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The map label for this gene is cofG

Identifier: 37521669

GI number: 37521669

Start: 2254380

End: 2255339

Strand: Reverse

Name: cofG

Synonym: gll2100

Alternate gene names: 37521669

Gene position: 2255339-2254380 (Counterclockwise)

Preceding gene: 37521670

Following gene: 37521668

Centisome position: 48.41

GC content: 66.25

Gene sequence:

>960_bases
ATGAGGGAGCGCACGGTCACCTACAGCCCTGCTTTTACGCTGGTGCCCACCCGCGAGTGCTTCAACCGTTGCGGCTACTG
CAATTTTCGGGCCGATCGCGGGGCTGCGTGGCTGCAGCCTGCCGAGGTGCGCGCGCTTCTGCTGCCGCTGGTGGGAAGCG
GTGTGGTCGAAATTCTGGTCCTCTCGGGGGAGGTGCACCCCCACGATCCCCGTCGGGGCGAATGGTTTGCGATGATTGAG
GACATCTGTGCAGTGGCCTTGGAGCTGGGATTTTTGCCCCACACCAACTGCGGCGTTCTGAGCTTCGAGGAGATGCGCGC
GCTGCAGCAGCTGAACGTCTCGCTGGGTCTGATGCTCGAAATCGACAGCAACAGGCTGCTGGGAGGCGTCCACCGCCATG
CCCCGAGCAAGATCCCGGCGCTGCGCACCGCGCAACTCGAATGGGCGGGTGCTTTGGGCATCCCCTTTACCACCGGTCTG
CTGTTGGGAATCGGCGAGACACCCGCCGAGCGCGAGGATACGTTGCGGACCATCGCCCGGCTGCAGGATCGCCACGGACA
CATCCAGGAGGTCATCCTGCAGCCCCACAGCCCCGGCGGCTCCCAAAGCTGGGCTGGAGAACCGCTGGGCGACGCACAAC
TGCTCGGAGTGGTGCGGCTGGCCCGGCAGATTCTGCCTGCCGAGATTACGATTCAGATCCCGCCCAACCTGGTGGGTGAC
CCCGTGCCGCTGCTGGAGGCGGGGGCGCGGGATCTGGGGGGGATTGGTCCAGTGGACGTGGTCAATCCCGACTATGCCCA
CCCGGTTGTGGAGCGGCTCGGCGAACGACTCGCGGCGGCGGGCTGGCGGTTGGAGCCGCGGCTTCCGGTGTATCCCCATC
TCGATAAACGGGTCGCCACCGCTTTGCAACCGCTGCTCGGCGAGCACCGCGCCCGGCTGTGTCAAGCGGCGGTGACTTGA

Upstream 100 bases:

>100_bases
GCCAGCACGCTCCTTTCTCCCCCGTCAACCCCCAGGTGATTGCCACGGGGTTGCAGGGCGAAGCGCTGGCCACCTTGCTT
GCCGAGGTGGGGATCGATCT

Downstream 100 bases:

>100_bases
AGGCGCTCCGTTAACCTGCACTTAGGGTGGGGACACTACGATCGCGCGGGTCCAACTCGTGGGTAAATATGGTGTCTGTA
AAGCTTCGCATTGAGATCAA

Product: FO synthase subunit 1

Products: NA

Alternate protein names: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 1

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MRERTVTYSPAFTLVPTRECFNRCGYCNFRADRGAAWLQPAEVRALLLPLVGSGVVEILVLSGEVHPHDPRRGEWFAMIE
DICAVALELGFLPHTNCGVLSFEEMRALQQLNVSLGLMLEIDSNRLLGGVHRHAPSKIPALRTAQLEWAGALGIPFTTGL
LLGIGETPAEREDTLRTIARLQDRHGHIQEVILQPHSPGGSQSWAGEPLGDAQLLGVVRLARQILPAEITIQIPPNLVGD
PVPLLEAGARDLGGIGPVDVVNPDYAHPVVERLGERLAAAGWRLEPRLPVYPHLDKRVATALQPLLGEHRARLCQAAVT

Sequences:

