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The map label for this gene is nadC [H]

Identifier: 37520457

GI number: 37520457

Start: 940053

End: 940943

Strand: Reverse

Name: nadC [H]

Synonym: gvip119

Alternate gene names: 37520457

Gene position: 940943-940053 (Counterclockwise)

Preceding gene: 37520460

Following gene: 37520456

Centisome position: 20.2

GC content: 64.53

Gene sequence:

>891_bases
ATGCTCACCAATCGCTACGCTCTGCCGCATCCACTGCTGCTCGATCCGCTGCTTTCCAGTTGGCTTGCCGAGGATTGGGG
CCGCGGAGACCGCACCAGTGAGGCGCTGTTTGCCGAAGAAAGCCCCGACGGCCACGGCAAAATTTTGCTCAAAGAAGCCG
GGGTAGTGGCGGGGCTGCCACTGGTGGAACGACTCTTTGCCATCGTCGATCCGGCGGTGCGCTTTGCGCCGATGTGCGAA
GAAGGGACCGCCGCCGAAGCGCGCACGGTGATTGCCGTTGTCGAAGGGCCGGTGCGCTCGCTGCTCATGGGAGAACGGGT
GGCCCTCAATCTGCTGCAGCGCCTCAGCGGCATCGCCACAATCACCCGCCGCTATGTCGAGCGGCTTGCGGGCCACCATG
CCCGGTTGGTCGACACGCGCAAGACCACACCGGGGCTGCGGCTCATCGAAAAGTACGCCGTGCGGGTGGGGGGTGCGCTC
AACCACCGCTTCGGCCTCGACGACGCCGCCATGATCAAAGACAACCATATCGAGGCAGCCGGGGGCATCCGGCCGGCAGT
CGAGCGCCTGCGTGGACGCATCCCGTTTTTGATGCCCATCGAAGTGGAGACCGAATCGCTCGAACAGGTCCAAGAAGCGC
TCGGGTGCGGCGTGCAGGTGATCATGCTCGACAACATGCCTGTCGAGCGCATGCGCGAGGCGGTGCAACTGATCGCCGGC
CGCGTTCTTACCGAGGCTTCGGGCAACATCACCCTCGATACATTGGGCGATGTCGCCGCGACCGGCGTTGATTACATCTC
CACCAGCGCCACGATCACCCGCGCCCCCTGGCTCGACATCAGCCTCGATTTGCGGCGCGTCCCGACAACGGATACCCTGC
CGCTCGATTGA

Upstream 100 bases:

>100_bases
CCTTGCGAGCAAACTGCACTGCAGGGGGGAAACAAAGAACTCCGGAAACAACGTGACGATGTCGATCCGCATTGCACCTG
ACGGGGCCTACGATCAGATT

Downstream 100 bases:

>100_bases
GCCGCCGCGACCGAACTTCCGTTAGCTTGGACGAGTCTGTAGATCTTTACCTATGTCTGCCTCCGCCTTCGCCGAACGCG
CCGGTACCTTGCAGCGAGAC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MLTNRYALPHPLLLDPLLSSWLAEDWGRGDRTSEALFAEESPDGHGKILLKEAGVVAGLPLVERLFAIVDPAVRFAPMCE
EGTAAEARTVIAVVEGPVRSLLMGERVALNLLQRLSGIATITRRYVERLAGHHARLVDTRKTTPGLRLIEKYAVRVGGAL
NHRFGLDDAAMIKDNHIEAAGGIRPAVERLRGRIPFLMPIEVETESLEQVQEALGCGVQVIMLDNMPVERMREAVQLIAG
RVLTEASGNITLDTLGDVAATGVDYISTSATITRAPWLDISLDLRRVPTTDTLPLD

Sequences:

>Translated_296_residues
MLTNRYALPHPLLLDPLLSSWLAEDWGRGDRTSEALFAEESPDGHGKILLKEAGVVAGLPLVERLFAIVDPAVRFAPMCE
EGTAAEARTVIAVVEGPVRSLLMGERVALNLLQRLSGIATITRRYVERLAGHHARLVDTRKTTPGLRLIEKYAVRVGGAL
NHRFGLDDAAMIKDNHIEAAGGIRPAVERLRGRIPFLMPIEVETESLEQVQEALGCGVQVIMLDNMPVERMREAVQLIAG
RVLTEASGNITLDTLGDVAATGVDYISTSATITRAPWLDISLDLRRVPTTDTLPLD
>Mature_296_residues
MLTNRYALPHPLLLDPLLSSWLAEDWGRGDRTSEALFAEESPDGHGKILLKEAGVVAGLPLVERLFAIVDPAVRFAPMCE
EGTAAEARTVIAVVEGPVRSLLMGERVALNLLQRLSGIATITRRYVERLAGHHARLVDTRKTTPGLRLIEKYAVRVGGAL
NHRFGLDDAAMIKDNHIEAAGGIRPAVERLRGRIPFLMPIEVETESLEQVQEALGCGVQVIMLDNMPVERMREAVQLIAG
RVLTEASGNITLDTLGDVAATGVDYISTSATITRAPWLDISLDLRRVPTTDTLPLD

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=279, Percent_Identity=37.9928315412186, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1786299, Length=247, Percent_Identity=45.748987854251, Blast_Score=184, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6321162, Length=281, Percent_Identity=34.1637010676157, Blast_Score=156, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 32260; Mature: 32260

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTNRYALPHPLLLDPLLSSWLAEDWGRGDRTSEALFAEESPDGHGKILLKEAGVVAGLP
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHEEECCCCCCCCEEEEECCCCCCCCH
LVERLFAIVDPAVRFAPMCEEGTAAEARTVIAVVEGPVRSLLMGERVALNLLQRLSGIAT
HHHHHHHHHCHHHHHCCCCCCCCCHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
ITRRYVERLAGHHARLVDTRKTTPGLRLIEKYAVRVGGALNHRFGLDDAAMIKDNHIEAA
HHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCC
GGIRPAVERLRGRIPFLMPIEVETESLEQVQEALGCGVQVIMLDNMPVERMREAVQLIAG
CCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHH
RVLTEASGNITLDTLGDVAATGVDYISTSATITRAPWLDISLDLRRVPTTDTLPLD
HHHHCCCCCEEEEEHHHHHHHCHHHHCCCCEEEECCCEEEEEEEEECCCCCCCCCC
>Mature Secondary Structure
MLTNRYALPHPLLLDPLLSSWLAEDWGRGDRTSEALFAEESPDGHGKILLKEAGVVAGLP
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHEEECCCCCCCCEEEEECCCCCCCCH
LVERLFAIVDPAVRFAPMCEEGTAAEARTVIAVVEGPVRSLLMGERVALNLLQRLSGIAT
HHHHHHHHHCHHHHHCCCCCCCCCHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHH
ITRRYVERLAGHHARLVDTRKTTPGLRLIEKYAVRVGGALNHRFGLDDAAMIKDNHIEAA
HHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCC
GGIRPAVERLRGRIPFLMPIEVETESLEQVQEALGCGVQVIMLDNMPVERMREAVQLIAG
CCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHH
RVLTEASGNITLDTLGDVAATGVDYISTSATITRAPWLDISLDLRRVPTTDTLPLD
HHHHCCCCCEEEEEHHHHHHHCHHHHCCCCEEEECCCEEEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]