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The map label for this gene is 37521214

Identifier: 37521214

GI number: 37521214

Start: 1759918

End: 1760196

Strand: Reverse

Name: 37521214

Synonym: gsl1645

Alternate gene names: NA

Gene position: 1760196-1759918 (Counterclockwise)

Preceding gene: 37521220

Following gene: 37521213

Centisome position: 37.78

GC content: 60.93

Gene sequence:

>279_bases
ATGAACAAGATGACTCCCGAAGAAATCGAGACGGCCCTCAAGCCGATTGCAGACTGGCAATTGAGCGAAGCGGACGGGGC
AACCGCCATCGAGCGGGTCTTTCGCTTCGACGATTTTGTGCAGGCGATCGCCTTCGTGAACAAAGTGGCCGAGCGGGCCG
AGACCGCCGGACACCACCCGGACATTCATATCCACTACAACCGTGTGCGGCTGGTGCTGAGCACCCACGACGCAGGCGGA
GTGACCTCCAAAGACCTCGAGATGGCGGCGGCCCTCTAG

Upstream 100 bases:

>100_bases
TTCTCGAAAGCCTTCCCAGTGTACCTTAGGGGGTTTGCAGGCCCACTTGCCGGTGCGGCAAGCGGGCCTATGATGAAACC
CAGGCAAGGAGCGCGCGGCA

Downstream 100 bases:

>100_bases
ACGCGGACGGCGGCGATCCCCGGCCCCTGGGTTTTTAAGTCACAATGGGCTAAATACCGTCCTTTAAATTCGAAGGAGCG
TGCATGTTTGTCCTGGCGGC

Product: pterin-4a-carbinolamine dehydratase

Products: NA

Alternate protein names: PHS 2; 4-alpha-hydroxy-tetrahydropterin dehydratase 2; Pterin carbinolamine dehydratase 2; PCD 2

Number of amino acids: Translated: 92; Mature: 92

Protein sequence:

>92_residues
MNKMTPEEIETALKPIADWQLSEADGATAIERVFRFDDFVQAIAFVNKVAERAETAGHHPDIHIHYNRVRLVLSTHDAGG
VTSKDLEMAAAL

Sequences:

>Translated_92_residues
MNKMTPEEIETALKPIADWQLSEADGATAIERVFRFDDFVQAIAFVNKVAERAETAGHHPDIHIHYNRVRLVLSTHDAGG
VTSKDLEMAAAL
>Mature_92_residues
MNKMTPEEIETALKPIADWQLSEADGATAIERVFRFDDFVQAIAFVNKVAERAETAGHHPDIHIHYNRVRLVLSTHDAGG
VTSKDLEMAAAL

Specific function: Unknown

COG id: COG2154

COG function: function code H; Pterin-4a-carbinolamine dehydratase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pterin-4-alpha-carbinolamine dehydratase family

Homologues:

Organism=Homo sapiens, GI134133240, Length=90, Percent_Identity=40, Blast_Score=65, Evalue=1e-11,
Organism=Homo sapiens, GI4557831, Length=88, Percent_Identity=34.0909090909091, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI115533705, Length=76, Percent_Identity=40.7894736842105, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45549100, Length=90, Percent_Identity=38.8888888888889, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PHS2_GLOVI (Q7NK35)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_924591.1
- ProteinModelPortal:   Q7NK35
- SMR:   Q7NK35
- GeneID:   2598518
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:gsl1645
- NMPDR:   fig|251221.1.peg.1645
- HOGENOM:   HBG705804
- OMA:   IALICEK
- BioCyc:   GVIO251221:GSL1645-MONOMER
- BRENDA:   4.2.1.96
- HAMAP:   MF_00434
- InterPro:   IPR001533
- Gene3D:   G3DSA:3.30.1360.20
- PANTHER:   PTHR12599

Pfam domain/function: PF01329 Pterin_4a; SSF55248 Trans_pterinDh

EC number: =4.2.1.96

Molecular weight: Translated: 10201; Mature: 10201

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKMTPEEIETALKPIADWQLSEADGATAIERVFRFDDFVQAIAFVNKVAERAETAGHHP
CCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DIHIHYNRVRLVLSTHDAGGVTSKDLEMAAAL
CEEEEEEEEEEEEEECCCCCCCCHHHHHHHCC
>Mature Secondary Structure
MNKMTPEEIETALKPIADWQLSEADGATAIERVFRFDDFVQAIAFVNKVAERAETAGHHP
CCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DIHIHYNRVRLVLSTHDAGGVTSKDLEMAAAL
CEEEEEEEEEEEEEECCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292