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The map label for this gene is folC [H]

Identifier: 37520857

GI number: 37520857

Start: 1367671

End: 1368828

Strand: Reverse

Name: folC [H]

Synonym: gvip191

Alternate gene names: 37520857

Gene position: 1368828-1367671 (Counterclockwise)

Preceding gene: 37520858

Following gene: 37520856

Centisome position: 29.38

GC content: 68.13

Gene sequence:

>1158_bases
GTGGGGGGCGCCGAACTGGTCGCTGGGACCCGTGCCCTGCTCGACAGGGTCGGCGCTCCGGATCGGACGATGGAGTGCGT
GCTGGTGGGGGGCACCAGCGGCAAGGGTTCGGTGGCGACCGGGCTCGCCGCCCATTGCGAGCGGGCGGGGGTGCGCGTCG
GCCTGCACACCTCGCCCTACCTGCAGGTGGCCACCGAAAAGATTCGCCTGGACGGCCAATACATCGGCGGGGCAGAATTT
GCCGAACTAGTGGAATGGATCTGGCCCCATTTGGAAGCGTGGCGCGATCCGGCCCACCTGCGGCGGCGCTATGGGGCTGT
CTCGCTGGTACTGGCGGCCGAGGCGATGCGGCGACACGGAGCGCAAGTGGGCGTCTTCGAGGTGGGTTGCGGCGGTCGCT
TCGACCCGGTCAACGCCCTCGCAGCTCGGGCAGTGGCCATTACGACCGTGGGCCTCGACCATGTCGCGTTACTCGGGCCG
ACCCTTGCAGATATCGCCTGGCAAAAAGCGGGTCTCATCAAGAGCGCCGCGCCGGTAGTAACCGCCGCCCGCGGTTTACC
CTTACAAATCATTCAACGAGAGGCGGCCAGCTACGGAGCGCCGGTGCGTTGCACACCCGCCGACAACGCCGCCCTTGCCG
GGGCGCTTTTTGAAGTTTGCCGGGGGACGCCTGCCCCACGCCTGCCCCCGCAGGCAGTTCGCCTACCCGGCAGGCTGGAG
CCGATGGGGGTGCAGCAGTGGGTCTGGCTGGACGGCGCCCATAACCCCGAGAAGCTGGCCTATCTGGTTCGTCAGCTGCA
CGGCAGACCGGCGGTCGTCCTGTTCGGCGCCCTTGCAGGCAAGTCGCACCGCCCGATGCTCAAGATTCTCTCGCGGTTGG
CCCGCACGCTCGTACTGTGCCCGATCGAGGTACCCGGCAAACTCCCCACGGATCTCGCAGAACTGACCCGACAGGCACAG
GAGTGGTTCGAGCGCGTCGAACCGGCCCCGAACCCGGAAGCCGCCCTGGCATTCGCTCTGCACCGGCGCCAACCCGACCA
GATTGTCGTAGTCACCGGCTCGCTGTACCTGGTGGGCCGGTTGCGCTCGCGCTGGTATCCGGCTGAGCGGGTCGTCGAAG
CGCGCAGCAGCTGGCCTCCCCGACTCGATGGGCCTTAG

Upstream 100 bases:

>100_bases
GAGGAGGCGTAATTTGGCCGGTACTTTCGCTTTGTACGCCGAGGCGAACCGGCGGCTCGAATCGCTGCTGGTAGGCAATA
GCCGCCTGCAGCCCGCGGCG

Downstream 100 bases:

>100_bases
AAATTGTTTACAACCGGTTGCCGCCGGTGCCGCTTGGTGCAACGATCGTCGTGAGCGGCATCTTCTGGAATCACCATGTT
GCAAGACCCCAAAACCATTC

Product: folyl-polyglutamate synthetase

Products: NA

Alternate protein names: Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolate synthase; Tetrahydrofolylpolyglutamate synthase [H]

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MGGAELVAGTRALLDRVGAPDRTMECVLVGGTSGKGSVATGLAAHCERAGVRVGLHTSPYLQVATEKIRLDGQYIGGAEF
AELVEWIWPHLEAWRDPAHLRRRYGAVSLVLAAEAMRRHGAQVGVFEVGCGGRFDPVNALAARAVAITTVGLDHVALLGP
TLADIAWQKAGLIKSAAPVVTAARGLPLQIIQREAASYGAPVRCTPADNAALAGALFEVCRGTPAPRLPPQAVRLPGRLE
PMGVQQWVWLDGAHNPEKLAYLVRQLHGRPAVVLFGALAGKSHRPMLKILSRLARTLVLCPIEVPGKLPTDLAELTRQAQ
EWFERVEPAPNPEAALAFALHRRQPDQIVVVTGSLYLVGRLRSRWYPAERVVEARSSWPPRLDGP

Sequences:

