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The map label for this gene is barA [H]

Identifier: 37521628

GI number: 37521628

Start: 2210423

End: 2212471

Strand: Direct

Name: barA [H]

Synonym: glr2059

Alternate gene names: 37521628

Gene position: 2210423-2212471 (Clockwise)

Preceding gene: 37521627

Following gene: 37521629

Centisome position: 47.44

GC content: 66.67

Gene sequence:

>2049_bases
ATGCAGCATCCAAACCGTCTGTCCTCTTTGTTGCCTTCGCTCGATCAAGCGATGGAGACCAGGGTCAAACTGGTCACACC
CGATACTGTCCTGAGCGACATCGTCGAGTGGATGGGCGGCCAGGCGGACTACCGTTGCGCCCTGCCCGAGCGCAAGGACC
GCACCCTGCGGCAATCGGGCGAATTGCAGCCCGATTGCGTGCTGGTGGCCGAAGGAGCACATCTGGTGGGGATCATCACC
GAGGGCGATATTGTGCGCCTGACGGCCCTGGGCAAAGATCTGGCGGCGGTGCGCGCCGGGGAGGTGATGTTGGGGGGAGT
GGTGACCCTCGTCCAGGATGGTCGCCAGGATATCCTGGGTGCCCTCGATCTGATGCGCAGGCACAACGTGCGCCACCTGC
CGGTGCTCGACGACGGCGGCCGGGTGACCGGTCTACTCAGCGCAGGCGGCATCCGGCGGACCTTGCAGCCGATTCACCTG
TTGACCTTGCGTTCGGTGGCCGAGGTGATGACCACTCCGGTCGTCCACGCCCCCGCCGGCAGCTTGCTGGTGAATCTGGC
CCGGCTGATGGCCGGCCGCCGCGTCAGCTGCGTGGTAATCGCCGAGCCGCACACCGACGGAGTACACGTTCGCCCGGTCG
GATTGATCACCGAGAGCGACATCGTTCAGTTTCGCTATTTGCAGTTCGACCTCACCCAGACCCGGGCGGCGGCGGTGATG
AGCGCGGTGGCGTCTCCCCTCAAGCCTTTCGAGTCGGTGCTGGTGGCCCACCAGCAGATGCTGCGCCGCCGGGTGCGCCG
GTTGGTGGTCACCGGCGAGCGGGGCGAACTGGTGGGCATCGTCACCCAGACCGGGCTGTTGCGCCTGCTCGATCCGCTCG
AAATTTTCGGTGTCATCGAAGCGCTCCAGCGCAGCGTCCACCAGCTGGAGGCCGAAAAAATGGAATTGTTGCAGGGGCGC
ACCCTGCAGCTGGAGCGGCTGGTGGAGGAGCGCACCGCCCAGGTGCAAGAACAGGCGCGCCGCGAGCAGCTGGCGCGGGC
GGCGGCGGAGAGCGCCCGGCAGGAGGCCGAAGAAGCCAACCGCATCAAGGACGAGTTTTTGGCCACCCTCAGCCACGAAC
TGCGCACCCCCCTCAACCCGATCATCGGTTTTACGCAGCTGTTGCGCAAAGGCCAGCTCGACGAAGCATCCGCGGCGCGG
GCGCTCGAAACGATCGAGCGCAACGCCCGCGCCCAAAGCCGAATCATCGAGGACATGCTCGATCTCTCGCGCATCATCAC
GGGCAAGCTGCGCCTGGAGGTGCGGCCGGTGGCCCTCGCCACGGTGGTGGAGGACGCCCTCGACACGGTGCGCTTCGCCG
CCCAGAGCAAAAATATCGAACTGCGCGCCCGCCTCGATCCGAACGTGGTCCTGCCTTTTGGCGATTCGAACCGTCTGCGG
CAGGTGGTCTGGAATTTGCTTTCCAACGCCATCAAATTTACTCCCGAGAACGGCAGCATCGAAGTGCAGCTCGAGCGGGG
GCGGGCGGAGGCGGTACTGACCGTTCGCGATTCGGGGGTAGGCATCGCCGGCGATTTTCTGCCCCACGTCTTTGAGCGCT
TCCGGCAGGCCAACAGCACCACCACCCGCAGCCACGGCGGCCTCGGGCTCGGCCTGGCCATCGTGCGCCAATTGGTCGAG
CTGCACGGCGGCACCGTCGGGGTCGAAAGCCCAGGAAGCGACCAGGGGGCGACATTTACCGTTCGCCTGCCGCTGTTGTT
GGGCCGGGGCGCCCGCACGAGCGCGACGCAAGCCCCGCTGCCTCCGGAGGCAATGGGTCTACAGGTGATCACCGTCGAGA
CCGGCTGCCTGCTCGACGGGCACACCCTGGCCGAGACCGACCTTCGCCGCCGCTACGGGGTGGTGGTGCACGCCCTGCGC
CGCGAAGGCCGGCTGATCGGTTTTCCGGACGCGGACACGCCCTTGCGCGAGGGCGATCAGTTGCTGGTCAGCGGCGGGTG
CGACCAGCTTGAGCGCCTCAAGCAACGCATGGCCGAGAGCCAGGGGTAA

