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The map label for this gene is trpE [H]

Identifier: 37521286

GI number: 37521286

Start: 1826186

End: 1827712

Strand: Direct

Name: trpE [H]

Synonym: gvip236

Alternate gene names: 37521286

Gene position: 1826186-1827712 (Clockwise)

Preceding gene: 37521284

Following gene: 37521287

Centisome position: 39.2

GC content: 64.96

Gene sequence:

>1527_bases
ATGGTTGCGCCGGACTTTGAGCGCTTCGAGACACTGGCAAAAGACGGCAATTTTATTCCTGTGTACCGCGAGATTCTGGC
GGATCTCGAAACGCCGGTCTCTGCCTGGTATCGAGTCTGTGACGGGGCGAGGGAAAGTTTTTTGCTCGAATCGGTCGAGG
GGGGCGAGAGGCTGGGACGCTACAGCTTCCTGGGGTGCGAGCCGCTCTGGACCCTCGCCGCCCGGGGCGATACGTGCGAG
CAGGTGTTTCGCGACGGTGGGCGGCTCACCCACACGGGCGACCCGTTCGCGGTGCTCGATCGCTGTTTGGAACCCTACCA
GCCGGTGCACCTGCCGGAGTTGCCGCCGGGAATCGGTGGGCTTTTTGGTTACTGGGGCTATGAACTGATTCGCTGGATCG
AACCGACGGTGCCCGTGTATAGCGATCCCGACGGCCTGCCCGACGGCTTCTGGATGCAGGTCGATTCGCTGCTCATCTTC
GATCAAATCAAGCGCAAGATCTGGGTGATCGCCTACGCGGATCTGCGCGAGGGCGACACGGCGAGCGCCTACCGGCTCGC
CGGCCAAAAAGTGGACGCGCTGGTGGAACGATTGGCCCGGCCCGCCGCCAAGGCCGAGCCCCTGGGCCTGGAGTGGACGC
CCCACAGGGTCCAAGCCCAAAGTACCTTCAGCCGCGAGCAGTACTGTGGGGCCGTCGAGCGCGCCCGCGAATATATCCGG
GCTGGGGATATCTTTCAGGTGGTACTCGCCCAGCGCTTCAGCACGCCCTTTGCGGGCGAGAGCTTTGATCTCTACCGGAT
GCTGAGGGCGATTAACCCTTCGCCCTACATGGCTTACTACCAGTTCGGCGATTTTCAACTGATCGGTTCGAGCCCGGAGG
TGATGGTGCGTCTGGATCGGCGCGACGGGGGAGCCCTCGCCACCGTCCGGCCGATCGCGGGCACCCGGCGGCGCGGCCAG
AGCGAAGCGGAGGACCGCTGGCTCGAAAAAGATCTGCTCGCCGATCCCAAGGAGGTGGCCGAGCACGTCATGCTCGTGGA
TCTGGGCCGCAACGACCTGGGCCGGGTGTGCAAACCGGGCAGCGTGCGGGTGGACGAACTGCTCACCGTCGAGCGCTACT
CCCACGTCATGCACATCGTCTCCAACGTCACCGGCGAACTAGCCTCCGGCCGAGGGGCCTGGGATCTGCTCAGGGCCACT
TTTCCGGCCGGTACGGTGAGTGGCGCCCCCAAAATCCGGGCGATGGAGATTATCCACGCACTGGAACCGTTTCGGCGCGG
ACCCTACGCGGGCGCCTACGGCTACTACAGCTTCGACGGCCAGCTCAACACCGCCATCACCATCCGCACGCTGGTCGTCC
ACGGGGGGCTCGCCAACATCCAGGCCGGGGCGGGGCTGGTGGCCGACTCGGTACCCGAGACCGAGTACGAGGAAACGCTC
AACAAAGCCCGCGGCATGCTCGAAACGATCGCCCGCCTCGCCCGGAGCGGGGGCGCGTCCGCTAACGTAGAAGGGCAAGT
GCAATAG

Upstream 100 bases:

>100_bases
AGCACATCCGGGCAGTAGGTGCCGGTCAGAACGTACTTTGGCATGGGTCGATTGTGCCACAAGGGGGAGGCGATAATGGC
GGGAAGACTGGAGGGTCGCG

Downstream 100 bases:

>100_bases
CAACCCATGGAAAGCGCCCCCGAGAACAAAACCGGCATCTGGCTGCGCAACGGCATCGTCGCGCTGGCCTCGGTGCTGAT
CGCGGTGCTCGTCTTTTTTG

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MVAPDFERFETLAKDGNFIPVYREILADLETPVSAWYRVCDGARESFLLESVEGGERLGRYSFLGCEPLWTLAARGDTCE
QVFRDGGRLTHTGDPFAVLDRCLEPYQPVHLPELPPGIGGLFGYWGYELIRWIEPTVPVYSDPDGLPDGFWMQVDSLLIF
DQIKRKIWVIAYADLREGDTASAYRLAGQKVDALVERLARPAAKAEPLGLEWTPHRVQAQSTFSREQYCGAVERAREYIR
AGDIFQVVLAQRFSTPFAGESFDLYRMLRAINPSPYMAYYQFGDFQLIGSSPEVMVRLDRRDGGALATVRPIAGTRRRGQ
SEAEDRWLEKDLLADPKEVAEHVMLVDLGRNDLGRVCKPGSVRVDELLTVERYSHVMHIVSNVTGELASGRGAWDLLRAT
FPAGTVSGAPKIRAMEIIHALEPFRRGPYAGAYGYYSFDGQLNTAITIRTLVVHGGLANIQAGAGLVADSVPETEYEETL
NKARGMLETIARLARSGGASANVEGQVQ

Sequences:

>Translated_508_residues
MVAPDFERFETLAKDGNFIPVYREILADLETPVSAWYRVCDGARESFLLESVEGGERLGRYSFLGCEPLWTLAARGDTCE
QVFRDGGRLTHTGDPFAVLDRCLEPYQPVHLPELPPGIGGLFGYWGYELIRWIEPTVPVYSDPDGLPDGFWMQVDSLLIF
DQIKRKIWVIAYADLREGDTASAYRLAGQKVDALVERLARPAAKAEPLGLEWTPHRVQAQSTFSREQYCGAVERAREYIR
AGDIFQVVLAQRFSTPFAGESFDLYRMLRAINPSPYMAYYQFGDFQLIGSSPEVMVRLDRRDGGALATVRPIAGTRRRGQ
SEAEDRWLEKDLLADPKEVAEHVMLVDLGRNDLGRVCKPGSVRVDELLTVERYSHVMHIVSNVTGELASGRGAWDLLRAT
FPAGTVSGAPKIRAMEIIHALEPFRRGPYAGAYGYYSFDGQLNTAITIRTLVVHGGLANIQAGAGLVADSVPETEYEETL
NKARGMLETIARLARSGGASANVEGQVQ
>Mature_508_residues
MVAPDFERFETLAKDGNFIPVYREILADLETPVSAWYRVCDGARESFLLESVEGGERLGRYSFLGCEPLWTLAARGDTCE
QVFRDGGRLTHTGDPFAVLDRCLEPYQPVHLPELPPGIGGLFGYWGYELIRWIEPTVPVYSDPDGLPDGFWMQVDSLLIF
DQIKRKIWVIAYADLREGDTASAYRLAGQKVDALVERLARPAAKAEPLGLEWTPHRVQAQSTFSREQYCGAVERAREYIR
AGDIFQVVLAQRFSTPFAGESFDLYRMLRAINPSPYMAYYQFGDFQLIGSSPEVMVRLDRRDGGALATVRPIAGTRRRGQ
SEAEDRWLEKDLLADPKEVAEHVMLVDLGRNDLGRVCKPGSVRVDELLTVERYSHVMHIVSNVTGELASGRGAWDLLRAT
FPAGTVSGAPKIRAMEIIHALEPFRRGPYAGAYGYYSFDGQLNTAITIRTLVVHGGLANIQAGAGLVADSVPETEYEETL
NKARGMLETIARLARSGGASANVEGQVQ

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=385, Percent_Identity=41.038961038961, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1788114, Length=449, Percent_Identity=35.1893095768374, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI87082077, Length=276, Percent_Identity=30.4347826086957, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786809, Length=318, Percent_Identity=27.6729559748428, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320935, Length=508, Percent_Identity=36.4173228346457, Blast_Score=317, Evalue=4e-87,
Organism=Saccharomyces cerevisiae, GI6324361, Length=404, Percent_Identity=24.7524752475248, Blast_Score=114, Evalue=3e-26,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 56418; Mature: 56418

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAPDFERFETLAKDGNFIPVYREILADLETPVSAWYRVCDGARESFLLESVEGGERLGR
CCCCCHHHHHHHHHCCCEEHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHCCHHHHCC
YSFLGCEPLWTLAARGDTCEQVFRDGGRLTHTGDPFAVLDRCLEPYQPVHLPELPPGIGG
CEEECCCHHHHHHCCCCHHHHHHHCCCCEEECCCCHHHHHHHHCCCCCCCCCCCCCCCHH
LFGYWGYELIRWIEPTVPVYSDPDGLPDGFWMQVDSLLIFDQIKRKIWVIAYADLREGDT
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCCC
ASAYRLAGQKVDALVERLARPAAKAEPLGLEWTPHRVQAQSTFSREQYCGAVERAREYIR
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AGDIFQVVLAQRFSTPFAGESFDLYRMLRAINPSPYMAYYQFGDFQLIGSSPEVMVRLDR
HCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCEEEECCCCEEEEEEEC
RDGGALATVRPIAGTRRRGQSEAEDRWLEKDLLADPKEVAEHVMLVDLGRNDLGRVCKPG
CCCCCEEEEECCCCHHHCCCCHHHHHHHHHHHCCCHHHHHHHEEEEECCCCCHHHCCCCC
SVRVDELLTVERYSHVMHIVSNVTGELASGRGAWDLLRATFPAGTVSGAPKIRAMEIIHA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHH
LEPFRRGPYAGAYGYYSFDGQLNTAITIRTLVVHGGLANIQAGAGLVADSVPETEYEETL
HHHHHCCCCCCCCCEEEECCCCCCEEEEEEHHHCCCHHHCCCCCCHHHCCCCCHHHHHHH
NKARGMLETIARLARSGGASANVEGQVQ
HHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MVAPDFERFETLAKDGNFIPVYREILADLETPVSAWYRVCDGARESFLLESVEGGERLGR
CCCCCHHHHHHHHHCCCEEHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHCCHHHHCC
YSFLGCEPLWTLAARGDTCEQVFRDGGRLTHTGDPFAVLDRCLEPYQPVHLPELPPGIGG
CEEECCCHHHHHHCCCCHHHHHHHCCCCEEECCCCHHHHHHHHCCCCCCCCCCCCCCCHH
LFGYWGYELIRWIEPTVPVYSDPDGLPDGFWMQVDSLLIFDQIKRKIWVIAYADLREGDT
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCCC
ASAYRLAGQKVDALVERLARPAAKAEPLGLEWTPHRVQAQSTFSREQYCGAVERAREYIR
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AGDIFQVVLAQRFSTPFAGESFDLYRMLRAINPSPYMAYYQFGDFQLIGSSPEVMVRLDR
HCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCEEEECCCCEEEEEEEC
RDGGALATVRPIAGTRRRGQSEAEDRWLEKDLLADPKEVAEHVMLVDLGRNDLGRVCKPG
CCCCCEEEEECCCCHHHCCCCHHHHHHHHHHHCCCHHHHHHHEEEEECCCCCHHHCCCCC
SVRVDELLTVERYSHVMHIVSNVTGELASGRGAWDLLRATFPAGTVSGAPKIRAMEIIHA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHH
LEPFRRGPYAGAYGYYSFDGQLNTAITIRTLVVHGGLANIQAGAGLVADSVPETEYEETL
HHHHHCCCCCCCCCEEEECCCCCCEEEEEEHHHCCCHHHCCCCCCHHHCCCCCHHHHHHH
NKARGMLETIARLARSGGASANVEGQVQ
HHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 3141423 [H]