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The map label for this gene is ctaB

Identifier: 37521735

GI number: 37521735

Start: 2315841

End: 2316758

Strand: Direct

Name: ctaB

Synonym: gvip301

Alternate gene names: 37521735

Gene position: 2315841-2316758 (Clockwise)

Preceding gene: 37521734

Following gene: 37521736

Centisome position: 49.71

GC content: 63.29

Gene sequence:

>918_bases
GTGCAAGAAACGCTTCTTTCCCGCGCCGAGCGCAGCGTACCGCGCCTGAGTGCCGCCCTCAACGACTACTACCAGCTCAC
CAAGCCGCGCATCCAGGTGCTGCTGCTTATCACGACCGCCGGTGCGATGTGGATCGCAGGCAAAGGCCACGTCGAGCCGC
TGTTGCTTCTGGTCACCCTGCTGGGGGGTACCCTGGCCGCGAGTTCCGCCAACGCCTTCAACTGTCTGATCGACCGCGAC
ATCGACCTGCTCATGGAGCGCACCCGCCGCCGGGCCATCCCGGCCGGGCGCATCCTGCCGTGGCAGGCGGCCCTCTTTGC
TACAGCCCTGGGGGTGGCCTCCTTCGCCGTGCTGGCAGCCTTTGCCAACCTGTTCGCCGCCTTGCTGGCCATCTCGGGCA
TCGGCTTCTACGTAGTTATCTATACTCTGTGGCTGAAGCGCACCACCACCCAGAACATCGTCATCGGCGGCGCGGCGGGG
GCCATTCCGCCGCTGGTGGGCTGGGCTGCGGTCACCGGCGACCTTGGTTGGTCGGCCTGGGTGCTGTTTGGCATTATCTT
TATGTGGACGCCGCCCCACTTCTGGGCCCTCGCCATGATGATCCGCGAGGACTACCGCAAGGCGGGCGTGCCGATGCTGC
CGGTGGTGGCGGGGGACGAGGCGACCGCGCGGCAGATCTTTATTTACACCCTGGTCCTGGTACCGGTCACGCTCGTACTC
TACCCGCTGGGTACAATGGGCTGGATATACCTGCTTGCGGCCGGTGCTTTGGGCCTCTGGCTGATCGAGGGGGCCTTCAG
GCTTTTGAAAGCTCCCAACGACCGCAAGGAATCTCGTTCCCTGTTTAAGCGCTCGATTTTTTATCTGATGTTGCTCTTTG
TGGCGATGGGTATCGACAGCATCTTCCTGTTTGCCTGA

Upstream 100 bases:

>100_bases
TCGGCGCCGCTCTATTCGGCAGCCTGGTCGTCCTCGCTGCGCTCGCCCTGGCCGCGCCCCACCGCTTTATCGACCGCCTG
CACCCATAGGACAACACCCC

Downstream 100 bases:

>100_bases
GAGGGTCCGGAGACTCACGGTGGAAGCGGCAATCGGAATCGAAGATTTGCACAAGTCCTACGGCTCCACCAAGGCCGTGG
ACGGTTTGTCGCTGACGGTG

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MQETLLSRAERSVPRLSAALNDYYQLTKPRIQVLLLITTAGAMWIAGKGHVEPLLLLVTLLGGTLAASSANAFNCLIDRD
IDLLMERTRRRAIPAGRILPWQAALFATALGVASFAVLAAFANLFAALLAISGIGFYVVIYTLWLKRTTTQNIVIGGAAG
AIPPLVGWAAVTGDLGWSAWVLFGIIFMWTPPHFWALAMMIREDYRKAGVPMLPVVAGDEATARQIFIYTLVLVPVTLVL
YPLGTMGWIYLLAAGALGLWLIEGAFRLLKAPNDRKESRSLFKRSIFYLMLLFVAMGIDSIFLFA

Sequences:

>Translated_305_residues
MQETLLSRAERSVPRLSAALNDYYQLTKPRIQVLLLITTAGAMWIAGKGHVEPLLLLVTLLGGTLAASSANAFNCLIDRD
IDLLMERTRRRAIPAGRILPWQAALFATALGVASFAVLAAFANLFAALLAISGIGFYVVIYTLWLKRTTTQNIVIGGAAG
AIPPLVGWAAVTGDLGWSAWVLFGIIFMWTPPHFWALAMMIREDYRKAGVPMLPVVAGDEATARQIFIYTLVLVPVTLVL
YPLGTMGWIYLLAAGALGLWLIEGAFRLLKAPNDRKESRSLFKRSIFYLMLLFVAMGIDSIFLFA
>Mature_305_residues
MQETLLSRAERSVPRLSAALNDYYQLTKPRIQVLLLITTAGAMWIAGKGHVEPLLLLVTLLGGTLAASSANAFNCLIDRD
IDLLMERTRRRAIPAGRILPWQAALFATALGVASFAVLAAFANLFAALLAISGIGFYVVIYTLWLKRTTTQNIVIGGAAG
AIPPLVGWAAVTGDLGWSAWVLFGIIFMWTPPHFWALAMMIREDYRKAGVPMLPVVAGDEATARQIFIYTLVLVPVTLVL
YPLGTMGWIYLLAAGALGLWLIEGAFRLLKAPNDRKESRSLFKRSIFYLMLLFVAMGIDSIFLFA

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=259, Percent_Identity=32.8185328185328, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1786631, Length=280, Percent_Identity=37.8571428571429, Blast_Score=180, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71998235, Length=281, Percent_Identity=32.3843416370107, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6325085, Length=281, Percent_Identity=30.2491103202847, Blast_Score=115, Evalue=6e-27,
Organism=Drosophila melanogaster, GI19921064, Length=278, Percent_Identity=30.9352517985612, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_GLOVI (Q7NIL7)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925112.1
- GeneID:   2600567
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.2166
- HOGENOM:   HBG656003
- OMA:   MALTEEW
- ProtClustDB:   PRK04375
- BioCyc:   GVIO251221:GLR2166-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 33404; Mature: 33404

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x14e4ff7c)-; HASH(0x137a7f94)-; HASH(0x147b4380)-; HASH(0x13c1be14)-; HASH(0x14047108)-; HASH(0x13a8af94)-; HASH(0x14741f00)-; HASH(0x145d11a4)-; HASH(0x14f40ba4)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQETLLSRAERSVPRLSAALNDYYQLTKPRIQVLLLITTAGAMWIAGKGHVEPLLLLVTL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCEEECCCCCHHHHHHHHHH
LGGTLAASSANAFNCLIDRDIDLLMERTRRRAIPAGRILPWQAALFATALGVASFAVLAA
HCCHHHCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FANLFAALLAISGIGFYVVIYTLWLKRTTTQNIVIGGAAGAIPPLVGWAAVTGDLGWSAW
HHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCCCCHHHH
VLFGIIFMWTPPHFWALAMMIREDYRKAGVPMLPVVAGDEATARQIFIYTLVLVPVTLVL
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
YPLGTMGWIYLLAAGALGLWLIEGAFRLLKAPNDRKESRSLFKRSIFYLMLLFVAMGIDS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHH
IFLFA
HHHCH
>Mature Secondary Structure
MQETLLSRAERSVPRLSAALNDYYQLTKPRIQVLLLITTAGAMWIAGKGHVEPLLLLVTL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCEEECCCCCHHHHHHHHHH
LGGTLAASSANAFNCLIDRDIDLLMERTRRRAIPAGRILPWQAALFATALGVASFAVLAA
HCCHHHCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FANLFAALLAISGIGFYVVIYTLWLKRTTTQNIVIGGAAGAIPPLVGWAAVTGDLGWSAW
HHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCCCCHHHH
VLFGIIFMWTPPHFWALAMMIREDYRKAGVPMLPVVAGDEATARQIFIYTLVLVPVTLVL
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
YPLGTMGWIYLLAAGALGLWLIEGAFRLLKAPNDRKESRSLFKRSIFYLMLLFVAMGIDS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHH
IFLFA
HHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14621292