWGEINLGDTAEVLAYGGFW
HCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHEEEEECCCCCCCCCCCCCHHHHHHCCCHH
KLAARHAGEGFKEIVRSLSKAAFVRSLQQLIPEVQPEDVVPAGSGVRAQALTRQGKLVDD
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCHHHH
FLFATGNHSLHVLNAPSPAATASIPIGKAVVERIPGSVTSRLTLTR
HHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCHHCCEEECC
>Mature Secondary Structure 
SAFDFAIVGGGIVGLSVGMALTERYPGARLLVLEKESSWAGHQTGHNSGVIHSGVYYKP
CCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCEECC
GSLKARFATAGRRAVVEFCQKHGIEYDICGKVIVATESRELPQLENLLARGLANGIPVER
CCCEEHHHHHHHHHHHHHHHHCCCCEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCHHH
IGAEQLRAIEPHVRGLAAIRVPTAGIVNYAQVAAAYARIVAERGGEVRLGTRVVNLAAAA
CCHHHHHHHCHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEECHHEEEHHHHC
DGITLETDRGSFFTRYFINCAGLFCDRVAELCGLATEAKIVPFRGEYYELVPEKRHLCRH
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHCCHHHHHHHH
LIYPVPNPDFPFLGVHFTRMIDGTVHAGPNAVLALAREGYSWGEINLGDTAEVLAYGGFW
HCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHEEEEECCCCCCCCCCCCCHHHHHHCCCHH
KLAARHAGEGFKEIVRSLSKAAFVRSLQQLIPEVQPEDVVPAGSGVRAQALTRQGKLVDD
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCHHHH
FLFATGNHSLHVLNAPSPAATASIPIGKAVVERIPGSVTSRLTLTR
HHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCHHCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 8297211; 7984428 [H]