Upstream 100 bases:

>100_bases
GGAGCATCGGCCGGTGTTCCTGGCGGCGGCTCAATCCCGGGGCGATAATTGGGTGAGCCGGTGTGCCCGTCGGCGTGAGG
AATATTCCGCAGAGACGTCC

Downstream 100 bases:

>100_bases
CCGCTCAGCCTATCCGCGGGCGGATGCCCGGGGCCGCCCGCCTGGCCACGATGGGCTTGCAGTCCGACTTCAATCACCAT
GGCCAATCCCACCGTGGAGC

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 682; Mature: 682

Protein sequence:

>682_residues
MQHPNRLSSLLPSLDQAMETRVKLVTPDTVLSDIVEWMGGQADYRCALPERKDRTLRQSGELQPDCVLVAEGAHLVGIIT
EGDIVRLTALGKDLAAVRAGEVMLGGVVTLVQDGRQDILGALDLMRRHNVRHLPVLDDGGRVTGLLSAGGIRRTLQPIHL
LTLRSVAEVMTTPVVHAPAGSLLVNLARLMAGRRVSCVVIAEPHTDGVHVRPVGLITESDIVQFRYLQFDLTQTRAAAVM
SAVASPLKPFESVLVAHQQMLRRRVRRLVVTGERGELVGIVTQTGLLRLLDPLEIFGVIEALQRSVHQLEAEKMELLQGR
TLQLERLVEERTAQVQEQARREQLARAAAESARQEAEEANRIKDEFLATLSHELRTPLNPIIGFTQLLRKGQLDEASAAR
ALETIERNARAQSRIIEDMLDLSRIITGKLRLEVRPVALATVVEDALDTVRFAAQSKNIELRARLDPNVVLPFGDSNRLR
QVVWNLLSNAIKFTPENGSIEVQLERGRAEAVLTVRDSGVGIAGDFLPHVFERFRQANSTTTRSHGGLGLGLAIVRQLVE
LHGGTVGVESPGSDQGATFTVRLPLLLGRGARTSATQAPLPPEAMGLQVITVETGCLLDGHTLAETDLRRRYGVVVHALR
REGRLIGFPDADTPLREGDQLLVSGGCDQLERLKQRMAESQG

Sequences:

