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The map label for this gene is 37521667

Identifier: 37521667

GI number: 37521667

Start: 2250880

End: 2252910

Strand: Reverse

Name: 37521667

Synonym: gll2098

Alternate gene names: NA

Gene position: 2252910-2250880 (Counterclockwise)

Preceding gene: 37521668

Following gene: 37521666

Centisome position: 48.36

GC content: 66.57

Gene sequence:

>2031_bases
ATGGCTCTCACAGCGTTGGGAGCGAGGGGCGTGGGACAGATTCGCCTAGGCGTGGATGTGGGAGGTACCTTCACCGACCT
GGTGGCCGTGGTCGAAGGCACAGTGATCACCGCCAAAGTGCCCACCACGGCCGATCAGTCGGAGGGGGTGATCGAGGCGT
TTGCGCGCACGGGGCTCGCAGGCGATGCAGTCGGCGTCTTTGCCCACGGGATGACCGTGGCCACCAATGCCCTGCTGGAA
GGCAAAGGAGCTTCGACCGCTTTTGTCACCACCGAGGGCTTTCGGGATTTGCTGCGCATCGGCCGCCAGAACCGGCCCCA
CCTGTATGACCTGACCCAGCCCCGACCCCGGCCGCTGGTGGCGCGCGAGCACTGCTTTACTGTGCGTGAACGGATGGGAC
CTGCAGGGGTGGTGATCCCTCTTGAAAACCAGGAACTGGCGGTGTTGGTCACCAAACTGGAACCGCTGATCGCCGCCGGT
GCGATCGAATCGGTGGCCGTCGGGTTTTTGTTCGCTTTTGGCCACTCCGAACACGAGCAGGCCGTGGCCCGCACTCTACA
AAAGGCGTTTCCGCAAGTGCATCTGTCGCTCTCAAGCGAGGTGGCTCCTGAGTTTCGGGAGTACGAACGCTTCAGTACCA
CGGTTGTGGATGCCTACTTGAGCCCGAAGCTGCGCTACTATCTCGACCGACTGGTGCAGCGCTGCCGGGAGCGGCAACTG
CCCGTGCCGCTCATCATGCAGTCGAGCGGCGGGGTAACCACCATCGAGCGGGCACGGGGGGCGGCGGCACTTTTGTCCGG
TCCGGCGGGCGGCGTGCGCGGAGCGGCCTTCGTGGCGGCCCAATCGGGGTTCGCCGATGTGCTCACCTTCGACATGGGCG
GCACCAGCACCGACGTGTCGCTCATCTTGCGGGGCCGGCCCCAGACCAGTGCCGAGGCGGTGGTGGTGGGGTACCCGGTA
CGACTGCCGCAGATCGACATCCACACCGTGAGCGCGGGGGGCGGCTCGGTGGCCTGGGCCGACGGCGGCGGCGCGCTGCG
GGTCGGTCCCCATTCGGCCGGTTCCATCCCCGGTCCTGCGGCCTACGGCCGGGGAGGAACCGAACCCACCGTCACCGACG
CCAATGTGTTTCTTGGCTATCTGGCGGACGGGGCGGTGTTGGGCGGAGCGCTCCAGATCGACAAATCCGCCGCTACCGCC
GCCCTTGAGCGGCTTGCAGACAAACTCGGCCTGGGGGTCGAGCGCACGGCGGTCGGTATCCGGGCGGTGGCGAACGCCCA
CATGGTCGCGGCCTTGCGGGTAATGTCGGTGGAGCGGGGGATCGATCCGCGCGCCCTGGCGCTACTGGCTTTCGGGGGGG
CCGGGCCGATGCACGGCTGCGACCTGGCCGCGCATCTGGGGATTTGGCGGGTGTTGGTGCCCGAGGCGGGAGGAGTGCTC
TCCGCCCTGGGGCTTGCCGTCTCCCCATTGAGGCGAGATTTCTCCCGTGCCGTGCTGCGGCGGCTGTCGGATCTGGACGA
ACCGTGGCGAAGCGAATTCACTGCCCTGGCCGCTCAGGTGCCACCGGAGCTTGCCGAGCGTGCGTACTTTGCCGATGTGC
ACTACCGCGGCCAGTCGTTCGAACTCACGGTGCCGGTAGATCTAGAGCAAAATCTCGAAGCTGTCGCCGCCACCTTTCAT
GAAGCGCATGCCCGCCGATACGGCTGGTCGGATCCGGCCCAGGCGATTGAACTGGTACAGGCGCGGCTGGTGGCCACCGA
GCCGGTGGCCTTGCCGGAGCTGTCGGCTGAGGCTGGCGATCAAGATGGGCCGCCGGCAGAGCGCCTTGCCTGGTTTGACG
GGGACTTTCAACCGGTGCCCGTCTACGACCGCACCCGCCTGGGGCCGCTCAGCCGCCTTGAAGGCCCCGCCCTGATCGAG
ATGCCCGAGGCCACCGTTGTCGTTCCGCTGGGATGGCAGGGAGTCATCGATCAATGCGGTACGCTGATATTAGAATTCCA
GACCGCCCGTGAAGACGTTCAAATCGGCTGA