>Translated_319_residues
MRERTVTYSPAFTLVPTRECFNRCGYCNFRADRGAAWLQPAEVRALLLPLVGSGVVEILVLSGEVHPHDPRRGEWFAMIE
DICAVALELGFLPHTNCGVLSFEEMRALQQLNVSLGLMLEIDSNRLLGGVHRHAPSKIPALRTAQLEWAGALGIPFTTGL
LLGIGETPAEREDTLRTIARLQDRHGHIQEVILQPHSPGGSQSWAGEPLGDAQLLGVVRLARQILPAEITIQIPPNLVGD
PVPLLEAGARDLGGIGPVDVVNPDYAHPVVERLGERLAAAGWRLEPRLPVYPHLDKRVATALQPLLGEHRARLCQAAVT
>Mature_319_residues
MRERTVTYSPAFTLVPTRECFNRCGYCNFRADRGAAWLQPAEVRALLLPLVGSGVVEILVLSGEVHPHDPRRGEWFAMIE
DICAVALELGFLPHTNCGVLSFEEMRALQQLNVSLGLMLEIDSNRLLGGVHRHAPSKIPALRTAQLEWAGALGIPFTTGL
LLGIGETPAEREDTLRTIARLQDRHGHIQEVILQPHSPGGSQSWAGEPLGDAQLLGVVRLARQILPAEITIQIPPNLVGD
PVPLLEAGARDLGGIGPVDVVNPDYAHPVVERLGERLAAAGWRLEPRLPVYPHLDKRVATALQPLLGEHRARLCQAAVT

Specific function: Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO)

COG id: COG1060

COG function: function code HR; Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. CofG family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COFG_GLOVI (Q7NIT2)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925046.1
- ProteinModelPortal:   Q7NIT2
- GeneID:   2600501
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:gll2100
- NMPDR:   fig|251221.1.peg.2100
- HOGENOM:   HBG321713
- OMA:   PTYECFN
- ProtClustDB:   PRK06245
- BioCyc:   GVIO251221:GLL2100-MONOMER
- HAMAP:   MF_01611
- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR019939
- InterPro:   IPR007197
- Gene3D:   G3DSA:3.20.20.70
- SMART:   SM00729
- TIGRFAMs:   TIGR03550

Pfam domain/function: PF04055 Radical_SAM

EC number: NA

Molecular weight: Translated: 34752; Mature: 34752

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRERTVTYSPAFTLVPTRECFNRCGYCNFRADRGAAWLQPAEVRALLLPLVGSGVVEILV
CCCCEEEECCCEEEEECHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEE
LSGEVHPHDPRRGEWFAMIEDICAVALELGFLPHTNCGVLSFEEMRALQQLNVSLGLMLE
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEE
IDSNRLLGGVHRHAPSKIPALRTAQLEWAGALGIPFTTGLLLGIGETPAEREDTLRTIAR
ECCCCHHHHHHHCCCCCCCCCEEEEEHCCCCCCCCHHHHHHEECCCCCCHHHHHHHHHHH
LQDRHGHIQEVILQPHSPGGSQSWAGEPLGDAQLLGVVRLARQILPAEITIQIPPNLVGD
HHHHCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
PVPLLEAGARDLGGIGPVDVVNPDYAHPVVERLGERLAAAGWRLEPRLPVYPHLDKRVAT
CCHHHHHCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
ALQPLLGEHRARLCQAAVT
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRERTVTYSPAFTLVPTRECFNRCGYCNFRADRGAAWLQPAEVRALLLPLVGSGVVEILV
CCCCEEEECCCEEEEECHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEE
LSGEVHPHDPRRGEWFAMIEDICAVALELGFLPHTNCGVLSFEEMRALQQLNVSLGLMLE
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEE
IDSNRLLGGVHRHAPSKIPALRTAQLEWAGALGIPFTTGLLLGIGETPAEREDTLRTIAR
ECCCCHHHHHHHCCCCCCCCCEEEEEHCCCCCCCCHHHHHHEECCCCCCHHHHHHHHHHH
LQDRHGHIQEVILQPHSPGGSQSWAGEPLGDAQLLGVVRLARQILPAEITIQIPPNLVGD
HHHHCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
PVPLLEAGARDLGGIGPVDVVNPDYAHPVVERLGERLAAAGWRLEPRLPVYPHLDKRVAT
CCHHHHHCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
ALQPLLGEHRARLCQAAVT
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292