>Translated_385_residues
MGGAELVAGTRALLDRVGAPDRTMECVLVGGTSGKGSVATGLAAHCERAGVRVGLHTSPYLQVATEKIRLDGQYIGGAEF
AELVEWIWPHLEAWRDPAHLRRRYGAVSLVLAAEAMRRHGAQVGVFEVGCGGRFDPVNALAARAVAITTVGLDHVALLGP
TLADIAWQKAGLIKSAAPVVTAARGLPLQIIQREAASYGAPVRCTPADNAALAGALFEVCRGTPAPRLPPQAVRLPGRLE
PMGVQQWVWLDGAHNPEKLAYLVRQLHGRPAVVLFGALAGKSHRPMLKILSRLARTLVLCPIEVPGKLPTDLAELTRQAQ
EWFERVEPAPNPEAALAFALHRRQPDQIVVVTGSLYLVGRLRSRWYPAERVVEARSSWPPRLDGP
>Mature_384_residues
GGAELVAGTRALLDRVGAPDRTMECVLVGGTSGKGSVATGLAAHCERAGVRVGLHTSPYLQVATEKIRLDGQYIGGAEFA
ELVEWIWPHLEAWRDPAHLRRRYGAVSLVLAAEAMRRHGAQVGVFEVGCGGRFDPVNALAARAVAITTVGLDHVALLGPT
LADIAWQKAGLIKSAAPVVTAARGLPLQIIQREAASYGAPVRCTPADNAALAGALFEVCRGTPAPRLPPQAVRLPGRLEP
MGVQQWVWLDGAHNPEKLAYLVRQLHGRPAVVLFGALAGKSHRPMLKILSRLARTLVLCPIEVPGKLPTDLAELTRQAQE
WFERVEPAPNPEAALAFALHRRQPDQIVVVTGSLYLVGRLRSRWYPAERVVEARSSWPPRLDGP

Specific function: Conversion of folates to polyglutamate derivatives. It preferes 5,10-methylenetetrahydrofolate, rather than 10- formyltetrahydrofolate as folate substrate [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932984, Length=197, Percent_Identity=29.4416243654822, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI66932990, Length=197, Percent_Identity=29.4416243654822, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1788654, Length=399, Percent_Identity=27.3182957393484, Blast_Score=88, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71984923, Length=427, Percent_Identity=25.0585480093677, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17553148, Length=431, Percent_Identity=25.0580046403712, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17553150, Length=427, Percent_Identity=25.0585480093677, Blast_Score=98, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6324815, Length=309, Percent_Identity=25.8899676375405, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6323760, Length=430, Percent_Identity=24.1860465116279, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24641571, Length=346, Percent_Identity=27.4566473988439, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24581568, Length=221, Percent_Identity=28.0542986425339, Blast_Score=93, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17 [H]

Molecular weight: Translated: 41419; Mature: 41287

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGAELVAGTRALLDRVGAPDRTMECVLVGGTSGKGSVATGLAAHCERAGVRVGLHTSPY
CCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCEEECCCCCH
LQVATEKIRLDGQYIGGAEFAELVEWIWPHLEAWRDPAHLRRRYGAVSLVLAAEAMRRHG
HHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHHHHHHCC
AQVGVFEVGCGGRFDPVNALAARAVAITTVGLDHVALLGPTLADIAWQKAGLIKSAAPVV
CEEEEEEECCCCCCCHHHHHHHHHHHHEEECHHHHHHHCCHHHHHHHHHHCCHHHCCHHH
TAARGLPLQIIQREAASYGAPVRCTPADNAALAGALFEVCRGTPAPRLPPQAVRLPGRLE
HHCCCCHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCC
PMGVQQWVWLDGAHNPEKLAYLVRQLHGRPAVVLFGALAGKSHRPMLKILSRLARTLVLC
CCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHEEC
PIEVPGKLPTDLAELTRQAQEWFERVEPAPNPEAALAFALHRRQPDQIVVVTGSLYLVGR
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEECCCHHHHH
LRSRWYPAERVVEARSSWPPRLDGP
HHHCCCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
GGAELVAGTRALLDRVGAPDRTMECVLVGGTSGKGSVATGLAAHCERAGVRVGLHTSPY
CCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCEEECCCCCH
LQVATEKIRLDGQYIGGAEFAELVEWIWPHLEAWRDPAHLRRRYGAVSLVLAAEAMRRHG
HHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHHHHHHCC
AQVGVFEVGCGGRFDPVNALAARAVAITTVGLDHVALLGPTLADIAWQKAGLIKSAAPVV
CEEEEEEECCCCCCCHHHHHHHHHHHHEEECHHHHHHHCCHHHHHHHHHHCCHHHCCHHH
TAARGLPLQIIQREAASYGAPVRCTPADNAALAGALFEVCRGTPAPRLPPQAVRLPGRLE
HHCCCCHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCC
PMGVQQWVWLDGAHNPEKLAYLVRQLHGRPAVVLFGALAGKSHRPMLKILSRLARTLVLC
CCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHEEC
PIEVPGKLPTDLAELTRQAQEWFERVEPAPNPEAALAFALHRRQPDQIVVVTGSLYLVGR
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEECCCHHHHH
LRSRWYPAERVVEARSSWPPRLDGP
HHHCCCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8419299; 9384377; 2553669 [H]