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The map label for this gene is luxQ [H]

Identifier: 37520203

GI number: 37520203

Start: 674979

End: 676997

Strand: Reverse

Name: luxQ [H]

Synonym: gll0634

Alternate gene names: 37520203

Gene position: 676997-674979 (Counterclockwise)

Preceding gene: 37520204

Following gene: 37520202

Centisome position: 14.53

GC content: 65.08

Gene sequence:

>2019_bases
ATGCCCGCCCCCGGTACCGCTGAACCCGTCACCATCCTGCTGGTCGACGACCGCTTCGAGAACTTGCTCGCCCTCGAAGC
GGTTCTCGGGGAGTTGGGCCAGAACCTGGTCAAAGCCCGCTCAGGCCCGGAGGCTCTGCGCCACCTGCTGCGTCAGGATT
TCGCCGTGATCTTGCTCGATGTGCAGATGCCGGGGATGGATGGCTTCGAGACCGCCCAGCTCATCCGCCAACGCGAGCGC
TCGCGCCACACACCGATCATCTTCCTGACCGCCTACAGCGCCAACGACAGTCTGATCTTCAAGGGTTACGCCCTGGGAGC
GGTGGATTATCTACTCAAACCGATTAACCCGAGCATCTTGATCTCGAAGGTGGTCGTCTTTATCGACCTGTTTCGCAAAA
GCGCCGAAATCGAGCGGCAGGCCGGGGCCCTCGTCGCCGTCAACCGGCAATTGCGCTCAAGCGAACAGCGGCTGCAGGAC
TTTTTGGACAACGCCAGCGATCTCATCGAGATCGTCTCTCCCGAAGGCCGCCTGCTCTACGTCAACCGCACCTGGCGCGA
GACGCTCGCGTATCCGGCAGATGACCTGGAGAAGATGACCTGTTTCGACGTCGTCGCCCCTGCCGACCGGCCCCTGCTGG
CCGAAGCCCTCGAGCGCGTGCAGCAATCCCAGCGCTCCGAGCGGCTGGAGGTCGCCTTTTTGGCCATGGGCGGCCGGGAG
ATCGCCGTCGAAGGTTCCCTCAACTGCCAATTCGACAAAGGTGTGCCCCAGGCTATCCGTTGCATCTTCCGCGACATCAC
CGAGCGTCGGCAGGCCGAGCAGGTCCGCGTCGAGATTCTGCGCGAGCAGGTAGCCCGCCAGCAGGCGGAGGAAGCCAGCC
GTATGAAGGACGAGTTTCTGGCGATGGTCTCCCATGAGCTGCGCACCCCGCTCAATTCGATCTTGGGTTGGGCGCAACTG
TTGCGCGCCCGCCGCATCGACGAGAAGGCCGCCACGGGCGCCCTCGAATCGATCGAGCGCAACGCCCGCATGCAGAACCG
GTTGATCGAAGATTTGTTGGACATCTCGCGTGTCGTCACCGGCCAGATGCGCCTGGAGCTCCAGCCGCTCGAACTGTCCG
GGGTGATCGCATCGGCCGTCGAGGCGGTGCAGCCCGCCGCCGCCGTCAAGCAAATCCAGCTGCGCTGCCGCATCGATGCC
GCCGTCGGCCCGGTGTTGGGCGACGTCGACCGCCTGCACCAAATCGCCTGGAATTTGCTTGCCAACGCCGTCAAGTTTAC
CCCCCAAGGCGGCACCGTCGAAGTCGACCTCGCCCAGGGCGAAATCCACGCGCAACTGGTGGTCCGCGACAACGGGATCG
GCATCTCGCCTGCGTTTTTGGACCAGATCTTCGAGCGCTTCCGACAGGCCGACAGCACCAGCACCCGGGTGCACGGCGGC
CTCGGCCTCGGCTTGTCGATTGTCCGCCACCTGGTCGAGCTGCACGGCGGCACCGCTGCGGCCGAGAGCGCGGGCAAAGG
GCAGGGGGCTACTTTTACGGTGCGCCTGCCGCTGTTGGCCGACGGCACCCCCATTCAGGACGAGGGGAAGCTCGTCCAGG
CCAATGGCCGCACCGAGGCGCTGACCGAGTTGGTACAGTGGCTGGCGGGATTGCGGGTGCTGGTCGTCGACGACGAGGTG
GACGCGCGCGAATTTGTCGCTACCGCCCTGGGCGAGTACGGCGTGCAGGTGGTGACGGTCGGTTCGGTCCGAGAAGCCCT
AAGCGCCCTCGCGGCCCAAAAAACGGACGTGTTGGTCAGCGACATCGGCATGCCCGGCGAGGACGGTTACGCGCTTATCC
GCGAGTTGCGCTCCCGCGGCAATACCCTCCCCGCCATCGCCTTCACCGCCTACGCCCGCGGCGAAGATCTCAAAGACGCC
CTGCAGGCCGGTTTTCAGTGCCACGTGCCCAAACCCGTCGAGATCGCCCAATTGGTGAGCGCCATCGCCAGCCTCTCGCG
CAACCGCAAAGCGACCTGA

