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The map label for this gene is ribH

Identifier: 37520611

GI number: 37520611

Start: 1116223

End: 1116765

Strand: Direct

Name: ribH

Synonym: gvip144

Alternate gene names: 37520611

Gene position: 1116223-1116765 (Clockwise)

Preceding gene: 37520610

Following gene: 37520612

Centisome position: 23.96

GC content: 64.64

Gene sequence:

>543_bases
ATGACCGTCTTCGAAGGCAACCTCCAGGACACCCGGGATCTAAAATTCGCCATTGTGATCGCGCGCTTCAACGACCTGGT
GGTCGGCAAATTGCTGTCCGCCTGTGAGGATTCCCTCAGGCGCCACGGCGTCGCCGTCGGTCCCGATTCGCACCAGGTCG
ATTATGCCTGGGTGCCGGGCTCCTTCGAGATCCCGATGGTGGCCCGCCAACTTGCCCTCTCCGGCCGCTACGACGCGATC
GTCTGCCTGGGGGCAGTCATCCGCGGCCAGACCAGCCACTACGACCACGTCGCCTCGGAAGTGGCCAAGGGCATCCAGGC
CCTCGCCTTTCAGACCGGGGTGCCGGTCACCTTCGGCGTGCTCACCACCGACACGATGCAGCAGGCGATCGAGCGGGCCG
GCATCAAGAGCAACCTCGGCTGGGAGTACGGCGAGAATGCCATCGAAATGGCCACCCTCACCCGCAAAATCCGCCACCTT
GTCGCCGTGCGCGCCGTTCAGCCCGAACTGCCCGAGCAAACCCCGCCCAGTTTGCTGCAGTAA

Upstream 100 bases:

>100_bases
CGGTTTATGGACCGCTACGCCGCCAGCAACGGCATGGAGTACCAGGACCGAGGCCCGCAGGACAAAATGAAACAGTAGTG
ACACCGTCTCCCCTACCGCT

Downstream 100 bases:

>100_bases
CCTGCCGATGCGCCGCTGTCTGCTGGTGTTGCTGGTATGGCTGTGGCCGTGGTCGGCGGTAGCTCAGACTTCGTTGAAAT
TTGACCTGGACGGCGATGGT

Product: 6,7-dimethyl-8-ribityllumazine synthase

Products: NA

Alternate protein names: DMRL synthase; Lumazine synthase; Riboflavin synthase beta chain

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MTVFEGNLQDTRDLKFAIVIARFNDLVVGKLLSACEDSLRRHGVAVGPDSHQVDYAWVPGSFEIPMVARQLALSGRYDAI
VCLGAVIRGQTSHYDHVASEVAKGIQALAFQTGVPVTFGVLTTDTMQQAIERAGIKSNLGWEYGENAIEMATLTRKIRHL
VAVRAVQPELPEQTPPSLLQ

Sequences:

>Translated_180_residues
MTVFEGNLQDTRDLKFAIVIARFNDLVVGKLLSACEDSLRRHGVAVGPDSHQVDYAWVPGSFEIPMVARQLALSGRYDAI
VCLGAVIRGQTSHYDHVASEVAKGIQALAFQTGVPVTFGVLTTDTMQQAIERAGIKSNLGWEYGENAIEMATLTRKIRHL
VAVRAVQPELPEQTPPSLLQ
>Mature_179_residues
TVFEGNLQDTRDLKFAIVIARFNDLVVGKLLSACEDSLRRHGVAVGPDSHQVDYAWVPGSFEIPMVARQLALSGRYDAIV
CLGAVIRGQTSHYDHVASEVAKGIQALAFQTGVPVTFGVLTTDTMQQAIERAGIKSNLGWEYGENAIEMATLTRKIRHLV
AVRAVQPELPEQTPPSLLQ

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes

COG id: COG0054

COG function: function code H; Riboflavin synthase beta-chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DMRL synthase family

Homologues:

Organism=Escherichia coli, GI1786617, Length=159, Percent_Identity=41.5094339622642, Blast_Score=129, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6324429, Length=152, Percent_Identity=28.9473684210526, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RISB_GLOVI (Q7NLS9)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_923988.1
- ProteinModelPortal:   Q7NLS9
- SMR:   Q7NLS9
- GeneID:   2599078
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.1042
- HOGENOM:   HBG311126
- OMA:   KAGNKGW
- ProtClustDB:   PRK00061
- BioCyc:   GVIO251221:GLR1042-MONOMER
- BRENDA:   2.5.1.9
- HAMAP:   MF_00178
- InterPro:   IPR002180
- Gene3D:   G3DSA:3.40.50.960
- PANTHER:   PTHR21058
- TIGRFAMs:   TIGR00114

Pfam domain/function: PF00885 DMRL_synthase; SSF52121 DMRL_synthase

EC number: =2.5.1.9

Molecular weight: Translated: 19656; Mature: 19525

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVFEGNLQDTRDLKFAIVIARFNDLVVGKLLSACEDSLRRHGVAVGPDSHQVDYAWVPG
CCEECCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEEECCC
SFEIPMVARQLALSGRYDAIVCLGAVIRGQTSHYDHVASEVAKGIQALAFQTGVPVTFGV
CCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEH
LTTDTMQQAIERAGIKSNLGWEYGENAIEMATLTRKIRHLVAVRAVQPELPEQTPPSLLQ
CCHHHHHHHHHHCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCC
>Mature Secondary Structure 
TVFEGNLQDTRDLKFAIVIARFNDLVVGKLLSACEDSLRRHGVAVGPDSHQVDYAWVPG
CEECCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEEECCC
SFEIPMVARQLALSGRYDAIVCLGAVIRGQTSHYDHVASEVAKGIQALAFQTGVPVTFGV
CCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEH
LTTDTMQQAIERAGIKSNLGWEYGENAIEMATLTRKIRHLVAVRAVQPELPEQTPPSLLQ
CCHHHHHHHHHHCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292