Click here to switch to the map view.

The map label for this gene is purC

Identifier: 37521485

GI number: 37521485

Start: 2036775

End: 2037518

Strand: Direct

Name: purC

Synonym: gvip262

Alternate gene names: 37521485

Gene position: 2036775-2037518 (Clockwise)

Preceding gene: 37521484

Following gene: 37521489

Centisome position: 43.72

GC content: 60.48

Gene sequence:

>744_bases
GTGATCTTGCAACCTGGAGCGTGGGCCGTGGCAGACATCCTCTACGAAGGCAAGGCAAAAATCATCTACCCCACCCCCGA
CCCGGCGATTGTGCTCGCGGTCTTCAAAGACGACGCCACCGCCTTCAACGCCCAAAAACGCGGCACGATCTCGGGCAAGG
GTGCCGTCAACGCCACGGTCTCAGCAAAATTGTTCTTGCTGTTGGAGCGCTCGGGTGTGCCCACCCACTACATCGACCAG
CCGGCGGCCAACCAGTTGCTGTTTCGCCGTCTGAAGATGATCCCGCTCGAAGTGGTGGTGCGCAATATCGTGGCGGGCAG
TCTCGCCAAGCGCACGGGACTGGCGAGCGGCACGGTGCTGGGCGAAGCGATCGTCGAGTTTTACTACAAAAACGACGCCC
TGGGCGACCCGCTGCTCAACGACGAACATATTCTCAAAGTGCTCACCACCGTCGACGCGCTGCAACTGGCCGAATTGCGC
CGCTCGGCTTTGCAGGTCAACGCCATTTTGAGCGCTTTCTACCGCGAGTGCGGCATCCGACTGGTGGACTTCAAACTGGA
GTACGGCTACGACGGGGCGGGGCAGTTGCAACTTGGAGACGAATTGAGCCCGGACAATTGCCGACTTTGGACCCTGGAGG
AAGACCGCATCCTCGACAAAGACCGCTTCCGCTTCGATATGGGCGAGGTCGAGGGCGCTTATCAGGAAGTCCTGGCCAGG
GTGATCGCCAAAGCCGGCCCCTAA

Upstream 100 bases:

>100_bases
CGGCATTTTGTCAACAAGCAGGTGCCCTACCAGAAATTGCAGGCTGTGCGTTCCGCCGCCCAGGGACGCTAAAAGCTCCC
GGCGCCCGGCATCTGCTAAC

Downstream 100 bases:

>100_bases
AGCGCAAAGCCCGCGGCTGGGATACAACCGCGGGCTTTGTTTAGAGGAGCAAGAGCGAACCTAGGCGGCAGCCTTGTTCA
GCGAGGTTTCGATGAGCTGT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MILQPGAWAVADILYEGKAKIIYPTPDPAIVLAVFKDDATAFNAQKRGTISGKGAVNATVSAKLFLLLERSGVPTHYIDQ
PAANQLLFRRLKMIPLEVVVRNIVAGSLAKRTGLASGTVLGEAIVEFYYKNDALGDPLLNDEHILKVLTTVDALQLAELR
RSALQVNAILSAFYRECGIRLVDFKLEYGYDGAGQLQLGDELSPDNCRLWTLEEDRILDKDRFRFDMGEVEGAYQEVLAR
VIAKAGP

Sequences:

>Translated_247_residues
MILQPGAWAVADILYEGKAKIIYPTPDPAIVLAVFKDDATAFNAQKRGTISGKGAVNATVSAKLFLLLERSGVPTHYIDQ
PAANQLLFRRLKMIPLEVVVRNIVAGSLAKRTGLASGTVLGEAIVEFYYKNDALGDPLLNDEHILKVLTTVDALQLAELR
RSALQVNAILSAFYRECGIRLVDFKLEYGYDGAGQLQLGDELSPDNCRLWTLEEDRILDKDRFRFDMGEVEGAYQEVLAR
VIAKAGP
>Mature_247_residues
MILQPGAWAVADILYEGKAKIIYPTPDPAIVLAVFKDDATAFNAQKRGTISGKGAVNATVSAKLFLLLERSGVPTHYIDQ
PAANQLLFRRLKMIPLEVVVRNIVAGSLAKRTGLASGTVLGEAIVEFYYKNDALGDPLLNDEHILKVLTTVDALQLAELR
RSALQVNAILSAFYRECGIRLVDFKLEYGYDGAGQLQLGDELSPDNCRLWTLEEDRILDKDRFRFDMGEVEGAYQEVLAR
VIAKAGP

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=226, Percent_Identity=30.5309734513274, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI5453539, Length=226, Percent_Identity=30.5309734513274, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI119220559, Length=233, Percent_Identity=29.1845493562232, Blast_Score=90, Evalue=1e-18,
Organism=Escherichia coli, GI1788820, Length=228, Percent_Identity=36.4035087719298, Blast_Score=149, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17531275, Length=227, Percent_Identity=30.3964757709251, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24583917, Length=259, Percent_Identity=30.1158301158301, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI18860083, Length=226, Percent_Identity=30.0884955752212, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI160714955, Length=112, Percent_Identity=30.3571428571429, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_GLOVI (Q7NJB6)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_924862.1
- ProteinModelPortal:   Q7NJB6
- SMR:   Q7NJB6
- GeneID:   2600318
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.1916
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- ProtClustDB:   PRK09362
- BioCyc:   GVIO251221:GLR1916-MONOMER
- BRENDA:   6.3.2.6
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 27166; Mature: 27166

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2; PS00037 MYB_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILQPGAWAVADILYEGKAKIIYPTPDPAIVLAVFKDDATAFNAQKRGTISGKGAVNATV
CEECCCCHHHHHHHHCCCEEEEEECCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEH
SAKLFLLLERSGVPTHYIDQPAANQLLFRRLKMIPLEVVVRNIVAGSLAKRTGLASGTVL
HEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCHHH
GEAIVEFYYKNDALGDPLLNDEHILKVLTTVDALQLAELRRSALQVNAILSAFYRECGIR
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
LVDFKLEYGYDGAGQLQLGDELSPDNCRLWTLEEDRILDKDRFRFDMGEVEGAYQEVLAR
EEEEEEECCCCCCCCEEECCCCCCCCCEEEEECCCCCCCCHHHEECHHHHCHHHHHHHHH
VIAKAGP
HHHHCCC
>Mature Secondary Structure
MILQPGAWAVADILYEGKAKIIYPTPDPAIVLAVFKDDATAFNAQKRGTISGKGAVNATV
CEECCCCHHHHHHHHCCCEEEEEECCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEH
SAKLFLLLERSGVPTHYIDQPAANQLLFRRLKMIPLEVVVRNIVAGSLAKRTGLASGTVL
HEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCHHH
GEAIVEFYYKNDALGDPLLNDEHILKVLTTVDALQLAELRRSALQVNAILSAFYRECGIR
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
LVDFKLEYGYDGAGQLQLGDELSPDNCRLWTLEEDRILDKDRFRFDMGEVEGAYQEVLAR
EEEEEEECCCCCCCCEEECCCCCCCCCEEEEECCCCCCCCHHHEECHHHHCHHHHHHHHH
VIAKAGP
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292