Upstream 100 bases:

>100_bases
CCTGGAGGCGGGCGCTTCGGACTACATCACCAAACCCGTCGACACCGAGCAGTTGTTGTCGCTGCTGCGGGTCTGGCTGT
CGCGCCGGGAGAACTAGCCC

Downstream 100 bases:

>100_bases
TATCGGATCCAGACCGGCCCAACCGGCTCAAGACGAAGCAAGCTTCCGGCAGTTATACTGGTTGGCAACTGGTTGAACTT
TCTTACCATGATCTTCACCG

Product: two-component hybrid sensor and regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 672; Mature: 671

Protein sequence:

>672_residues
MPAPGTAEPVTILLVDDRFENLLALEAVLGELGQNLVKARSGPEALRHLLRQDFAVILLDVQMPGMDGFETAQLIRQRER
SRHTPIIFLTAYSANDSLIFKGYALGAVDYLLKPINPSILISKVVVFIDLFRKSAEIERQAGALVAVNRQLRSSEQRLQD
FLDNASDLIEIVSPEGRLLYVNRTWRETLAYPADDLEKMTCFDVVAPADRPLLAEALERVQQSQRSERLEVAFLAMGGRE
IAVEGSLNCQFDKGVPQAIRCIFRDITERRQAEQVRVEILREQVARQQAEEASRMKDEFLAMVSHELRTPLNSILGWAQL
LRARRIDEKAATGALESIERNARMQNRLIEDLLDISRVVTGQMRLELQPLELSGVIASAVEAVQPAAAVKQIQLRCRIDA
AVGPVLGDVDRLHQIAWNLLANAVKFTPQGGTVEVDLAQGEIHAQLVVRDNGIGISPAFLDQIFERFRQADSTSTRVHGG
LGLGLSIVRHLVELHGGTAAAESAGKGQGATFTVRLPLLADGTPIQDEGKLVQANGRTEALTELVQWLAGLRVLVVDDEV
DAREFVATALGEYGVQVVTVGSVREALSALAAQKTDVLVSDIGMPGEDGYALIRELRSRGNTLPAIAFTAYARGEDLKDA
LQAGFQCHVPKPVEIAQLVSAIASLSRNRKAT

Sequences:

