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The map label for this gene is tuaD [H]

Identifier: 37520538

GI number: 37520538

Start: 1029221

End: 1030591

Strand: Reverse

Name: tuaD [H]

Synonym: gll0969

Alternate gene names: 37520538

Gene position: 1030591-1029221 (Counterclockwise)

Preceding gene: 37520543

Following gene: 37520536

Centisome position: 22.12

GC content: 63.68

Gene sequence:

>1371_bases
ATGAAAGTGGGAGTGATTGGCACAGGGTACGTCGGTCTGGTTACCGGCGCCTGTCTGGCCCGGGTCGGCCATCGGGTGTG
TTGCATGGACAACGATACCGCCAAGGTTGACCGCCTCAAGCGGGGAATCATGCCCATCTATGAGCCTGGGCTGGAGGAAC
TGGTCCGTCAGGGTGTCGAGGAGGGGCTGCTGGAATTTACGGACGCTCTGGCTGCGGTTGTCGAGCATGCCGAAGTACTG
TTCATCACCGTGGGTACCCCTTCACGCCCGGACGGATCGCCGGATCTTTCCGCTGTCCGGGCCGTGGCCCGTGGCATCGG
TCAGCATCTAGACGGACGCTACCGCGTCATTGTCAACAAATCGACCGTGCCGGTCGGTTCGGGCAACTGGGTACGGATGC
TGGTCGAGGACGGCGCCCGCAAAACCGTGCCGGCCCTCACCGACGGCGGCGGTGCAGGTGCGCAGGCGGGTGAGCCCGAC
TTCAACGTCGTAAGCAACCCCGAGTTCCTGCGCGAAGGCAGCGCCGTTTGGGACACCTTTCATCCCGACCGCATCGTCAT
TGGTGCTGAATCTGAGCGCGCCGAGCAGGTGATGCGCGAGCTGTACCGCCATTGGGTGAGCCCCGATGAGCCCGAGCGCG
AGCCTGTGCCGCTGGTGGTGACCGATCTGGCCTCCGCCGAGATGATCAAGTACGCTGCAAATGCTTTTCTGGCCACCAAG
ATTTCGTTCATCAACGAGATCGCCAATATCTGCGAACGGGTCGGCGCCGATGTCTCGCGGGTGGCCCAGGCGATTGGTCT
CGACAAGCGCATCGGCAACCAGTTTCTCAACGCCGGTGCCGGGTGGGGCGGCTCGTGCTTTCCCAAAGACGTCTCGGCCC
TGGTAAGCACCGGTCAGGAATACGGCTACGAGTGCGCCCTGCTCAAGGCGACGCTGTCGGTCAACGACACCCAAAGAAAA
CGGATCATCGAGAAGCTGCAGCGGGAACTGCGCATCCTCAAGGGCCGGACGATCGCCATCTGGGGCCTGGCCTTCAAGCC
GCACACCGACGACATCCGCAGCGCCCCGGCCCTGGAAGTGGCCAACCAGTTACTCAATTTGGGCTGCCGGGTGGTGGCCC
ACGACCCGGTGGTGACGGCCGCTCAAGCCCACAGCCAGGTGCCGGATCTCCAGATAGCCGACAGTGCCCTCGGCGCTCTC
GATCAAGCCGACGCCCTGGTAGTGATGACCGAATGGCCCGAGTACCCGCAACTCGACTTGGGTGAAGTCGGCCGCCGCTT
GCGCGGGCGCGTGATTATCGACGGCCGAAACTGCCTCAAGCGCGAGATGGTCCAGGAACTGGGCCTGGTCTACGTCGGCA
TCGGTCGCTGA

Upstream 100 bases:

>100_bases
GAGTGTCGCCTGTTTGAGACTTTTCCTTTTAGCGTACTCTAATGTGAAGTGCCGCAGTGACCTTCCGGGGGCGCCGAATG
CTGATTGAGGAAAACATTGC

Downstream 100 bases:

>100_bases
GGTGGGCCGGGTGTCCAGGGTGCCCTAGCAGCGCCGCCGATCGGGGCTTGCTCCCGGCCCGCCAACGGGTCCGCGGGGAT
TCTCCCAGTTGGTTCCGGGG

Product: UDP-glucose dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; Teichuronic acid biosynthesis protein tuaD [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MKVGVIGTGYVGLVTGACLARVGHRVCCMDNDTAKVDRLKRGIMPIYEPGLEELVRQGVEEGLLEFTDALAAVVEHAEVL
FITVGTPSRPDGSPDLSAVRAVARGIGQHLDGRYRVIVNKSTVPVGSGNWVRMLVEDGARKTVPALTDGGGAGAQAGEPD
FNVVSNPEFLREGSAVWDTFHPDRIVIGAESERAEQVMRELYRHWVSPDEPEREPVPLVVTDLASAEMIKYAANAFLATK
ISFINEIANICERVGADVSRVAQAIGLDKRIGNQFLNAGAGWGGSCFPKDVSALVSTGQEYGYECALLKATLSVNDTQRK
RIIEKLQRELRILKGRTIAIWGLAFKPHTDDIRSAPALEVANQLLNLGCRVVAHDPVVTAAQAHSQVPDLQIADSALGAL
DQADALVVMTEWPEYPQLDLGEVGRRLRGRVIIDGRNCLKREMVQELGLVYVGIGR

Sequences:

