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The map label for this gene is argH

Identifier: 37520620

GI number: 37520620

Start: 1123637

End: 1125043

Strand: Reverse

Name: argH

Synonym: gvip145

Alternate gene names: 37520620

Gene position: 1125043-1123637 (Counterclockwise)

Preceding gene: 37520622

Following gene: 37520618

Centisome position: 24.15

GC content: 63.75

Gene sequence:

>1407_bases
ATGACCGCCACCCCCTGGAGCGCCCGCTTTGAAGCGGGCCTGCACCCGACCGTCGCCGCCTTTAATGCGAGCATCGGCTT
CGACATCGAGCTTATCGAGTACGACCTGAGCGGCTCGGCGGCCCACGCCCGGATGCTGGCGCATAGCGGCATCCTCAGCG
AAGCGGAGGCTGAGGCTCTAGTCGGTGGTCTTGAGCAGATCCGCTCGGAGTGGCGCACCGGTCAGTTCCGCCCGGGTCTT
GAACAGGAGGATGTGCACTATGCCGTCGAGCGGCGGCTGGTGGAACTGGTGGGCGAGGTGGGCAAGAAACTGCACACGGC
CCGTTCGCGCAACGATCAGGTGGGTACCGACCTCAGGCTGTGGCTGCGCGAGCGTATCGACCGGATTGTCGGCCGACTTG
GCGTATTTCAGCGCACCCTGCTGGATCTGGCCGCTTGCCACGTCGAGACGCTCATTCCCGGTTACACCCACCTGCAGCGG
GCACAACCGGTGAGCCTCGCCCACCACCTGCTTGCCTACATCGAGATGGGCGAGCGCGACATCGAGCGGCTGACGCAGAT
CCGCGAGCGCGTCAACGTCTGTCCGCTCGGTTCCGGGGCGCTCGCCGGAACGGTCCTACCCATCGACCGGCACTACACCG
CCCGGCTTCTGGGTTTTGTCGCCCTCAGCGAAAATTCGCTCGATGCGGTGAGCGACCGCGACTATGTGGTCGAATTTCTG
GCGGCAGCGAGCCTGATTGCCGTGCACCTGAGCCGGCTTTCAGAAGAAATCATCCTCTGGGCTTCGCAAGAATTTCGCTT
TCTTACCCTCACCGATCGCTGTGCCACCGGCTCCAGCCTGATGCCCCAGAAGAAAAATCCGGACGTGCCGGAACTGGTGC
GCGGTAAGACGGGCCGCATCTTCGGCCACCTGATGGGGATGCTCACCGTGCTCAAGGGGTTGCCGCTCGCCTACAACAAA
GACCTGCAGGAGGACAAAGAGGGCATCTTCGACGCGGCGCGCTCGGTCGAAAGTTCTCTAGAAGCGATGACGATTCTGAT
GGCCGAAGGCATCGTCTTTCAGCCCGACCGGCTTGCCGGGGCTGTCGAAGAAGATTTCTCCAACGCCACCGACGCCGCCG
ACTATCTGGTGCGCAAGGGGGTACCCTTTCGGGAGGCCTACGGCGTCATCGGCGCAGTGGTCAAGCACTGCTTAAAATCA
AATGCACTGCTGCGGGATCTGCCCATTGCCCAGTGGCGGCACTTCCATCCGGCCTTCGACGATGATCTCTACGCGGCTAT
CACCCCCAGAACGGTGGTGGCCGCCCGCAACAGCTACGGCGGCACCGGCTTCGAGCAGGTGCGCGCCGCCCTCGGGCGCG
CCGAGGCCCGCTGGCAAGGACATTTCCCCTCCGCTTCGGCCCATTAA

Upstream 100 bases:

>100_bases
AGGTGTTTTGTAGTCTGAGATACGCTCTTCGGGTGTGCTACGGGAGGCTTCGGCAGCGGCGTGAGGATATGCTGATGAAG
TTGTCTGTCTGCTGTTCACC

Downstream 100 bases:

