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The map label for this gene is luxQ [H]

Identifier: 37520808

GI number: 37520808

Start: 1318140

End: 1320281

Strand: Direct

Name: luxQ [H]

Synonym: glr1239

Alternate gene names: 37520808

Gene position: 1318140-1320281 (Clockwise)

Preceding gene: 37520807

Following gene: 37520813

Centisome position: 28.29

GC content: 65.59

Gene sequence:

>2142_bases
ATGGACGAATTGCTGGTGGACAACGGAACCGACGGGGGGCACCGGCGGGCGCTTGAGCAAAGCGAATTGCGCTACCGGCA
GTTGGTCGAACTGTCCCCCGACGCGATTTTCGTGCAGTGCGAGGGCAAAGTCGTCTTCATCAACGGGGCCGGGGGCCGGC
TGCTGGGTGCAGAGACGTCCGCACAGATCGTCGGTAAGCCGGTACTCGAACTGATTCATCCGTGCGATCGCGAGGCGGTC
AGGCGGCGTATGGAACTGCTGCAGGCCGGTACGGCGGTGCCGCTGCTGGAGGAACGGTTTTTGCGCCTGGACGGCACGGT
GGTCGAAGTCGAAGTGCTCGCCTCGGCGATGACCTACCAGGGCAAACCCGCCGCCCATGTCCTGGCCCGCGACATCGGCG
AGCGCAAGCGCGCCCAGCACGAACGCGAACAACTGCTGGAGCGGCGGCGGCAGGCCCTTGCCACCGCCGAGCAGAGCGAA
GAGCGCTACCGGTTGCTCATCGAGGCGATCCCGCAACTGGTGTGGACGACGACCGCCGACGGCCGGTGCGACTATCTCAG
TCAGCAGTGGGTCCATTACACGGGCATCCCGGAGGCCGAACAGTTGGGTATGGGCTGGCTGGCGGCCGTCCATCCCGAGG
ACCGCCCTCGGGCGAGCGCCTGCTGGCTGGCGGCGGTGGCCGATCGCGCAATTTATGATCTGGAGTACCGTTTGCGGGCG
GCGGACGGCTCCTACCGCTGGTTTAAGACCCGGGGCAGGCCGGTCCGCGACGCCGGCGGCCGGATTGTCCGCTGGTTTGG
CACCTGCACCGACATGCAGGATCAAAAAACCGCCCAGGAGGAGCGCGAGCGGCTCATCGCGCACCAGCAGCAGTACGCGG
CGCGCCTCAAAAAACTCTCAGAAGCGTCGCTCGCCATCAACCTGGCCCTTTCGGTGGAGGAAGTGGTGGAGGTGATCACC
TTCCAGGCCAGTGCGATCATCGGCACCCACCAAGCGGTGACAAGCATGACCATCGACGCCGACTGGGGCCGGGCAATCAA
TGCGGTCTATCTCTCAGAAAAGTACGCCGCCTGGCGCGATTTTCGCGGCCGACCGAACGGAGCGGCCATCTACGCGCGCG
TGTGCGACACCAATCGGCCGATGCGCCTGAACCAGGCGCAACTGGATGCACACCCGCACTGGCGGACCTTCGGCAACGCC
GATACGGAACACCCGCCGCTGCGCGGTTGGCTTGCGGCCCCCCTGGTGGCCCGGGACGGGCGCAATATCGGGCTTATCCA
GCTTTCGGACAAGTGCGAGGAGGAATTTACCGCCGAGGACGAGGCGATCGTGGTGCAGTTGGCTCAGATGGCCTCGGTGG
CGATCGAGAACGCCCGGCTATTCGAGGCGGAGCAGACCGCCCGCGCCCTTGCAGAGCAAGCCCGCCGCGAAGCGGAAGCC
GCCAACCGCGCCAAAGACGAGTTTCTGGCGGTGCTCAGCCACGAGTTGCGCACTCCCCTCAACCCGATCATCGGTTTTGC
TCAGCTTTTGCGCCGCAAAAGCGGTCTGAGTGCGGCAGACTACCGGGCGCTTGAGACTATCGAGCGCAACGGTCGCCTGC
AGGCGCAACTCATCGACGATGTGCTCGATGTGTCGCGCATCATCTCGGGCAAGATGCGCGTCGAGTTGCGTGCGGTCGAC
CTGTTGCCCGTGGTGGCTGCTGCCATCGAAGCGGTGCGCTCCCCGGCCGAGCTCAAGGGCATCTGCCTGTCGGGCCGGCT
CGACGATGGGGCGACGGCGGTGGCAGACCCGACCCGGATGCAGCAGGTGGTCTGGAATTTGCTCACCAACGCGATCAAAT
TTACCCCCGAGGGCGGCCGGGTGGTGATCGATCTGTGCCGCGGCGACCGCACGCTTCTCATCCGCGTGAGCGACTCGGGT
ATCGGCATCAGCCCCGACTTCTTGCCCTACGTCTTTGAGCGCTTTCGCCAGGCGGACGGCACCAGTACCCGCAAGCACAG
CGGCCTGGGGCTGGGTCTCGCCATCGTGCGGCACATCGTGGAATTGCACGGCGGCGCGGTAAGCGCCCAGAGCGACGGCG
TCGGTCAGGGCACCACTTTTTGCGTCGAGTTGCCGCTCTATACCTGTGAACCGACAGCTTAA

