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The map label for this gene is dut [H]

Identifier: 37521034

GI number: 37521034

Start: 1575013

End: 1575492

Strand: Direct

Name: dut [H]

Synonym: glr1465

Alternate gene names: 37521034

Gene position: 1575013-1575492 (Clockwise)

Preceding gene: 37521030

Following gene: 37521035

Centisome position: 33.81

GC content: 64.38

Gene sequence:

>480_bases
GTGTGGGAGATCCGTTTGCCGCTATTTCTATTGTCGATGGACCCGGTCCGTGTTGCCATCCAGCGCCTTGCTCACTGCTT
TGCGCTTCCTACCTGCGCCCATCCCGGCGACGCCGGGCTCGACCTGTTCGCCGCCCATGCAGTCCCCTTGAGTATCGCTC
CCGGCCGCTTCACGCGCGTGCCCACGGGGATCGCTCTCGGTCTACCTGCAGGGTACATGGCCTTTGTCCAACCGCGCTCG
GGCCTCGCGGCGCGCCACGGCATCAGCGTGCTCAATACCCCGGGCCTTATCGACTGCGGCTACCGCGGCGAGATTCAGGT
ATTGCTCATCAACCACGGCGAGGTTCCCGTCGTCGTCTCGCGTGGGGATCGCATCGCCCAACTGGTCGTGCTGCCGGTGC
CGCAGGTGCAGTTTGTCGAAGTCAGCACACTCGAAAGCTCCGAACGTCAGACCGGGAGCTTCGGCAGCAGCGGCTACTAA

Upstream 100 bases:

>100_bases
CGCCGCTTCGCCGTCGAGCGCGTCGGCACGAGCAATTCCAACTTTGTGAAAGCCGAGAGCCCTGGCTCTCGATTTGATTT
GCGCCGCCGTCGGTGCCATT

Downstream 100 bases:

>100_bases
GAGGCCACCCAAATAGAACGGCCTCTACGATGGTTGTAGAACGTTAAATATTGTGTGGTTTCGAAACAGATGTAAACCGA
TATTTTCATTAGGTATTACA

Product: deoxyuridine 5'triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MWEIRLPLFLLSMDPVRVAIQRLAHCFALPTCAHPGDAGLDLFAAHAVPLSIAPGRFTRVPTGIALGLPAGYMAFVQPRS
GLAARHGISVLNTPGLIDCGYRGEIQVLLINHGEVPVVVSRGDRIAQLVVLPVPQVQFVEVSTLESSERQTGSFGSSGY

Sequences:

>Translated_159_residues
MWEIRLPLFLLSMDPVRVAIQRLAHCFALPTCAHPGDAGLDLFAAHAVPLSIAPGRFTRVPTGIALGLPAGYMAFVQPRS
GLAARHGISVLNTPGLIDCGYRGEIQVLLINHGEVPVVVSRGDRIAQLVVLPVPQVQFVEVSTLESSERQTGSFGSSGY
>Mature_159_residues
MWEIRLPLFLLSMDPVRVAIQRLAHCFALPTCAHPGDAGLDLFAAHAVPLSIAPGRFTRVPTGIALGLPAGYMAFVQPRS
GLAARHGISVLNTPGLIDCGYRGEIQVLLINHGEVPVVVSRGDRIAQLVVLPVPQVQFVEVSTLESSERQTGSFGSSGY

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=137, Percent_Identity=40.8759124087591, Blast_Score=91, Evalue=3e-19,
Organism=Homo sapiens, GI4503423, Length=137, Percent_Identity=40.8759124087591, Blast_Score=90, Evalue=6e-19,
Organism=Homo sapiens, GI70906441, Length=137, Percent_Identity=40.8759124087591, Blast_Score=88, Evalue=3e-18,
Organism=Escherichia coli, GI1790071, Length=144, Percent_Identity=39.5833333333333, Blast_Score=102, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71988561, Length=147, Percent_Identity=43.5374149659864, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6319729, Length=141, Percent_Identity=35.4609929078014, Blast_Score=86, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24583610, Length=149, Percent_Identity=34.8993288590604, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19921126, Length=149, Percent_Identity=34.8993288590604, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 16966; Mature: 16966

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWEIRLPLFLLSMDPVRVAIQRLAHCFALPTCAHPGDAGLDLFAAHAVPLSIAPGRFTRV
CEEEECEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCEEEEECCCCCEEC
PTGIALGLPAGYMAFVQPRSGLAARHGISVLNTPGLIDCGYRGEIQVLLINHGEVPVVVS
CCCEEECCCCCEEEEECCCCCCCHHCCCEEECCCCEEECCCCCCEEEEEECCCCEEEEEE
RGDRIAQLVVLPVPQVQFVEVSTLESSERQTGSFGSSGY
CCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MWEIRLPLFLLSMDPVRVAIQRLAHCFALPTCAHPGDAGLDLFAAHAVPLSIAPGRFTRV
CEEEECEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCEEEEECCCCCEEC
PTGIALGLPAGYMAFVQPRSGLAARHGISVLNTPGLIDCGYRGEIQVLLINHGEVPVVVS
CCCEEECCCCCEEEEECCCCCCCHHCCCEEECCCCEEECCCCCCEEEEEECCCCEEEEEE
RGDRIAQLVVLPVPQVQFVEVSTLESSERQTGSFGSSGY
CCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292 [H]