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The map label for this gene is hisB

Identifier: 37520338

GI number: 37520338

Start: 821215

End: 821808

Strand: Reverse

Name: hisB

Synonym: gvip088

Alternate gene names: 37520338

Gene position: 821808-821215 (Counterclockwise)

Preceding gene: 37520339

Following gene: 37520337

Centisome position: 17.64

GC content: 64.14

Gene sequence:

>594_bases
ATGGAACCACGCATTGCTTCGACAGTACGCACGACGCGCGAAACCGACATCCAGATTCGCCTCGACCTCGACGGCACCGG
CCGGGTCCAGGCTGAGACGGGTGTCCCTTTTCTCGACCACATGCTCGCCCAGATTGCCACCCATGGCCTGATCGACATCG
ACGTGAGCGCCCAGGGCGACTTGCACATCGACGATCACCACACCAATGAGGATGTCGGCATCGCCTTCGGGCAATGCCTG
GCCAAGGCCCTGGGCGACAAGCGGGGTATCTCGCGCTTCGGGCATTTTGCCGCCCCCCTCGACGAAGCGCTCGTGCAGGT
GGTGCTTGATCTTTCCGGTCGCCCGCACCTGAGCTACGGCCTGGAGATCCCCACCCAGCGCGTCGGCAGCTACGACACCC
AACTGGTGCGCGAGTTTTACCAGGCGGTGGTCAACAACAGCTCTATGACCCTGCACCTGCGCCAGTGGGCCGGGATCAAC
TCCCACCACATCATCGAGGCGTCTTTCAAGGCGTTTGCCCGCGCTTTGCGCTTGGCGGTCGAGATCGATCCCCGCCGCGC
CGGCAGCCTACCCAGCAGCAAGGGGGCGCTCTAG

Upstream 100 bases:

>100_bases
GGTAACGAAACCAGGTTTGCCTGATGCTCCACCCCCAAGGAGGCTCCACGGACGCGGATTTGAGCGACGGAATTTATCGG
CGCTCGTTAGACTGAAAAGC

Downstream 100 bases:

>100_bases
CCGATGGAGAACCCCAGTTTGCAGCCCTATCTCGAAGAAGTCCTGCCCAAAGCCTACCGCAGGGGTTTGAACCTGGCCGT
GCAGGAAACGAACTTGTCCT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MEPRIASTVRTTRETDIQIRLDLDGTGRVQAETGVPFLDHMLAQIATHGLIDIDVSAQGDLHIDDHHTNEDVGIAFGQCL
AKALGDKRGISRFGHFAAPLDEALVQVVLDLSGRPHLSYGLEIPTQRVGSYDTQLVREFYQAVVNNSSMTLHLRQWAGIN
SHHIIEASFKAFARALRLAVEIDPRRAGSLPSSKGAL

Sequences:

>Translated_197_residues
MEPRIASTVRTTRETDIQIRLDLDGTGRVQAETGVPFLDHMLAQIATHGLIDIDVSAQGDLHIDDHHTNEDVGIAFGQCL
AKALGDKRGISRFGHFAAPLDEALVQVVLDLSGRPHLSYGLEIPTQRVGSYDTQLVREFYQAVVNNSSMTLHLRQWAGIN
SHHIIEASFKAFARALRLAVEIDPRRAGSLPSSKGAL
>Mature_197_residues
MEPRIASTVRTTRETDIQIRLDLDGTGRVQAETGVPFLDHMLAQIATHGLIDIDVSAQGDLHIDDHHTNEDVGIAFGQCL
AKALGDKRGISRFGHFAAPLDEALVQVVLDLSGRPHLSYGLEIPTQRVGSYDTQLVREFYQAVVNNSSMTLHLRQWAGIN
SHHIIEASFKAFARALRLAVEIDPRRAGSLPSSKGAL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=49.4845360824742, Blast_Score=189, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6324776, Length=221, Percent_Identity=38.4615384615385, Blast_Score=144, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_GLOVI (Q7NMJ6)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_923715.1
- ProteinModelPortal:   Q7NMJ6
- SMR:   Q7NMJ6
- GeneID:   2599388
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.769
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- ProtClustDB:   PRK00951
- BioCyc:   GVIO251221:GLL0769-MONOMER
- BRENDA:   4.2.1.19
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21582; Mature: 21582

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPRIASTVRTTRETDIQIRLDLDGTGRVQAETGVPFLDHMLAQIATHGLIDIDVSAQGD
CCCCHHHHHHHCCCCCEEEEEECCCCCCEEECCCCCHHHHHHHHHHHCCEEEEEECCCCC
LHIDDHHTNEDVGIAFGQCLAKALGDKRGISRFGHFAAPLDEALVQVVLDLSGRPHLSYG
EEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEC
LEIPTQRVGSYDTQLVREFYQAVVNNSSMTLHLRQWAGINSHHIIEASFKAFARALRLAV
CCCCHHHCCCHHHHHHHHHHHHHHCCCCEEEEEHHHCCCCCCEEHHHHHHHHHHHHHHHE
EIDPRRAGSLPSSKGAL
EECCCCCCCCCCCCCCC
>Mature Secondary Structure
MEPRIASTVRTTRETDIQIRLDLDGTGRVQAETGVPFLDHMLAQIATHGLIDIDVSAQGD
CCCCHHHHHHHCCCCCEEEEEECCCCCCEEECCCCCHHHHHHHHHHHCCEEEEEECCCCC
LHIDDHHTNEDVGIAFGQCLAKALGDKRGISRFGHFAAPLDEALVQVVLDLSGRPHLSYG
EEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEC
LEIPTQRVGSYDTQLVREFYQAVVNNSSMTLHLRQWAGINSHHIIEASFKAFARALRLAV
CCCCHHHCCCHHHHHHHHHHHHHHCCCCEEEEEHHHCCCCCCEEHHHHHHHHHHHHHHHE
EIDPRRAGSLPSSKGAL
EECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292