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The map label for this gene is comEC [H]

Identifier: 37521448

GI number: 37521448

Start: 1995490

End: 1997652

Strand: Direct

Name: comEC [H]

Synonym: glr1879

Alternate gene names: 37521448

Gene position: 1995490-1997652 (Clockwise)

Preceding gene: 37521447

Following gene: 37521449

Centisome position: 42.83

GC content: 70.0

Gene sequence:

>2163_bases
GTGAAGCCGATGGAGCGCAACGGCTATTTTTTGGTGAGTGGGGCATACTTTGCCGGATTATTGCTCTCGGGGTGGGCCTG
GGGCTGGTTGGCTCTCGGGATTGTGGGCGTGGTGGGAACGGTCGCCTCGCTGCGGGTCTTTTCACTGCCTTCCTGGCGTT
TCTGGGTGGTGGCGTTCGTCTTTGCCGTGGGCGCGGGAGCTTACCTGCATCTGCGCACCCCCCGGCCTGCGCCCACCGAC
GTCAGTTGGAATGCTCCACGTTCATCGGTCGTGTTCACCGGCACAGTCGGCGGTTCTGTGCGTCTGGGGCCTGCCGGGCA
GCGCTTTTTGCTCACCCTGGATTTGCCCGAGTCGGGCAAAATCTGGGTGCGCGCCCCGGGAAGGCCGCCGGTGCGCCCCG
GCGATCGGGTGCACATCAGCGGCGCTTTGCGCCGTCCGGCTGTGCCTGCCAACCCCAACAGCTTCGACGAGCGGGCGTAC
TTGAGCAGGCAGGGAGCCTTTGCCGTGCTGAAGGCCGAGGCGCTCGCCGTGCTGGGCGCCCCGGCTCCCGACTGGCTCGC
CCTGGCCAGGGAGCGCATCGCCGCAACCCACAAGCGCTTTTTGGGAGAAGAGGCGGGGGCGTTGCTGGGTGCTCTGGTGG
TCGGGGCGGATGCGGTGACCTTGCCGAAAGCCGTCGAGGAGCGCTACCGCGCCGTCGGCCTCGCCCATCTGCTCGCCGCT
TCCGGCGCCCAGGTCTCGATCTTGCTGGGGGCGGCTCTGGTCTTGCTGCGCGGCTATCCGCCGCCGGTGCAGGCGGCCGT
GGGAGGGATTTTGCTCGCGGGATTCGTGGCCCTTGCCGGGGGCGGACCGTCGATATTGCGGGCGGCGGCCATGGGCGCGG
TGGCGCTGCTGGCCATCGTCCTGGGCGAAAAGGCGGAGCCGCTCGGAGCCCTCTGGGCTGCCGCCTTTGTCCTGCTCGTC
GCCGATCCGCTGATGATCTGGGATCTGGGCTTTGCCTTCAGTTTTCTGGCCACCCTCGGGCTGGTGGTGAGCGTCCCGAG
ACTGACTGCCCGCTTGGAGGGCCTGCCGGGAACGATCGCAGCCGCCCTCGCCGTGGGCTTCGCCGCCACCCTTTGGACGC
TGCCGCTGCAACTGTTGATTTTCGGCCAGTGGAGCCCCTACGCCCTGGCGCTCAACCTGCTGGCCGCCCCGGTTGTCGAA
GTGCTCACCCTGGGTGGAATGGCGGCAAGCGCCCTCGCCCTGGTCCACCCGAACGCCGCCGGGGTGCTGGACATTCCTTT
GGGCTGGCTACTGGCGGCGCTCGACGCGCTGGTGCGGCAGGTGGCGGATTGGCCGGGCAGCCTCGCCACGCCCGGTCTGC
TGCTGCCGGTGCAGGCGGTGGCCCTTTACGCCCTGCTCGTCGCGGCCCACACCCACCTACCCTGGCGGCCCCTCACCCTC
GCCGCCGCTCTGGTGCTGGTGGCTCCCGGTTGGCTGCCCCGGCCCGCGGTCACCCTCGCGGTGCTCGCGAGCGGCGGCTC
CGAAGCGCTGGTGATCGAGACACGGCGCCGCACCCTGGTGCTGGGCGGCGGCTCGGTTGGGGCGGTGGTCGGGGTGCTGG
TACCGTATCTCGAAGCGCGCGGCCGTCTGGCCGTCGATGCGGTCGTCGCCACCGGCGAAGCCCCCTGGCAAACCGGCGGG
CTGCGGGAGTTGCTTGAAGCGGCCGAAGTTGAGAGACTTTACGACGCCGTGCCGCCGCCGCGCTCCGCCCATTGGCAGCA
AACCCTCGCGCGGCTGGGTACAACCCGCCGCATCCCCCTTCTAGCCGGTGAGCGCATCGAACTGGAGGATGAGGTCGAGC
TGCGGCTGCTGGCGAGCGAGCCCCCGGCGCTTTTGTTGGAAGCGGCCGGATCGACGCTGCTGTTGGCCGGATCGCCCAGC
CTGCTTGAGCAGCGCTGGCTGTTGCAGGAGCATCGCGGTACACTCGGCCCGGTGCAATGGCTGTGGAGCGGCGGGCGGCT
GCCGGAGGCTTTGCTGAGGCTCGACCGCCTGCAGGGCGTACTCGTCAGCGGTCGCGAACGGGGCCGCCCGCCCGCCCGAT
TGCCCCGCTGGAGCACCGAGCGGCACGGAGGGCTTATCTGGGAAGCCTGGCCCGGCGGCGCACGGGTCAGTGCAAACAGG
TAG

Upstream 100 bases:

>100_bases
GGTCATTGCCCGACGCATTGCCGCACATCCCGGTACACTGCCGGCCTTAAATTTCGCTCCGCACGCCCAAACCGGTCACA
ATCGCCGGGTCGGGGTCGGG

Downstream 100 bases:

>100_bases
CATGTGTGAAAAACCGGCGCCACCAGGAGAAAGGCTGCAATGGGAGAACCGGCCGAGAATGCAAACGGCGGCGTTTTATT
AACCCGCATCAGTACCAACG

Product: competence protein ComE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 720; Mature: 720

Protein sequence:

>720_residues
MKPMERNGYFLVSGAYFAGLLLSGWAWGWLALGIVGVVGTVASLRVFSLPSWRFWVVAFVFAVGAGAYLHLRTPRPAPTD
VSWNAPRSSVVFTGTVGGSVRLGPAGQRFLLTLDLPESGKIWVRAPGRPPVRPGDRVHISGALRRPAVPANPNSFDERAY
LSRQGAFAVLKAEALAVLGAPAPDWLALARERIAATHKRFLGEEAGALLGALVVGADAVTLPKAVEERYRAVGLAHLLAA
SGAQVSILLGAALVLLRGYPPPVQAAVGGILLAGFVALAGGGPSILRAAAMGAVALLAIVLGEKAEPLGALWAAAFVLLV
ADPLMIWDLGFAFSFLATLGLVVSVPRLTARLEGLPGTIAAALAVGFAATLWTLPLQLLIFGQWSPYALALNLLAAPVVE
VLTLGGMAASALALVHPNAAGVLDIPLGWLLAALDALVRQVADWPGSLATPGLLLPVQAVALYALLVAAHTHLPWRPLTL
AAALVLVAPGWLPRPAVTLAVLASGGSEALVIETRRRTLVLGGGSVGAVVGVLVPYLEARGRLAVDAVVATGEAPWQTGG
LRELLEAAEVERLYDAVPPPRSAHWQQTLARLGTTRRIPLLAGERIELEDEVELRLLASEPPALLLEAAGSTLLLAGSPS
LLEQRWLLQEHRGTLGPVQWLWSGGRLPEALLRLDRLQGVLVSGRERGRPPARLPRWSTERHGGLIWEAWPGGARVSANR

Sequences:

>Translated_720_residues
MKPMERNGYFLVSGAYFAGLLLSGWAWGWLALGIVGVVGTVASLRVFSLPSWRFWVVAFVFAVGAGAYLHLRTPRPAPTD
VSWNAPRSSVVFTGTVGGSVRLGPAGQRFLLTLDLPESGKIWVRAPGRPPVRPGDRVHISGALRRPAVPANPNSFDERAY
LSRQGAFAVLKAEALAVLGAPAPDWLALARERIAATHKRFLGEEAGALLGALVVGADAVTLPKAVEERYRAVGLAHLLAA
SGAQVSILLGAALVLLRGYPPPVQAAVGGILLAGFVALAGGGPSILRAAAMGAVALLAIVLGEKAEPLGALWAAAFVLLV
ADPLMIWDLGFAFSFLATLGLVVSVPRLTARLEGLPGTIAAALAVGFAATLWTLPLQLLIFGQWSPYALALNLLAAPVVE
VLTLGGMAASALALVHPNAAGVLDIPLGWLLAALDALVRQVADWPGSLATPGLLLPVQAVALYALLVAAHTHLPWRPLTL
AAALVLVAPGWLPRPAVTLAVLASGGSEALVIETRRRTLVLGGGSVGAVVGVLVPYLEARGRLAVDAVVATGEAPWQTGG
LRELLEAAEVERLYDAVPPPRSAHWQQTLARLGTTRRIPLLAGERIELEDEVELRLLASEPPALLLEAAGSTLLLAGSPS
LLEQRWLLQEHRGTLGPVQWLWSGGRLPEALLRLDRLQGVLVSGRERGRPPARLPRWSTERHGGLIWEAWPGGARVSANR
>Mature_720_residues
MKPMERNGYFLVSGAYFAGLLLSGWAWGWLALGIVGVVGTVASLRVFSLPSWRFWVVAFVFAVGAGAYLHLRTPRPAPTD
VSWNAPRSSVVFTGTVGGSVRLGPAGQRFLLTLDLPESGKIWVRAPGRPPVRPGDRVHISGALRRPAVPANPNSFDERAY
LSRQGAFAVLKAEALAVLGAPAPDWLALARERIAATHKRFLGEEAGALLGALVVGADAVTLPKAVEERYRAVGLAHLLAA
SGAQVSILLGAALVLLRGYPPPVQAAVGGILLAGFVALAGGGPSILRAAAMGAVALLAIVLGEKAEPLGALWAAAFVLLV
ADPLMIWDLGFAFSFLATLGLVVSVPRLTARLEGLPGTIAAALAVGFAATLWTLPLQLLIFGQWSPYALALNLLAAPVVE
VLTLGGMAASALALVHPNAAGVLDIPLGWLLAALDALVRQVADWPGSLATPGLLLPVQAVALYALLVAAHTHLPWRPLTL
AAALVLVAPGWLPRPAVTLAVLASGGSEALVIETRRRTLVLGGGSVGAVVGVLVPYLEARGRLAVDAVVATGEAPWQTGG
LRELLEAAEVERLYDAVPPPRSAHWQQTLARLGTTRRIPLLAGERIELEDEVELRLLASEPPALLLEAAGSTLLLAGSPS
LLEQRWLLQEHRGTLGPVQWLWSGGRLPEALLRLDRLQGVLVSGRERGRPPARLPRWSTERHGGLIWEAWPGGARVSANR

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 75616; Mature: 75616

Theoretical pI: Translated: 10.54; Mature: 10.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPMERNGYFLVSGAYFAGLLLSGWAWGWLALGIVGVVGTVASLRVFSLPSWRFWVVAFV
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
FAVGAGAYLHLRTPRPAPTDVSWNAPRSSVVFTGTVGGSVRLGPAGQRFLLTLDLPESGK
HHHCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCEEEECCCCCEEEEEEECCCCCC
IWVRAPGRPPVRPGDRVHISGALRRPAVPANPNSFDERAYLSRQGAFAVLKAEALAVLGA
EEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHCCCCEEEEHHHHHHEECC
PAPDWLALARERIAATHKRFLGEEAGALLGALVVGADAVTLPKAVEERYRAVGLAHLLAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
SGAQVSILLGAALVLLRGYPPPVQAAVGGILLAGFVALAGGGPSILRAAAMGAVALLAIV
CCCEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LGEKAEPLGALWAAAFVLLVADPLMIWDLGFAFSFLATLGLVVSVPRLTARLEGLPGTIA
HCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
AALAVGFAATLWTLPLQLLIFGQWSPYALALNLLAAPVVEVLTLGGMAASALALVHPNAA
HHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHEEEECCCCC
GVLDIPLGWLLAALDALVRQVADWPGSLATPGLLLPVQAVALYALLVAAHTHLPWRPLTL
CEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
AAALVLVAPGWLPRPAVTLAVLASGGSEALVIETRRRTLVLGGGSVGAVVGVLVPYLEAR
HHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHCC
GRLAVDAVVATGEAPWQTGGLRELLEAAEVERLYDAVPPPRSAHWQQTLARLGTTRRIPL
CCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEE
LAGERIELEDEVELRLLASEPPALLLEAAGSTLLLAGSPSLLEQRWLLQEHRGTLGPVQW
ECCCCCCCCCCCEEEEECCCCCCEEEECCCCEEEEECCHHHHHHHHHHHHHCCCCCCHHH
LWSGGRLPEALLRLDRLQGVLVSGRERGRPPARLPRWSTERHGGLIWEAWPGGARVSANR
HHCCCCCHHHHHHHHHHHHHEECCHHCCCCCCCCCCCCCCCCCCEEEEECCCCCEECCCC
>Mature Secondary Structure
MKPMERNGYFLVSGAYFAGLLLSGWAWGWLALGIVGVVGTVASLRVFSLPSWRFWVVAFV
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
FAVGAGAYLHLRTPRPAPTDVSWNAPRSSVVFTGTVGGSVRLGPAGQRFLLTLDLPESGK
HHHCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCEEEECCCCCEEEEEEECCCCCC
IWVRAPGRPPVRPGDRVHISGALRRPAVPANPNSFDERAYLSRQGAFAVLKAEALAVLGA
EEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHCCCCEEEEHHHHHHEECC
PAPDWLALARERIAATHKRFLGEEAGALLGALVVGADAVTLPKAVEERYRAVGLAHLLAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
SGAQVSILLGAALVLLRGYPPPVQAAVGGILLAGFVALAGGGPSILRAAAMGAVALLAIV
CCCEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LGEKAEPLGALWAAAFVLLVADPLMIWDLGFAFSFLATLGLVVSVPRLTARLEGLPGTIA
HCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
AALAVGFAATLWTLPLQLLIFGQWSPYALALNLLAAPVVEVLTLGGMAASALALVHPNAA
HHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHEEEECCCCC
GVLDIPLGWLLAALDALVRQVADWPGSLATPGLLLPVQAVALYALLVAAHTHLPWRPLTL
CEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
AAALVLVAPGWLPRPAVTLAVLASGGSEALVIETRRRTLVLGGGSVGAVVGVLVPYLEAR
HHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHCC
GRLAVDAVVATGEAPWQTGGLRELLEAAEVERLYDAVPPPRSAHWQQTLARLGTTRRIPL
CCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEE
LAGERIELEDEVELRLLASEPPALLLEAAGSTLLLAGSPSLLEQRWLLQEHRGTLGPVQW
ECCCCCCCCCCCEEEEECCCCCCEEEECCCCEEEEECCHHHHHHHHHHHHHCCCCCCHHH
LWSGGRLPEALLRLDRLQGVLVSGRERGRPPARLPRWSTERHGGLIWEAWPGGARVSANR
HHCCCCCHHHHHHHHHHHHHEECCHHCCCCCCCCCCCCCCCCCCEEEEECCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]