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The map label for this gene is dnaA

Identifier: 37521042

GI number: 37521042

Start: 1583759

End: 1585087

Strand: Reverse

Name: dnaA

Synonym: gvip205

Alternate gene names: 37521042

Gene position: 1585087-1583759 (Counterclockwise)

Preceding gene: 37521046

Following gene: 37521040

Centisome position: 34.02

GC content: 56.88

Gene sequence:

>1329_bases
GTGGAAACGCTCTGGGATGGTATCCTAAGTCACCTGAAGGGCCGGCTCAGCCGTCCCACCTTTGAAACATGGATAAAGCC
GGCAACGGCCCAACAATTCGAGCAAGACTGTCTGATCATTCGCACGCCGAACCCTTTTGCACGCAGTTGGTTACAACAGC
ATTACGCCGGCGCGATTGCCCAGGCAGGTGAACAGGTAATCGGCCGACCCATTCAAGTTGATTTCATCGTTTCCGAGCAG
TCCGAGGAGGCGTTAAAGCCTGTCATAGAGCGAGAGCCTGCCCCGGCTGCTCCGCCTGCCAATGTCGCTTCGCTCAATTC
CAAATACACTTTTTCGCGCTTCGTGGTTGGGGCGAACAATCGCATGGCCCACGTGGCGGCTCTTGCCGTGGCGGAGATGC
CGGGTTGCAACTATAACCCCCTGTTTTTGTGCGGTGGCGTTGGATTGGGGAAAACCCACTTGATGCAGGCAATTGGTCAT
TATCGGCTCGATATCGATACAAGGACCAAAATTGCTTATGTCAGTACCGAAAGATTCGCCAATGAACTTATCGAAGCTAT
CCGGCGCGATGCAATGCAAACCTTTCGCGAGCATTATCGCCGCGTCGATCTGTTGATGATCGACGATATTCAGTTCATCG
AAGGCAAAGAGTACACCCAGGAAGAGTTTTTCCACACCTTCAACGCCCTCTACGAGTCGGGCAAGCAGATAGTGATCGCC
TCCGATCGCCCTCCCCAGCTGATCCCGCGTCTGCAGGAGCGTTTGTCTTCTCGCTTTTCGATGGGACTGATTACGGACAT
TCAGCAGCCCGATATCGAGACGCGCATGGCGATCCTTCAAAAAAAGGCCGAGTACGAGAACATGTTCGTTCCGCAGGATG
TCATCCACCACATCGCCTCCGCCTACACCACCAACATTCGCGAACTGGAGGGGGCGCTCATCCGGGCGGTTGCCTACGTG
TCGATTTCGGGGCTGCCGATGACCGTCGAGACGATTAGTCCAATTCTCTCGCCACCGCGCACCCGCGGCGAAATCACCGA
CGAAGCGATCCTCGAACTGGTCTGCGACGAACTGAAGGTGAGCGCCGAGGACATGCGCAGCGACTCCCGCCGCCGGGATA
TTTCCCAGGCGCGGCAGCTGTGCATGTATCTGCTCAGAAAGTACACCGATTTGAGCCTGCCCAAGATCGGCCAGGCCCTG
GGCGGCAAGGACCATACCACCGTTCTGTACGCCATCGACAAAATTGAGCAATCGAAGATCCGCGACCCCGAGGTGCAGCG
CCTCCTGCAGAGGCTGGGCAACCGCCTGGAGGCGGACGCCCGCCACTAG

Upstream 100 bases:

>100_bases
GCAAATCGCAAATTGAGGATGGACGGATGGCGGATCTTTGGATAAGATTGCACACTAAAGCGTCGGCGTCCGGCATAGAT
ATATTTAGGTGTAAACATTG

Downstream 100 bases:

>100_bases
CTACGGTGCAAACGGCAAAGCGACGACGGCAACTTCCCGCTCCCCCGCCTGCACACGCCCGCTCGGTTTGGCTTTCTGCC
AGCGGGTTCGGGCGAGGGCA

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
METLWDGILSHLKGRLSRPTFETWIKPATAQQFEQDCLIIRTPNPFARSWLQQHYAGAIAQAGEQVIGRPIQVDFIVSEQ
SEEALKPVIEREPAPAAPPANVASLNSKYTFSRFVVGANNRMAHVAALAVAEMPGCNYNPLFLCGGVGLGKTHLMQAIGH
YRLDIDTRTKIAYVSTERFANELIEAIRRDAMQTFREHYRRVDLLMIDDIQFIEGKEYTQEEFFHTFNALYESGKQIVIA
SDRPPQLIPRLQERLSSRFSMGLITDIQQPDIETRMAILQKKAEYENMFVPQDVIHHIASAYTTNIRELEGALIRAVAYV
SISGLPMTVETISPILSPPRTRGEITDEAILELVCDELKVSAEDMRSDSRRRDISQARQLCMYLLRKYTDLSLPKIGQAL
GGKDHTTVLYAIDKIEQSKIRDPEVQRLLQRLGNRLEADARH

Sequences:

>Translated_442_residues
METLWDGILSHLKGRLSRPTFETWIKPATAQQFEQDCLIIRTPNPFARSWLQQHYAGAIAQAGEQVIGRPIQVDFIVSEQ
SEEALKPVIEREPAPAAPPANVASLNSKYTFSRFVVGANNRMAHVAALAVAEMPGCNYNPLFLCGGVGLGKTHLMQAIGH
YRLDIDTRTKIAYVSTERFANELIEAIRRDAMQTFREHYRRVDLLMIDDIQFIEGKEYTQEEFFHTFNALYESGKQIVIA
SDRPPQLIPRLQERLSSRFSMGLITDIQQPDIETRMAILQKKAEYENMFVPQDVIHHIASAYTTNIRELEGALIRAVAYV
SISGLPMTVETISPILSPPRTRGEITDEAILELVCDELKVSAEDMRSDSRRRDISQARQLCMYLLRKYTDLSLPKIGQAL
GGKDHTTVLYAIDKIEQSKIRDPEVQRLLQRLGNRLEADARH
>Mature_442_residues
METLWDGILSHLKGRLSRPTFETWIKPATAQQFEQDCLIIRTPNPFARSWLQQHYAGAIAQAGEQVIGRPIQVDFIVSEQ
SEEALKPVIEREPAPAAPPANVASLNSKYTFSRFVVGANNRMAHVAALAVAEMPGCNYNPLFLCGGVGLGKTHLMQAIGH
YRLDIDTRTKIAYVSTERFANELIEAIRRDAMQTFREHYRRVDLLMIDDIQFIEGKEYTQEEFFHTFNALYESGKQIVIA
SDRPPQLIPRLQERLSSRFSMGLITDIQQPDIETRMAILQKKAEYENMFVPQDVIHHIASAYTTNIRELEGALIRAVAYV
SISGLPMTVETISPILSPPRTRGEITDEAILELVCDELKVSAEDMRSDSRRRDISQARQLCMYLLRKYTDLSLPKIGQAL
GGKDHTTVLYAIDKIEQSKIRDPEVQRLLQRLGNRLEADARH

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=445, Percent_Identity=37.752808988764, Blast_Score=302, Evalue=3e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_GLOVI (Q7NKK4)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_924419.1
- ProteinModelPortal:   Q7NKK4
- GeneID:   2598651
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.1473
- HOGENOM:   HBG695666
- OMA:   CHTLNAL
- ProtClustDB:   PRK00149
- BioCyc:   GVIO251221:GLL1473-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 50135; Mature: 50135

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METLWDGILSHLKGRLSRPTFETWIKPATAQQFEQDCLIIRTPNPFARSWLQQHYAGAIA
CCHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHH
QAGEQVIGRPIQVDFIVSEQSEEALKPVIEREPAPAAPPANVASLNSKYTFSRFVVGANN
HHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCHHHCCCCCEEEHEEEECCC
RMAHVAALAVAEMPGCNYNPLFLCGGVGLGKTHLMQAIGHYRLDIDTRTKIAYVSTERFA
CHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHCEEEEECCCCEEEEEHHHHHH
NELIEAIRRDAMQTFREHYRRVDLLMIDDIQFIEGKEYTQEEFFHTFNALYESGKQIVIA
HHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHCCCCHHHHHHHHHHHHHHHCCCEEEEE
SDRPPQLIPRLQERLSSRFSMGLITDIQQPDIETRMAILQKKAEYENMFVPQDVIHHIAS
CCCCHHHHHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AYTTNIRELEGALIRAVAYVSISGLPMTVETISPILSPPRTRGEITDEAILELVCDELKV
HHHHHHHHHHHHHHHHHHHHEECCCCEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHC
SAEDMRSDSRRRDISQARQLCMYLLRKYTDLSLPKIGQALGGKDHTTVLYAIDKIEQSKI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEEEHHHHHHCC
RDPEVQRLLQRLGNRLEADARH
CCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
METLWDGILSHLKGRLSRPTFETWIKPATAQQFEQDCLIIRTPNPFARSWLQQHYAGAIA
CCHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHH
QAGEQVIGRPIQVDFIVSEQSEEALKPVIEREPAPAAPPANVASLNSKYTFSRFVVGANN
HHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCHHHCCCCCEEEHEEEECCC
RMAHVAALAVAEMPGCNYNPLFLCGGVGLGKTHLMQAIGHYRLDIDTRTKIAYVSTERFA
CHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHCEEEEECCCCEEEEEHHHHHH
NELIEAIRRDAMQTFREHYRRVDLLMIDDIQFIEGKEYTQEEFFHTFNALYESGKQIVIA
HHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHCCCCHHHHHHHHHHHHHHHCCCEEEEE
SDRPPQLIPRLQERLSSRFSMGLITDIQQPDIETRMAILQKKAEYENMFVPQDVIHHIAS
CCCCHHHHHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AYTTNIRELEGALIRAVAYVSISGLPMTVETISPILSPPRTRGEITDEAILELVCDELKV
HHHHHHHHHHHHHHHHHHHHEECCCCEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHC
SAEDMRSDSRRRDISQARQLCMYLLRKYTDLSLPKIGQALGGKDHTTVLYAIDKIEQSKI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEEEHHHHHHCC
RDPEVQRLLQRLGNRLEADARH
CCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292