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The map label for this gene is lexA [H]

Identifier: 37520278

GI number: 37520278

Start: 753705

End: 754280

Strand: Reverse

Name: lexA [H]

Synonym: gll0709

Alternate gene names: 37520278

Gene position: 754280-753705 (Counterclockwise)

Preceding gene: 37520280

Following gene: 37520274

Centisome position: 16.19

GC content: 61.81

Gene sequence:

>576_bases
ATGATTACGCTCCGCCAGAAAGAATTTCTGCAGCAACTGATCGAAACCTACGGCTCGACGCCGCTGCCCCCAATTCGCAC
CCTCGCCCAAGAGCTTGACCAGCACCGCACCACGGTCTACCGCTGGTTGCAGTTGCTCGAACAGATGGGTTATCTCAAGG
CCCAGGGCAATCGCTACTACATCGACCCCGACCTGTTGGGAATTCCACTCCTCGAAAACCGGGTTCCTGCCGGTTCGCCG
GTGACCGTCGAAGAGGACTTGCTCAACAGCCGCATGTCCCTCGACGAATACCTGGTCGAAGAGCGCACCGGCACTTTTTT
GCTGCGGGTCAAGGGCGACTCGATGATAGAAGCGGGCATCTTCGAGGGCGACATCGTCGTGGTCAACCAGAACCGGCGGG
CGGCCGACGGCGATGTGGTCATCGCCCGGGTCGACGGCGAGATGACCCTCAAAACCTTGCGCCGCCGCAACCAGCAGACC
TGGCTGGAGCCCGCCAACAGCCGCTACTCCCCCATCCACCCGGCCAGCGGCCTGGAGGTGTTGGGGGTAGTCGTCGGCCT
GGTGCGCAAGTACTAA

Upstream 100 bases:

>100_bases
ATCCTGACTCGAAGAACGGGTATAGAGCTGAAGTTCGGGTGAACACTTGCGCCTGTGCCCGGACAATGCCAAACTGTGGA
CAGGTGTTCATCGTACAACC

Downstream 100 bases:

>100_bases
GGCTCCTCCGGCTCCTCCGATTCGACCCTCGGGGCCCCTTCGATGGCTCCGAGGGGATGTTGTGTGGGCAAGCCCGCCGG
GCGCGGGAATACCCTGAGCC

Product: LexA repressor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MITLRQKEFLQQLIETYGSTPLPPIRTLAQELDQHRTTVYRWLQLLEQMGYLKAQGNRYYIDPDLLGIPLLENRVPAGSP
VTVEEDLLNSRMSLDEYLVEERTGTFLLRVKGDSMIEAGIFEGDIVVVNQNRRAADGDVVIARVDGEMTLKTLRRRNQQT
WLEPANSRYSPIHPASGLEVLGVVVGLVRKY

Sequences:

>Translated_191_residues
MITLRQKEFLQQLIETYGSTPLPPIRTLAQELDQHRTTVYRWLQLLEQMGYLKAQGNRYYIDPDLLGIPLLENRVPAGSP
VTVEEDLLNSRMSLDEYLVEERTGTFLLRVKGDSMIEAGIFEGDIVVVNQNRRAADGDVVIARVDGEMTLKTLRRRNQQT
WLEPANSRYSPIHPASGLEVLGVVVGLVRKY
>Mature_191_residues
MITLRQKEFLQQLIETYGSTPLPPIRTLAQELDQHRTTVYRWLQLLEQMGYLKAQGNRYYIDPDLLGIPLLENRVPAGSP
VTVEEDLLNSRMSLDEYLVEERTGTFLLRVKGDSMIEAGIFEGDIVVVNQNRRAADGDVVIARVDGEMTLKTLRRRNQQT
WLEPANSRYSPIHPASGLEVLGVVVGLVRKY

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1787431, Length=128, Percent_Identity=38.28125, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1790476, Length=198, Percent_Identity=29.7979797979798, Blast_Score=76, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 21738; Mature: 21738

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITLRQKEFLQQLIETYGSTPLPPIRTLAQELDQHRTTVYRWLQLLEQMGYLKAQGNRYY
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEE
IDPDLLGIPLLENRVPAGSPVTVEEDLLNSRMSLDEYLVEERTGTFLLRVKGDSMIEAGI
ECCCCCCCCHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEECCC
FEGDIVVVNQNRRAADGDVVIARVDGEMTLKTLRRRNQQTWLEPANSRYSPIHPASGLEV
CCCCEEEECCCCCCCCCCEEEEEECCHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCHHHH
LGVVVGLVRKY
HHHHHHHHHCC
>Mature Secondary Structure
MITLRQKEFLQQLIETYGSTPLPPIRTLAQELDQHRTTVYRWLQLLEQMGYLKAQGNRYY
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEE
IDPDLLGIPLLENRVPAGSPVTVEEDLLNSRMSLDEYLVEERTGTFLLRVKGDSMIEAGI
ECCCCCCCCHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEECCC
FEGDIVVVNQNRRAADGDVVIARVDGEMTLKTLRRRNQQTWLEPANSRYSPIHPASGLEV
CCCCEEEECCCCCCCCCCEEEEEECCHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCHHHH
LGVVVGLVRKY
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA