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The map label for this gene is mutL [H]

Identifier: 37520848

GI number: 37520848

Start: 1360286

End: 1362007

Strand: Direct

Name: mutL [H]

Synonym: gvip188

Alternate gene names: 37520848

Gene position: 1360286-1362007 (Clockwise)

Preceding gene: 37520842

Following gene: 37520851

Centisome position: 29.2

GC content: 65.04

Gene sequence:

>1722_bases
ATGTGGTGTGAGCACCCCCGCGAATATCGAGCGCTCCGATCGTATTGCTTCTTGCGGCGGTTCGTTTGCGACCAAAGTCG
CCATCGCCTAGCCTTGATAAGCACATTGGTCAGGAGCAATTCGCCTTTGGGAGCGATCCGGCCGCTGGCCGACCAGACCG
TGCGTCTGCTCGCCGCAGGAGAAGTAATCGATTCGCCCGCAGCGGTGGTGCGCGAACTGGTGGACAACAGCCTGGATGCC
GGGGCGGATCGCATCCGGGTGAGCTTCTGGCCCGAATCGTGGCGCGTCCAAGTCCAGGACAACGGCCTGGGCTTCGAGGC
GGAGGAATTGCCGATGGCGGCCCGCTCCCATGCCACCAGCAAACTGGGCGCCATCGAAGATCTCTGGCGGTTGCGCACCC
TGGGCTTTCGCGGCGAGGGGCTGCACAGCATCGCCGTGGTGGCGCGGCTGGAAATTCTCACCTGCACACCTACTGCCCGC
ACCGCCACCCGCGCCCGCTACGACCATAAGGGCGAACTGGTCGAATCGCAGCCGGCCGCCGCTGCTCCTGGAACGGTGGT
GACGGTTAGCGAACTATTCGAGTTGCAACCGGTGCGCCGCCGCTTTCTGGCGGACACCAAAGCTCAAGTGCGCGCCGTCA
CCCAGCTTGTGCACCGCTACGCCCTTGCCTATCCGGGGCATTTATTTGAATTGGCGGTGGACGGCAGGCTGCAGTTGCAG
CTGTGGGCCGCCCCCGGCCTCAAGCAGCGCGCGCTGCAACTGTTGAATTCCTATGACGAGCACGACCTGCGCGAGGTACA
CCTGGAGCGCGACGGCCGCCGCGTTCGCCTGGCGATCGGTTTACCTGATCGCTGCTCGCGGGCGCGCGCCGATTGGCTGC
AGATCTATATCAACGGTCGCTTCGTGCGCCACGGCGAACTGGAGCAGGCGGTGCGCGCCGGATTTGAACGCACGCTGCGT
CCCGGCCGCCAGCCGGTGTGCATTGTGCAACTGATACTTCCTGCGGACGAGGTGGACTGGAACCGTCACCCGGCCAAGCT
CGAAGTGCAACTGGCCGGGACCGCTCCTGCCTGCGAACTGGTGGTAGCGGCCATTGGCGAGGGGCTGCGCCACTTTGCCC
CGAAGCCCGCCGCCGCGCTGTTGCGTCTGGCGGAGGCGCACCTGCCTTACGCAGCAGAAAGCACAGGCGGCGAGTTGTTG
CTCAAAGCCCTCGCCCAGCTCCACCAGACCTATATCCTGGCTGAGTATCCCGGCGGTGTTTGTCTGGTCGAACAGCACGT
CGCCCACGAGCGGGTGCTCTTCGAAGCACTGGAATCGGACTGGCAGGTGGTGCCGCTTGAGCCGCCCCTGGCACTGGAAC
TATCTTCTCGTCAGGCGCAGAATCTCACAGAGCACGGCATCGAGGTCGAAGCTTTCGGTGAGCGCAGTTGGTTGGTGCGT
TCGGCACCGGTGGCCCTCGTCGGACGGGTGGACTGTGCGGAGGGTCTGATGGAACTGGCCGACCAAGAAGATGCCGCCCA
GATGCGCGCCGCGCTCTCCTGCCGGACGGCCATCCGCAACGGCACCGCGCTTTCACCTCTCCAGATGCAGCAACTGCTCG
ATCGCTGGCAGCGCACCCGCAATCCCCACACCTGCCCCCACGGTCGCCCCATCTACATGCCGCTCACCGACGGGGAACTG
GCCCGTTTTTTCCGCAGGCGCTGGCACATCTGCGGTTCCTAG

Upstream 100 bases:

>100_bases
GGGCGCGGTGGAGACGCTGGAGCAGTTCGGCGAACGCTTCGGTGTGCGACACAGCTCACATTGTAGGACTGACCGGGAAG
TTATGCCTGAGCGGCGCTAA

Downstream 100 bases:

>100_bases
CGCTCAAGAAATCCGGTACGCTCTTTCAAGCCGCCGGAGCGCCGTCTGCCTTTGCAGGTGCAACGATTTGGCAAACAGGG
GCCAGGCCAGCTTCCAGGCC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 573; Mature: 573

Protein sequence:

>573_residues
MWCEHPREYRALRSYCFLRRFVCDQSRHRLALISTLVRSNSPLGAIRPLADQTVRLLAAGEVIDSPAAVVRELVDNSLDA
GADRIRVSFWPESWRVQVQDNGLGFEAEELPMAARSHATSKLGAIEDLWRLRTLGFRGEGLHSIAVVARLEILTCTPTAR
TATRARYDHKGELVESQPAAAAPGTVVTVSELFELQPVRRRFLADTKAQVRAVTQLVHRYALAYPGHLFELAVDGRLQLQ
LWAAPGLKQRALQLLNSYDEHDLREVHLERDGRRVRLAIGLPDRCSRARADWLQIYINGRFVRHGELEQAVRAGFERTLR
PGRQPVCIVQLILPADEVDWNRHPAKLEVQLAGTAPACELVVAAIGEGLRHFAPKPAAALLRLAEAHLPYAAESTGGELL
LKALAQLHQTYILAEYPGGVCLVEQHVAHERVLFEALESDWQVVPLEPPLALELSSRQAQNLTEHGIEVEAFGERSWLVR
SAPVALVGRVDCAEGLMELADQEDAAQMRAALSCRTAIRNGTALSPLQMQQLLDRWQRTRNPHTCPHGRPIYMPLTDGEL
ARFFRRRWHICGS

Sequences:

>Translated_573_residues
MWCEHPREYRALRSYCFLRRFVCDQSRHRLALISTLVRSNSPLGAIRPLADQTVRLLAAGEVIDSPAAVVRELVDNSLDA
GADRIRVSFWPESWRVQVQDNGLGFEAEELPMAARSHATSKLGAIEDLWRLRTLGFRGEGLHSIAVVARLEILTCTPTAR
TATRARYDHKGELVESQPAAAAPGTVVTVSELFELQPVRRRFLADTKAQVRAVTQLVHRYALAYPGHLFELAVDGRLQLQ
LWAAPGLKQRALQLLNSYDEHDLREVHLERDGRRVRLAIGLPDRCSRARADWLQIYINGRFVRHGELEQAVRAGFERTLR
PGRQPVCIVQLILPADEVDWNRHPAKLEVQLAGTAPACELVVAAIGEGLRHFAPKPAAALLRLAEAHLPYAAESTGGELL
LKALAQLHQTYILAEYPGGVCLVEQHVAHERVLFEALESDWQVVPLEPPLALELSSRQAQNLTEHGIEVEAFGERSWLVR
SAPVALVGRVDCAEGLMELADQEDAAQMRAALSCRTAIRNGTALSPLQMQQLLDRWQRTRNPHTCPHGRPIYMPLTDGEL
ARFFRRRWHICGS
>Mature_573_residues
MWCEHPREYRALRSYCFLRRFVCDQSRHRLALISTLVRSNSPLGAIRPLADQTVRLLAAGEVIDSPAAVVRELVDNSLDA
GADRIRVSFWPESWRVQVQDNGLGFEAEELPMAARSHATSKLGAIEDLWRLRTLGFRGEGLHSIAVVARLEILTCTPTAR
TATRARYDHKGELVESQPAAAAPGTVVTVSELFELQPVRRRFLADTKAQVRAVTQLVHRYALAYPGHLFELAVDGRLQLQ
LWAAPGLKQRALQLLNSYDEHDLREVHLERDGRRVRLAIGLPDRCSRARADWLQIYINGRFVRHGELEQAVRAGFERTLR
PGRQPVCIVQLILPADEVDWNRHPAKLEVQLAGTAPACELVVAAIGEGLRHFAPKPAAALLRLAEAHLPYAAESTGGELL
LKALAQLHQTYILAEYPGGVCLVEQHVAHERVLFEALESDWQVVPLEPPLALELSSRQAQNLTEHGIEVEAFGERSWLVR
SAPVALVGRVDCAEGLMELADQEDAAQMRAALSCRTAIRNGTALSPLQMQQLLDRWQRTRNPHTCPHGRPIYMPLTDGEL
ARFFRRRWHICGS

