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The map label for this gene is purM

Identifier: 37520289

GI number: 37520289

Start: 764354

End: 765367

Strand: Reverse

Name: purM

Synonym: gvip076

Alternate gene names: 37520289

Gene position: 765367-764354 (Counterclockwise)

Preceding gene: 37520290

Following gene: 37520283

Centisome position: 16.43

GC content: 64.3

Gene sequence:

>1014_bases
ATGGATTACAAATCGGCGGGGGTGGATGTCGAGGCGGGGTACGAATTTGTCGCCCGCATCCGGGGAGCGGTGGAGCGCAC
CCGTAGGCCGGAGCAACTGGGTGGGTTGGGCGGCTTCGGGGGACTTTTCGCTCTACCCGCGGGCTACCGCGAGCCGGTGT
TGGTGGCGGGCACCGACGGGGTGGGCACCAAGCTCAAACTCGCCTTCGCCCTCGATCGCCACGACACGATCGGCATCGAC
TGTGTGGCGATGTGCGTCAACGACGTGCTCGCCCAGGGGGCGGAGCCGCTGTTTTTTCTCGATTACCTGGCTACGGGCAA
ACTTTCTCCGGCACAGCTTGCCGGGGTGGTCGAAGGGATCGCAGCGGGCTGCCTGGAGGCCGGCTGCACGCTGTTGGGCG
GTGAGACGGCGGAGATGCCCGGATTTTACGCGGCGGGCGAGTACGACGTGGCCGGATTCTGCGTCGGGATCGTCGAGAGA
AGCCAAATCATCGACGGCAATCGCGTGCAGGTGGGAGATGCGTTGTTGGGACTCTCTAGCAGCGGCGTGCACAGCAACGG
TTTCAGCCTGGTGCGGCGAATCGTCGAGCTGGCGGGACTGGACTGGCACCACAGACCCGAGGATTTCCCAGCATCATTGG
GTGAAGTGCTGCTCACCCCCACCCGCATTTACGTTAAACCGGTGCGCGCCGCCCTGGAAGCCGGTTTTGACATTCGGGGA
ATTGCCCACATCACCGGGGGCGGGCTCATCGAGAACGTTCCGCGCGCCCTGGGCGGGCTCGGTGCCTGCCTGGAGCGAAA
CAGCTGGCCGGTGCCGCCCGTTTTTACCTGGCTTGAGCGCACCGGCGGTGTCGGCCGACAGGACATGGATCAGACTTTCA
ATCTCGGATTGGGCCTTGTCCTTGCCTGTCCGACAGAACAGGCGGATGCGCTTCAAGCCTATCTGGCCAAGCAGGGCGAA
CAGGTATTGCGTATAGGTGCCGTCGTCGAAGCCGCCGGGGTGCGCTTTGCCTGA

Upstream 100 bases:

>100_bases
CGGTCTATCCAATTTTGAAGTTCGTGCGGTATCTGGGTAACTATTCGTAGCGCTGAAGCTTGCTTCAGAATGGGGATTAC
CTAAGAGGTCCAGGAAACCC

Downstream 100 bases:

>100_bases
GCTGGTTAGTGCGCCCAGTCGGGCTTGATCGCCTTGCGGCTATTGAGGAAGCGGTCGATGGCCATCGCCGCGATGCAGCC
GTCCCCCGCCGCCACCACCG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MDYKSAGVDVEAGYEFVARIRGAVERTRRPEQLGGLGGFGGLFALPAGYREPVLVAGTDGVGTKLKLAFALDRHDTIGID
CVAMCVNDVLAQGAEPLFFLDYLATGKLSPAQLAGVVEGIAAGCLEAGCTLLGGETAEMPGFYAAGEYDVAGFCVGIVER
SQIIDGNRVQVGDALLGLSSSGVHSNGFSLVRRIVELAGLDWHHRPEDFPASLGEVLLTPTRIYVKPVRAALEAGFDIRG
IAHITGGGLIENVPRALGGLGACLERNSWPVPPVFTWLERTGGVGRQDMDQTFNLGLGLVLACPTEQADALQAYLAKQGE
QVLRIGAVVEAAGVRFA

Sequences:

>Translated_337_residues
MDYKSAGVDVEAGYEFVARIRGAVERTRRPEQLGGLGGFGGLFALPAGYREPVLVAGTDGVGTKLKLAFALDRHDTIGID
CVAMCVNDVLAQGAEPLFFLDYLATGKLSPAQLAGVVEGIAAGCLEAGCTLLGGETAEMPGFYAAGEYDVAGFCVGIVER
SQIIDGNRVQVGDALLGLSSSGVHSNGFSLVRRIVELAGLDWHHRPEDFPASLGEVLLTPTRIYVKPVRAALEAGFDIRG
IAHITGGGLIENVPRALGGLGACLERNSWPVPPVFTWLERTGGVGRQDMDQTFNLGLGLVLACPTEQADALQAYLAKQGE
QVLRIGAVVEAAGVRFA
>Mature_337_residues
MDYKSAGVDVEAGYEFVARIRGAVERTRRPEQLGGLGGFGGLFALPAGYREPVLVAGTDGVGTKLKLAFALDRHDTIGID
CVAMCVNDVLAQGAEPLFFLDYLATGKLSPAQLAGVVEGIAAGCLEAGCTLLGGETAEMPGFYAAGEYDVAGFCVGIVER
SQIIDGNRVQVGDALLGLSSSGVHSNGFSLVRRIVELAGLDWHHRPEDFPASLGEVLLTPTRIYVKPVRAALEAGFDIRG
IAHITGGGLIENVPRALGGLGACLERNSWPVPPVFTWLERTGGVGRQDMDQTFNLGLGLVLACPTEQADALQAYLAKQGE
QVLRIGAVVEAAGVRFA

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=337, Percent_Identity=49.2581602373887, Blast_Score=308, Evalue=3e-84,
Organism=Homo sapiens, GI209869995, Length=337, Percent_Identity=49.2581602373887, Blast_Score=308, Evalue=3e-84,
Organism=Homo sapiens, GI209869993, Length=337, Percent_Identity=49.2581602373887, Blast_Score=308, Evalue=3e-84,
Organism=Escherichia coli, GI1788845, Length=329, Percent_Identity=56.5349544072948, Blast_Score=372, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17567511, Length=336, Percent_Identity=38.9880952380952, Blast_Score=229, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6321203, Length=337, Percent_Identity=47.4777448071217, Blast_Score=290, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24582400, Length=275, Percent_Identity=44.3636363636364, Blast_Score=227, Evalue=8e-60,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_GLOVI (Q7NMP5)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_923666.1
- ProteinModelPortal:   Q7NMP5
- SMR:   Q7NMP5
- GeneID:   2599439
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.720
- HOGENOM:   HBG531222
- OMA:   GIDMIAM
- ProtClustDB:   PRK05385
- BioCyc:   GVIO251221:GLL0720-MONOMER
- BRENDA:   6.3.3.1
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 35367; Mature: 35367

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKSAGVDVEAGYEFVARIRGAVERTRRPEQLGGLGGFGGLFALPAGYREPVLVAGTDG
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHCCCCCCCCEEEECCCC
VGTKLKLAFALDRHDTIGIDCVAMCVNDVLAQGAEPLFFLDYLATGKLSPAQLAGVVEGI
CCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCCHHHHHHHHHHH
AAGCLEAGCTLLGGETAEMPGFYAAGEYDVAGFCVGIVERSQIIDGNRVQVGDALLGLSS
HHHHHHHCCEEECCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHCCCC
SGVHSNGFSLVRRIVELAGLDWHHRPEDFPASLGEVLLTPTRIYVKPVRAALEAGFDIRG
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEE
IAHITGGGLIENVPRALGGLGACLERNSWPVPPVFTWLERTGGVGRQDMDQTFNLGLGLV
EEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCEEE
LACPTEQADALQAYLAKQGEQVLRIGAVVEAAGVRFA
EECCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDYKSAGVDVEAGYEFVARIRGAVERTRRPEQLGGLGGFGGLFALPAGYREPVLVAGTDG
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHCCCCCCCCEEEECCCC
VGTKLKLAFALDRHDTIGIDCVAMCVNDVLAQGAEPLFFLDYLATGKLSPAQLAGVVEGI
CCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCCHHHHHHHHHHH
AAGCLEAGCTLLGGETAEMPGFYAAGEYDVAGFCVGIVERSQIIDGNRVQVGDALLGLSS
HHHHHHHCCEEECCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHCCCC
SGVHSNGFSLVRRIVELAGLDWHHRPEDFPASLGEVLLTPTRIYVKPVRAALEAGFDIRG
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEE
IAHITGGGLIENVPRALGGLGACLERNSWPVPPVFTWLERTGGVGRQDMDQTFNLGLGLV
EEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCEEE
LACPTEQADALQAYLAKQGEQVLRIGAVVEAAGVRFA
EECCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292