>100_bases
GTGGACAAATTGTCTACTGGATGTCCAGCGGCATAAGTCGGTAAGACATGGCGAAAACCCGCGCCATTAGAGGTTGTGGG
CGAGGCGCAACACCTCGATA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MTATPWSARFEAGLHPTVAAFNASIGFDIELIEYDLSGSAAHARMLAHSGILSEAEAEALVGGLEQIRSEWRTGQFRPGL
EQEDVHYAVERRLVELVGEVGKKLHTARSRNDQVGTDLRLWLRERIDRIVGRLGVFQRTLLDLAACHVETLIPGYTHLQR
AQPVSLAHHLLAYIEMGERDIERLTQIRERVNVCPLGSGALAGTVLPIDRHYTARLLGFVALSENSLDAVSDRDYVVEFL
AAASLIAVHLSRLSEEIILWASQEFRFLTLTDRCATGSSLMPQKKNPDVPELVRGKTGRIFGHLMGMLTVLKGLPLAYNK
DLQEDKEGIFDAARSVESSLEAMTILMAEGIVFQPDRLAGAVEEDFSNATDAADYLVRKGVPFREAYGVIGAVVKHCLKS
NALLRDLPIAQWRHFHPAFDDDLYAAITPRTVVAARNSYGGTGFEQVRAALGRAEARWQGHFPSASAH

Sequences:

>Translated_468_residues
MTATPWSARFEAGLHPTVAAFNASIGFDIELIEYDLSGSAAHARMLAHSGILSEAEAEALVGGLEQIRSEWRTGQFRPGL
EQEDVHYAVERRLVELVGEVGKKLHTARSRNDQVGTDLRLWLRERIDRIVGRLGVFQRTLLDLAACHVETLIPGYTHLQR
AQPVSLAHHLLAYIEMGERDIERLTQIRERVNVCPLGSGALAGTVLPIDRHYTARLLGFVALSENSLDAVSDRDYVVEFL
AAASLIAVHLSRLSEEIILWASQEFRFLTLTDRCATGSSLMPQKKNPDVPELVRGKTGRIFGHLMGMLTVLKGLPLAYNK
DLQEDKEGIFDAARSVESSLEAMTILMAEGIVFQPDRLAGAVEEDFSNATDAADYLVRKGVPFREAYGVIGAVVKHCLKS
NALLRDLPIAQWRHFHPAFDDDLYAAITPRTVVAARNSYGGTGFEQVRAALGRAEARWQGHFPSASAH
>Mature_467_residues
TATPWSARFEAGLHPTVAAFNASIGFDIELIEYDLSGSAAHARMLAHSGILSEAEAEALVGGLEQIRSEWRTGQFRPGLE
QEDVHYAVERRLVELVGEVGKKLHTARSRNDQVGTDLRLWLRERIDRIVGRLGVFQRTLLDLAACHVETLIPGYTHLQRA
QPVSLAHHLLAYIEMGERDIERLTQIRERVNVCPLGSGALAGTVLPIDRHYTARLLGFVALSENSLDAVSDRDYVVEFLA
AASLIAVHLSRLSEEIILWASQEFRFLTLTDRCATGSSLMPQKKNPDVPELVRGKTGRIFGHLMGMLTVLKGLPLAYNKD
LQEDKEGIFDAARSVESSLEAMTILMAEGIVFQPDRLAGAVEEDFSNATDAADYLVRKGVPFREAYGVIGAVVKHCLKSN
ALLRDLPIAQWRHFHPAFDDDLYAAITPRTVVAARNSYGGTGFEQVRAALGRAEARWQGHFPSASAH

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=458, Percent_Identity=43.8864628820961, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI68303542, Length=458, Percent_Identity=43.8864628820961, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI68303549, Length=458, Percent_Identity=41.2663755458515, Blast_Score=338, Evalue=9e-93,
Organism=Homo sapiens, GI68303547, Length=458, Percent_Identity=41.0480349344978, Blast_Score=337, Evalue=1e-92,
Organism=Escherichia coli, GI1790398, Length=456, Percent_Identity=45.3947368421053, Blast_Score=388, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6321806, Length=463, Percent_Identity=40.6047516198704, Blast_Score=333, Evalue=4e-92,
Organism=Drosophila melanogaster, GI221473854, Length=460, Percent_Identity=43.4782608695652, Blast_Score=359, Evalue=2e-99,
Organism=Drosophila melanogaster, GI78706858, Length=460, Percent_Identity=43.4782608695652, Blast_Score=359, Evalue=2e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_GLOVI (Q7NLS0)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_923997.1
- ProteinModelPortal:   Q7NLS0
- SMR:   Q7NLS0
- GeneID:   2599087
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.1051
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- ProtClustDB:   PRK00855
- BioCyc:   GVIO251221:GLL1051-MONOMER
- BRENDA:   4.3.2.1
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 51678; Mature: 51546

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATPWSARFEAGLHPTVAAFNASIGFDIELIEYDLSGSAAHARMLAHSGILSEAEAEAL
CCCCCCCHHHHCCCCCHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHH
VGGLEQIRSEWRTGQFRPGLEQEDVHYAVERRLVELVGEVGKKLHTARSRNDQVGTDLRL
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
WLRERIDRIVGRLGVFQRTLLDLAACHVETLIPGYTHLQRAQPVSLAHHLLAYIEMGERD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHCHHH
IERLTQIRERVNVCPLGSGALAGTVLPIDRHYTARLLGFVALSENSLDAVSDRDYVVEFL
HHHHHHHHHHCCCCCCCCCCHHCEEEECCCHHHHHHHHHHHCCCCCCCHHCCHHHHHHHH
AAASLIAVHLSRLSEEIILWASQEFRFLTLTDRCATGSSLMPQKKNPDVPELVRGKTGRI
HHHHHHHHHHHHHHHHHEEEECCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHCCCCHHH
FGHLMGMLTVLKGLPLAYNKDLQEDKEGIFDAARSVESSLEAMTILMAEGIVFQPDRLAG
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHH
AVEEDFSNATDAADYLVRKGVPFREAYGVIGAVVKHCLKSNALLRDLPIAQWRHFHPAFD
HHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHCCCCCCC
DDLYAAITPRTVVAARNSYGGTGFEQVRAALGRAEARWQGHFPSASAH
CCCEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TATPWSARFEAGLHPTVAAFNASIGFDIELIEYDLSGSAAHARMLAHSGILSEAEAEAL
CCCCCCHHHHCCCCCHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHH
VGGLEQIRSEWRTGQFRPGLEQEDVHYAVERRLVELVGEVGKKLHTARSRNDQVGTDLRL
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
WLRERIDRIVGRLGVFQRTLLDLAACHVETLIPGYTHLQRAQPVSLAHHLLAYIEMGERD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHCHHH
IERLTQIRERVNVCPLGSGALAGTVLPIDRHYTARLLGFVALSENSLDAVSDRDYVVEFL
HHHHHHHHHHCCCCCCCCCCHHCEEEECCCHHHHHHHHHHHCCCCCCCHHCCHHHHHHHH
AAASLIAVHLSRLSEEIILWASQEFRFLTLTDRCATGSSLMPQKKNPDVPELVRGKTGRI
HHHHHHHHHHHHHHHHHEEEECCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHCCCCHHH
FGHLMGMLTVLKGLPLAYNKDLQEDKEGIFDAARSVESSLEAMTILMAEGIVFQPDRLAG
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHH
AVEEDFSNATDAADYLVRKGVPFREAYGVIGAVVKHCLKSNALLRDLPIAQWRHFHPAFD
HHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHCCCCCCC
DDLYAAITPRTVVAARNSYGGTGFEQVRAALGRAEARWQGHFPSASAH
CCCEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292