>Translated_672_residues
MPAPGTAEPVTILLVDDRFENLLALEAVLGELGQNLVKARSGPEALRHLLRQDFAVILLDVQMPGMDGFETAQLIRQRER
SRHTPIIFLTAYSANDSLIFKGYALGAVDYLLKPINPSILISKVVVFIDLFRKSAEIERQAGALVAVNRQLRSSEQRLQD
FLDNASDLIEIVSPEGRLLYVNRTWRETLAYPADDLEKMTCFDVVAPADRPLLAEALERVQQSQRSERLEVAFLAMGGRE
IAVEGSLNCQFDKGVPQAIRCIFRDITERRQAEQVRVEILREQVARQQAEEASRMKDEFLAMVSHELRTPLNSILGWAQL
LRARRIDEKAATGALESIERNARMQNRLIEDLLDISRVVTGQMRLELQPLELSGVIASAVEAVQPAAAVKQIQLRCRIDA
AVGPVLGDVDRLHQIAWNLLANAVKFTPQGGTVEVDLAQGEIHAQLVVRDNGIGISPAFLDQIFERFRQADSTSTRVHGG
LGLGLSIVRHLVELHGGTAAAESAGKGQGATFTVRLPLLADGTPIQDEGKLVQANGRTEALTELVQWLAGLRVLVVDDEV
DAREFVATALGEYGVQVVTVGSVREALSALAAQKTDVLVSDIGMPGEDGYALIRELRSRGNTLPAIAFTAYARGEDLKDA
LQAGFQCHVPKPVEIAQLVSAIASLSRNRKAT
>Mature_671_residues
PAPGTAEPVTILLVDDRFENLLALEAVLGELGQNLVKARSGPEALRHLLRQDFAVILLDVQMPGMDGFETAQLIRQRERS
RHTPIIFLTAYSANDSLIFKGYALGAVDYLLKPINPSILISKVVVFIDLFRKSAEIERQAGALVAVNRQLRSSEQRLQDF
LDNASDLIEIVSPEGRLLYVNRTWRETLAYPADDLEKMTCFDVVAPADRPLLAEALERVQQSQRSERLEVAFLAMGGREI
AVEGSLNCQFDKGVPQAIRCIFRDITERRQAEQVRVEILREQVARQQAEEASRMKDEFLAMVSHELRTPLNSILGWAQLL
RARRIDEKAATGALESIERNARMQNRLIEDLLDISRVVTGQMRLELQPLELSGVIASAVEAVQPAAAVKQIQLRCRIDAA
VGPVLGDVDRLHQIAWNLLANAVKFTPQGGTVEVDLAQGEIHAQLVVRDNGIGISPAFLDQIFERFRQADSTSTRVHGGL
GLGLSIVRHLVELHGGTAAAESAGKGQGATFTVRLPLLADGTPIQDEGKLVQANGRTEALTELVQWLAGLRVLVVDDEVD
AREFVATALGEYGVQVVTVGSVREALSALAAQKTDVLVSDIGMPGEDGYALIRELRSRGNTLPAIAFTAYARGEDLKDAL
QAGFQCHVPKPVEIAQLVSAIASLSRNRKAT

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=416, Percent_Identity=28.6057692307692, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1789149, Length=416, Percent_Identity=29.8076923076923, Blast_Score=148, Evalue=9e-37,
Organism=Escherichia coli, GI87081816, Length=385, Percent_Identity=32.2077922077922, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI48994928, Length=527, Percent_Identity=28.0834914611006, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI145693157, Length=320, Percent_Identity=32.1875, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788393, Length=232, Percent_Identity=31.0344827586207, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1790436, Length=240, Percent_Identity=30.4166666666667, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1786600, Length=246, Percent_Identity=30.0813008130081, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1786912, Length=238, Percent_Identity=32.3529411764706, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI1786783, Length=264, Percent_Identity=27.6515151515151, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1788549, Length=267, Percent_Identity=27.7153558052434, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI1787894, Length=224, Percent_Identity=29.0178571428571, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1789403, Length=275, Percent_Identity=29.8181818181818, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790346, Length=222, Percent_Identity=30.1801801801802, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1788279, Length=225, Percent_Identity=26.6666666666667, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790861, Length=241, Percent_Identity=31.1203319502075, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1790299, Length=110, Percent_Identity=38.1818181818182, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=36.4485981308411, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1789809, Length=116, Percent_Identity=32.7586206896552, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1787375, Length=117, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1790437, Length=111, Percent_Identity=35.1351351351351, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI87082012, Length=115, Percent_Identity=34.7826086956522, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1790551, Length=220, Percent_Identity=29.0909090909091, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1786911, Length=120, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=8e-11,
Organism=Escherichia coli, GI87082128, Length=228, Percent_Identity=27.6315789473684, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 73609; Mature: 73478

