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The map label for this gene is lepB [H]

Identifier: 37521592

GI number: 37521592

Start: 2174273

End: 2174848

Strand: Direct

Name: lepB [H]

Synonym: glr2023

Alternate gene names: 37521592

Gene position: 2174273-2174848 (Clockwise)

Preceding gene: 37521591

Following gene: 37521596

Centisome position: 46.67

GC content: 60.24

Gene sequence:

>576_bases
GTGGTGGAGCATCCAAATTCGACCGAGCCATCCCGGCCATCCGTTGCCCACGGTTTCTGGCGCTGGTTCTCCAGTCAGCG
CGAAAACCTCCAGACCATCGTGCTTGCTGTCTTCCTGGCGCTATTTATTCGCTCGTTCGTCGCCGAGGCGCGCTATATCC
CTTCCGGTTCGATGGAGCCGACCTTGCGCATCGACGACCGGCTCATCGTCGAAAAGCTCAGCTACGAATTTCAACAGCCC
GAGCGCGGCCAGGTGATCGTCTTCACACCGCCCAAGCGCACCAACATCGACCAAGCCTTCATCAAGCGCGTCATCGGCCT
GCCGGGGGACACCATCGAAGTCAAAAACGGCAAAGTCCTCCTCAACGGCAGGACTTTAAACGAGCCCTACATTGCCACTC
CCCCCGCCTACATCCTGCCTCGCCAGAAAGTACCGGCGGGTCATTTTTTTGTGATGGGCGACAACCGCAACAACAGCTTC
GACTCGCACCTGTGGGGCTTCCTGCCGCGCCAGAACGTGATCGGCCGGGCCGTCTTCCGCTTCTGGCCCCTCGAACGGGT
CGGGGCAATCGAGTGA

Upstream 100 bases:

>100_bases
TGGATCACTTATCTTGGGGTCAACTTCCTGGCCCAGGGCCTGCACAGCTACGGCTGGCTGTCTGGAAACTGAAGCGCGTC
ACGAGTGCGGGGAGCCTGAC

Downstream 100 bases:

>100_bases
AGCTGTTGTTGAGCAGCTGCGTACCCTCAAAATCGTGGTCTTGTCCGGAAAAACTTCTCCAGAGATCAGCTCTTCCTGTG
TTTTGGTGTGCCCTGAAACG

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MVEHPNSTEPSRPSVAHGFWRWFSSQRENLQTIVLAVFLALFIRSFVAEARYIPSGSMEPTLRIDDRLIVEKLSYEFQQP
ERGQVIVFTPPKRTNIDQAFIKRVIGLPGDTIEVKNGKVLLNGRTLNEPYIATPPAYILPRQKVPAGHFFVMGDNRNNSF
DSHLWGFLPRQNVIGRAVFRFWPLERVGAIE

Sequences:

>Translated_191_residues
MVEHPNSTEPSRPSVAHGFWRWFSSQRENLQTIVLAVFLALFIRSFVAEARYIPSGSMEPTLRIDDRLIVEKLSYEFQQP
ERGQVIVFTPPKRTNIDQAFIKRVIGLPGDTIEVKNGKVLLNGRTLNEPYIATPPAYILPRQKVPAGHFFVMGDNRNNSF
DSHLWGFLPRQNVIGRAVFRFWPLERVGAIE
>Mature_191_residues
MVEHPNSTEPSRPSVAHGFWRWFSSQRENLQTIVLAVFLALFIRSFVAEARYIPSGSMEPTLRIDDRLIVEKLSYEFQQP
ERGQVIVFTPPKRTNIDQAFIKRVIGLPGDTIEVKNGKVLLNGRTLNEPYIATPPAYILPRQKVPAGHFFVMGDNRNNSF
DSHLWGFLPRQNVIGRAVFRFWPLERVGAIE

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Homo sapiens, GI21450679, Length=134, Percent_Identity=33.5820895522388, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1788921, Length=91, Percent_Identity=42.8571428571429, Blast_Score=66, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24642241, Length=134, Percent_Identity=28.3582089552239, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 21904; Mature: 21904

Theoretical pI: Translated: 10.30; Mature: 10.30

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEHPNSTEPSRPSVAHGFWRWFSSQRENLQTIVLAVFLALFIRSFVAEARYIPSGSMEP
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TLRIDDRLIVEKLSYEFQQPERGQVIVFTPPKRTNIDQAFIKRVIGLPGDTIEVKNGKVL
EEEECHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCEEEECCCEEE
LNGRTLNEPYIATPPAYILPRQKVPAGHFFVMGDNRNNSFDSHLWGFLPRQNVIGRAVFR
ECCCCCCCCEEECCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHH
FWPLERVGAIE
HCCHHHCCCCC
>Mature Secondary Structure
MVEHPNSTEPSRPSVAHGFWRWFSSQRENLQTIVLAVFLALFIRSFVAEARYIPSGSMEP
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TLRIDDRLIVEKLSYEFQQPERGQVIVFTPPKRTNIDQAFIKRVIGLPGDTIEVKNGKVL
EEEECHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCEEEECCCEEE
LNGRTLNEPYIATPPAYILPRQKVPAGHFFVMGDNRNNSFDSHLWGFLPRQNVIGRAVFR
ECCCCCCCCEEECCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHH
FWPLERVGAIE
HCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7865790 [H]