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The map label for this gene is htrA [H]

Identifier: 37521676

GI number: 37521676

Start: 2258485

End: 2259708

Strand: Direct

Name: htrA [H]

Synonym: glr2107

Alternate gene names: 37521676

Gene position: 2258485-2259708 (Clockwise)

Preceding gene: 37521673

Following gene: 37521677

Centisome position: 48.48

GC content: 62.99

Gene sequence:

>1224_bases
GTGGCCAAGTTATCAACATATCTTTACAGGACGGTCTGTCCAGGGGCTGAACAAGTTTGTTGTGGGGAGCACAAATTCGT
TTCGCCGGATGATAGCCCAGTACATGCTTTGTGCAGCCGACTCGACAGACGAAGCGCTTGTGCTAGCTTGGGCTTTTCCT
ATCCAGTCGCAGGGGAGCGTAGGATGGCAGGGATTCTTAGGCTGGTCTCAGACAGTGCATTCGCAGGCGAATCGGTGCCT
TTGTCACAAGCTGGCTCTCCCGAAGACGGGGAATTGCTGGACGCTTACTCGAACGCGGTGACTCGCGCCGCCGAGACTGT
GAGCCGCTCGGTGGTCAATATCGACGTGCACAAAAGCACACGGGGACGCCGGGGCAACCAGCAGACGCAGGGCAACGGCT
CGGGTTTTTTGTTTACCCCCGACGGCTACATCCTCACCAACAGCCACGTCGTTCATGGGGCCGGCGAAGTAGGGGTGACG
CTGCAGGACGGTCGGCGGATGGCGGCAACCCCTGTGGGCGACGACCCCGACAGTGACCTCGCTGTCATCCGCATCGACGG
GGCCAACCTCTACCCCGTCAAATTGGGCGATTCCCAGAAAGTGCGCGTCGGCCAGTTGGCCATCGCCATCGGCAGCCCCT
ACGGTTTTCAGTACACGGTGACCGCCGGGGTGGTGAGCGCCCTTGGCCGTTCGCTGCGCTCCGGCTCCGGGCGGCTCATC
GACAACATTGTCCAGACCGACGCCGCCCTCAACCCGGGCAACTCCGGCGGACCGCTGGTCAACTCGCGCGGCGAGGTGAT
CGGGGTGAATTCGGCGGTCATCCTGCCGGCACAGGGCATTTGCTTTGCGATCGCCGTCAACACCGCCAAATTTGTCGCAG
GCCAACTCATCAATGGGGGCCGGGTGCGCCGTAGCTTTATCGGTGTGGGCGGGCAGACGGTGCCGCTGCCGCGCTTTGTG
ATGCGCTTTCACAATCTCGCGGCCGAAACCGGGGTGCTGGTGGTTTCTGTCGAGGCCGACAGCCCCGCTTCGCAGGCGGG
TTTGCGCGAAGGAGATGTGATCGTCGAACTGGCCGGGCAGGCGGTGAGCGACATCGACGCCCTGCACCGCGCCTTGAGTG
ACAAGCAGGTGGGGGTGCGCTCGTCGCTGACCGTCCTACGGCGCAACGACAAGCTCAGCCTGGAGATTGTCCCGGCGGAG
TCACCACAGCGGTCCGGCCGCTAA

Upstream 100 bases:

>100_bases
AGAGTCTGCCAAGCCTTTCTAAAAGGCTCGGTAGGCCTTGCCTGGATCCGGCACGTACTGCTTTTGGTGGCCACACGGCT
GAAGCCAAGCGAGTCGCACT

Downstream 100 bases:

>100_bases
GTCGCTCGCTCCCGCGCTCTAAACTAGGGCATAGGAACGCATTTGGAGACGCACCATGGCCCGTACCGCTTCGACGATGA
TGGAGCTTGATACGCTGGCA

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MAKLSTYLYRTVCPGAEQVCCGEHKFVSPDDSPVHALCSRLDRRSACASLGFSYPVAGERRMAGILRLVSDSAFAGESVP
LSQAGSPEDGELLDAYSNAVTRAAETVSRSVVNIDVHKSTRGRRGNQQTQGNGSGFLFTPDGYILTNSHVVHGAGEVGVT
LQDGRRMAATPVGDDPDSDLAVIRIDGANLYPVKLGDSQKVRVGQLAIAIGSPYGFQYTVTAGVVSALGRSLRSGSGRLI
DNIVQTDAALNPGNSGGPLVNSRGEVIGVNSAVILPAQGICFAIAVNTAKFVAGQLINGGRVRRSFIGVGGQTVPLPRFV
MRFHNLAAETGVLVVSVEADSPASQAGLREGDVIVELAGQAVSDIDALHRALSDKQVGVRSSLTVLRRNDKLSLEIVPAE
SPQRSGR

Sequences:

>Translated_407_residues
MAKLSTYLYRTVCPGAEQVCCGEHKFVSPDDSPVHALCSRLDRRSACASLGFSYPVAGERRMAGILRLVSDSAFAGESVP
LSQAGSPEDGELLDAYSNAVTRAAETVSRSVVNIDVHKSTRGRRGNQQTQGNGSGFLFTPDGYILTNSHVVHGAGEVGVT
LQDGRRMAATPVGDDPDSDLAVIRIDGANLYPVKLGDSQKVRVGQLAIAIGSPYGFQYTVTAGVVSALGRSLRSGSGRLI
DNIVQTDAALNPGNSGGPLVNSRGEVIGVNSAVILPAQGICFAIAVNTAKFVAGQLINGGRVRRSFIGVGGQTVPLPRFV
MRFHNLAAETGVLVVSVEADSPASQAGLREGDVIVELAGQAVSDIDALHRALSDKQVGVRSSLTVLRRNDKLSLEIVPAE
SPQRSGR
>Mature_406_residues
AKLSTYLYRTVCPGAEQVCCGEHKFVSPDDSPVHALCSRLDRRSACASLGFSYPVAGERRMAGILRLVSDSAFAGESVPL
SQAGSPEDGELLDAYSNAVTRAAETVSRSVVNIDVHKSTRGRRGNQQTQGNGSGFLFTPDGYILTNSHVVHGAGEVGVTL
QDGRRMAATPVGDDPDSDLAVIRIDGANLYPVKLGDSQKVRVGQLAIAIGSPYGFQYTVTAGVVSALGRSLRSGSGRLID
NIVQTDAALNPGNSGGPLVNSRGEVIGVNSAVILPAQGICFAIAVNTAKFVAGQLINGGRVRRSFIGVGGQTVPLPRFVM
RFHNLAAETGVLVVSVEADSPASQAGLREGDVIVELAGQAVSDIDALHRALSDKQVGVRSSLTVLRRNDKLSLEIVPAES
PQRSGR

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI24308541, Length=411, Percent_Identity=31.8734793187348, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI4506141, Length=332, Percent_Identity=31.6265060240964, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI22129776, Length=319, Percent_Identity=34.1692789968652, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI7019477, Length=291, Percent_Identity=35.3951890034364, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1786356, Length=277, Percent_Identity=40.072202166065, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI1789629, Length=275, Percent_Identity=37.0909090909091, Blast_Score=178, Evalue=6e-46,
Organism=Escherichia coli, GI1789630, Length=339, Percent_Identity=33.9233038348083, Blast_Score=155, Evalue=5e-39,
Organism=Drosophila melanogaster, GI24646839, Length=311, Percent_Identity=36.0128617363344, Blast_Score=141, Evalue=6e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 42600; Mature: 42468

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLSTYLYRTVCPGAEQVCCGEHKFVSPDDSPVHALCSRLDRRSACASLGFSYPVAGER
CCCHHHHHHHHHCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCH
RMAGILRLVSDSAFAGESVPLSQAGSPEDGELLDAYSNAVTRAAETVSRSVVNIDVHKST
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCEEEEEEEECCC
RGRRGNQQTQGNGSGFLFTPDGYILTNSHVVHGAGEVGVTLQDGRRMAATPVGDDPDSDL
CCCCCCCCCCCCCCEEEECCCCEEEECCEEEECCCCEEEEECCCCEEEECCCCCCCCCCE
AVIRIDGANLYPVKLGDSQKVRVGQLAIAIGSPYGFQYTVTAGVVSALGRSLRSGSGRLI
EEEEECCCEEEEEEECCCCCEEEEEEEEEECCCCCEEEEEHHHHHHHHHHHHHCCCCHHH
DNIVQTDAALNPGNSGGPLVNSRGEVIGVNSAVILPAQGICFAIAVNTAKFVAGQLINGG
HHHHHHCCCCCCCCCCCCCCCCCCCEEECCCEEEECCCCEEEEEEECHHHHHHHHHCCCC
RVRRSFIGVGGQTVPLPRFVMRFHNLAAETGVLVVSVEADSPASQAGLREGDVIVELAGQ
CEEEHEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCHHHCCCCCCCEEEEECCH
AVSDIDALHRALSDKQVGVRSSLTVLRRNDKLSLEIVPAESPQRSGR
HHHHHHHHHHHHCCCCCCCHHHEEEEECCCCEEEEEEECCCCCCCCC
>Mature Secondary Structure 
AKLSTYLYRTVCPGAEQVCCGEHKFVSPDDSPVHALCSRLDRRSACASLGFSYPVAGER
CCHHHHHHHHHCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCH
RMAGILRLVSDSAFAGESVPLSQAGSPEDGELLDAYSNAVTRAAETVSRSVVNIDVHKST
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCEEEEEEEECCC
RGRRGNQQTQGNGSGFLFTPDGYILTNSHVVHGAGEVGVTLQDGRRMAATPVGDDPDSDL
CCCCCCCCCCCCCCEEEECCCCEEEECCEEEECCCCEEEEECCCCEEEECCCCCCCCCCE
AVIRIDGANLYPVKLGDSQKVRVGQLAIAIGSPYGFQYTVTAGVVSALGRSLRSGSGRLI
EEEEECCCEEEEEEECCCCCEEEEEEEEEECCCCCEEEEEHHHHHHHHHHHHHCCCCHHH
DNIVQTDAALNPGNSGGPLVNSRGEVIGVNSAVILPAQGICFAIAVNTAKFVAGQLINGG
HHHHHHCCCCCCCCCCCCCCCCCCCEEECCCEEEECCCCEEEEEEECHHHHHHHHHCCCC
RVRRSFIGVGGQTVPLPRFVMRFHNLAAETGVLVVSVEADSPASQAGLREGDVIVELAGQ
CEEEHEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCHHHCCCCCCCEEEEECCH
AVSDIDALHRALSDKQVGVRSSLTVLRRNDKLSLEIVPAESPQRSGR
HHHHHHHHHHHHCCCCCCCHHHEEEEECCCCEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]