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The map label for this gene is prs

Identifier: 37520470

GI number: 37520470

Start: 957315

End: 958313

Strand: Reverse

Name: prs

Synonym: gll0901

Alternate gene names: 37520470

Gene position: 958313-957315 (Counterclockwise)

Preceding gene: 37520476

Following gene: 37520469

Centisome position: 20.57

GC content: 62.66

Gene sequence:

>999_bases
GTGGTTTTTCCTGACTTGCTGCCGCGCAGATCCACGGTACAACCGGTGCGCCTGATGGGTGACGAGCGGCTGAGATTGTT
CTCCGGTTCGGCCAATCCGGAACTGGCCCAACTGGTGGCCCGCTACCTGGGCCTGGCCCCCGGACCGCTGGTGCGCAAGT
CCTTTGCCGACGGCGAATTGTACGTTCAGATTCAAGAGTCTATCCGCGGCTGCGACGTCTATCTGGTCCAGCCCACCTGT
AGCCCCGTCAACGACAGCTTGATGGAGTTGCTGATTCTCATCGATGCCTGCCGCCGCGCTTCCGCCCGCCAGATTACCGC
CGTGCTTCCTTACTACGGCTACGCCCGCGCCGACCGCAAGACCGCCGGTCGCGAATCGATCACCGCCAAATTGGTGGCCA
ACTTGATCACAGCGGCAGGTGTCGACCGGGTGCTTGCCATGGACCTGCACTCCGCTCAGATCCAGGCCTATTTCGACATT
CCCCTCGACCACGTCTACGGCTCGCCGGTCCTGCTGCAGTACATCAAAGAAAAGCAGCTGGGCGATATGGTGATCGTTTC
CCCCGACGTGGGCGGTGTCAGCCGGGCGCGCGCCTTTGCCAAAAAACTCGATGACGCCCCGCTTGCCATCGTCGACAAGC
GCCGCCAGGCTCCCAACGAAGTCGAAGTCATGAACGTGATTGGCGACGTCAAGGGCAAAACCGCCATCCTGGTCGACGAC
ATGATCGACACCGCCGGCACCATCTCGGAGGCGGCCAAGGTGCTGTTGCGCCAGGGGGCCAAAGAAGTCTACGCCTGCGC
CACCCATGCGGTCTTCTCCTCCCGGGCCATCGACCGCCTCTCCGACGGCACTTTCACCGAGGTGCTGGTCACCAATACCA
TCCCGGTGCCGCCCGATCGTCGCTTCCCGCAACTGCGGGTGCTCTCGGTGGCGGATCTGATCGGCGAGGCGATCTGGCGC
ATCCACGAAGATTCCTCCGTCAGCAGCATGTTTCGCTGA

Upstream 100 bases:

>100_bases
TTCCGGGTCTATGTTAAACTGACCGCAGCCAGGGCCTAGACTGTCTTGGACTGCCCGTAGCGCCCGAGCGGTTCGCTGTC
TCTATAAATGGGTACATAAG

Downstream 100 bases:

>100_bases
GCCTTGCTTACCAACTGGTCGATCGCGCTTGCCGTCAACACCCTTCTGGGCGCCCTGGCTTTCCCGGCCAAGTTGCTCAC
CAACTGGGGCCTGCTCAACG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MVFPDLLPRRSTVQPVRLMGDERLRLFSGSANPELAQLVARYLGLAPGPLVRKSFADGELYVQIQESIRGCDVYLVQPTC
SPVNDSLMELLILIDACRRASARQITAVLPYYGYARADRKTAGRESITAKLVANLITAAGVDRVLAMDLHSAQIQAYFDI
PLDHVYGSPVLLQYIKEKQLGDMVIVSPDVGGVSRARAFAKKLDDAPLAIVDKRRQAPNEVEVMNVIGDVKGKTAILVDD
MIDTAGTISEAAKVLLRQGAKEVYACATHAVFSSRAIDRLSDGTFTEVLVTNTIPVPPDRRFPQLRVLSVADLIGEAIWR
IHEDSSVSSMFR

Sequences:

>Translated_332_residues
MVFPDLLPRRSTVQPVRLMGDERLRLFSGSANPELAQLVARYLGLAPGPLVRKSFADGELYVQIQESIRGCDVYLVQPTC
SPVNDSLMELLILIDACRRASARQITAVLPYYGYARADRKTAGRESITAKLVANLITAAGVDRVLAMDLHSAQIQAYFDI
PLDHVYGSPVLLQYIKEKQLGDMVIVSPDVGGVSRARAFAKKLDDAPLAIVDKRRQAPNEVEVMNVIGDVKGKTAILVDD
MIDTAGTISEAAKVLLRQGAKEVYACATHAVFSSRAIDRLSDGTFTEVLVTNTIPVPPDRRFPQLRVLSVADLIGEAIWR
IHEDSSVSSMFR
>Mature_332_residues
MVFPDLLPRRSTVQPVRLMGDERLRLFSGSANPELAQLVARYLGLAPGPLVRKSFADGELYVQIQESIRGCDVYLVQPTC
SPVNDSLMELLILIDACRRASARQITAVLPYYGYARADRKTAGRESITAKLVANLITAAGVDRVLAMDLHSAQIQAYFDI
PLDHVYGSPVLLQYIKEKQLGDMVIVSPDVGGVSRARAFAKKLDDAPLAIVDKRRQAPNEVEVMNVIGDVKGKTAILVDD
MIDTAGTISEAAKVLLRQGAKEVYACATHAVFSSRAIDRLSDGTFTEVLVTNTIPVPPDRRFPQLRVLSVADLIGEAIWR
IHEDSSVSSMFR

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family

Homologues:

Organism=Homo sapiens, GI4506129, Length=309, Percent_Identity=47.2491909385113, Blast_Score=294, Evalue=9e-80,
Organism=Homo sapiens, GI4506127, Length=312, Percent_Identity=46.474358974359, Blast_Score=292, Evalue=3e-79,
Organism=Homo sapiens, GI84875539, Length=312, Percent_Identity=47.1153846153846, Blast_Score=289, Evalue=2e-78,
Organism=Homo sapiens, GI28557709, Length=312, Percent_Identity=46.1538461538462, Blast_Score=288, Evalue=4e-78,
Organism=Homo sapiens, GI4506133, Length=345, Percent_Identity=35.6521739130435, Blast_Score=188, Evalue=5e-48,
Organism=Homo sapiens, GI194018537, Length=344, Percent_Identity=33.7209302325581, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI310128524, Length=144, Percent_Identity=33.3333333333333, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI310115209, Length=144, Percent_Identity=33.3333333333333, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI310118259, Length=144, Percent_Identity=33.3333333333333, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI310119946, Length=144, Percent_Identity=33.3333333333333, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1787458, Length=310, Percent_Identity=49.6774193548387, Blast_Score=323, Evalue=7e-90,
Organism=Caenorhabditis elegans, GI25149168, Length=312, Percent_Identity=43.9102564102564, Blast_Score=273, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI17554702, Length=312, Percent_Identity=43.9102564102564, Blast_Score=273, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI71989924, Length=312, Percent_Identity=43.9102564102564, Blast_Score=271, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI17554704, Length=309, Percent_Identity=44.336569579288, Blast_Score=271, Evalue=4e-73,
Organism=Caenorhabditis elegans, GI17570245, Length=347, Percent_Identity=33.7175792507205, Blast_Score=189, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6320946, Length=316, Percent_Identity=43.6708860759494, Blast_Score=264, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6319403, Length=317, Percent_Identity=42.9022082018927, Blast_Score=260, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6321776, Length=317, Percent_Identity=41.9558359621451, Blast_Score=253, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=42.3469387755102, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6324511, Length=117, Percent_Identity=41.8803418803419, Blast_Score=92, Evalue=9e-20,
Organism=Drosophila melanogaster, GI21355239, Length=312, Percent_Identity=46.474358974359, Blast_Score=289, Evalue=2e-78,
Organism=Drosophila melanogaster, GI45551540, Length=335, Percent_Identity=43.8805970149254, Blast_Score=276, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24651458, Length=352, Percent_Identity=33.2386363636364, Blast_Score=191, Evalue=5e-49,
Organism=Drosophila melanogaster, GI24651456, Length=352, Percent_Identity=33.2386363636364, Blast_Score=191, Evalue=5e-49,
Organism=Drosophila melanogaster, GI281362873, Length=352, Percent_Identity=33.2386363636364, Blast_Score=191, Evalue=5e-49,
Organism=Drosophila melanogaster, GI24651454, Length=352, Percent_Identity=33.2386363636364, Blast_Score=191, Evalue=5e-49,
Organism=Drosophila melanogaster, GI45552010, Length=180, Percent_Identity=36.6666666666667, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24651462, Length=180, Percent_Identity=36.6666666666667, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24651464, Length=180, Percent_Identity=36.6666666666667, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): KPRS_GLOVI (Q7NM67)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_923847.1
- ProteinModelPortal:   Q7NM67
- SMR:   Q7NM67
- GeneID:   2599220
- GenomeReviews:   BA000045_GR
- KEGG:   gvi:gll0901
- NMPDR:   fig|251221.1.peg.901
- HOGENOM:   HBG519284
- OMA:   CATHAVF
- ProtClustDB:   PRK02812
- BioCyc:   GVIO251221:GLL0901-MONOMER
- BRENDA:   2.7.6.1
- GO:   GO:0005737
- HAMAP:   MF_00583_B
- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01251

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.7.6.1

Molecular weight: Translated: 36392; Mature: 36392

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS00114 PRPP_SYNTHASE; PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFPDLLPRRSTVQPVRLMGDERLRLFSGSANPELAQLVARYLGLAPGPLVRKSFADGEL
CCCCCCCCCCCCCCHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCCHHHHHCCCCCEE
YVQIQESIRGCDVYLVQPTCSPVNDSLMELLILIDACRRASARQITAVLPYYGYARADRK
EEEEHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCHHHHEEECCCCCCHHCCHH
TAGRESITAKLVANLITAAGVDRVLAMDLHSAQIQAYFDIPLDHVYGSPVLLQYIKEKQL
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHCCCHHHHHHHHHHCC
GDMVIVSPDVGGVSRARAFAKKLDDAPLAIVDKRRQAPNEVEVMNVIGDVKGKTAILVDD
CCEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEHH
MIDTAGTISEAAKVLLRQGAKEVYACATHAVFSSRAIDRLSDGTFTEVLVTNTIPVPPDR
HHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCC
RFPQLRVLSVADLIGEAIWRIHEDSSVSSMFR
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHCC
>Mature Secondary Structure
MVFPDLLPRRSTVQPVRLMGDERLRLFSGSANPELAQLVARYLGLAPGPLVRKSFADGEL
CCCCCCCCCCCCCCHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCCCHHHHHCCCCCEE
YVQIQESIRGCDVYLVQPTCSPVNDSLMELLILIDACRRASARQITAVLPYYGYARADRK
EEEEHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCHHHHEEECCCCCCHHCCHH
TAGRESITAKLVANLITAAGVDRVLAMDLHSAQIQAYFDIPLDHVYGSPVLLQYIKEKQL
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHCCCHHHHHHHHHHCC
GDMVIVSPDVGGVSRARAFAKKLDDAPLAIVDKRRQAPNEVEVMNVIGDVKGKTAILVDD
CCEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEHH
MIDTAGTISEAAKVLLRQGAKEVYACATHAVFSSRAIDRLSDGTFTEVLVTNTIPVPPDR
HHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCC
RFPQLRVLSVADLIGEAIWRIHEDSSVSSMFR
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292