Click here to switch to the map view.

The map label for this gene is tuaD [H]

Identifier: 37520631

GI number: 37520631

Start: 1137408

End: 1138799

Strand: Direct

Name: tuaD [H]

Synonym: glr1062

Alternate gene names: 37520631

Gene position: 1137408-1138799 (Clockwise)

Preceding gene: 37520630

Following gene: 37520632

Centisome position: 24.41

GC content: 63.72

Gene sequence:

>1392_bases
ATGCGCGTCTGCGTTATCGGTACTGGCTATGTTGGTTTGGTTACGGGAGCCTGTCTGGCCCATATCGGCCACGACGTTGT
GGGCGTGGACAACAACGCCGCCAAGGTCGCCCAGATGCAAGCGGGAATCTCCCCCATTGTTGAACCGGGCCTCGAAACGA
TCATGACCGGGGCGATGCAGGCGCAGCGGCTGGCGTTTACGACCGATATCGCCGCCGGGGTGCGCCACGGCGAGGTGATC
TTTATTGCCGTCGGCACCCCGGCTCTGCCGAGCGGCGAGAGCGATACACGGGCGGTCGAAGCGGTGGCTAGGGCGATCGG
CACCCACCTGGACGGCAACTACAAAGTGATCGTCAACAAGTCGACCGTGCCCATCGGCTCGGGGGACTGGGTGCGGATGC
TGGTGAGCGAAAACGCTGCGCCGGATGTCGATTTTGATGTCGTGAGCAACCCCGAATTTCTGCGCGAAGGCTCGGCAGTA
TTCGATACCTTCAATCCGGATCGCATCGTGCTTGGGGGCAGCGGCAGGCGGGCCGTCGCTTTGATGAAAAAGCTCTATGA
ACCGATTACCCAACGGCAAGTGGCCGCCGAGGCCGCTTTGCCCCCGGTGCCGGTGGTGGTGACGGACCTGGCCTCTGCCG
AGATGATCAAGTACGCGGCGAACGCCTTTTTGGCCACCAAAATCAGCTTCATCAACGAAGTAGCCAATATCTGCGACCGG
GTCGGCGCCGATGTGCAGCAGGTGGCCCTGGGCATGGGCCTCGATTCGCGCATCGGCGGCAAATTTTTGCAGGCGGGTCT
TGGTTGGGGAGGATCTTGCTTTCCCAAGGATGTCGCAGCCCTGGTGCACACTGCCTGCGACTACGGCTATGAAGCGAAGC
TGCTGGCGGCGGCGGTGGCGGTCAACCGCTCCCAGCGCTATCTGGCTATCGAAAAATTGCGCCAATCGCTGGGTATCCTC
AAAGGCAAGACGATCGGTCTGTTGGGTCTTACTTTCAAGCCCGATACCGACGATCTGCGCGACGCCCCGGCCTTGGATCT
GGCCGCCGAGTGCCGGAGATTGGGGGCTCGGGTGAAAGCCTACGACCCGACCGTCCGCCCGGAGCGTCCGCCCGCGGGCC
TCGAAGCGGGTGTGGCCGTCTGCCCCGAGAGCCTCGCAGTCGGTTGCGACGCCCTGGTGCTGGTGACCGAGTGGGCCGAA
TTTCGTACCCTCGACTACGCCGGCCTGGCCCGGTCGATGGCAAGAGCGCTAATCGTGGACGGGCGCAACTTTCTCGATCC
CCAGATTCTCGCAGCGGCGGGCTTTACCTACGTGGGCATCGGCAAACCCGGGGCCAAAGCGGCGCCGGCCGCCCCCGAAA
AAGCGGCGCCGGTGCTCGCCATCGCCGGCTGA

Upstream 100 bases:

>100_bases
CGCAAGTGCGACGGGCCGACAATCCGGCCGGTCAGATCGTCTTGAGTAGGAGCGGCCGGATTATCAGATTAATTGCCAAC
AACTGATGAGGGGTTATTTT

Downstream 100 bases:

>100_bases
CCTTTCGCATCCACACTCACACAAGGACCTGCGGCGATGAGAATTACCGTGTATTCTCACGATTCCTACGGCCTCGGCAA
TGTGCGCAGGATGATCGCCA

Product: UDP-glucose dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; Teichuronic acid biosynthesis protein tuaD [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MRVCVIGTGYVGLVTGACLAHIGHDVVGVDNNAAKVAQMQAGISPIVEPGLETIMTGAMQAQRLAFTTDIAAGVRHGEVI
FIAVGTPALPSGESDTRAVEAVARAIGTHLDGNYKVIVNKSTVPIGSGDWVRMLVSENAAPDVDFDVVSNPEFLREGSAV
FDTFNPDRIVLGGSGRRAVALMKKLYEPITQRQVAAEAALPPVPVVVTDLASAEMIKYAANAFLATKISFINEVANICDR
VGADVQQVALGMGLDSRIGGKFLQAGLGWGGSCFPKDVAALVHTACDYGYEAKLLAAAVAVNRSQRYLAIEKLRQSLGIL
KGKTIGLLGLTFKPDTDDLRDAPALDLAAECRRLGARVKAYDPTVRPERPPAGLEAGVAVCPESLAVGCDALVLVTEWAE
FRTLDYAGLARSMARALIVDGRNFLDPQILAAAGFTYVGIGKPGAKAAPAAPEKAAPVLAIAG

Sequences:

>Translated_463_residues
MRVCVIGTGYVGLVTGACLAHIGHDVVGVDNNAAKVAQMQAGISPIVEPGLETIMTGAMQAQRLAFTTDIAAGVRHGEVI
FIAVGTPALPSGESDTRAVEAVARAIGTHLDGNYKVIVNKSTVPIGSGDWVRMLVSENAAPDVDFDVVSNPEFLREGSAV
FDTFNPDRIVLGGSGRRAVALMKKLYEPITQRQVAAEAALPPVPVVVTDLASAEMIKYAANAFLATKISFINEVANICDR
VGADVQQVALGMGLDSRIGGKFLQAGLGWGGSCFPKDVAALVHTACDYGYEAKLLAAAVAVNRSQRYLAIEKLRQSLGIL
KGKTIGLLGLTFKPDTDDLRDAPALDLAAECRRLGARVKAYDPTVRPERPPAGLEAGVAVCPESLAVGCDALVLVTEWAE
FRTLDYAGLARSMARALIVDGRNFLDPQILAAAGFTYVGIGKPGAKAAPAAPEKAAPVLAIAG
>Mature_463_residues
MRVCVIGTGYVGLVTGACLAHIGHDVVGVDNNAAKVAQMQAGISPIVEPGLETIMTGAMQAQRLAFTTDIAAGVRHGEVI
FIAVGTPALPSGESDTRAVEAVARAIGTHLDGNYKVIVNKSTVPIGSGDWVRMLVSENAAPDVDFDVVSNPEFLREGSAV
FDTFNPDRIVLGGSGRRAVALMKKLYEPITQRQVAAEAALPPVPVVVTDLASAEMIKYAANAFLATKISFINEVANICDR
VGADVQQVALGMGLDSRIGGKFLQAGLGWGGSCFPKDVAALVHTACDYGYEAKLLAAAVAVNRSQRYLAIEKLRQSLGIL
KGKTIGLLGLTFKPDTDDLRDAPALDLAAECRRLGARVKAYDPTVRPERPPAGLEAGVAVCPESLAVGCDALVLVTEWAE
FRTLDYAGLARSMARALIVDGRNFLDPQILAAAGFTYVGIGKPGAKAAPAAPEKAAPVLAIAG

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=491, Percent_Identity=34.2158859470468, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI296040438, Length=392, Percent_Identity=35.2040816326531, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI296040443, Length=339, Percent_Identity=35.693215339233, Blast_Score=186, Evalue=5e-47,
Organism=Escherichia coli, GI1788340, Length=374, Percent_Identity=29.6791443850267, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI48994968, Length=424, Percent_Identity=28.0660377358491, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17560350, Length=490, Percent_Identity=34.2857142857143, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI17136908, Length=471, Percent_Identity=36.0934182590234, Blast_Score=276, Evalue=2e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 48340; Mature: 48340

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVCVIGTGYVGLVTGACLAHIGHDVVGVDNNAAKVAQMQAGISPIVEPGLETIMTGAMQ
CEEEEEECCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
AQRLAFTTDIAAGVRHGEVIFIAVGTPALPSGESDTRAVEAVARAIGTHLDGNYKVIVNK
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEC
STVPIGSGDWVRMLVSENAAPDVDFDVVSNPEFLREGSAVFDTFNPDRIVLGGSGRRAVA
CCCCCCCCCCEEEEECCCCCCCCCEEECCCHHHHHCCCCEEECCCCCEEEECCCCCHHHH
LMKKLYEPITQRQVAAEAALPPVPVVVTDLASAEMIKYAANAFLATKISFINEVANICDR
HHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGADVQQVALGMGLDSRIGGKFLQAGLGWGGSCFPKDVAALVHTACDYGYEAKLLAAAVA
HCCCHHHHHHHCCCCHHHCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
VNRSQRYLAIEKLRQSLGILKGKTIGLLGLTFKPDTDDLRDAPALDLAAECRRLGARVKA
HCCCHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHCCCCCHHHHHHHHHHCCEEEE
YDPTVRPERPPAGLEAGVAVCPESLAVGCDALVLVTEWAEFRTLDYAGLARSMARALIVD
CCCCCCCCCCCCCCCCCHHHCCHHHHCCCCEEEEEECHHHHHHCCHHHHHHHHHHHHHCC
GRNFLDPQILAAAGFTYVGIGKPGAKAAPAAPEKAAPVLAIAG
CCCCCCHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCEEEECC
>Mature Secondary Structure
MRVCVIGTGYVGLVTGACLAHIGHDVVGVDNNAAKVAQMQAGISPIVEPGLETIMTGAMQ
CEEEEEECCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
AQRLAFTTDIAAGVRHGEVIFIAVGTPALPSGESDTRAVEAVARAIGTHLDGNYKVIVNK
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEC
STVPIGSGDWVRMLVSENAAPDVDFDVVSNPEFLREGSAVFDTFNPDRIVLGGSGRRAVA
CCCCCCCCCCEEEEECCCCCCCCCEEECCCHHHHHCCCCEEECCCCCEEEECCCCCHHHH
LMKKLYEPITQRQVAAEAALPPVPVVVTDLASAEMIKYAANAFLATKISFINEVANICDR
HHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGADVQQVALGMGLDSRIGGKFLQAGLGWGGSCFPKDVAALVHTACDYGYEAKLLAAAVA
HCCCHHHHHHHCCCCHHHCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
VNRSQRYLAIEKLRQSLGILKGKTIGLLGLTFKPDTDDLRDAPALDLAAECRRLGARVKA
HCCCHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHCCCCCHHHHHHHHHHCCEEEE
YDPTVRPERPPAGLEAGVAVCPESLAVGCDALVLVTEWAEFRTLDYAGLARSMARALIVD
CCCCCCCCCCCCCCCCCHHHCCHHHHCCCCEEEEEECHHHHHHCCHHHHHHHHHHHHHCC
GRNFLDPQILAAAGFTYVGIGKPGAKAAPAAPEKAAPVLAIAG
CCCCCCHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10048024; 9384377; 10376820 [H]