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS50112 PAS ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAPGTAEPVTILLVDDRFENLLALEAVLGELGQNLVKARSGPEALRHLLRQDFAVILLD
CCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEE
VQMPGMDGFETAQLIRQRERSRHTPIIFLTAYSANDSLIFKGYALGAVDYLLKPINPSIL
EECCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEECHHHHHHHHHHCCCCHHHH
ISKVVVFIDLFRKSAEIERQAGALVAVNRQLRSSEQRLQDFLDNASDLIEIVSPEGRLLY
HHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCEEE
VNRTWRETLAYPADDLEKMTCFDVVAPADRPLLAEALERVQQSQRSERLEVAFLAMGGRE
EECHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEECCEE
IAVEGSLNCQFDKGVPQAIRCIFRDITERRQAEQVRVEILREQVARQQAEEASRMKDEFL
EEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMVSHELRTPLNSILGWAQLLRARRIDEKAATGALESIERNARMQNRLIEDLLDISRVVT
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQMRLELQPLELSGVIASAVEAVQPAAAVKQIQLRCRIDAAVGPVLGDVDRLHQIAWNLL
CHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHH
ANAVKFTPQGGTVEVDLAQGEIHAQLVVRDNGIGISPAFLDQIFERFRQADSTSTRVHGG
HHHHEECCCCCEEEEEEECCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEECCC
LGLGLSIVRHLVELHGGTAAAESAGKGQGATFTVRLPLLADGTPIQDEGKLVQANGRTEA
CCHHHHHHHHHHHHCCCCHHHCCCCCCCCCEEEEEEEEEECCCCCCCCCCEEECCCCHHH
LTELVQWLAGLRVLVVDDEVDAREFVATALGEYGVQVVTVGSVREALSALAAQKTDVLVS
HHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHH
DIGMPGEDGYALIRELRSRGNTLPAIAFTAYARGEDLKDALQAGFQCHVPKPVEIAQLVS
HCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHCCCEECCCCCHHHHHHHH
AIASLSRNRKAT
HHHHHHCCCCCC
>Mature Secondary Structure 
PAPGTAEPVTILLVDDRFENLLALEAVLGELGQNLVKARSGPEALRHLLRQDFAVILLD
CCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEE
VQMPGMDGFETAQLIRQRERSRHTPIIFLTAYSANDSLIFKGYALGAVDYLLKPINPSIL
EECCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEECHHHHHHHHHHCCCCHHHH
ISKVVVFIDLFRKSAEIERQAGALVAVNRQLRSSEQRLQDFLDNASDLIEIVSPEGRLLY
HHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCEEE
VNRTWRETLAYPADDLEKMTCFDVVAPADRPLLAEALERVQQSQRSERLEVAFLAMGGRE
EECHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEECCEE
IAVEGSLNCQFDKGVPQAIRCIFRDITERRQAEQVRVEILREQVARQQAEEASRMKDEFL
EEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMVSHELRTPLNSILGWAQLLRARRIDEKAATGALESIERNARMQNRLIEDLLDISRVVT
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQMRLELQPLELSGVIASAVEAVQPAAAVKQIQLRCRIDAAVGPVLGDVDRLHQIAWNLL
CHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHH
ANAVKFTPQGGTVEVDLAQGEIHAQLVVRDNGIGISPAFLDQIFERFRQADSTSTRVHGG
HHHHEECCCCCEEEEEEECCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEECCC
LGLGLSIVRHLVELHGGTAAAESAGKGQGATFTVRLPLLADGTPIQDEGKLVQANGRTEA
CCHHHHHHHHHHHHCCCCHHHCCCCCCCCCEEEEEEEEEECCCCCCCCCCEEECCCCHHH
LTELVQWLAGLRVLVVDDEVDAREFVATALGEYGVQVVTVGSVREALSALAAQKTDVLVS
HHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHH
DIGMPGEDGYALIRELRSRGNTLPAIAFTAYARGEDLKDALQAGFQCHVPKPVEIAQLVS
HCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHCCCEECCCCCHHHHHHHH
AIASLSRNRKAT
HHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]