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=311, Percent_Identity=29.2604501607717, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI189458898, Length=451, Percent_Identity=24.390243902439, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI4505911, Length=451, Percent_Identity=24.390243902439, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI310128478, Length=190, Percent_Identity=35.2631578947368, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI4505913, Length=190, Percent_Identity=35.2631578947368, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI189458896, Length=451, Percent_Identity=24.6119733924612, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI310128480, Length=132, Percent_Identity=34.8484848484849, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI91992160, Length=229, Percent_Identity=30.5676855895196, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI91992162, Length=229, Percent_Identity=30.5676855895196, Blast_Score=92, Evalue=2e-18,
Organism=Escherichia coli, GI1790612, Length=311, Percent_Identity=34.7266881028939, Blast_Score=160, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71991825, Length=322, Percent_Identity=28.8819875776398, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17562796, Length=347, Percent_Identity=27.9538904899135, Blast_Score=125, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6323819, Length=319, Percent_Identity=30.0940438871473, Blast_Score=128, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6324247, Length=355, Percent_Identity=26.4788732394366, Blast_Score=113, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6325093, Length=173, Percent_Identity=28.9017341040462, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI17136968, Length=311, Percent_Identity=30.5466237942122, Blast_Score=136, Evalue=5e-32,
Organism=Drosophila melanogaster, GI17136970, Length=186, Percent_Identity=34.9462365591398, Blast_Score=107, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 64145; Mature: 64145

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWCEHPREYRALRSYCFLRRFVCDQSRHRLALISTLVRSNSPLGAIRPLADQTVRLLAAG
CCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHC
EVIDSPAAVVRELVDNSLDAGADRIRVSFWPESWRVQVQDNGLGFEAEELPMAARSHATS
CHHCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEECCCCCCCHHHCCHHHHHHHHH
KLGAIEDLWRLRTLGFRGEGLHSIAVVARLEILTCTPTARTATRARYDHKGELVESQPAA
HHHHHHHHHHHHHCCCCCCCHHHHHHHHEEEEEEECCCHHHHHHHCCCCCCCCCCCCCCC
AAPGTVVTVSELFELQPVRRRFLADTKAQVRAVTQLVHRYALAYPGHLFELAVDGRLQLQ
CCCCCEEEHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEE
LWAAPGLKQRALQLLNSYDEHDLREVHLERDGRRVRLAIGLPDRCSRARADWLQIYINGR
EECCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCEEEEEEECE
FVRHGELEQAVRAGFERTLRPGRQPVCIVQLILPADEVDWNRHPAKLEVQLAGTAPACEL
EEECCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCEEEEEECCCCHHHHH
VVAAIGEGLRHFAPKPAAALLRLAEAHLPYAAESTGGELLLKALAQLHQTYILAEYPGGV
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCCE
CLVEQHVAHERVLFEALESDWQVVPLEPPLALELSSRQAQNLTEHGIEVEAFGERSWLVR
EEEHHHHHHHHHHHHHHHCCCEEEECCCCCEEEECCHHHHHHHHCCCEEEEECCCCEEEE
SAPVALVGRVDCAEGLMELADQEDAAQMRAALSCRTAIRNGTALSPLQMQQLLDRWQRTR
CCCEEEEECHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC
NPHTCPHGRPIYMPLTDGELARFFRRRWHICGS
CCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MWCEHPREYRALRSYCFLRRFVCDQSRHRLALISTLVRSNSPLGAIRPLADQTVRLLAAG
CCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHC
EVIDSPAAVVRELVDNSLDAGADRIRVSFWPESWRVQVQDNGLGFEAEELPMAARSHATS
CHHCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEECCCCCCCHHHCCHHHHHHHHH
KLGAIEDLWRLRTLGFRGEGLHSIAVVARLEILTCTPTARTATRARYDHKGELVESQPAA
HHHHHHHHHHHHHCCCCCCCHHHHHHHHEEEEEEECCCHHHHHHHCCCCCCCCCCCCCCC
AAPGTVVTVSELFELQPVRRRFLADTKAQVRAVTQLVHRYALAYPGHLFELAVDGRLQLQ
CCCCCEEEHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEE
LWAAPGLKQRALQLLNSYDEHDLREVHLERDGRRVRLAIGLPDRCSRARADWLQIYINGR
EECCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCEEEEEEECE
FVRHGELEQAVRAGFERTLRPGRQPVCIVQLILPADEVDWNRHPAKLEVQLAGTAPACEL
EEECCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCEEEEEECCCCHHHHH
VVAAIGEGLRHFAPKPAAALLRLAEAHLPYAAESTGGELLLKALAQLHQTYILAEYPGGV
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCCE
CLVEQHVAHERVLFEALESDWQVVPLEPPLALELSSRQAQNLTEHGIEVEAFGERSWLVR
EEEHHHHHHHHHHHHHHHCCCEEEECCCCCEEEECCHHHHHHHHCCCEEEEECCCCEEEE
SAPVALVGRVDCAEGLMELADQEDAAQMRAALSCRTAIRNGTALSPLQMQQLLDRWQRTR
CCCEEEEECHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC
NPHTCPHGRPIYMPLTDGELARFFRRRWHICGS
CCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA