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The map label for this gene is ptrB [C]

Identifier: 37520194

GI number: 37520194

Start: 666613

End: 668673

Strand: Reverse

Name: ptrB [C]

Synonym: gll0625

Alternate gene names: 37520194

Gene position: 668673-666613 (Counterclockwise)

Preceding gene: 37520196

Following gene: 37520191

Centisome position: 14.35

GC content: 60.21

Gene sequence:

>2061_bases
GTGACTTCACCGTTTACCTACCCGCCATCGCGCCGCGACGATCAAGTGGACGACTACCACGGCACGCCGGTGGCCGATCC
GTACCGCTGGCTGGAGGATGCCGAATCTCCCGGGACCAAAGCCTGGGTGGAAGCGCAAAACCAGGTGACGTTCGGCTTTC
TGGAGACGATCCCTGAGCGCGAAGCGATCCGGGAACGGCTCACCCACATCTGGAATTACGAGCGCTACGGCACCCCTTTT
CGGGAGGGAGGACGCTACTTTCTGTTCAAAAACACCGGTCTGCAAAACCAGAGCGTACTCTACACCGTGCCGGATCTTGA
AGGCGAGTTGCGGTTGCTGCTCGATCCGAATGCGCTATCTGCAGACGGCACGGTGGCGCTTTCCGGTCTAGCGGTAAGCG
ACGACGGCAAGTATCTGGCCTATGGCACCTCCGCCTCCGGCTCCGACTGGCAGCAGTGGCGGGTGCTGGATATCGAGACG
GGCGAGGATCTGCCGGATATGGTGCAGTGGGTCAAGTTTTCCGGTGCTTCCTGGCTTAAGGACGGCAAGGGCTTTTTCTA
CAGCCGCTACGACGAGCCGAACGCCGCCGGCCAGTTTCAGGATGTCAATTACTTTCAAAAGCTTTACTTCCACCGCCTGG
GCACTCCGCAGGATCAAGACGTACTGGTCTACGAACGCAAAGATCAAAAAGAGTGGGGCTTCGGCGGCGAGGTGAGCGAG
GACGGACGCTACCTCGTCATCAGCGTCAGCCAGGGCACCGACCCCAAAAACAGGGTGTTCTACAAAGATCTGGCCGACCC
GGCTTCGGCGGTGGTCGAACTGTTGCCCGAGGCCGACGCCGCCTACGAATTTATCGACAACGACGGCCCGTTATTTTGGT
TCACCACCGACAAGGACGCGCCGCGCGGACGGGTGGTGGCCATCGACATCACCCAACCTCTACACCTAAACGAGTTGATC
CCCGAAAGCGAAGACACGCTGCAAGGGGTCAGCATTCTCGACAACAAATTTTTCGCCAATTATCTCAAAGACGCCCATAC
CCAGGTGCGCATCTACGACCTGCAAGGGCAGTACGTGGGAGAAGTCGAATTGCTGGGCATCGGCAGCGCCGGGGGCTTCG
GCGGCAAGCGCACGGACACCGAGACGTTTTATGCCTTTACCAGCTTCACCACCCCCACCACCATCTACCGCTACGACATC
CCCACTGCCAAAAGCACCGTGCTCTTCCAGCCTAAAGTCGACTTCGACCCCACCGCCTACACCACCGAGCAGGTCTTCTT
CAACAGCAAGGACGGCACCCGCATCCCGATGTTCATCACCTATAAAAAAGGCACCCCCCGCAACGCCCTCAACCCTACCT
ACCTCTATGGCTACGGCGGTTTCAACGTTTCTATTACCCCCACTTTTTCACCCAGCAACCTGCTGTGGTTGGAAATGGGC
GGCCTCTACGCCGTCCCCAACCTGCGCGGCGGCGGCGAGTACGGCGAGGATTGGCATCAGGCGGGCACCAGGCTCAACAA
GCAAAACGTCTTCGATGACTTTCTCGCCGCGGCCGAATACCTGATCGCCAATAAATACACCTCGCCGGAGAAATTGGCGA
TCGGCGGCGGCAGCAACGGTGGTTTGCTGGTGGGAGCTGCCATGACCCAGCGCCCGGAGTTGTTTGCTGCTGCGCTGCCC
GCGGTCGGGGTGATGGACATGCTGCGCTTTGAGCAGTTCACGATTGGCTGGGCGTGGGTGTCCGATTACGGCTCTTCGCA
AGACCCCGAGCAGTTCCAGGCGTTGTATGCCTACTCGCCTTTGCACAACTTGAAGGCAGGGACACGCTACCCGGCGACGC
TGGTGACGACGGCGGACACCGACGACCGGGTGGTGCCGGGACACAGTTACAAGTTCACAGCGGCGCTACAGGCGGCGCAG
GCGGGCGAAGGACCGGTGTTGATCCGCATCGAGACGAAGGCGGGCCACGGAGCGGGCAAGCCGACCACCAAGCTGATCGA
AGAAGCGGCGGACCGCTGGGCGTTTCTGGTGGCCAACCTCCGCATGCAACTGAAGTTTTGA

Upstream 100 bases:

>100_bases
CTAATGCTGTCGGTCGGCCCGGTGCTGCTCAATAGCGTACTGGCTTGGCTGACCAGCAAGTTACGATCGGCTGGCCGTCT
CTAGCATTCAGGACTTTGCT

Downstream 100 bases:

>100_bases
CGGCGGGCGCCGCGATGCTGCGATCGCCCTTTTACCCGTTGTTGCCGCGCTGCTCCAAAATATTGAGGATGCGGCGATTT
TCCAGTTGCAGCCCGCGCAC

Product: prolyl endopeptidase

Products: NA

Alternate protein names: PE; Post-proline cleaving enzyme [H]

Number of amino acids: Translated: 686; Mature: 685

Protein sequence:

>686_residues
MTSPFTYPPSRRDDQVDDYHGTPVADPYRWLEDAESPGTKAWVEAQNQVTFGFLETIPEREAIRERLTHIWNYERYGTPF
REGGRYFLFKNTGLQNQSVLYTVPDLEGELRLLLDPNALSADGTVALSGLAVSDDGKYLAYGTSASGSDWQQWRVLDIET
GEDLPDMVQWVKFSGASWLKDGKGFFYSRYDEPNAAGQFQDVNYFQKLYFHRLGTPQDQDVLVYERKDQKEWGFGGEVSE
DGRYLVISVSQGTDPKNRVFYKDLADPASAVVELLPEADAAYEFIDNDGPLFWFTTDKDAPRGRVVAIDITQPLHLNELI
PESEDTLQGVSILDNKFFANYLKDAHTQVRIYDLQGQYVGEVELLGIGSAGGFGGKRTDTETFYAFTSFTTPTTIYRYDI
PTAKSTVLFQPKVDFDPTAYTTEQVFFNSKDGTRIPMFITYKKGTPRNALNPTYLYGYGGFNVSITPTFSPSNLLWLEMG
GLYAVPNLRGGGEYGEDWHQAGTRLNKQNVFDDFLAAAEYLIANKYTSPEKLAIGGGSNGGLLVGAAMTQRPELFAAALP
AVGVMDMLRFEQFTIGWAWVSDYGSSQDPEQFQALYAYSPLHNLKAGTRYPATLVTTADTDDRVVPGHSYKFTAALQAAQ
AGEGPVLIRIETKAGHGAGKPTTKLIEEAADRWAFLVANLRMQLKF

Sequences:

>Translated_686_residues
MTSPFTYPPSRRDDQVDDYHGTPVADPYRWLEDAESPGTKAWVEAQNQVTFGFLETIPEREAIRERLTHIWNYERYGTPF
REGGRYFLFKNTGLQNQSVLYTVPDLEGELRLLLDPNALSADGTVALSGLAVSDDGKYLAYGTSASGSDWQQWRVLDIET
GEDLPDMVQWVKFSGASWLKDGKGFFYSRYDEPNAAGQFQDVNYFQKLYFHRLGTPQDQDVLVYERKDQKEWGFGGEVSE
DGRYLVISVSQGTDPKNRVFYKDLADPASAVVELLPEADAAYEFIDNDGPLFWFTTDKDAPRGRVVAIDITQPLHLNELI
PESEDTLQGVSILDNKFFANYLKDAHTQVRIYDLQGQYVGEVELLGIGSAGGFGGKRTDTETFYAFTSFTTPTTIYRYDI
PTAKSTVLFQPKVDFDPTAYTTEQVFFNSKDGTRIPMFITYKKGTPRNALNPTYLYGYGGFNVSITPTFSPSNLLWLEMG
GLYAVPNLRGGGEYGEDWHQAGTRLNKQNVFDDFLAAAEYLIANKYTSPEKLAIGGGSNGGLLVGAAMTQRPELFAAALP
AVGVMDMLRFEQFTIGWAWVSDYGSSQDPEQFQALYAYSPLHNLKAGTRYPATLVTTADTDDRVVPGHSYKFTAALQAAQ
AGEGPVLIRIETKAGHGAGKPTTKLIEEAADRWAFLVANLRMQLKF
>Mature_685_residues
TSPFTYPPSRRDDQVDDYHGTPVADPYRWLEDAESPGTKAWVEAQNQVTFGFLETIPEREAIRERLTHIWNYERYGTPFR
EGGRYFLFKNTGLQNQSVLYTVPDLEGELRLLLDPNALSADGTVALSGLAVSDDGKYLAYGTSASGSDWQQWRVLDIETG
EDLPDMVQWVKFSGASWLKDGKGFFYSRYDEPNAAGQFQDVNYFQKLYFHRLGTPQDQDVLVYERKDQKEWGFGGEVSED
GRYLVISVSQGTDPKNRVFYKDLADPASAVVELLPEADAAYEFIDNDGPLFWFTTDKDAPRGRVVAIDITQPLHLNELIP
ESEDTLQGVSILDNKFFANYLKDAHTQVRIYDLQGQYVGEVELLGIGSAGGFGGKRTDTETFYAFTSFTTPTTIYRYDIP
TAKSTVLFQPKVDFDPTAYTTEQVFFNSKDGTRIPMFITYKKGTPRNALNPTYLYGYGGFNVSITPTFSPSNLLWLEMGG
LYAVPNLRGGGEYGEDWHQAGTRLNKQNVFDDFLAAAEYLIANKYTSPEKLAIGGGSNGGLLVGAAMTQRPELFAAALPA
VGVMDMLRFEQFTIGWAWVSDYGSSQDPEQFQALYAYSPLHNLKAGTRYPATLVTTADTDDRVVPGHSYKFTAALQAAQA
GEGPVLIRIETKAGHGAGKPTTKLIEEAADRWAFLVANLRMQLKF

Specific function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Has an absolute requirement for an X-Pro bond in the trans configuration immediately preceding the Pro-Y scissible bond [H]

COG id: COG1505

COG function: function code E; Serine proteases of the peptidase family S9A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=705, Percent_Identity=47.0921985815603, Blast_Score=648, Evalue=0.0,
Organism=Homo sapiens, GI284172438, Length=273, Percent_Identity=25.6410256410256, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI284172431, Length=273, Percent_Identity=25.6410256410256, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI284172420, Length=273, Percent_Identity=25.6410256410256, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI284172413, Length=273, Percent_Identity=25.6410256410256, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI108860686, Length=273, Percent_Identity=25.6410256410256, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI70778815, Length=273, Percent_Identity=25.6410256410256, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI108860692, Length=225, Percent_Identity=26.2222222222222, Blast_Score=84, Evalue=4e-16,
Organism=Escherichia coli, GI1788150, Length=701, Percent_Identity=27.6747503566334, Blast_Score=225, Evalue=7e-60,
Organism=Drosophila melanogaster, GI24583414, Length=715, Percent_Identity=47.1328671328671, Blast_Score=616, Evalue=1e-176,
Organism=Drosophila melanogaster, GI221510989, Length=711, Percent_Identity=45.0070323488045, Blast_Score=586, Evalue=1e-167,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.26 [H]

Molecular weight: Translated: 76549; Mature: 76418

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00708 PRO_ENDOPEP_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPFTYPPSRRDDQVDDYHGTPVADPYRWLEDAESPGTKAWVEAQNQVTFGFLETIPER
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCEEEHHHHHCCCH
EAIRERLTHIWNYERYGTPFREGGRYFLFKNTGLQNQSVLYTVPDLEGELRLLLDPNALS
HHHHHHHHHHHCHHHCCCCHHHCCCEEEEECCCCCCCEEEEECCCCCCCEEEEECCCCCC
ADGTVALSGLAVSDDGKYLAYGTSASGSDWQQWRVLDIETGEDLPDMVQWVKFSGASWLK
CCCEEEEEEEEECCCCCEEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCHHC
DGKGFFYSRYDEPNAAGQFQDVNYFQKLYFHRLGTPQDQDVLVYERKDQKEWGFGGEVSE
CCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCC
DGRYLVISVSQGTDPKNRVFYKDLADPASAVVELLPEADAAYEFIDNDGPLFWFTTDKDA
CCCEEEEEECCCCCCCCCEEEHHHCCHHHHHHHHHCCCCCHHHEECCCCCEEEEECCCCC
PRGRVVAIDITQPLHLNELIPESEDTLQGVSILDNKFFANYLKDAHTQVRIYDLQGQYVG
CCCEEEEEEECCCCCHHHHCCCCCHHHCCHHHHHHHHHHHHHHCCCCEEEEEEECCCEEC
EVELLGIGSAGGFGGKRTDTETFYAFTSFTTPTTIYRYDIPTAKSTVLFQPKVDFDPTAY
EEEEEEECCCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCEEEEECCCCCCCCCE
TTEQVFFNSKDGTRIPMFITYKKGTPRNALNPTYLYGYGGFNVSITPTFSPSNLLWLEMG
EEEEEEEECCCCCEEEEEEEECCCCCCCCCCCCEEEEECCEEEEEEECCCCCCEEEEEEC
GLYAVPNLRGGGEYGEDWHQAGTRLNKQNVFDDFLAAAEYLIANKYTSPEKLAIGGGSNG
CEEECCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCC
GLLVGAAMTQRPELFAAALPAVGVMDMLRFEQFTIGWAWVSDYGSSQDPEQFQALYAYSP
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCHHHHHHHHHCCC
LHNLKAGTRYPATLVTTADTDDRVVPGHSYKFTAALQAAQAGEGPVLIRIETKAGHGAGK
HHHCCCCCCCCEEEEEECCCCCCCCCCCCEEEHHHHHHHCCCCCCEEEEEECCCCCCCCC
PTTKLIEEAADRWAFLVANLRMQLKF
CHHHHHHHHHHHHEEEEEEEEEEEEC
>Mature Secondary Structure 
TSPFTYPPSRRDDQVDDYHGTPVADPYRWLEDAESPGTKAWVEAQNQVTFGFLETIPER
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCEEEHHHHHCCCH
EAIRERLTHIWNYERYGTPFREGGRYFLFKNTGLQNQSVLYTVPDLEGELRLLLDPNALS
HHHHHHHHHHHCHHHCCCCHHHCCCEEEEECCCCCCCEEEEECCCCCCCEEEEECCCCCC
ADGTVALSGLAVSDDGKYLAYGTSASGSDWQQWRVLDIETGEDLPDMVQWVKFSGASWLK
CCCEEEEEEEEECCCCCEEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCHHC
DGKGFFYSRYDEPNAAGQFQDVNYFQKLYFHRLGTPQDQDVLVYERKDQKEWGFGGEVSE
CCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCC
DGRYLVISVSQGTDPKNRVFYKDLADPASAVVELLPEADAAYEFIDNDGPLFWFTTDKDA
CCCEEEEEECCCCCCCCCEEEHHHCCHHHHHHHHHCCCCCHHHEECCCCCEEEEECCCCC
PRGRVVAIDITQPLHLNELIPESEDTLQGVSILDNKFFANYLKDAHTQVRIYDLQGQYVG
CCCEEEEEEECCCCCHHHHCCCCCHHHCCHHHHHHHHHHHHHHCCCCEEEEEEECCCEEC
EVELLGIGSAGGFGGKRTDTETFYAFTSFTTPTTIYRYDIPTAKSTVLFQPKVDFDPTAY
EEEEEEECCCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCEEEEECCCCCCCCCE
TTEQVFFNSKDGTRIPMFITYKKGTPRNALNPTYLYGYGGFNVSITPTFSPSNLLWLEMG
EEEEEEEECCCCCEEEEEEEECCCCCCCCCCCCEEEEECCEEEEEEECCCCCCEEEEEEC
GLYAVPNLRGGGEYGEDWHQAGTRLNKQNVFDDFLAAAEYLIANKYTSPEKLAIGGGSNG
CEEECCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCC
GLLVGAAMTQRPELFAAALPAVGVMDMLRFEQFTIGWAWVSDYGSSQDPEQFQALYAYSP
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCHHHHHHHHHCCC
LHNLKAGTRYPATLVTTADTDDRVVPGHSYKFTAALQAAQAGEGPVLIRIETKAGHGAGK
HHHCCCCCCCCEEEEEECCCCCCCCCCCCEEEHHHHHHHCCCCCCEEEEEECCCCCCCCC
PTTKLIEEAADRWAFLVANLRMQLKF
CHHHHHHHHHHHHEEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8370677 [H]