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The map label for this gene is aqpM [H]

Identifier: 37520731

GI number: 37520731

Start: 1237640

End: 1238548

Strand: Direct

Name: aqpM [H]

Synonym: glr1162

Alternate gene names: 37520731

Gene position: 1237640-1238548 (Clockwise)

Preceding gene: 37520730

Following gene: 37520732

Centisome position: 26.56

GC content: 67.11

Gene sequence:

>909_bases
GTGCGCCGCTTCGCCCGCCGGGCAACCGCGATACTGGCCGCAGAGAAACGCTTCTTAAGGAGTTCTCCTGTGCGGACGCG
CAGAACCCCGGCCAGTGGCGGCGCCACCGCGGACCGCTTGCGCCGCCACTGGCCCGAATATCTGATCGAAGCCTGGGGCT
TGGGCACGTTCATGGTCTCGGCCGTCCTGTTCACGGCCCTCCTCGAATACCCCGGCTGGGGGCTGCCGCAGTGGTTGCCC
GAGCCCGACCGACGGCGGTTGCTCATCGCCCTCGCCATGGGCCTCACGGCTCTCTGCATCATCTACTCGCCCTGGGGCAA
GCGCTCGGGCGCCCACATCAACCCGGCGGTCACCTTCACCTTCTGGCGGCTGGGCAAGATCCGCACTGCCGACGCCCTTT
TCTACGCGGCGGCCCAGTTCGCGGGCGGCACGGCGGGGGTACTGCTGAGCGCTCTTTTGCTCGGGCCGGTGATCGCCGCC
CCGAGCGTCAACTACGCGGTCACCGTGCCGGGGCCCGCGGGGGTGGGCGTCGCCTTCGCGTGCGAATTTGTAATCGCTTT
TTTGATGATGACGACGGTACTCCACACCTCCAACCGTCCCCGCTTTGCTCCCTTCACCGGGTTGTTCGCGGGGGGGCTCA
TCGTGCTCTATGTGGGTTTCGAGTCTCCTTTTTCGGGTTTCGGCATGAACCCGGCGCGCACCTTCGCCTCCGCCCTGCCC
GCCGGGGTCTGGACGGCCGCCTGGATCTACTTCGTCGTCCCCGTGGCGGCGATGCTCTCGGCCGCGGAAATCTACGTGCG
CACTCACGGGATTTCCCGCGTCCGCTGCGCCAAGCTGCAGCACGGCGATGCCGAGCAGTGCATCTTCCGGTGCGGATACC
GACAACCTCCTACACAGAACCTGCCATGA

Upstream 100 bases:

>100_bases
AACGACATCTCGGCTTCCGGCGGGGCTTCCTCGTCCGCGATCCGGACGGGCACGTGTTGCAAATCGTTGAGCGCTAAAAA
GTCGTCGCTAACTCGTTTAA

Downstream 100 bases:

>100_bases
GTGACCCGGACCTGCATTACGACCTCATCGTCATCGGCACCGGTGCCGGCGGCAGCACCCTCACCCACCGCCTCGCCCCC
ACCGGCAAACGGATATTGAT

Product: pore-forming membrane protein SmpX-like protein

Products: glycerol [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MRRFARRATAILAAEKRFLRSSPVRTRRTPASGGATADRLRRHWPEYLIEAWGLGTFMVSAVLFTALLEYPGWGLPQWLP
EPDRRRLLIALAMGLTALCIIYSPWGKRSGAHINPAVTFTFWRLGKIRTADALFYAAAQFAGGTAGVLLSALLLGPVIAA
PSVNYAVTVPGPAGVGVAFACEFVIAFLMMTTVLHTSNRPRFAPFTGLFAGGLIVLYVGFESPFSGFGMNPARTFASALP
AGVWTAAWIYFVVPVAAMLSAAEIYVRTHGISRVRCAKLQHGDAEQCIFRCGYRQPPTQNLP

Sequences:

>Translated_302_residues
MRRFARRATAILAAEKRFLRSSPVRTRRTPASGGATADRLRRHWPEYLIEAWGLGTFMVSAVLFTALLEYPGWGLPQWLP
EPDRRRLLIALAMGLTALCIIYSPWGKRSGAHINPAVTFTFWRLGKIRTADALFYAAAQFAGGTAGVLLSALLLGPVIAA
PSVNYAVTVPGPAGVGVAFACEFVIAFLMMTTVLHTSNRPRFAPFTGLFAGGLIVLYVGFESPFSGFGMNPARTFASALP
AGVWTAAWIYFVVPVAAMLSAAEIYVRTHGISRVRCAKLQHGDAEQCIFRCGYRQPPTQNLP
>Mature_302_residues
MRRFARRATAILAAEKRFLRSSPVRTRRTPASGGATADRLRRHWPEYLIEAWGLGTFMVSAVLFTALLEYPGWGLPQWLP
EPDRRRLLIALAMGLTALCIIYSPWGKRSGAHINPAVTFTFWRLGKIRTADALFYAAAQFAGGTAGVLLSALLLGPVIAA
PSVNYAVTVPGPAGVGVAFACEFVIAFLMMTTVLHTSNRPRFAPFTGLFAGGLIVLYVGFESPFSGFGMNPARTFASALP
AGVWTAAWIYFVVPVAAMLSAAEIYVRTHGISRVRCAKLQHGDAEQCIFRCGYRQPPTQNLP

Specific function: Channel that permits osmotically driven movement of water in both directions [H]

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI6912506, Length=204, Percent_Identity=34.3137254901961, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI4502181, Length=188, Percent_Identity=31.3829787234043, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI4755125, Length=188, Percent_Identity=31.3829787234043, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24652747, Length=257, Percent_Identity=29.9610894941634, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45551084, Length=257, Percent_Identity=29.9610894941634, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 32866; Mature: 32866

Theoretical pI: Translated: 10.96; Mature: 10.96

Prosite motif: PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRFARRATAILAAEKRFLRSSPVRTRRTPASGGATADRLRRHWPEYLIEAWGLGTFMVS
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHH
AVLFTALLEYPGWGLPQWLPEPDRRRLLIALAMGLTALCIIYSPWGKRSGAHINPAVTFT
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHEEH
FWRLGKIRTADALFYAAAQFAGGTAGVLLSALLLGPVIAAPSVNYAVTVPGPAGVGVAFA
HHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHH
CEFVIAFLMMTTVLHTSNRPRFAPFTGLFAGGLIVLYVGFESPFSGFGMNPARTFASALP
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHCC
AGVWTAAWIYFVVPVAAMLSAAEIYVRTHGISRVRCAKLQHGDAEQCIFRCGYRQPPTQN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHCCCCCCCCCC
LP
CC
>Mature Secondary Structure
MRRFARRATAILAAEKRFLRSSPVRTRRTPASGGATADRLRRHWPEYLIEAWGLGTFMVS
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHH
AVLFTALLEYPGWGLPQWLPEPDRRRLLIALAMGLTALCIIYSPWGKRSGAHINPAVTFT
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHEEH
FWRLGKIRTADALFYAAAQFAGGTAGVLLSALLLGPVIAAPSVNYAVTVPGPAGVGVAFA
HHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHH
CEFVIAFLMMTTVLHTSNRPRFAPFTGLFAGGLIVLYVGFESPFSGFGMNPARTFASALP
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHCC
AGVWTAAWIYFVVPVAAMLSAAEIYVRTHGISRVRCAKLQHGDAEQCIFRCGYRQPPTQN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHCCCCCCCCCC
LP
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glycerol [Periplasm] [C]

Specific reaction: glycerol [Periplasm] = glycerol [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]