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The map label for this gene is ndhA

Identifier: 37521153

GI number: 37521153

Start: 1701549

End: 1702772

Strand: Reverse

Name: ndhA

Synonym: gvip222

Alternate gene names: 37521153

Gene position: 1702772-1701549 (Counterclockwise)

Preceding gene: 37521154

Following gene: 37521152

Centisome position: 36.55

GC content: 59.48

Gene sequence:

>1224_bases
ATGGAAGGAATCGATTTGGGCAATGCGTTTGCCCAAAGCTTGAGTGGCTTGGGAGTACCGGCGGACGTCGCCCGCGCCCT
GTGGTTGCCCCTGCCGATGATCGTCATTTTGCTCACCGTCACCGTCGGGGTGATCGCCGCCGTCTGGGGTGAGCGCAAGT
GGTCGGGCATGATGCAGCAGCGCATGGGTCCGACGATTATCGGTCTGGGCGGCTCGATCCAGGGTGCGGCGGACGGGGTG
AAGCTGCTGGTCAAAGAGGACATCATCCCGGTCAAAGCCGATCCGTGGCTATTTACCCTCGGGCCGGCCATCGTGATTAT
CCCGGTGTTTTTCTCCTACCTGGTCATTCCGTTTGGTCAGGGACTGGTGCTCTCGGATATCACCATCGGCATTTTCTTCA
TCATCGCCGTGGCGAGCATTTCGCCCATCGGCGCGCTGATGGCGGGTTACGCCTCCAACAACAAGTACGCCCTTCTGGGG
GGTCTGCGGGCGGCGGCCCAATCGATCTCCTACGAAATTCCGCTGGCACTCTCGGTGCTCGCCATCGTGATGATGTCGAG
TTCGCTTTCGACCGTCGACATCGTCGAGCAGCAGGAGACGCTCGGACTGTTTTCGTTTTTCTCCTGGAACATCTGGCGCC
AACCGATCGGTTTTGTGATTTTCTTGATTTCGGCGTTGGCTGAGACCGAGCGCGCCCCGTTCGATCTGCCGGAGGCGGAG
TCGGAACTGGTGGCGGGCCACCACACCGAGTACACGGGTATGAAGTTTGCCCTGTTCTATCTCTCCGAGTACGCCAATTT
GATCCTCGCCTCGCTCATCGCCTCGGTGCTGTTTTTGGGCGGTTGGAGCTTCATCGTGCCGCTGGAACCGCTGGCGGCGC
TCTTCGGCATCGAGGCTTCCAACCCGATCTTCCAGGTGGTCAATGCCCTGGTCGGTATCAGTGTGACGATCTTGAAGGCG
ACGTTCTTCGTGTTCCTCGCTATCCTGGCGCGTTGGACCCTGCCCAGGGTGCGCATCGACCAACTATTGGATCTGGGCTG
GAAATTTCTGCTGCCGGTGTCGCTTTTTAACTTGTTGTTGACCGCCGCCCTGGTGTTGCTCTCCAACACGCTCAAGACGA
CGCTGCCTTTGTATCTGCCGCTGATAATCTTTGTGGGGCTCGTCTTCGTGGCGATGTCGCTGCAGAAGCGGCCCGCCGCC
AAACCGACCGCCGCAAGAGCATGA

Upstream 100 bases:

>100_bases
GCAACATCGACTATTACGTCTTCTGGCTGCGCAACCTCAACGCCAAGCAGCGCCAGCAGCTTGTCCAGGCCCTGGAAACC
GAGTAGGTAGGCACGTTTAG

Downstream 100 bases:

>100_bases
TGTATCACCCCATTGCCCTCTCACTGGTACTCGCAGCGGCCCTTCTGGCCGGTTGCCAGGCGAGCACCCCCTCGACCGCC
AGGACCGCCGAGGAGCGGCC

Product: NADH dehydrogenase subunit H

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I subunit 1; NDH-1 subunit 1; NDH-A

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MEGIDLGNAFAQSLSGLGVPADVARALWLPLPMIVILLTVTVGVIAAVWGERKWSGMMQQRMGPTIIGLGGSIQGAADGV
KLLVKEDIIPVKADPWLFTLGPAIVIIPVFFSYLVIPFGQGLVLSDITIGIFFIIAVASISPIGALMAGYASNNKYALLG
GLRAAAQSISYEIPLALSVLAIVMMSSSLSTVDIVEQQETLGLFSFFSWNIWRQPIGFVIFLISALAETERAPFDLPEAE
SELVAGHHTEYTGMKFALFYLSEYANLILASLIASVLFLGGWSFIVPLEPLAALFGIEASNPIFQVVNALVGISVTILKA
TFFVFLAILARWTLPRVRIDQLLDLGWKFLLPVSLFNLLLTAALVLLSNTLKTTLPLYLPLIIFVGLVFVAMSLQKRPAA
KPTAARA

Sequences:

>Translated_407_residues
MEGIDLGNAFAQSLSGLGVPADVARALWLPLPMIVILLTVTVGVIAAVWGERKWSGMMQQRMGPTIIGLGGSIQGAADGV
KLLVKEDIIPVKADPWLFTLGPAIVIIPVFFSYLVIPFGQGLVLSDITIGIFFIIAVASISPIGALMAGYASNNKYALLG
GLRAAAQSISYEIPLALSVLAIVMMSSSLSTVDIVEQQETLGLFSFFSWNIWRQPIGFVIFLISALAETERAPFDLPEAE
SELVAGHHTEYTGMKFALFYLSEYANLILASLIASVLFLGGWSFIVPLEPLAALFGIEASNPIFQVVNALVGISVTILKA
TFFVFLAILARWTLPRVRIDQLLDLGWKFLLPVSLFNLLLTAALVLLSNTLKTTLPLYLPLIIFVGLVFVAMSLQKRPAA
KPTAARA
>Mature_407_residues
MEGIDLGNAFAQSLSGLGVPADVARALWLPLPMIVILLTVTVGVIAAVWGERKWSGMMQQRMGPTIIGLGGSIQGAADGV
KLLVKEDIIPVKADPWLFTLGPAIVIIPVFFSYLVIPFGQGLVLSDITIGIFFIIAVASISPIGALMAGYASNNKYALLG
GLRAAAQSISYEIPLALSVLAIVMMSSSLSTVDIVEQQETLGLFSFFSWNIWRQPIGFVIFLISALAETERAPFDLPEAE
SELVAGHHTEYTGMKFALFYLSEYANLILASLIASVLFLGGWSFIVPLEPLAALFGIEASNPIFQVVNALVGISVTILKA
TFFVFLAILARWTLPRVRIDQLLDLGWKFLLPVSLFNLLLTAALVLLSNTLKTTLPLYLPLIIFVGLVFVAMSLQKRPAA
KPTAARA

Specific function: NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=305, Percent_Identity=34.7540983606557, Blast_Score=166, Evalue=3e-41,
Organism=Escherichia coli, GI1788618, Length=333, Percent_Identity=39.9399399399399, Blast_Score=244, Evalue=9e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NU1C_GLOVI (Q7NK94)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_924530.1
- GeneID:   2598550
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.1584
- HOGENOM:   HBG727670
- OMA:   IFWICAL
- ProtClustDB:   PRK06076
- BioCyc:   GVIO251221:GLL1584-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: 1.6.5.3

Molecular weight: Translated: 43836; Mature: 43836

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x12353d54)-; HASH(0x1329cf94)-; HASH(0x135c6180)-; HASH(0x1177590c)-; HASH(0x1031865c)-; HASH(0x137a74ac)-; HASH(0x13612200)-; HASH(0x135427f4)-; HASH(0x13e58570)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGIDLGNAFAQSLSGLGVPADVARALWLPLPMIVILLTVTVGVIAAVWGERKWSGMMQQ
CCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
RMGPTIIGLGGSIQGAADGVKLLVKEDIIPVKADPWLFTLGPAIVIIPVFFSYLVIPFGQ
HCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCC
GLVLSDITIGIFFIIAVASISPIGALMAGYASNNKYALLGGLRAAAQSISYEIPLALSVL
CEEHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCCHHHHHHH
AIVMMSSSLSTVDIVEQQETLGLFSFFSWNIWRQPIGFVIFLISALAETERAPFDLPEAE
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
SELVAGHHTEYTGMKFALFYLSEYANLILASLIASVLFLGGWSFIVPLEPLAALFGIEAS
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECHHHHHHHHCCCCC
NPIFQVVNALVGISVTILKATFFVFLAILARWTLPRVRIDQLLDLGWKFLLPVSLFNLLL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TAALVLLSNTLKTTLPLYLPLIIFVGLVFVAMSLQKRPAAKPTAARA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
>Mature Secondary Structure
MEGIDLGNAFAQSLSGLGVPADVARALWLPLPMIVILLTVTVGVIAAVWGERKWSGMMQQ
CCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
RMGPTIIGLGGSIQGAADGVKLLVKEDIIPVKADPWLFTLGPAIVIIPVFFSYLVIPFGQ
HCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCC
GLVLSDITIGIFFIIAVASISPIGALMAGYASNNKYALLGGLRAAAQSISYEIPLALSVL
CEEHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCCHHHHHHH
AIVMMSSSLSTVDIVEQQETLGLFSFFSWNIWRQPIGFVIFLISALAETERAPFDLPEAE
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
SELVAGHHTEYTGMKFALFYLSEYANLILASLIASVLFLGGWSFIVPLEPLAALFGIEAS
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECHHHHHHHHCCCCC
NPIFQVVNALVGISVTILKATFFVFLAILARWTLPRVRIDQLLDLGWKFLLPVSLFNLLL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TAALVLLSNTLKTTLPLYLPLIIFVGLVFVAMSLQKRPAAKPTAARA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 14621292