>Translated_682_residues
MQHPNRLSSLLPSLDQAMETRVKLVTPDTVLSDIVEWMGGQADYRCALPERKDRTLRQSGELQPDCVLVAEGAHLVGIIT
EGDIVRLTALGKDLAAVRAGEVMLGGVVTLVQDGRQDILGALDLMRRHNVRHLPVLDDGGRVTGLLSAGGIRRTLQPIHL
LTLRSVAEVMTTPVVHAPAGSLLVNLARLMAGRRVSCVVIAEPHTDGVHVRPVGLITESDIVQFRYLQFDLTQTRAAAVM
SAVASPLKPFESVLVAHQQMLRRRVRRLVVTGERGELVGIVTQTGLLRLLDPLEIFGVIEALQRSVHQLEAEKMELLQGR
TLQLERLVEERTAQVQEQARREQLARAAAESARQEAEEANRIKDEFLATLSHELRTPLNPIIGFTQLLRKGQLDEASAAR
ALETIERNARAQSRIIEDMLDLSRIITGKLRLEVRPVALATVVEDALDTVRFAAQSKNIELRARLDPNVVLPFGDSNRLR
QVVWNLLSNAIKFTPENGSIEVQLERGRAEAVLTVRDSGVGIAGDFLPHVFERFRQANSTTTRSHGGLGLGLAIVRQLVE
LHGGTVGVESPGSDQGATFTVRLPLLLGRGARTSATQAPLPPEAMGLQVITVETGCLLDGHTLAETDLRRRYGVVVHALR
REGRLIGFPDADTPLREGDQLLVSGGCDQLERLKQRMAESQG
>Mature_682_residues
MQHPNRLSSLLPSLDQAMETRVKLVTPDTVLSDIVEWMGGQADYRCALPERKDRTLRQSGELQPDCVLVAEGAHLVGIIT
EGDIVRLTALGKDLAAVRAGEVMLGGVVTLVQDGRQDILGALDLMRRHNVRHLPVLDDGGRVTGLLSAGGIRRTLQPIHL
LTLRSVAEVMTTPVVHAPAGSLLVNLARLMAGRRVSCVVIAEPHTDGVHVRPVGLITESDIVQFRYLQFDLTQTRAAAVM
SAVASPLKPFESVLVAHQQMLRRRVRRLVVTGERGELVGIVTQTGLLRLLDPLEIFGVIEALQRSVHQLEAEKMELLQGR
TLQLERLVEERTAQVQEQARREQLARAAAESARQEAEEANRIKDEFLATLSHELRTPLNPIIGFTQLLRKGQLDEASAAR
ALETIERNARAQSRIIEDMLDLSRIITGKLRLEVRPVALATVVEDALDTVRFAAQSKNIELRARLDPNVVLPFGDSNRLR
QVVWNLLSNAIKFTPENGSIEVQLERGRAEAVLTVRDSGVGIAGDFLPHVFERFRQANSTTTRSHGGLGLGLAIVRQLVE
LHGGTVGVESPGSDQGATFTVRLPLLLGRGARTSATQAPLPPEAMGLQVITVETGCLLDGHTLAETDLRRRYGVVVHALR
REGRLIGFPDADTPLREGDQLLVSGGCDQLERLKQRMAESQG

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=331, Percent_Identity=34.441087613293, Blast_Score=166, Evalue=5e-42,
Organism=Escherichia coli, GI48994928, Length=236, Percent_Identity=36.0169491525424, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI145693157, Length=234, Percent_Identity=37.6068376068376, Blast_Score=129, Evalue=6e-31,
Organism=Escherichia coli, GI1788713, Length=270, Percent_Identity=31.1111111111111, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI1788393, Length=230, Percent_Identity=31.7391304347826, Blast_Score=108, Evalue=2e-24,
Organism=Escherichia coli, GI87081816, Length=319, Percent_Identity=32.2884012539185, Blast_Score=105, Evalue=9e-24,
Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=31.8385650224215, Blast_Score=103, Evalue=5e-23,
Organism=Escherichia coli, GI1790436, Length=224, Percent_Identity=33.4821428571429, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1786783, Length=226, Percent_Identity=30.9734513274336, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1786912, Length=245, Percent_Identity=31.0204081632653, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788549, Length=243, Percent_Identity=28.8065843621399, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1790861, Length=226, Percent_Identity=32.7433628318584, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1790346, Length=222, Percent_Identity=30.1801801801802, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788279, Length=227, Percent_Identity=26.431718061674, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1787894, Length=246, Percent_Identity=26.8292682926829, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1789403, Length=212, Percent_Identity=28.3018867924528, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI87082128, Length=228, Percent_Identity=28.5087719298246, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=146, Percent_Identity=33.5616438356164, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR019247
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF09984 DUF2222; PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 74690; Mature: 74690

