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The map label for this gene is serS

Identifier: 37520285

GI number: 37520285

Start: 758606

End: 759895

Strand: Direct

Name: serS

Synonym: gvip075

Alternate gene names: 37520285

Gene position: 758606-759895 (Clockwise)

Preceding gene: 37520284

Following gene: 37520286

Centisome position: 16.28

GC content: 62.64

Gene sequence:

>1290_bases
GTGCTCGACCCCAAACTGTTGCGCGACGATCCCGCCAAGCTCATCGAACGGCTCAACACCCGCGGCGGCGACTTTACCGA
AGTGATTGAACAACTGGTGGCCCTGGATTCCCAGCGGCGGGCCAGCCAGACCGCATTCAACCGCGCCCAGGCCGAGGGCA
ACCAGATTGGCAAGCAGGTGGGCGAACGGCTGCGCCGGGGTACTGCCGTCGGCGACCCCGAGGTGCTCGCCCTCAAGCAG
CGGGGAATCGATCTCAAAGCCACCCTCGCCCTACTGCAGGATCAAGAGCGCGAGCTTGCCGAGCGCTTCGCGGCACTGTT
GCCGACTTTGCCCAACGTGCCCCGCCCCGAGGTACCGATCGGCAAAGACGAAAACGACAACCGCGAGATGCGCTTCTGGG
GCACCCCCCCTATCTTCGATTTTGAGCCGGCGGCCCACTGGGATCTGGGCGAACGGTTGGGACTGATGAATTTCGCGCGG
GCAACCCTGGTGGCCCAGGCCCGCTTTGTGACCCTGATGGGCGACGGGGCGCTGCTGGAGCGCGCTTTGATCGCTTTTAT
GCTCGATCGCCACCGCGCCCACGGCTATATCGAAATTCTGCCTCCATACCTGGTCAACACCGCTTCGATGACTGGGACCG
GACAGTTGCCCAAATTTGCCGAGGACAGCTTCCGCTGCCGGGACGACGATCTGTGGCTGATTCCAACGGCGGAGGTGCCG
GTCACCAACCTCTACCGAGACGAAATCCTGACAGACATGCAGTTGCCCATTCACCACTGCGCCTTTACCCCCTGCTTCCG
GCGCGAGGCGGGCAGCTACGGCCGCGACACCCGGGGACTTATTCGCCTGCATCAGTTTCACAAAGTCGAACTGGTCAAAT
TCTGCCGCCCGGAGCATTCGCCCACCGAGCACGAAAAACTGGTGGCCGACGCCGAGGATGTGCTGCAGCAACTGGAACTG
CCCTACCGGGTCATCGAGCTGTGTACCGGGGATCTGGGCTTTGGCGCCGCCCGTTGCTTCGATCTGGAGGTGTGGCTACC
CAGCCAGAACCGCTACCGCGAAATTTCCTCCTGCTCGAACTTCGAAGATTTTCAGGCCCGCCGCGCCAATCTGCGCTTCA
AAGCGCCCGACAAAAAAGGCACCGAGTTCGTCCACACCCTCAACGGCTCGGGATTGGCCGTCGGGCGTACCTTCGCCGCC
ATTCTCGAAAATTACCAGAACCGCGACGGCACAGTGCGCGTGCCCGAAGCCCTGAAACCTTACGTGCGCAGGGACGTGCT
CAGCCGGTAA

Upstream 100 bases:

>100_bases
ATCCGCGCGGTGCGCCTCGCTCCCGACAACTACATCGAAGCGCAGAACTGGCTGAAGACCACCGGCCGCTTCGAGCTGCT
CTACTAGACGGATCTGCGCG

Downstream 100 bases:

>100_bases
GCCAAGGAACGACTGCCCGCTCACCCCGGCTGTCGCCGCACTCTAGAATCCAGCCCCTCCTGATCGATACAATCGTCGGT
ATTGTCCGGGAGTGCTGTCT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MLDPKLLRDDPAKLIERLNTRGGDFTEVIEQLVALDSQRRASQTAFNRAQAEGNQIGKQVGERLRRGTAVGDPEVLALKQ
RGIDLKATLALLQDQERELAERFAALLPTLPNVPRPEVPIGKDENDNREMRFWGTPPIFDFEPAAHWDLGERLGLMNFAR
ATLVAQARFVTLMGDGALLERALIAFMLDRHRAHGYIEILPPYLVNTASMTGTGQLPKFAEDSFRCRDDDLWLIPTAEVP
VTNLYRDEILTDMQLPIHHCAFTPCFRREAGSYGRDTRGLIRLHQFHKVELVKFCRPEHSPTEHEKLVADAEDVLQQLEL
PYRVIELCTGDLGFGAARCFDLEVWLPSQNRYREISSCSNFEDFQARRANLRFKAPDKKGTEFVHTLNGSGLAVGRTFAA
ILENYQNRDGTVRVPEALKPYVRRDVLSR

Sequences:

>Translated_429_residues
MLDPKLLRDDPAKLIERLNTRGGDFTEVIEQLVALDSQRRASQTAFNRAQAEGNQIGKQVGERLRRGTAVGDPEVLALKQ
RGIDLKATLALLQDQERELAERFAALLPTLPNVPRPEVPIGKDENDNREMRFWGTPPIFDFEPAAHWDLGERLGLMNFAR
ATLVAQARFVTLMGDGALLERALIAFMLDRHRAHGYIEILPPYLVNTASMTGTGQLPKFAEDSFRCRDDDLWLIPTAEVP
VTNLYRDEILTDMQLPIHHCAFTPCFRREAGSYGRDTRGLIRLHQFHKVELVKFCRPEHSPTEHEKLVADAEDVLQQLEL
PYRVIELCTGDLGFGAARCFDLEVWLPSQNRYREISSCSNFEDFQARRANLRFKAPDKKGTEFVHTLNGSGLAVGRTFAA
ILENYQNRDGTVRVPEALKPYVRRDVLSR
>Mature_429_residues
MLDPKLLRDDPAKLIERLNTRGGDFTEVIEQLVALDSQRRASQTAFNRAQAEGNQIGKQVGERLRRGTAVGDPEVLALKQ
RGIDLKATLALLQDQERELAERFAALLPTLPNVPRPEVPIGKDENDNREMRFWGTPPIFDFEPAAHWDLGERLGLMNFAR
ATLVAQARFVTLMGDGALLERALIAFMLDRHRAHGYIEILPPYLVNTASMTGTGQLPKFAEDSFRCRDDDLWLIPTAEVP
VTNLYRDEILTDMQLPIHHCAFTPCFRREAGSYGRDTRGLIRLHQFHKVELVKFCRPEHSPTEHEKLVADAEDVLQQLEL
PYRVIELCTGDLGFGAARCFDLEVWLPSQNRYREISSCSNFEDFQARRANLRFKAPDKKGTEFVHTLNGSGLAVGRTFAA
ILENYQNRDGTVRVPEALKPYVRRDVLSR

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=464, Percent_Identity=33.4051724137931, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI8923421, Length=368, Percent_Identity=33.4239130434783, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI225579074, Length=339, Percent_Identity=33.9233038348083, Blast_Score=194, Evalue=1e-49,
Organism=Escherichia coli, GI1787120, Length=433, Percent_Identity=51.5011547344111, Blast_Score=406, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17539260, Length=433, Percent_Identity=30.715935334873, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17542084, Length=261, Percent_Identity=32.183908045977, Blast_Score=136, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6320226, Length=415, Percent_Identity=31.566265060241, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6321799, Length=362, Percent_Identity=30.6629834254144, Blast_Score=187, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24581334, Length=467, Percent_Identity=31.0492505353319, Blast_Score=201, Evalue=8e-52,
Organism=Drosophila melanogaster, GI17737985, Length=257, Percent_Identity=31.5175097276265, Blast_Score=135, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_GLOVI (Q7NMP9)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_923662.1
- ProteinModelPortal:   Q7NMP9
- SMR:   Q7NMP9
- GeneID:   2599435
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.716
- HOGENOM:   HBG629391
- OMA:   AHWDLGP
- ProtClustDB:   PRK05431
- BioCyc:   GVIO251221:GLR0716-MONOMER
- BRENDA:   6.1.1.11
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48687; Mature: 48687

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 290-290 BINDING 390-390

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDPKLLRDDPAKLIERLNTRGGDFTEVIEQLVALDSQRRASQTAFNRAQAEGNQIGKQV
CCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
GERLRRGTAVGDPEVLALKQRGIDLKATLALLQDQERELAERFAALLPTLPNVPRPEVPI
HHHHHHCCCCCCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GKDENDNREMRFWGTPPIFDFEPAAHWDLGERLGLMNFARATLVAQARFVTLMGDGALLE
CCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHH
RALIAFMLDRHRAHGYIEILPPYLVNTASMTGTGQLPKFAEDSFRCRDDDLWLIPTAEVP
HHHHHHHHHHHHCCCEEEECCHHHHCCCCCCCCCCCCCHHCCCCCCCCCCEEEEECCCCC
VTNLYRDEILTDMQLPIHHCAFTPCFRREAGSYGRDTRGLIRLHQFHKVELVKFCRPEHS
HHHHHHHHHHHHCCCCHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
PTEHEKLVADAEDVLQQLELPYRVIELCTGDLGFGAARCFDLEVWLPSQNRYREISSCSN
CCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEEEEEECCCCHHHHHHHHCCC
FEDFQARRANLRFKAPDKKGTEFVHTLNGSGLAVGRTFAAILENYQNRDGTVRVPEALKP
CHHHHHHHCCCEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEECCHHHHH
YVRRDVLSR
HHHHHHHCC
>Mature Secondary Structure
MLDPKLLRDDPAKLIERLNTRGGDFTEVIEQLVALDSQRRASQTAFNRAQAEGNQIGKQV
CCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
GERLRRGTAVGDPEVLALKQRGIDLKATLALLQDQERELAERFAALLPTLPNVPRPEVPI
HHHHHHCCCCCCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GKDENDNREMRFWGTPPIFDFEPAAHWDLGERLGLMNFARATLVAQARFVTLMGDGALLE
CCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHH
RALIAFMLDRHRAHGYIEILPPYLVNTASMTGTGQLPKFAEDSFRCRDDDLWLIPTAEVP
HHHHHHHHHHHHCCCEEEECCHHHHCCCCCCCCCCCCCHHCCCCCCCCCCEEEEECCCCC
VTNLYRDEILTDMQLPIHHCAFTPCFRREAGSYGRDTRGLIRLHQFHKVELVKFCRPEHS
HHHHHHHHHHHHCCCCHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
PTEHEKLVADAEDVLQQLELPYRVIELCTGDLGFGAARCFDLEVWLPSQNRYREISSCSN
CCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEEEEEECCCCHHHHHHHHCCC
FEDFQARRANLRFKAPDKKGTEFVHTLNGSGLAVGRTFAAILENYQNRDGTVRVPEALKP
CHHHHHHHCCCEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEECCHHHHH
YVRRDVLSR
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292