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The map label for this gene is pgi

Identifier: 37521261

GI number: 37521261

Start: 1802608

End: 1804254

Strand: Reverse

Name: pgi

Synonym: gll1692

Alternate gene names: 37521261

Gene position: 1804254-1802608 (Counterclockwise)

Preceding gene: 37521262

Following gene: 37521257

Centisome position: 38.73

GC content: 62.6

Gene sequence:

>1647_bases
ATGACCTCGACATTCGCACCCACACCGCTCACCCAGCGCGCGGCCTGGCAGGCGCTTGCAGCTCATTACGAGCAAATCCG
CGAGATCCATCTGCGCGCGCTTTTTGCTGAAGATCCTAGCCGCGGCGAGCGGTTTGCCCTCGAAGCGGAAGGCTTCTACC
TCGATTACTCCAAAAATCGGCTCACCGACGAGACCTTGCGCCTGCTGTCGGTCTTGGCGGAGGAGTCGGACCTGCGCGGC
CGCATTGAGGCGATGTTCTCAGGCGAGAAGATCAACACCACCGAGCAGCGCTCCGTGCTGCATACCGCCTTGCGCGCACC
CCGGGGAGCCACGGTGATCGAGGACGGCGAGAATGTCGTGCCCGAGGTGCACGCCGTTCTCGACCGGATGGCCGAATTTG
CCGACCGGGTGCGCGGCGGCGAGTGGAGAGGCTACACCGGCAGGCGTATCCGCACCGTCGTCAATATCGGCATCGGCGGC
TCTTATCTCGGTCCGGACATGGCCTACGACGCGCTCAAGCACTACAGCGACCGCGACTTGAAAGTGCGCTTCGCAGCCAA
CGTCGATGGTTCCAACTTTGCCGAGGTGATCCACGACCTTGAACCCGACGAAACGTTGTTTATCGTCTGCTCTAAGACCT
TTACGACCCTGGAGACGATGACCAACGCCCACAGCGCCCGGCAGTGGTGTCTCGCGGCTTTGGGAGACGAGCAAGCAATC
GCCAAGCACTTCGTGGCCGTCTCCACCAACGCGGCCGAGGTCGAAAAGTTCGGCATCGACACCGCCCACATGTTTGGTTT
TTGGGACTGGGTGGGGGGACGCTACTCGATGGATTCGGCCATCGGCCTCTCGACGATGATCGCGGTGGGGCCTGAGCATT
TCCGCGCCATGCTCGCCGGTTTCCACGCGATGGACGAGCACTTTCGCACCGCCCCCTTTGAGCGCAACCTGCCGGTGCTG
ATGGCGCTGATTGGCCTGTGGTACAACAACTTTTTCGGCGCCCAGACACTCGCAGTGCTGCCCTACGACTACTACCTGGG
CAAGCTGCCCGCCTATTTGCAGCAGCTCGACATGGAGAGCAACGGCAAGCACGTCGACATCGACGGCCAGCCGGTCACCT
ATCAGACCGGTCCGATCATCTGGGGCCAGCCGGGCACCGACGGGCAGCACTCGTTCTACCAACTCATCCACCAGGGCACC
AAGCTCATCCCCTGCGACTTTATCGGCTTTTGCCAGACGCTCAATCCGATTGCCCCGCACCACGATCAGCTGATGGCCAA
CTTCTTCGCCCAGACCGAGGCGCTCGCCTTCGGCAAGACCGAAGCCGAGGTGCGCGCCGAGGGGGTGGCCGACTGGCTGT
TGCCCCACCGGGTCTTCGAGGGCAACCGGCCCACCAACACGCTGCTGGCCGAGCGGCTCACCCCGGAGGTCTTGGGCAAG
CTCATCGCCCTTTACGAGCACAAAGTCTTTACCCAGGGCGTCATCTGGAACCTCGATTCGTTCGATCAGTGGGGGGTGGA
ACTGGGCAAGGTGCTTGCCGGGCGGATCATTCCCGAGCTGGAAAGCGCCGAGGAACCCGAATTGGCCCACGACAGCTCCA
CCAATGCCCTGATCCGGCGCTACCGCCGAGCGAAGCGGCAAAATTAA

Upstream 100 bases:

>100_bases
CGCACCGACCCGGTTGCAAACGGCTCTTCGCGCGCATTTAGTCTCGCGTTAACGCCCTGCGGCTATTCTCAAAACAATCT
CAAGGGAGACGGCTTTTCGT

Downstream 100 bases:

>100_bases
AGCGAGATCAGCGCAAAGCGGGGATCAAGCAGGTCGCGCGAACAGGTCGCCGATCACCACAACCAAATCCGCAAAAGCTG
GCGGCGAGATCGGCATCGGG

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MTSTFAPTPLTQRAAWQALAAHYEQIREIHLRALFAEDPSRGERFALEAEGFYLDYSKNRLTDETLRLLSVLAEESDLRG
RIEAMFSGEKINTTEQRSVLHTALRAPRGATVIEDGENVVPEVHAVLDRMAEFADRVRGGEWRGYTGRRIRTVVNIGIGG
SYLGPDMAYDALKHYSDRDLKVRFAANVDGSNFAEVIHDLEPDETLFIVCSKTFTTLETMTNAHSARQWCLAALGDEQAI
AKHFVAVSTNAAEVEKFGIDTAHMFGFWDWVGGRYSMDSAIGLSTMIAVGPEHFRAMLAGFHAMDEHFRTAPFERNLPVL
MALIGLWYNNFFGAQTLAVLPYDYYLGKLPAYLQQLDMESNGKHVDIDGQPVTYQTGPIIWGQPGTDGQHSFYQLIHQGT
KLIPCDFIGFCQTLNPIAPHHDQLMANFFAQTEALAFGKTEAEVRAEGVADWLLPHRVFEGNRPTNTLLAERLTPEVLGK
LIALYEHKVFTQGVIWNLDSFDQWGVELGKVLAGRIIPELESAEEPELAHDSSTNALIRRYRRAKRQN

Sequences:

>Translated_548_residues
MTSTFAPTPLTQRAAWQALAAHYEQIREIHLRALFAEDPSRGERFALEAEGFYLDYSKNRLTDETLRLLSVLAEESDLRG
RIEAMFSGEKINTTEQRSVLHTALRAPRGATVIEDGENVVPEVHAVLDRMAEFADRVRGGEWRGYTGRRIRTVVNIGIGG
SYLGPDMAYDALKHYSDRDLKVRFAANVDGSNFAEVIHDLEPDETLFIVCSKTFTTLETMTNAHSARQWCLAALGDEQAI
AKHFVAVSTNAAEVEKFGIDTAHMFGFWDWVGGRYSMDSAIGLSTMIAVGPEHFRAMLAGFHAMDEHFRTAPFERNLPVL
MALIGLWYNNFFGAQTLAVLPYDYYLGKLPAYLQQLDMESNGKHVDIDGQPVTYQTGPIIWGQPGTDGQHSFYQLIHQGT
KLIPCDFIGFCQTLNPIAPHHDQLMANFFAQTEALAFGKTEAEVRAEGVADWLLPHRVFEGNRPTNTLLAERLTPEVLGK
LIALYEHKVFTQGVIWNLDSFDQWGVELGKVLAGRIIPELESAEEPELAHDSSTNALIRRYRRAKRQN
>Mature_547_residues
TSTFAPTPLTQRAAWQALAAHYEQIREIHLRALFAEDPSRGERFALEAEGFYLDYSKNRLTDETLRLLSVLAEESDLRGR
IEAMFSGEKINTTEQRSVLHTALRAPRGATVIEDGENVVPEVHAVLDRMAEFADRVRGGEWRGYTGRRIRTVVNIGIGGS
YLGPDMAYDALKHYSDRDLKVRFAANVDGSNFAEVIHDLEPDETLFIVCSKTFTTLETMTNAHSARQWCLAALGDEQAIA
KHFVAVSTNAAEVEKFGIDTAHMFGFWDWVGGRYSMDSAIGLSTMIAVGPEHFRAMLAGFHAMDEHFRTAPFERNLPVLM
ALIGLWYNNFFGAQTLAVLPYDYYLGKLPAYLQQLDMESNGKHVDIDGQPVTYQTGPIIWGQPGTDGQHSFYQLIHQGTK
LIPCDFIGFCQTLNPIAPHHDQLMANFFAQTEALAFGKTEAEVRAEGVADWLLPHRVFEGNRPTNTLLAERLTPEVLGKL
IALYEHKVFTQGVIWNLDSFDQWGVELGKVLAGRIIPELESAEEPELAHDSSTNALIRRYRRAKRQN

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=556, Percent_Identity=52.3381294964029, Blast_Score=581, Evalue=1e-166,
Organism=Homo sapiens, GI296080693, Length=556, Percent_Identity=48.9208633093525, Blast_Score=525, Evalue=1e-149,
Organism=Escherichia coli, GI1790457, Length=541, Percent_Identity=58.9648798521257, Blast_Score=659, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996708, Length=551, Percent_Identity=52.2686025408348, Blast_Score=560, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI71996703, Length=544, Percent_Identity=52.5735294117647, Blast_Score=559, Evalue=1e-159,
Organism=Saccharomyces cerevisiae, GI6319673, Length=542, Percent_Identity=51.6605166051661, Blast_Score=558, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24651916, Length=547, Percent_Identity=54.2961608775137, Blast_Score=585, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24651914, Length=547, Percent_Identity=54.2961608775137, Blast_Score=585, Evalue=1e-167,
Organism=Drosophila melanogaster, GI17737445, Length=547, Percent_Identity=54.2961608775137, Blast_Score=585, Evalue=1e-167,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_GLOVI (Q7NJY9)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_924638.1
- ProteinModelPortal:   Q7NJY9
- SMR:   Q7NJY9
- GeneID:   2598472
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:gll1692
- NMPDR:   fig|251221.1.peg.1692
- HOGENOM:   HBG352954
- OMA:   RTSITSA
- ProtClustDB:   PRK00179
- BioCyc:   GVIO251221:GLL1692-MONOMER
- BRENDA:   5.3.1.9
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 61509; Mature: 61378

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 359-359 ACT_SITE 390-390 ACT_SITE 510-510

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTFAPTPLTQRAAWQALAAHYEQIREIHLRALFAEDPSRGERFALEAEGFYLDYSKNR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCEEEECCCCC
LTDETLRLLSVLAEESDLRGRIEAMFSGEKINTTEQRSVLHTALRAPRGATVIEDGENVV
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCH
PEVHAVLDRMAEFADRVRGGEWRGYTGRRIRTVVNIGIGGSYLGPDMAYDALKHYSDRDL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHCCCCCE
KVRFAANVDGSNFAEVIHDLEPDETLFIVCSKTFTTLETMTNAHSARQWCLAALGDEQAI
EEEEEECCCCCHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHH
AKHFVAVSTNAAEVEKFGIDTAHMFGFWDWVGGRYSMDSAIGLSTMIAVGPEHFRAMLAG
HHHHHHCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHH
FHAMDEHFRTAPFERNLPVLMALIGLWYNNFFGAQTLAVLPYDYYLGKLPAYLQQLDMES
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHCCCC
NGKHVDIDGQPVTYQTGPIIWGQPGTDGQHSFYQLIHQGTKLIPCDFIGFCQTLNPIAPH
CCCEEECCCCEEEEECCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCC
HDQLMANFFAQTEALAFGKTEAEVRAEGVADWLLPHRVFEGNRPTNTLLAERLTPEVLGK
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHH
LIALYEHKVFTQGVIWNLDSFDQWGVELGKVLAGRIIPELESAEEPELAHDSSTNALIRR
HHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHH
YRRAKRQN
HHHHHCCC
>Mature Secondary Structure 
TSTFAPTPLTQRAAWQALAAHYEQIREIHLRALFAEDPSRGERFALEAEGFYLDYSKNR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCEEEECCCCC
LTDETLRLLSVLAEESDLRGRIEAMFSGEKINTTEQRSVLHTALRAPRGATVIEDGENVV
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCH
PEVHAVLDRMAEFADRVRGGEWRGYTGRRIRTVVNIGIGGSYLGPDMAYDALKHYSDRDL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHCCCCCE
KVRFAANVDGSNFAEVIHDLEPDETLFIVCSKTFTTLETMTNAHSARQWCLAALGDEQAI
EEEEEECCCCCHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHH
AKHFVAVSTNAAEVEKFGIDTAHMFGFWDWVGGRYSMDSAIGLSTMIAVGPEHFRAMLAG
HHHHHHCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHH
FHAMDEHFRTAPFERNLPVLMALIGLWYNNFFGAQTLAVLPYDYYLGKLPAYLQQLDMES
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHCCCC
NGKHVDIDGQPVTYQTGPIIWGQPGTDGQHSFYQLIHQGTKLIPCDFIGFCQTLNPIAPH
CCCEEECCCCEEEEECCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCC
HDQLMANFFAQTEALAFGKTEAEVRAEGVADWLLPHRVFEGNRPTNTLLAERLTPEVLGK
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHH
LIALYEHKVFTQGVIWNLDSFDQWGVELGKVLAGRIIPELESAEEPELAHDSSTNALIRR
HHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHH
YRRAKRQN
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292