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The map label for this gene is pyrFE [H]

Identifier: 37520648

GI number: 37520648

Start: 1158172

End: 1159626

Strand: Direct

Name: pyrFE [H]

Synonym: glr1079

Alternate gene names: 37520648

Gene position: 1158172-1159626 (Clockwise)

Preceding gene: 37520646

Following gene: 37520653

Centisome position: 24.86

GC content: 64.33

Gene sequence:

>1455_bases
ATGAATTTTTTCGACAAACTGGACAAGGCCATCGCGCAGCAAGGCAGTCTGCTGTTTGTCGGCCTCGATCCCAACCCCGA
GATGCTGCCCGAGCGCTACGGCCGGACCGCGTCGATTGCTGCTTTGCGCGACTGGATGCGCGCCCTCGTCGAGCAGACCG
CCGCTTCTATCTGCGCCTTCAAACCGACCCTCGGTTTCTATCAGGCCCTCGGTCCGGCCGGGATCGACCTGTTGCTGGAG
GTGCTCGAGTGGATCCCGCCGCACCTGCCGGTCATTTTGGATGCCAAACACGGCGATCTCAACACCGGTACGCAGCTCGC
GCGCACGTTCTTTGAGGACTGGGGGGTCGATGCGGTCACCATCAATCCCTTTGCCGGTCAGGATGCGGTGGCGCCGTTTT
TGCTCTACCCGCGCAAAGGGGTATTCGTCCTCTGCCACACCGCCAATCCGGCGGCCCAGGCGATGCAAGCGCACCCGGGC
CAGCAACCGCCGCTGTATCAACAGGTGGTCCGCGAGGCGAGGGGTTGGGGTCTGCCCGAACAACTGGGCCTGGAGGTGGG
TACGGTCCGGCCGGAGATCCTGGCGCGCGTGCGCGCCGCCGCACCCGAGCGGCTCATCATGGTGCGCAGCCTCTGGGCCG
CACCGCCGGGGGCGCTCGCGTCGATGCTCGCCGCCGGCCTCGATGCAGCGGGGGCCGGTTTGCTGGTGCCGGTGCCCCAG
GAGTGTCTGGGGGCAGACACTCCTGGCCTCAGCGTCGCAGCGCTGCGCTGCGAAATTGAAGCGATCCGGACTGTCCCCGG
GGATGTACCGAGCAGCTGCACCCTCTGGCAACCGGATGTCTGCCTCATCGAAACCGATCGGCTCCTGGATCTGGCCTTGC
AGCTGTTCGACACCGGCTGTATTCTCTTCGGCGAGTACGTCCAGGCCAGCGGTGCGGTGTTTCCGTACTACATCGATCTC
AGGCGGATTATCTCCAACCCGCAGCTCTTTCAGCAGGTGCTGCTCGCCTACGCGGAAATCTTGAGCACCCTGTCCTTCGA
TCGCATCGCAGGAATTCCCTACGGCTCGCTGCCCACCGCCACCGGACTGGCGCTTCACCTCAACCGGCCGCTGATCTTCC
CGCGCAAGGAAGTCAAAGCCCACGGCACCCGGCGGGCGATCGAGGGCACCTTCTATCCGGGCGAAACGGTCGTGGTGATC
GACGACATCTTGATCACCGGCAACAGCGCCGTAGAAGGGGCGCGCAAGCTCCAGTCCGTCGGATTGGTGGTCCGCGATAT
CGTCGTGCTCATCGAGCACGGTCCTGAGGCGAGCGCCTTTTTGCAATCGCAAGGGTACAATGCCTACGCCGTACTGCCCT
TTGAACGTATCGCCCGCACTCTGCATCAGGCTGGACGTATCGACGACAGCCAGTACGCCGCCCTCGGCGAAGACAAGCTT
GCGAGCGCGAGTTGA

Upstream 100 bases:

>100_bases
TGCAACCGGTGCAGCGAAAAACCGGGAGGTTTGTCCTGGGGCATGCCGCTGGAGTCGATAACTGCGCCTATCATGGCCCA
AAGGGCGGCGGTATAGAGCC

Downstream 100 bases:

>100_bases
GCCGCCTCAGGCCAACTTTTGCAACGCAGGCTCGGTCCTTTGCGATGGTGCGAGGCCCTGCTCGCTGCGTTGCCAGGCTC
GCCAGTAGGCGCCCAAACGC

Product: bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein

Products: NA

Alternate protein names: Orotidine 5'-phosphate decarboxylase; OMP decarboxylase; OMPDCase; OMPdecase; Orotate phosphoribosyltransferase; OPRT; OPRTase [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MNFFDKLDKAIAQQGSLLFVGLDPNPEMLPERYGRTASIAALRDWMRALVEQTAASICAFKPTLGFYQALGPAGIDLLLE
VLEWIPPHLPVILDAKHGDLNTGTQLARTFFEDWGVDAVTINPFAGQDAVAPFLLYPRKGVFVLCHTANPAAQAMQAHPG
QQPPLYQQVVREARGWGLPEQLGLEVGTVRPEILARVRAAAPERLIMVRSLWAAPPGALASMLAAGLDAAGAGLLVPVPQ
ECLGADTPGLSVAALRCEIEAIRTVPGDVPSSCTLWQPDVCLIETDRLLDLALQLFDTGCILFGEYVQASGAVFPYYIDL
RRIISNPQLFQQVLLAYAEILSTLSFDRIAGIPYGSLPTATGLALHLNRPLIFPRKEVKAHGTRRAIEGTFYPGETVVVI
DDILITGNSAVEGARKLQSVGLVVRDIVVLIEHGPEASAFLQSQGYNAYAVLPFERIARTLHQAGRIDDSQYAALGEDKL
ASAS

Sequences:

>Translated_484_residues
MNFFDKLDKAIAQQGSLLFVGLDPNPEMLPERYGRTASIAALRDWMRALVEQTAASICAFKPTLGFYQALGPAGIDLLLE
VLEWIPPHLPVILDAKHGDLNTGTQLARTFFEDWGVDAVTINPFAGQDAVAPFLLYPRKGVFVLCHTANPAAQAMQAHPG
QQPPLYQQVVREARGWGLPEQLGLEVGTVRPEILARVRAAAPERLIMVRSLWAAPPGALASMLAAGLDAAGAGLLVPVPQ
ECLGADTPGLSVAALRCEIEAIRTVPGDVPSSCTLWQPDVCLIETDRLLDLALQLFDTGCILFGEYVQASGAVFPYYIDL
RRIISNPQLFQQVLLAYAEILSTLSFDRIAGIPYGSLPTATGLALHLNRPLIFPRKEVKAHGTRRAIEGTFYPGETVVVI
DDILITGNSAVEGARKLQSVGLVVRDIVVLIEHGPEASAFLQSQGYNAYAVLPFERIARTLHQAGRIDDSQYAALGEDKL
ASAS
>Mature_484_residues
MNFFDKLDKAIAQQGSLLFVGLDPNPEMLPERYGRTASIAALRDWMRALVEQTAASICAFKPTLGFYQALGPAGIDLLLE
VLEWIPPHLPVILDAKHGDLNTGTQLARTFFEDWGVDAVTINPFAGQDAVAPFLLYPRKGVFVLCHTANPAAQAMQAHPG
QQPPLYQQVVREARGWGLPEQLGLEVGTVRPEILARVRAAAPERLIMVRSLWAAPPGALASMLAAGLDAAGAGLLVPVPQ
ECLGADTPGLSVAALRCEIEAIRTVPGDVPSSCTLWQPDVCLIETDRLLDLALQLFDTGCILFGEYVQASGAVFPYYIDL
RRIISNPQLFQQVLLAYAEILSTLSFDRIAGIPYGSLPTATGLALHLNRPLIFPRKEVKAHGTRRAIEGTFYPGETVVVI
DDILITGNSAVEGARKLQSVGLVVRDIVVLIEHGPEASAFLQSQGYNAYAVLPFERIARTLHQAGRIDDSQYAALGEDKL
ASAS

Specific function: Catalyzes the decarboxylation of orotidine monophosphate (OMP) to uridine monophosphate (UMP) [H]

