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The map label for this gene is cysU [H]

Identifier: 37521642

GI number: 37521642

Start: 2225827

End: 2226681

Strand: Direct

Name: cysU [H]

Synonym: glr2073

Alternate gene names: 37521642

Gene position: 2225827-2226681 (Clockwise)

Preceding gene: 37521641

Following gene: 37521643

Centisome position: 47.77

GC content: 62.46

Gene sequence:

>855_bases
GTGGCAAGGAAACGCACCATGACCCTACTGGCATTCAAAAAGCACAGCGTCCTGCCCGGCTTCGGGCTCAGTCTGGGGTA
CACCGTCTTCTACCTCAGCATGATTGTCTTGATTCCCTTGTCGGCTCTGTTTTTCAAATCGGCGACGATGGGCTGGGCAC
AGTTCTGGACGACAGTCACCGACCCACGGGTGGTCGCCGCCTACCAGCTCACCTTCGGCGCTTCGCTGGTGGCCGCCCTC
ATCAACGCCGTCTTCGGGCTGTTGGTGGCCTGGGTGCTGGTGCGCTACACCTTTCCGGGCAAGCGCATCCTCGACGCGCT
GGTGGATCTGCCCTTTGCGCTGCCCACCGCCGTGGCCGGTATCGCCCTGACCAGCCTCTACGCCCCGAACGGCTGGATCG
GGCAGTACCTCGACCCGCTCGGGATCAAAGTCGCCTTTACCCCGATCGGCATCATTATTGCGCTGACGTTTATCGGGTTT
CCGTTTGTCGTGCGCACGGTGCAACCGGTGCTGCAGGATCTGGAGCTTGAGAGCGAGGAAGCCGCTGCCTGCCTGGGGGC
AAGCCGCCTGCAGACGTTTCTCACCGTCATCCTGCCCACGCTGATGCCGTCGCTGCTGACGGGCTTTACGCTGGCCTTTG
CCCGCGCCCTGGGCGAGTACGGTTCGGTGGTCTTCATCTCGGGCAACATGCCCGGCAAGACTGAAATCGCCTCGCTGCTC
ATCATCACCAAGCTCGAACAGTACGACTACGCTGGGGCCACGGCCATCGCCGTGGTGATGCTGGTGGCGGCCTTCGTACT
GCTCTTTGCCATCAATTTGATCCAGCGCTGGAGCAGCCGCTTCGCCGCCCGCTAA

Upstream 100 bases:

>100_bases
CGGCGGCTGGGAGAAAACCCAGAAAAAGCACTTCGACGACGGCGGCATCTTCGATCAGATCTACAAGCCCAAGTAAGTTC
TCCCATCCCTGCCTGCCTTC

Downstream 100 bases:

>100_bases
CCCGCAGGAGGATATCCTATGGTTGCTGTCATCGAAAAACGCCCGCAAAGGCGGGAATTCTGGGAGCGAGCCACTACCGA
ACCTGCCTGGCTGCGCTGGG

Product: sulfate ABC transporter permease protein

Products: ADP; phosphate; S2O32- [Cytoplasm]; SO42- [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MARKRTMTLLAFKKHSVLPGFGLSLGYTVFYLSMIVLIPLSALFFKSATMGWAQFWTTVTDPRVVAAYQLTFGASLVAAL
INAVFGLLVAWVLVRYTFPGKRILDALVDLPFALPTAVAGIALTSLYAPNGWIGQYLDPLGIKVAFTPIGIIIALTFIGF
PFVVRTVQPVLQDLELESEEAAACLGASRLQTFLTVILPTLMPSLLTGFTLAFARALGEYGSVVFISGNMPGKTEIASLL
IITKLEQYDYAGATAIAVVMLVAAFVLLFAINLIQRWSSRFAAR

Sequences:

>Translated_284_residues
MARKRTMTLLAFKKHSVLPGFGLSLGYTVFYLSMIVLIPLSALFFKSATMGWAQFWTTVTDPRVVAAYQLTFGASLVAAL
INAVFGLLVAWVLVRYTFPGKRILDALVDLPFALPTAVAGIALTSLYAPNGWIGQYLDPLGIKVAFTPIGIIIALTFIGF
PFVVRTVQPVLQDLELESEEAAACLGASRLQTFLTVILPTLMPSLLTGFTLAFARALGEYGSVVFISGNMPGKTEIASLL
IITKLEQYDYAGATAIAVVMLVAAFVLLFAINLIQRWSSRFAAR
>Mature_283_residues
ARKRTMTLLAFKKHSVLPGFGLSLGYTVFYLSMIVLIPLSALFFKSATMGWAQFWTTVTDPRVVAAYQLTFGASLVAALI
NAVFGLLVAWVLVRYTFPGKRILDALVDLPFALPTAVAGIALTSLYAPNGWIGQYLDPLGIKVAFTPIGIIIALTFIGFP
FVVRTVQPVLQDLELESEEAAACLGASRLQTFLTVILPTLMPSLLTGFTLAFARALGEYGSVVFISGNMPGKTEIASLLI
ITKLEQYDYAGATAIAVVMLVAAFVLLFAINLIQRWSSRFAAR

Specific function: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0555

COG function: function code O; ABC-type sulfate transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788764, Length=276, Percent_Identity=52.8985507246377, Blast_Score=266, Evalue=1e-72,
Organism=Escherichia coli, GI87082099, Length=241, Percent_Identity=34.8547717842324, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1786980, Length=228, Percent_Identity=35.0877192982456, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1787369, Length=223, Percent_Identity=26.457399103139, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1786254, Length=242, Percent_Identity=26.4462809917355, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787368, Length=243, Percent_Identity=27.1604938271605, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515
- InterPro:   IPR011865
- InterPro:   IPR005667 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 30755; Mature: 30624

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKRTMTLLAFKKHSVLPGFGLSLGYTVFYLSMIVLIPLSALFFKSATMGWAQFWTTVT
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DPRVVAAYQLTFGASLVAALINAVFGLLVAWVLVRYTFPGKRILDALVDLPFALPTAVAG
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHH
IALTSLYAPNGWIGQYLDPLGIKVAFTPIGIIIALTFIGFPFVVRTVQPVLQDLELESEE
HHHHHHHCCCCCHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
AAACLGASRLQTFLTVILPTLMPSLLTGFTLAFARALGEYGSVVFISGNMPGKTEIASLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHH
IITKLEQYDYAGATAIAVVMLVAAFVLLFAINLIQRWSSRFAAR
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ARKRTMTLLAFKKHSVLPGFGLSLGYTVFYLSMIVLIPLSALFFKSATMGWAQFWTTVT
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DPRVVAAYQLTFGASLVAALINAVFGLLVAWVLVRYTFPGKRILDALVDLPFALPTAVAG
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHH
IALTSLYAPNGWIGQYLDPLGIKVAFTPIGIIIALTFIGFPFVVRTVQPVLQDLELESEE
HHHHHHHCCCCCHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
AAACLGASRLQTFLTVILPTLMPSLLTGFTLAFARALGEYGSVVFISGNMPGKTEIASLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHH
IITKLEQYDYAGATAIAVVMLVAAFVLLFAINLIQRWSSRFAAR
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; S2O32- [Periplasm]; H2O; SO42- [Periplasm]; ATP [C]

Specific reaction: ATP + S2O32- [Periplasm] + H2O = ADP + phosphate + S2O32- [Cytoplasm] SO42- [Periplasm] + H2O + ATP = SO42- [Cytoplasm] + phosphate + ADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2188958; 9205837; 9278503; 2188959 [H]