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The map label for this gene is zwf [H]

Identifier: 37520739

GI number: 37520739

Start: 1247017

End: 1248555

Strand: Reverse

Name: zwf [H]

Synonym: gvip152

Alternate gene names: 37520739

Gene position: 1248555-1247017 (Counterclockwise)

Preceding gene: 37520740

Following gene: 37520738

Centisome position: 26.8

GC content: 65.3

Gene sequence:

>1539_bases
ATGGCAACCGATTCGACGACGCCCTTCCCAATCGCCCCACCGGCTGGACCCTGCGCGATGGTCGTCTTCGGGGCGGCTGG
AGATCTTACCGGTCGGCTACTGGTGCCGGCGCTCTATAACCTGGCCGCGGGCGGGCTATTAGGTGAAAAATTTGTCTTGA
TCGGGCTGGCCCGCGCCCCGCTCACCGACACGAATTTTCGGACACAACTGGGCGAGGCGCTGCAGCGCCATGGCACTGCT
GCAGTCAATCCGGCCGTCTGGGATGCCCTTGCGCAGCGATTTTTTTATCTGGAAGCCAACTTCGAAGCTCCCGATACCTA
CGCCCGCCTGCGGCAGCGGCTGGCCGAGGCGGAAGCCGAATTCAACACGGACGGCAACACGCTATTTTATCTGGCGACCG
CCCCTGAGCACTTCGGCGGCATTGTCGAGCAGTTGGGCTGGGCTGGGCTGTCCCGCGAGGAGACCGGTCACTGGCGACGC
GTCGTCCTCGAAAAACCCTTCGGTCAGGATCTCGCCTCCGCCCAAGCCCTCAACGCCCGCCTCCGGCGCGACCTCTCCGA
AAGCCAGGTCTACCGCATCGATCACTACCTGGGCAAAGAAACCGTCCAGAACATCCTGGTCCTGCGCTTCGCCAACGGCC
TGTTCGAGCCCCTCTGGAACCGCAACCACATCGACCACGTGCAGATCACCGTCGCCGAGAGCGTCGGGGTCGAAAAGCGG
GGCGGTTACTACGAGCGGGCCGGGGCGCTCAGGGACATGGTGCCCAACCATCTTTTCCAGTTGCTGGCCCTCACCGCGAT
GGAGCCGCCCACCTGCTTCGGGGCCGACGCCGTGCGCACCGAAAAGACCAAGCTGCTGGAAGCCGTCCAGACCCTCAAGC
CCGCCCAGATCTCCACCCACGTCGTGCGCGCTCAGTACGCCGCGGGTACGGTCGGGGAGCGGGCACTGCCGGACTACCGC
GCCGAGCCGCGGGTGGCGCCGGATTCGACCACCGAGACGTTCGTCGCCCTCAAACTCGCCGTCGACAACTGGCGGTGGGC
GGGGGTGCCCTTTTATCTGCGCACCGGCAAGGCCCTGGCCAGGCGCAGCACCGAGATCGCCATCCGCTTCAAGCAGGCGC
CCTACGCGATGTTTCGCGACACGCCGGTGGAGCGCCTCACACCCAACTATCTGGTGCTCCACATCCAGCCGGAGGAGCGC
ATCAGCCTCGAATTCGGCGCCAAAGTGCCGGGACCGGCGGTGCGCATGGCCGGCGTCGGCATGGACTTTTGCTACAATCG
CCACTTCGGCGGCGAGCGGGCGATCGGCTATGAAACGTTGCTCTACGACTGCATGATGGGCGATGCTACCCTGTTTCAGC
GCTCGGATACGGTGGAGGCGGCCTGGCAGGTCGTCGAACCGATCTTTGCTGCCTGGAACGATTCAACTGCCGACCTGGTC
ACCTATCCGGCCGGCAGTTGGGGTCCGCAGCAGGCGGAGGAGTTGCTCGGGCGCGACGGTCGGCAGTGGCGGAGAGCGGA
CCATGATTCTTGCGGGTGA

Upstream 100 bases:

>100_bases
AGTGTGTAGTCTACAACCGCACCGCCGAGAAAGTGCTCTCGGCGGTGCGCTTTCAGTTCGGCGAGCACACCGAGCACACC
GGCGCGGGAGGGTAAGGACG

Downstream 100 bases:

>100_bases
TGTGGGCGGAACCAACACGCGGCTGGCCGGCTTCGAGCCGGTCGCGGGCAACTTGATGCCGATCGTCTCCGAGACCTATG
CCAGCCGGGATTACTCCAGT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 512; Mature: 511

Protein sequence:

>512_residues
MATDSTTPFPIAPPAGPCAMVVFGAAGDLTGRLLVPALYNLAAGGLLGEKFVLIGLARAPLTDTNFRTQLGEALQRHGTA
AVNPAVWDALAQRFFYLEANFEAPDTYARLRQRLAEAEAEFNTDGNTLFYLATAPEHFGGIVEQLGWAGLSREETGHWRR
VVLEKPFGQDLASAQALNARLRRDLSESQVYRIDHYLGKETVQNILVLRFANGLFEPLWNRNHIDHVQITVAESVGVEKR
GGYYERAGALRDMVPNHLFQLLALTAMEPPTCFGADAVRTEKTKLLEAVQTLKPAQISTHVVRAQYAAGTVGERALPDYR
AEPRVAPDSTTETFVALKLAVDNWRWAGVPFYLRTGKALARRSTEIAIRFKQAPYAMFRDTPVERLTPNYLVLHIQPEER
ISLEFGAKVPGPAVRMAGVGMDFCYNRHFGGERAIGYETLLYDCMMGDATLFQRSDTVEAAWQVVEPIFAAWNDSTADLV
TYPAGSWGPQQAEELLGRDGRQWRRADHDSCG

Sequences:

>Translated_512_residues
MATDSTTPFPIAPPAGPCAMVVFGAAGDLTGRLLVPALYNLAAGGLLGEKFVLIGLARAPLTDTNFRTQLGEALQRHGTA
AVNPAVWDALAQRFFYLEANFEAPDTYARLRQRLAEAEAEFNTDGNTLFYLATAPEHFGGIVEQLGWAGLSREETGHWRR
VVLEKPFGQDLASAQALNARLRRDLSESQVYRIDHYLGKETVQNILVLRFANGLFEPLWNRNHIDHVQITVAESVGVEKR
GGYYERAGALRDMVPNHLFQLLALTAMEPPTCFGADAVRTEKTKLLEAVQTLKPAQISTHVVRAQYAAGTVGERALPDYR
AEPRVAPDSTTETFVALKLAVDNWRWAGVPFYLRTGKALARRSTEIAIRFKQAPYAMFRDTPVERLTPNYLVLHIQPEER
ISLEFGAKVPGPAVRMAGVGMDFCYNRHFGGERAIGYETLLYDCMMGDATLFQRSDTVEAAWQVVEPIFAAWNDSTADLV
TYPAGSWGPQQAEELLGRDGRQWRRADHDSCG
>Mature_511_residues
ATDSTTPFPIAPPAGPCAMVVFGAAGDLTGRLLVPALYNLAAGGLLGEKFVLIGLARAPLTDTNFRTQLGEALQRHGTAA
VNPAVWDALAQRFFYLEANFEAPDTYARLRQRLAEAEAEFNTDGNTLFYLATAPEHFGGIVEQLGWAGLSREETGHWRRV
VLEKPFGQDLASAQALNARLRRDLSESQVYRIDHYLGKETVQNILVLRFANGLFEPLWNRNHIDHVQITVAESVGVEKRG
GYYERAGALRDMVPNHLFQLLALTAMEPPTCFGADAVRTEKTKLLEAVQTLKPAQISTHVVRAQYAAGTVGERALPDYRA
EPRVAPDSTTETFVALKLAVDNWRWAGVPFYLRTGKALARRSTEIAIRFKQAPYAMFRDTPVERLTPNYLVLHIQPEERI
SLEFGAKVPGPAVRMAGVGMDFCYNRHFGGERAIGYETLLYDCMMGDATLFQRSDTVEAAWQVVEPIFAAWNDSTADLVT
YPAGSWGPQQAEELLGRDGRQWRRADHDSCG

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=486, Percent_Identity=35.59670781893, Blast_Score=289, Evalue=4e-78,
Organism=Homo sapiens, GI108773793, Length=486, Percent_Identity=35.59670781893, Blast_Score=288, Evalue=6e-78,
Organism=Homo sapiens, GI52145310, Length=504, Percent_Identity=29.9603174603175, Blast_Score=159, Evalue=8e-39,
Organism=Escherichia coli, GI1788158, Length=496, Percent_Identity=39.1129032258064, Blast_Score=361, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17538218, Length=489, Percent_Identity=34.3558282208589, Blast_Score=299, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6324088, Length=492, Percent_Identity=34.1463414634146, Blast_Score=276, Evalue=7e-75,
Organism=Drosophila melanogaster, GI24643352, Length=480, Percent_Identity=33.9583333333333, Blast_Score=267, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24643350, Length=480, Percent_Identity=33.9583333333333, Blast_Score=267, Evalue=2e-71,
Organism=Drosophila melanogaster, GI221513548, Length=476, Percent_Identity=29.4117647058824, Blast_Score=203, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56744; Mature: 56613

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATDSTTPFPIAPPAGPCAMVVFGAAGDLTGRLLVPALYNLAAGGLLGEKFVLIGLARAP
CCCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCC
LTDTNFRTQLGEALQRHGTAAVNPAVWDALAQRFFYLEANFEAPDTYARLRQRLAEAEAE
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHC
FNTDGNTLFYLATAPEHFGGIVEQLGWAGLSREETGHWRRVVLEKPFGQDLASAQALNAR
CCCCCCEEEEEEECCHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
LRRDLSESQVYRIDHYLGKETVQNILVLRFANGLFEPLWNRNHIDHVQITVAESVGVEKR
HHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHCCCCCC
GGYYERAGALRDMVPNHLFQLLALTAMEPPTCFGADAVRTEKTKLLEAVQTLKPAQISTH
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHH
VVRAQYAAGTVGERALPDYRAEPRVAPDSTTETFVALKLAVDNWRWAGVPFYLRTGKALA
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCEECCCCEEEECCHHHH
RRSTEIAIRFKQAPYAMFRDTPVERLTPNYLVLHIQPEERISLEFGAKVPGPAVRMAGVG
HCCCEEEEEEECCCHHHHCCCCHHHCCCCEEEEEECCCCCEEEEECCCCCCCHHHHCCCC
MDFCYNRHFGGERAIGYETLLYDCMMGDATLFQRSDTVEAAWQVVEPIFAAWNDSTADLV
HHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEE
TYPAGSWGPQQAEELLGRDGRQWRRADHDSCG
EECCCCCCHHHHHHHHCCCCHHHHHCCCCCCC
>Mature Secondary Structure 
ATDSTTPFPIAPPAGPCAMVVFGAAGDLTGRLLVPALYNLAAGGLLGEKFVLIGLARAP
CCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCC
LTDTNFRTQLGEALQRHGTAAVNPAVWDALAQRFFYLEANFEAPDTYARLRQRLAEAEAE
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHC
FNTDGNTLFYLATAPEHFGGIVEQLGWAGLSREETGHWRRVVLEKPFGQDLASAQALNAR
CCCCCCEEEEEEECCHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
LRRDLSESQVYRIDHYLGKETVQNILVLRFANGLFEPLWNRNHIDHVQITVAESVGVEKR
HHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHCCCCCC
GGYYERAGALRDMVPNHLFQLLALTAMEPPTCFGADAVRTEKTKLLEAVQTLKPAQISTH
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHH
VVRAQYAAGTVGERALPDYRAEPRVAPDSTTETFVALKLAVDNWRWAGVPFYLRTGKALA
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCEECCCCEEEECCHHHH
RRSTEIAIRFKQAPYAMFRDTPVERLTPNYLVLHIQPEERISLEFGAKVPGPAVRMAGVG
HCCCEEEEEEECCCHHHHCCCCHHHCCCCEEEEEECCCCCEEEEECCCCCCCHHHHCCCC
MDFCYNRHFGGERAIGYETLLYDCMMGDATLFQRSDTVEAAWQVVEPIFAAWNDSTADLV
HHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEE
TYPAGSWGPQQAEELLGRDGRQWRRADHDSCG
EECCCCCCHHHHHHHHCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1643289 [H]