>Translated_456_residues
MKVGVIGTGYVGLVTGACLARVGHRVCCMDNDTAKVDRLKRGIMPIYEPGLEELVRQGVEEGLLEFTDALAAVVEHAEVL
FITVGTPSRPDGSPDLSAVRAVARGIGQHLDGRYRVIVNKSTVPVGSGNWVRMLVEDGARKTVPALTDGGGAGAQAGEPD
FNVVSNPEFLREGSAVWDTFHPDRIVIGAESERAEQVMRELYRHWVSPDEPEREPVPLVVTDLASAEMIKYAANAFLATK
ISFINEIANICERVGADVSRVAQAIGLDKRIGNQFLNAGAGWGGSCFPKDVSALVSTGQEYGYECALLKATLSVNDTQRK
RIIEKLQRELRILKGRTIAIWGLAFKPHTDDIRSAPALEVANQLLNLGCRVVAHDPVVTAAQAHSQVPDLQIADSALGAL
DQADALVVMTEWPEYPQLDLGEVGRRLRGRVIIDGRNCLKREMVQELGLVYVGIGR
>Mature_456_residues
MKVGVIGTGYVGLVTGACLARVGHRVCCMDNDTAKVDRLKRGIMPIYEPGLEELVRQGVEEGLLEFTDALAAVVEHAEVL
FITVGTPSRPDGSPDLSAVRAVARGIGQHLDGRYRVIVNKSTVPVGSGNWVRMLVEDGARKTVPALTDGGGAGAQAGEPD
FNVVSNPEFLREGSAVWDTFHPDRIVIGAESERAEQVMRELYRHWVSPDEPEREPVPLVVTDLASAEMIKYAANAFLATK
ISFINEIANICERVGADVSRVAQAIGLDKRIGNQFLNAGAGWGGSCFPKDVSALVSTGQEYGYECALLKATLSVNDTQRK
RIIEKLQRELRILKGRTIAIWGLAFKPHTDDIRSAPALEVANQLLNLGCRVVAHDPVVTAAQAHSQVPDLQIADSALGAL
DQADALVVMTEWPEYPQLDLGEVGRRLRGRVIIDGRNCLKREMVQELGLVYVGIGR

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=491, Percent_Identity=34.0122199592668, Blast_Score=244, Evalue=9e-65,
Organism=Homo sapiens, GI296040438, Length=391, Percent_Identity=35.5498721227622, Blast_Score=202, Evalue=8e-52,
Organism=Homo sapiens, GI296040443, Length=367, Percent_Identity=35.149863760218, Blast_Score=184, Evalue=1e-46,
Organism=Escherichia coli, GI1788340, Length=379, Percent_Identity=28.2321899736148, Blast_Score=161, Evalue=1e-40,
Organism=Escherichia coli, GI48994968, Length=446, Percent_Identity=28.9237668161435, Blast_Score=134, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17560350, Length=489, Percent_Identity=33.7423312883436, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI17136908, Length=484, Percent_Identity=32.8512396694215, Blast_Score=239, Evalue=3e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 49385; Mature: 49385

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVGVIGTGYVGLVTGACLARVGHRVCCMDNDTAKVDRLKRGIMPIYEPGLEELVRQGVE
CEEEEEECCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHH
EGLLEFTDALAAVVEHAEVLFITVGTPSRPDGSPDLSAVRAVARGIGQHLDGRYRVIVNK
HHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEC
STVPVGSGNWVRMLVEDGARKTVPALTDGGGAGAQAGEPDFNVVSNPEFLREGSAVWDTF
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCC
HPDRIVIGAESERAEQVMRELYRHWVSPDEPEREPVPLVVTDLASAEMIKYAANAFLATK
CCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHH
ISFINEIANICERVGADVSRVAQAIGLDKRIGNQFLNAGAGWGGSCFPKDVSALVSTGQE
HHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHH
YGYECALLKATLSVNDTQRKRIIEKLQRELRILKGRTIAIWGLAFKPHTDDIRSAPALEV
HCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHCCCHHHH
ANQLLNLGCRVVAHDPVVTAAQAHSQVPDLQIADSALGALDQADALVVMTEWPEYPQLDL
HHHHHHCCCEEEECCCCHHHHHHHCCCCCCEEHHHHHCCCCCCCEEEEEECCCCCCCCCH
GEVGRRLRGRVIIDGRNCLKREMVQELGLVYVGIGR
HHHHHHHCCEEEECCHHHHHHHHHHHCCEEEEECCC
>Mature Secondary Structure
MKVGVIGTGYVGLVTGACLARVGHRVCCMDNDTAKVDRLKRGIMPIYEPGLEELVRQGVE
CEEEEEECCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHH
EGLLEFTDALAAVVEHAEVLFITVGTPSRPDGSPDLSAVRAVARGIGQHLDGRYRVIVNK
HHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEC
STVPVGSGNWVRMLVEDGARKTVPALTDGGGAGAQAGEPDFNVVSNPEFLREGSAVWDTF
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCC
HPDRIVIGAESERAEQVMRELYRHWVSPDEPEREPVPLVVTDLASAEMIKYAANAFLATK
CCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHH
ISFINEIANICERVGADVSRVAQAIGLDKRIGNQFLNAGAGWGGSCFPKDVSALVSTGQE
HHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHH
YGYECALLKATLSVNDTQRKRIIEKLQRELRILKGRTIAIWGLAFKPHTDDIRSAPALEV
HCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHCCCHHHH
ANQLLNLGCRVVAHDPVVTAAQAHSQVPDLQIADSALGALDQADALVVMTEWPEYPQLDL
HHHHHHCCCEEEECCCCHHHHHHHCCCCCCEEHHHHHCCCCCCCEEEEEECCCCCCCCCH
GEVGRRLRGRVIIDGRNCLKREMVQELGLVYVGIGR
HHHHHHHCCEEEECCHHHHHHHHHHHCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10048024; 9384377; 10376820 [H]