Upstream 100 bases:

>100_bases
CCGAAGAAGGCCGAGCGATTGCCTGGTCGGCCTTTTTTTGCTATGACCGTTCGGTGCGGGCAACCTGAGACCGGCTGCCG
CGATCACTTGGAAAGGTCGA

Downstream 100 bases:

>100_bases
CGGCCTACGCTCCGAACAGCCGCCGGTAGAAACCGGCGGAAAAATCGCCGGGAGAGCCTCCTGCGGCGAGCGATTCGGCC
AAAAAACCGACCAGTTCAAA

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 713; Mature: 713

Protein sequence:

>713_residues
MDELLVDNGTDGGHRRALEQSELRYRQLVELSPDAIFVQCEGKVVFINGAGGRLLGAETSAQIVGKPVLELIHPCDREAV
RRRMELLQAGTAVPLLEERFLRLDGTVVEVEVLASAMTYQGKPAAHVLARDIGERKRAQHEREQLLERRRQALATAEQSE
ERYRLLIEAIPQLVWTTTADGRCDYLSQQWVHYTGIPEAEQLGMGWLAAVHPEDRPRASACWLAAVADRAIYDLEYRLRA
ADGSYRWFKTRGRPVRDAGGRIVRWFGTCTDMQDQKTAQEERERLIAHQQQYAARLKKLSEASLAINLALSVEEVVEVIT
FQASAIIGTHQAVTSMTIDADWGRAINAVYLSEKYAAWRDFRGRPNGAAIYARVCDTNRPMRLNQAQLDAHPHWRTFGNA
DTEHPPLRGWLAAPLVARDGRNIGLIQLSDKCEEEFTAEDEAIVVQLAQMASVAIENARLFEAEQTARALAEQARREAEA
ANRAKDEFLAVLSHELRTPLNPIIGFAQLLRRKSGLSAADYRALETIERNGRLQAQLIDDVLDVSRIISGKMRVELRAVD
LLPVVAAAIEAVRSPAELKGICLSGRLDDGATAVADPTRMQQVVWNLLTNAIKFTPEGGRVVIDLCRGDRTLLIRVSDSG
IGISPDFLPYVFERFRQADGTSTRKHSGLGLGLAIVRHIVELHGGAVSAQSDGVGQGTTFCVELPLYTCEPTA

Sequences:

>Translated_713_residues
MDELLVDNGTDGGHRRALEQSELRYRQLVELSPDAIFVQCEGKVVFINGAGGRLLGAETSAQIVGKPVLELIHPCDREAV
RRRMELLQAGTAVPLLEERFLRLDGTVVEVEVLASAMTYQGKPAAHVLARDIGERKRAQHEREQLLERRRQALATAEQSE
ERYRLLIEAIPQLVWTTTADGRCDYLSQQWVHYTGIPEAEQLGMGWLAAVHPEDRPRASACWLAAVADRAIYDLEYRLRA
ADGSYRWFKTRGRPVRDAGGRIVRWFGTCTDMQDQKTAQEERERLIAHQQQYAARLKKLSEASLAINLALSVEEVVEVIT
FQASAIIGTHQAVTSMTIDADWGRAINAVYLSEKYAAWRDFRGRPNGAAIYARVCDTNRPMRLNQAQLDAHPHWRTFGNA
DTEHPPLRGWLAAPLVARDGRNIGLIQLSDKCEEEFTAEDEAIVVQLAQMASVAIENARLFEAEQTARALAEQARREAEA
ANRAKDEFLAVLSHELRTPLNPIIGFAQLLRRKSGLSAADYRALETIERNGRLQAQLIDDVLDVSRIISGKMRVELRAVD
LLPVVAAAIEAVRSPAELKGICLSGRLDDGATAVADPTRMQQVVWNLLTNAIKFTPEGGRVVIDLCRGDRTLLIRVSDSG
IGISPDFLPYVFERFRQADGTSTRKHSGLGLGLAIVRHIVELHGGAVSAQSDGVGQGTTFCVELPLYTCEPTA
>Mature_713_residues
MDELLVDNGTDGGHRRALEQSELRYRQLVELSPDAIFVQCEGKVVFINGAGGRLLGAETSAQIVGKPVLELIHPCDREAV
RRRMELLQAGTAVPLLEERFLRLDGTVVEVEVLASAMTYQGKPAAHVLARDIGERKRAQHEREQLLERRRQALATAEQSE
ERYRLLIEAIPQLVWTTTADGRCDYLSQQWVHYTGIPEAEQLGMGWLAAVHPEDRPRASACWLAAVADRAIYDLEYRLRA
ADGSYRWFKTRGRPVRDAGGRIVRWFGTCTDMQDQKTAQEERERLIAHQQQYAARLKKLSEASLAINLALSVEEVVEVIT
FQASAIIGTHQAVTSMTIDADWGRAINAVYLSEKYAAWRDFRGRPNGAAIYARVCDTNRPMRLNQAQLDAHPHWRTFGNA
DTEHPPLRGWLAAPLVARDGRNIGLIQLSDKCEEEFTAEDEAIVVQLAQMASVAIENARLFEAEQTARALAEQARREAEA
ANRAKDEFLAVLSHELRTPLNPIIGFAQLLRRKSGLSAADYRALETIERNGRLQAQLIDDVLDVSRIISGKMRVELRAVD
LLPVVAAAIEAVRSPAELKGICLSGRLDDGATAVADPTRMQQVVWNLLTNAIKFTPEGGRVVIDLCRGDRTLLIRVSDSG
IGISPDFLPYVFERFRQADGTSTRKHSGLGLGLAIVRHIVELHGGAVSAQSDGVGQGTTFCVELPLYTCEPTA

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=236, Percent_Identity=37.2881355932203, Blast_Score=137, Evalue=3e-33,
Organism=Escherichia coli, GI87081816, Length=240, Percent_Identity=37.9166666666667, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI145693157, Length=249, Percent_Identity=35.3413654618474, Blast_Score=123, Evalue=5e-29,
Organism=Escherichia coli, GI48994928, Length=244, Percent_Identity=31.9672131147541, Blast_Score=116, Evalue=5e-27,
Organism=Escherichia coli, GI1788393, Length=228, Percent_Identity=33.3333333333333, Blast_Score=116, Evalue=6e-27,
Organism=Escherichia coli, GI1788713, Length=242, Percent_Identity=33.4710743801653, Blast_Score=113, Evalue=5e-26,
Organism=Escherichia coli, GI1786600, Length=222, Percent_Identity=29.7297297297297, Blast_Score=110, Evalue=4e-25,
Organism=Escherichia coli, GI1786783, Length=249, Percent_Identity=29.3172690763052, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1786912, Length=246, Percent_Identity=32.520325203252, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI1790436, Length=218, Percent_Identity=29.3577981651376, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790346, Length=229, Percent_Identity=30.5676855895196, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790861, Length=228, Percent_Identity=32.4561403508772, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI1788279, Length=226, Percent_Identity=29.2035398230088, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1787894, Length=231, Percent_Identity=32.4675324675325, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87082128, Length=226, Percent_Identity=30.5309734513274, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1788549, Length=252, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 79074; Mature: 79074