Upstream 100 bases:

>100_bases
GCAGTCGCTGGCTAAAGCATTCCCCAGCCCGCTTGCGATCGACACAACCAGCTGGAATCCGCGCACCGGCTACGGGCTCT
AGCTCCCGCCCCATGCCAAG

Downstream 100 bases:

>100_bases
AGTGCTGATTATCGCCCTGCTGGCCGCTACCGGCGGCGCCGCCGGCAGCTATTTTGCGGTGAGCCGGGTGTCGGCCCCTG
CCGCGCCCTCCACCCCAGCT

Product: hydantoinase

Products: ADP; phosphate; N-carbamoylsarcosine

Alternate protein names: NA

Number of amino acids: Translated: 676; Mature: 675

Protein sequence:

>676_residues
MALTALGARGVGQIRLGVDVGGTFTDLVAVVEGTVITAKVPTTADQSEGVIEAFARTGLAGDAVGVFAHGMTVATNALLE
GKGASTAFVTTEGFRDLLRIGRQNRPHLYDLTQPRPRPLVAREHCFTVRERMGPAGVVIPLENQELAVLVTKLEPLIAAG
AIESVAVGFLFAFGHSEHEQAVARTLQKAFPQVHLSLSSEVAPEFREYERFSTTVVDAYLSPKLRYYLDRLVQRCRERQL
PVPLIMQSSGGVTTIERARGAAALLSGPAGGVRGAAFVAAQSGFADVLTFDMGGTSTDVSLILRGRPQTSAEAVVVGYPV
RLPQIDIHTVSAGGGSVAWADGGGALRVGPHSAGSIPGPAAYGRGGTEPTVTDANVFLGYLADGAVLGGALQIDKSAATA
ALERLADKLGLGVERTAVGIRAVANAHMVAALRVMSVERGIDPRALALLAFGGAGPMHGCDLAAHLGIWRVLVPEAGGVL
SALGLAVSPLRRDFSRAVLRRLSDLDEPWRSEFTALAAQVPPELAERAYFADVHYRGQSFELTVPVDLEQNLEAVAATFH
EAHARRYGWSDPAQAIELVQARLVATEPVALPELSAEAGDQDGPPAERLAWFDGDFQPVPVYDRTRLGPLSRLEGPALIE
MPEATVVVPLGWQGVIDQCGTLILEFQTAREDVQIG

Sequences:

>Translated_676_residues
MALTALGARGVGQIRLGVDVGGTFTDLVAVVEGTVITAKVPTTADQSEGVIEAFARTGLAGDAVGVFAHGMTVATNALLE
GKGASTAFVTTEGFRDLLRIGRQNRPHLYDLTQPRPRPLVAREHCFTVRERMGPAGVVIPLENQELAVLVTKLEPLIAAG
AIESVAVGFLFAFGHSEHEQAVARTLQKAFPQVHLSLSSEVAPEFREYERFSTTVVDAYLSPKLRYYLDRLVQRCRERQL
PVPLIMQSSGGVTTIERARGAAALLSGPAGGVRGAAFVAAQSGFADVLTFDMGGTSTDVSLILRGRPQTSAEAVVVGYPV
RLPQIDIHTVSAGGGSVAWADGGGALRVGPHSAGSIPGPAAYGRGGTEPTVTDANVFLGYLADGAVLGGALQIDKSAATA
ALERLADKLGLGVERTAVGIRAVANAHMVAALRVMSVERGIDPRALALLAFGGAGPMHGCDLAAHLGIWRVLVPEAGGVL
SALGLAVSPLRRDFSRAVLRRLSDLDEPWRSEFTALAAQVPPELAERAYFADVHYRGQSFELTVPVDLEQNLEAVAATFH
EAHARRYGWSDPAQAIELVQARLVATEPVALPELSAEAGDQDGPPAERLAWFDGDFQPVPVYDRTRLGPLSRLEGPALIE
MPEATVVVPLGWQGVIDQCGTLILEFQTAREDVQIG
>Mature_675_residues
ALTALGARGVGQIRLGVDVGGTFTDLVAVVEGTVITAKVPTTADQSEGVIEAFARTGLAGDAVGVFAHGMTVATNALLEG
KGASTAFVTTEGFRDLLRIGRQNRPHLYDLTQPRPRPLVAREHCFTVRERMGPAGVVIPLENQELAVLVTKLEPLIAAGA
IESVAVGFLFAFGHSEHEQAVARTLQKAFPQVHLSLSSEVAPEFREYERFSTTVVDAYLSPKLRYYLDRLVQRCRERQLP
VPLIMQSSGGVTTIERARGAAALLSGPAGGVRGAAFVAAQSGFADVLTFDMGGTSTDVSLILRGRPQTSAEAVVVGYPVR
LPQIDIHTVSAGGGSVAWADGGGALRVGPHSAGSIPGPAAYGRGGTEPTVTDANVFLGYLADGAVLGGALQIDKSAATAA
LERLADKLGLGVERTAVGIRAVANAHMVAALRVMSVERGIDPRALALLAFGGAGPMHGCDLAAHLGIWRVLVPEAGGVLS
ALGLAVSPLRRDFSRAVLRRLSDLDEPWRSEFTALAAQVPPELAERAYFADVHYRGQSFELTVPVDLEQNLEAVAATFHE
AHARRYGWSDPAQAIELVQARLVATEPVALPELSAEAGDQDGPPAERLAWFDGDFQPVPVYDRTRLGPLSRLEGPALIEM
PEATVVVPLGWQGVIDQCGTLILEFQTAREDVQIG

Specific function: Unknown

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=735, Percent_Identity=32.9251700680272, Blast_Score=248, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI133901900, Length=708, Percent_Identity=27.9661016949153, Blast_Score=196, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6322634, Length=721, Percent_Identity=27.877947295423, Blast_Score=226, Evalue=8e-60,
Organism=Drosophila melanogaster, GI45550492, Length=743, Percent_Identity=31.0901749663526, Blast_Score=248, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: 3.5.2.14

