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The map label for this gene is menA [H]

Identifier: 37521147

GI number: 37521147

Start: 1697538

End: 1698425

Strand: Reverse

Name: menA [H]

Synonym: gvip220

Alternate gene names: 37521147

Gene position: 1698425-1697538 (Counterclockwise)

Preceding gene: 37521148

Following gene: 37521144

Centisome position: 36.45

GC content: 63.4

Gene sequence:

>888_bases
GTGTCCGGCAGCCCCCTCAGGCCCTGGCTGAACAGTTTCAATCCGCTGATTTATACCGCCTCGGTCATCCCGATTCTGGT
GGGCACGGCCTTCGCCTGGTGGCAGGGGGGCGTGTTCGACCTGCAGCGCTTTGCTTTAACCCTCGCCGGGCTTGTCTTCG
TACACGCCTGGATCAACCTCACTAACGACGTGTTCGACTGGGACACCGGTGTGGACCGCAACAAGCTGAATTCGCTGGTG
CGCACCACCGGCAGCCGCTCCCAGGTGCTCTGGGTGGGCAATATTTTTTTGAGCATTGGGTACGTGTGCTTCTGGGCGCT
GCAGGACTGGTGGCTACTCGCTTTCGGCAGCCTCGGCATCTTTTTGGGGTACGCCTACCAGGGACCGCCCTTCCGCCTGG
CCTACAAGGGTCTGGGCGAGTGGATCAGCAGCAGTTGCTTTGGACCAATCGCGGTGCTCACCGCCACCCGCGCCCAGACC
GGCAGCTGGGAACTGGGGGCGCTCCTGGCGGGAATCGCCGTGGGCAGTTGGACCGCCACGATTCTCTACGCCCACCACTT
CTACCAGTACGAGGACGACCGGGAATTCGACAAGCGCACCCCGGTGGTGCGCTGGGGACCGGAACTGGCTGCAAAGCGCT
TCTGGTGGGTGATTTCTCCTTCCTACGTTGTCCTCCTTCTAGCCGTGATTGGCGGCTTTTTGCCCTGGACGGTGCTGGCG
GCGCTGGCGACCATTCCCCTGGCGGTTTCGCTGGTAAGCTTCGTGCGCGAAAATGCAACGAACCCGGCCGTGGTAGTGGG
GGCTCTGCCGCTCGCGGCGCGCTTTCACCTGGTCAGCGGCGCCTTGCTCACCCTGGGTTTGCTCGCGGGGACGCTGTTGC
CGCGCTAA

Upstream 100 bases:

>100_bases
CGCGGCGAACTGGTGCGCTGGGGGATGTGCGGCAGTTGCGCCGTGCGGCCTTGAGCGGTTTTGGTGCCACAATGACCAGG
GAAAAGATGGAGAACCACCC

Downstream 100 bases:

>100_bases
GACCGATTGGGTGCCTGGAGAATCTATCGACCGTGTTTTTTGGGTGCGATTACGATGCCGAAGTGCCTGTCGGTTATACC
GAAACGGTCGCAATTCCCTT

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MSGSPLRPWLNSFNPLIYTASVIPILVGTAFAWWQGGVFDLQRFALTLAGLVFVHAWINLTNDVFDWDTGVDRNKLNSLV
RTTGSRSQVLWVGNIFLSIGYVCFWALQDWWLLAFGSLGIFLGYAYQGPPFRLAYKGLGEWISSSCFGPIAVLTATRAQT
GSWELGALLAGIAVGSWTATILYAHHFYQYEDDREFDKRTPVVRWGPELAAKRFWWVISPSYVVLLLAVIGGFLPWTVLA
ALATIPLAVSLVSFVRENATNPAVVVGALPLAARFHLVSGALLTLGLLAGTLLPR

Sequences:

>Translated_295_residues
MSGSPLRPWLNSFNPLIYTASVIPILVGTAFAWWQGGVFDLQRFALTLAGLVFVHAWINLTNDVFDWDTGVDRNKLNSLV
RTTGSRSQVLWVGNIFLSIGYVCFWALQDWWLLAFGSLGIFLGYAYQGPPFRLAYKGLGEWISSSCFGPIAVLTATRAQT
GSWELGALLAGIAVGSWTATILYAHHFYQYEDDREFDKRTPVVRWGPELAAKRFWWVISPSYVVLLLAVIGGFLPWTVLA
ALATIPLAVSLVSFVRENATNPAVVVGALPLAARFHLVSGALLTLGLLAGTLLPR
>Mature_294_residues
SGSPLRPWLNSFNPLIYTASVIPILVGTAFAWWQGGVFDLQRFALTLAGLVFVHAWINLTNDVFDWDTGVDRNKLNSLVR
TTGSRSQVLWVGNIFLSIGYVCFWALQDWWLLAFGSLGIFLGYAYQGPPFRLAYKGLGEWISSSCFGPIAVLTATRAQTG
SWELGALLAGIAVGSWTATILYAHHFYQYEDDREFDKRTPVVRWGPELAAKRFWWVISPSYVVLLLAVIGGFLPWTVLAA
LATIPLAVSLVSFVRENATNPAVVVGALPLAARFHLVSGALLTLGLLAGTLLPR

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=267, Percent_Identity=28.4644194756554, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI17737429, Length=203, Percent_Identity=28.0788177339901, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011937
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 32421; Mature: 32290

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGSPLRPWLNSFNPLIYTASVIPILVGTAFAWWQGGVFDLQRFALTLAGLVFVHAWINL
CCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
TNDVFDWDTGVDRNKLNSLVRTTGSRSQVLWVGNIFLSIGYVCFWALQDWWLLAFGSLGI
CCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLGYAYQGPPFRLAYKGLGEWISSSCFGPIAVLTATRAQTGSWELGALLAGIAVGSWTAT
HHEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHH
ILYAHHFYQYEDDREFDKRTPVVRWGPELAAKRFWWVISPSYVVLLLAVIGGFLPWTVLA
HHHHHHHHCCCCCCCHHHCCCEEEECHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHHHH
ALATIPLAVSLVSFVRENATNPAVVVGALPLAARFHLVSGALLTLGLLAGTLLPR
HHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SGSPLRPWLNSFNPLIYTASVIPILVGTAFAWWQGGVFDLQRFALTLAGLVFVHAWINL
CCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
TNDVFDWDTGVDRNKLNSLVRTTGSRSQVLWVGNIFLSIGYVCFWALQDWWLLAFGSLGI
CCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLGYAYQGPPFRLAYKGLGEWISSSCFGPIAVLTATRAQTGSWELGALLAGIAVGSWTAT
HHEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHH
ILYAHHFYQYEDDREFDKRTPVVRWGPELAAKRFWWVISPSYVVLLLAVIGGFLPWTVLA
HHHHHHHHCCCCCCCHHHCCCEEEECHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHHHH
ALATIPLAVSLVSFVRENATNPAVVVGALPLAARFHLVSGALLTLGLLAGTLLPR
HHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]