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHPNRLSSLLPSLDQAMETRVKLVTPDTVLSDIVEWMGGQADYRCALPERKDRTLRQSG
CCCHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHCC
ELQPDCVLVAEGAHLVGIITEGDIVRLTALGKDLAAVRAGEVMLGGVVTLVQDGRQDILG
CCCCCEEEEECCCEEEEEEECCCEEEEEECCCHHHHHHHCCHHHHHHHHHHHCCHHHHHH
ALDLMRRHNVRHLPVLDDGGRVTGLLSAGGIRRTLQPIHLLTLRSVAEVMTTPVVHAPAG
HHHHHHHCCCCCCCEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCHH
SLLVNLARLMAGRRVSCVVIAEPHTDGVHVRPVGLITESDIVQFRYLQFDLTQTRAAAVM
HHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEEEEEECCCHHEEEEEEEEHHHHHHHHHH
SAVASPLKPFESVLVAHQQMLRRRVRRLVVTGERGELVGIVTQTGLLRLLDPLEIFGVIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHH
ALQRSVHQLEAEKMELLQGRTLQLERLVEERTAQVQEQARREQLARAAAESARQEAEEAN
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RIKDEFLATLSHELRTPLNPIIGFTQLLRKGQLDEASAARALETIERNARAQSRIIEDML
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DLSRIITGKLRLEVRPVALATVVEDALDTVRFAAQSKNIELRARLDPNVVLPFGDSNRLR
HHHHHHHCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEECCCCHHHH
QVVWNLLSNAIKFTPENGSIEVQLERGRAEAVLTVRDSGVGIAGDFLPHVFERFRQANST
HHHHHHHHHHEEECCCCCCEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCC
TTRSHGGLGLGLAIVRQLVELHGGTVGVESPGSDQGATFTVRLPLLLGRGARTSATQAPL
CCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEEHHHCCCCCCCCCCCCCC
PPEAMGLQVITVETGCLLDGHTLAETDLRRRYGVVVHALRREGRLIGFPDADTPLREGDQ
CCHHHCEEEEEEECCCEECCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCE
LLVSGGCDQLERLKQRMAESQG
EEEECCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQHPNRLSSLLPSLDQAMETRVKLVTPDTVLSDIVEWMGGQADYRCALPERKDRTLRQSG
CCCHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHCC
ELQPDCVLVAEGAHLVGIITEGDIVRLTALGKDLAAVRAGEVMLGGVVTLVQDGRQDILG
CCCCCEEEEECCCEEEEEEECCCEEEEEECCCHHHHHHHCCHHHHHHHHHHHCCHHHHHH
ALDLMRRHNVRHLPVLDDGGRVTGLLSAGGIRRTLQPIHLLTLRSVAEVMTTPVVHAPAG
HHHHHHHCCCCCCCEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCHH
SLLVNLARLMAGRRVSCVVIAEPHTDGVHVRPVGLITESDIVQFRYLQFDLTQTRAAAVM
HHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEEEEEECCCHHEEEEEEEEHHHHHHHHHH
SAVASPLKPFESVLVAHQQMLRRRVRRLVVTGERGELVGIVTQTGLLRLLDPLEIFGVIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHH
ALQRSVHQLEAEKMELLQGRTLQLERLVEERTAQVQEQARREQLARAAAESARQEAEEAN
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RIKDEFLATLSHELRTPLNPIIGFTQLLRKGQLDEASAARALETIERNARAQSRIIEDML
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DLSRIITGKLRLEVRPVALATVVEDALDTVRFAAQSKNIELRARLDPNVVLPFGDSNRLR
HHHHHHHCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEECCCCHHHH
QVVWNLLSNAIKFTPENGSIEVQLERGRAEAVLTVRDSGVGIAGDFLPHVFERFRQANST
HHHHHHHHHHEEECCCCCCEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCC
TTRSHGGLGLGLAIVRQLVELHGGTVGVESPGSDQGATFTVRLPLLLGRGARTSATQAPL
CCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEEHHHCCCCCCCCCCCCCC
PPEAMGLQVITVETGCLLDGHTLAETDLRRRYGVVVHALRREGRLIGFPDADTPLREGDQ
CCHHHCEEEEEEECCCEECCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCE
LLVSGGCDQLERLKQRMAESQG
EEEECCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]