COG id: COG0284

COG function: function code F; Orotidine-5'-phosphate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=184, Percent_Identity=36.9565217391304, Blast_Score=125, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI17508631, Length=170, Percent_Identity=36.4705882352941, Blast_Score=121, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17554964, Length=189, Percent_Identity=29.6296296296296, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI17933654, Length=196, Percent_Identity=33.6734693877551, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011995
- InterPro:   IPR001754
- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00215 OMPdecase; PF00156 Pribosyltran [H]

EC number: =4.1.1.23; =2.4.2.10 [H]

Molecular weight: Translated: 52286; Mature: 52286

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFFDKLDKAIAQQGSLLFVGLDPNPEMLPERYGRTASIAALRDWMRALVEQTAASICAF
CCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
KPTLGFYQALGPAGIDLLLEVLEWIPPHLPVILDAKHGDLNTGTQLARTFFEDWGVDAVT
CCHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCEEE
INPFAGQDAVAPFLLYPRKGVFVLCHTANPAAQAMQAHPGQQPPLYQQVVREARGWGLPE
ECCCCCCCCCCCCEEECCCCEEEEEECCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCH
QLGLEVGTVRPEILARVRAAAPERLIMVRSLWAAPPGALASMLAAGLDAAGAGLLVPVPQ
HHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEEECCH
ECLGADTPGLSVAALRCEIEAIRTVPGDVPSSCTLWQPDVCLIETDRLLDLALQLFDTGC
HHCCCCCCCCEEEEHHHHHHHHHCCCCCCCCCCEEECCCEEEEEHHHHHHHHHHHHHCCH
ILFGEYVQASGAVFPYYIDLRRIISNPQLFQQVLLAYAEILSTLSFDRIAGIPYGSLPTA
HEEHHHHHHCCCEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCC
TGLALHLNRPLIFPRKEVKAHGTRRAIEGTFYPGETVVVIDDILITGNSAVEGARKLQSV
CCEEEEECCCCCCCCHHHHHCCCHHHCCCCCCCCCEEEEEEEEEEECCHHHHHHHHHHHH
GLVVRDIVVLIEHGPEASAFLQSQGYNAYAVLPFERIARTLHQAGRIDDSQYAALGEDKL
HHHHHHHHHHHHCCCCHHHHHHHCCCCEEEECCHHHHHHHHHHHCCCCCCHHHHCCCCHH
ASAS
CCCC
>Mature Secondary Structure
MNFFDKLDKAIAQQGSLLFVGLDPNPEMLPERYGRTASIAALRDWMRALVEQTAASICAF
CCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
KPTLGFYQALGPAGIDLLLEVLEWIPPHLPVILDAKHGDLNTGTQLARTFFEDWGVDAVT
CCHHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCEEE
INPFAGQDAVAPFLLYPRKGVFVLCHTANPAAQAMQAHPGQQPPLYQQVVREARGWGLPE
ECCCCCCCCCCCCEEECCCCEEEEEECCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCH
QLGLEVGTVRPEILARVRAAAPERLIMVRSLWAAPPGALASMLAAGLDAAGAGLLVPVPQ
HHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEEECCH
ECLGADTPGLSVAALRCEIEAIRTVPGDVPSSCTLWQPDVCLIETDRLLDLALQLFDTGC
HHCCCCCCCCEEEEHHHHHHHHHCCCCCCCCCCEEECCCEEEEEHHHHHHHHHHHHHCCH
ILFGEYVQASGAVFPYYIDLRRIISNPQLFQQVLLAYAEILSTLSFDRIAGIPYGSLPTA
HEEHHHHHHCCCEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCC
TGLALHLNRPLIFPRKEVKAHGTRRAIEGTFYPGETVVVIDDILITGNSAVEGARKLQSV
CCEEEEECCCCCCCCHHHHHCCCHHHCCCCCCCCCEEEEEEEEEEECCHHHHHHHHHHHH
GLVVRDIVVLIEHGPEASAFLQSQGYNAYAVLPFERIARTLHQAGRIDDSQYAALGEDKL
HHHHHHHHHHHHCCCCHHHHHHHCCCCEEEECCHHHHHHHHHHHCCCCCCHHHHCCCCHH
ASAS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]