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The map label for this gene is spoT [H]

Identifier: 37521684

GI number: 37521684

Start: 2268579

End: 2269211

Strand: Reverse

Name: spoT [H]

Synonym: gll2115

Alternate gene names: 37521684

Gene position: 2269211-2268579 (Counterclockwise)

Preceding gene: 37521686

Following gene: 37521675

Centisome position: 48.71

GC content: 59.72

Gene sequence:

>633_bases
ATGTCTATCTACTCCGTCCGCTACAACGACGCCCTTATTCTTGCCGCTAGAGCCCACTGCGACCAACTGCGCAAGGGCAC
CGACATTCCCTACGTCATGCATCCTTTTCACGTCTCGCTGCTGCTCATCCGCTGCGGTTACAGCGAAGATGTGGCGATTG
CCGCCCTGCTGCACGATGTGGTCGAAGACTGCAATGTCAGCCTGGAAGCGATCGAGACGGCCTTCGGCCTGCAAGTCGCC
CGGTTGGTGGAGGCAGTCTCCGAGATCAAATTGCGCAATGGTGAGAAGATTGCCTGGGAAGAACGCAAGCGACTCGCCAT
CGGGCACCTGTGCACCGCCGGGCCAGAGGTGGCCGCCTTAAAAGCGGCCGACACCCTGCACAATATCCAATCGATGATCC
ACGAACTGCGCACCCATGGTCCCGGAGTTTGGGCTCACTTTGGGCGCGGTCCGCAACCGACTTTTCGGTACTACCGTGAG
GTGCTCTCTGCCGTACGTCGCTGGCTGGACAGCGCCCATCCGCTTTTGGTCGAACTGGAGCAGGCCGTCCAAGCGGTCGA
AAATCTCTCCCGTGACGGCGGTGAGGGATCCTTGTCCGTGAAGGTTGACGCTCTATCGGATCTGCCCCCATAA

Upstream 100 bases:

>100_bases
TCCGGCAACGCGCGGGGGTCTGTCAAAAGACAGCCCGTCAGACTTACGCCCAAAGCAGCCGGGGTGATAGCCTGAATGCC
AGGATCGCGCTCTACGTCCC

Downstream 100 bases:

>100_bases
TAAGAGACTGTGCCTCGCCCCCATCGTCTAGAGGCCCAGGACACCTCCCTTTCACGGAGGCGACACCGGTTCGAATCCGG
TTGGGGGTACTATTGTTAAT

Product: hypothetical protein

Products: NA

Alternate protein names: Penta-phosphate guanosine-3'-pyrophosphohydrolase; (ppGpp)ase [H]

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MSIYSVRYNDALILAARAHCDQLRKGTDIPYVMHPFHVSLLLIRCGYSEDVAIAALLHDVVEDCNVSLEAIETAFGLQVA
RLVEAVSEIKLRNGEKIAWEERKRLAIGHLCTAGPEVAALKAADTLHNIQSMIHELRTHGPGVWAHFGRGPQPTFRYYRE
VLSAVRRWLDSAHPLLVELEQAVQAVENLSRDGGEGSLSVKVDALSDLPP

Sequences:

>Translated_210_residues
MSIYSVRYNDALILAARAHCDQLRKGTDIPYVMHPFHVSLLLIRCGYSEDVAIAALLHDVVEDCNVSLEAIETAFGLQVA
RLVEAVSEIKLRNGEKIAWEERKRLAIGHLCTAGPEVAALKAADTLHNIQSMIHELRTHGPGVWAHFGRGPQPTFRYYRE
VLSAVRRWLDSAHPLLVELEQAVQAVENLSRDGGEGSLSVKVDALSDLPP
>Mature_209_residues
SIYSVRYNDALILAARAHCDQLRKGTDIPYVMHPFHVSLLLIRCGYSEDVAIAALLHDVVEDCNVSLEAIETAFGLQVAR
LVEAVSEIKLRNGEKIAWEERKRLAIGHLCTAGPEVAALKAADTLHNIQSMIHELRTHGPGVWAHFGRGPQPTFRYYREV
LSAVRRWLDSAHPLLVELEQAVQAVENLSRDGGEGSLSVKVDALSDLPP

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the degradation of ppGpp into G

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=126, Percent_Identity=37.3015873015873, Blast_Score=74, Evalue=8e-14,
Organism=Escherichia coli, GI1790082, Length=129, Percent_Identity=31.7829457364341, Blast_Score=65, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24650996, Length=170, Percent_Identity=34.1176470588235, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =3.1.7.2 [H]

Molecular weight: Translated: 23236; Mature: 23105

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIYSVRYNDALILAARAHCDQLRKGTDIPYVMHPFHVSLLLIRCGYSEDVAIAALLHDV
CCEEEEECCCEEEEHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHCCCCCHHHHHHHHHHH
VEDCNVSLEAIETAFGLQVARLVEAVSEIKLRNGEKIAWEERKRLAIGHLCTAGPEVAAL
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHH
KAADTLHNIQSMIHELRTHGPGVWAHFGRGPQPTFRYYREVLSAVRRWLDSAHPLLVELE
HHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
QAVQAVENLSRDGGEGSLSVKVDALSDLPP
HHHHHHHHHHCCCCCCEEEEEEECCCCCCC
>Mature Secondary Structure 
SIYSVRYNDALILAARAHCDQLRKGTDIPYVMHPFHVSLLLIRCGYSEDVAIAALLHDV
CEEEEECCCEEEEHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHCCCCCHHHHHHHHHHH
VEDCNVSLEAIETAFGLQVARLVEAVSEIKLRNGEKIAWEERKRLAIGHLCTAGPEVAAL
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHH
KAADTLHNIQSMIHELRTHGPGVWAHFGRGPQPTFRYYREVLSAVRRWLDSAHPLLVELE
HHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
QAVQAVENLSRDGGEGSLSVKVDALSDLPP
HHHHHHHHHHCCCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]