Molecular weight: Translated: 71378; Mature: 71247

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALTALGARGVGQIRLGVDVGGTFTDLVAVVEGTVITAKVPTTADQSEGVIEAFARTGLA
CCEECCCCCCCCEEEEEEECCCHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHCCCC
GDAVGVFAHGMTVATNALLEGKGASTAFVTTEGFRDLLRIGRQNRPHLYDLTQPRPRPLV
CCHHHHHHCCHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHCCCCCCCEEECCCCCCCCCC
AREHCFTVRERMGPAGVVIPLENQELAVLVTKLEPLIAAGAIESVAVGFLFAFGHSEHEQ
HHHHHHHHHHHCCCCEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
AVARTLQKAFPQVHLSLSSEVAPEFREYERFSTTVVDAYLSPKLRYYLDRLVQRCRERQL
HHHHHHHHHCCCEEEECCHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
PVPLIMQSSGGVTTIERARGAAALLSGPAGGVRGAAFVAAQSGFADVLTFDMGGTSTDVS
CCCEEEECCCCEEHHHHHCCCEEEECCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCEE
LILRGRPQTSAEAVVVGYPVRLPQIDIHTVSAGGGSVAWADGGGALRVGPHSAGSIPGPA
EEEECCCCCCCCEEEEECCEECCEEEEEEEECCCCEEEEECCCCEEEECCCCCCCCCCCC
AYGRGGTEPTVTDANVFLGYLADGAVLGGALQIDKSAATAALERLADKLGLGVERTAVGI
CCCCCCCCCCEECHHHHHHHHHCCCEECCEEEECHHHHHHHHHHHHHHHCCCHHHHHHHH
RAVANAHMVAALRVMSVERGIDPRALALLAFGGAGPMHGCDLAAHLGIWRVLVPEAGGVL
HHHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCCCCCCHHHHHHHCCCEEECCCCCHHH
SALGLAVSPLRRDFSRAVLRRLSDLDEPWRSEFTALAAQVPPELAERAYFADVHYRGQSF
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHEEEEEEEECCCEE
ELTVPVDLEQNLEAVAATFHEAHARRYGWSDPAQAIELVQARLVATEPVALPELSAEAGD
EEEEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
QDGPPAERLAWFDGDFQPVPVYDRTRLGPLSRLEGPALIEMPEATVVVPLGWQGVIDQCG
CCCCCHHHEEEECCCCCCCCCCCCCCCCCHHHCCCCEEEECCCCEEEEECCCHHHHHHCC
TLILEFQTAREDVQIG
CEEEEEECCCCCCCCC
>Mature Secondary Structure 
ALTALGARGVGQIRLGVDVGGTFTDLVAVVEGTVITAKVPTTADQSEGVIEAFARTGLA
CEECCCCCCCCEEEEEEECCCHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHCCCC
GDAVGVFAHGMTVATNALLEGKGASTAFVTTEGFRDLLRIGRQNRPHLYDLTQPRPRPLV
CCHHHHHHCCHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHCCCCCCCEEECCCCCCCCCC
AREHCFTVRERMGPAGVVIPLENQELAVLVTKLEPLIAAGAIESVAVGFLFAFGHSEHEQ
HHHHHHHHHHHCCCCEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
AVARTLQKAFPQVHLSLSSEVAPEFREYERFSTTVVDAYLSPKLRYYLDRLVQRCRERQL
HHHHHHHHHCCCEEEECCHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
PVPLIMQSSGGVTTIERARGAAALLSGPAGGVRGAAFVAAQSGFADVLTFDMGGTSTDVS
CCCEEEECCCCEEHHHHHCCCEEEECCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCEE
LILRGRPQTSAEAVVVGYPVRLPQIDIHTVSAGGGSVAWADGGGALRVGPHSAGSIPGPA
EEEECCCCCCCCEEEEECCEECCEEEEEEEECCCCEEEEECCCCEEEECCCCCCCCCCCC
AYGRGGTEPTVTDANVFLGYLADGAVLGGALQIDKSAATAALERLADKLGLGVERTAVGI
CCCCCCCCCCEECHHHHHHHHHCCCEECCEEEECHHHHHHHHHHHHHHHCCCHHHHHHHH
RAVANAHMVAALRVMSVERGIDPRALALLAFGGAGPMHGCDLAAHLGIWRVLVPEAGGVL
HHHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCCCCCCHHHHHHHCCCEEECCCCCHHH
SALGLAVSPLRRDFSRAVLRRLSDLDEPWRSEFTALAAQVPPELAERAYFADVHYRGQSF
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHEEEEEEEECCCEE
ELTVPVDLEQNLEAVAATFHEAHARRYGWSDPAQAIELVQARLVATEPVALPELSAEAGD
EEEEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
QDGPPAERLAWFDGDFQPVPVYDRTRLGPLSRLEGPALIEMPEATVVVPLGWQGVIDQCG
CCCCCHHHEEEECCCCCCCCCCCCCCCCCHHHCCCCEEEECCCCEEEEECCCHHHHHHCC
TLILEFQTAREDVQIG
CEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; N-methylimidazolidine-2,4-dione; H2O

Specific reaction: ATP + N-methylimidazolidine-2,4-dione + 2 H2O = ADP + phosphate + N-carbamoylsarcosine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]