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDELLVDNGTDGGHRRALEQSELRYRQLVELSPDAIFVQCEGKVVFINGAGGRLLGAETS
CCCCEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEEECCCCCEECCCCC
AQIVGKPVLELIHPCDREAVRRRMELLQAGTAVPLLEERFLRLDGTVVEVEVLASAMTYQ
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEHHHHHHHHHCC
GKPAAHVLARDIGERKRAQHEREQLLERRRQALATAEQSEERYRLLIEAIPQLVWTTTAD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCC
GRCDYLSQQWVHYTGIPEAEQLGMGWLAAVHPEDRPRASACWLAAVADRAIYDLEYRLRA
CCCHHHHHCCEEECCCCCHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHEEEEEEEEE
ADGSYRWFKTRGRPVRDAGGRIVRWFGTCTDMQDQKTAQEERERLIAHQQQYAARLKKLS
CCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EASLAINLALSVEEVVEVITFQASAIIGTHQAVTSMTIDADWGRAINAVYLSEKYAAWRD
HHHEEEEEEECHHHHHHHHHHHHHHHHCCHHHHHEEEEECCCCCCEEEEEEHHHHHHHHH
FRGRPNGAAIYARVCDTNRPMRLNQAQLDAHPHWRTFGNADTEHPPLRGWLAAPLVARDG
CCCCCCCCEEEEEEECCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHCCC
RNIGLIQLSDKCEEEFTAEDEAIVVQLAQMASVAIENARLFEAEQTARALAEQARREAEA
CCEEEEEECCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANRAKDEFLAVLSHELRTPLNPIIGFAQLLRRKSGLSAADYRALETIERNGRLQAQLIDD
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHH
VLDVSRIISGKMRVELRAVDLLPVVAAAIEAVRSPAELKGICLSGRLDDGATAVADPTRM
HHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHCCCHHHCCEEEECCCCCCCCCCCCHHHH
QQVVWNLLTNAIKFTPEGGRVVIDLCRGDRTLLIRVSDSGIGISPDFLPYVFERFRQADG
HHHHHHHHHHHEEECCCCCEEEEEEECCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCC
TSTRKHSGLGLGLAIVRHIVELHGGAVSAQSDGVGQGTTFCVELPLYTCEPTA
CCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEECCEECCCCC
>Mature Secondary Structure
MDELLVDNGTDGGHRRALEQSELRYRQLVELSPDAIFVQCEGKVVFINGAGGRLLGAETS
CCCCEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEEECCCCCEECCCCC
AQIVGKPVLELIHPCDREAVRRRMELLQAGTAVPLLEERFLRLDGTVVEVEVLASAMTYQ
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEHHHHHHHHHCC
GKPAAHVLARDIGERKRAQHEREQLLERRRQALATAEQSEERYRLLIEAIPQLVWTTTAD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCC
GRCDYLSQQWVHYTGIPEAEQLGMGWLAAVHPEDRPRASACWLAAVADRAIYDLEYRLRA
CCCHHHHHCCEEECCCCCHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHEEEEEEEEE
ADGSYRWFKTRGRPVRDAGGRIVRWFGTCTDMQDQKTAQEERERLIAHQQQYAARLKKLS
CCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EASLAINLALSVEEVVEVITFQASAIIGTHQAVTSMTIDADWGRAINAVYLSEKYAAWRD
HHHEEEEEEECHHHHHHHHHHHHHHHHCCHHHHHEEEEECCCCCCEEEEEEHHHHHHHHH
FRGRPNGAAIYARVCDTNRPMRLNQAQLDAHPHWRTFGNADTEHPPLRGWLAAPLVARDG
CCCCCCCCEEEEEEECCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHCCC
RNIGLIQLSDKCEEEFTAEDEAIVVQLAQMASVAIENARLFEAEQTARALAEQARREAEA
CCEEEEEECCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANRAKDEFLAVLSHELRTPLNPIIGFAQLLRRKSGLSAADYRALETIERNGRLQAQLIDD
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHH
VLDVSRIISGKMRVELRAVDLLPVVAAAIEAVRSPAELKGICLSGRLDDGATAVADPTRM
HHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHCCCHHHCCEEEECCCCCCCCCCCCHHHH
QQVVWNLLTNAIKFTPEGGRVVIDLCRGDRTLLIRVSDSGIGISPDFLPYVFERFRQADG
HHHHHHHHHHHEEECCCCCEEEEEEECCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCC
TSTRKHSGLGLGLAIVRHIVELHGGAVSAQSDGVGQGTTFCVELPLYTCEPTA
CCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEECCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]