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The map label for this gene is hmuU [H]

Identifier: 37520148

GI number: 37520148

Start: 617188

End: 618255

Strand: Reverse

Name: hmuU [H]

Synonym: gll0579

Alternate gene names: 37520148

Gene position: 618255-617188 (Counterclockwise)

Preceding gene: 37520149

Following gene: 37520147

Centisome position: 13.27

GC content: 70.32

Gene sequence:

>1068_bases
GTGAGCAAGGCCGGGTTTTTGCCTGCCAAGGGCACCGGCCGGGCACTGCGCGTCGCTGCGCCGCGCCTGGGTCTGGTGGG
GCTGCTCGTCGCTCTGGTGCTCTTTGCCGTCGGCAATGGGGCGGTAGCCATCGCCCCCACCCAGGTGGCGGCGATCCTGG
CAGGGCAAATCGGTGTGGCACTGCCCTGGGCGTTCGAACCGCAGCAGGAGGCGGTGCTGCTCGCCGTGCGGCTGCCGCGG
GTGTTGCTCGGGGCACTGGTGGGGGCGGCACTGGCCACGGCCGGGGCGGCGATGCAGGGCTTGTTTCGCAACCCCCTCGC
CGATCCGGGCCTCATTGGCGTCTCGAGCGGTGCGGCGCTCGCGGCGGTGGGGGCGATTGTCCTGGGAACCGGAAGCCTTG
CGGGGCCGTTTACCCTGCCGGTCGCCGCCTTCGCGGGGGGACTGGTCACGACGCTGCTGGTCTACCGGCTCGCGAGTGCA
GAGGGGCGCACCAGCGTGGCCACGATGCTGCTGGCCGGGATTGCCGTCAACGCACTGGCGGGGGCGGGCACGGGGCTGTT
GACCTTCGCGGCCACCGACGCCCAATTGCGCAGTATTACTTTCTGGAGCCTGGGCAGCCTCGGGGGGGCCACCTGGGAGG
CACTGGCTGGGGTAGCCCCGCCGCTACTTGCCGCCATCGTGCTGCTGCCGACCCTCGCCCGGCCGCTCAACGCCTTTTTG
CTCGGCGAAGCGGAAGCGGTTCACCTCGGAGTTGACATCGAGCGGGTGAAGGCGGCGGCGATCGTGCTTGCGGCCCTCGC
GGTCGGCGCGGCGGTCTCTATCTCGGGGATCATCGGCTTTGTCGGTCTGGCCGTGCCGCATCTGCTGAGATTCTGGTCGG
GACCGGACCACCGCCATTTGCTGATCGATGCGAGCTTGCTGGGGGCGGCGCTGCTCATCGCCGCGGACTGGTTGTGCCGG
ACCGTCGTCGCCCCGGCGGAGTTGCCCATCGGCATTCTGACTGCCGCTCTCGGAGCGCCCTTCTTTTTGTGGTTGCTGCT
GCGGGAGCGCTCGCAGGGGTGGGGCTGA

Upstream 100 bases:

>100_bases
TGGACGATCTGTACCTATTGGGCTTCGGGCCGCGCCTCGCTCAGGCCGTGCGCGATCTGAGCCGACAGCTGCGATCCCCG
GCCCCGGCGGGGGCGAAGGT

Downstream 100 bases:

>100_bases
TGCTCAAGGCCGCGGGAATCGGTGTGCGCCTCGCGGGGCGGTGGCTTCTTGAGCAGGTGAACCTGGAAGCTCTCCCCGGC
GAGGTGCTCGCCGTCGTCGG

Product: hemin ABC transporter permease protein

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MSKAGFLPAKGTGRALRVAAPRLGLVGLLVALVLFAVGNGAVAIAPTQVAAILAGQIGVALPWAFEPQQEAVLLAVRLPR
VLLGALVGAALATAGAAMQGLFRNPLADPGLIGVSSGAALAAVGAIVLGTGSLAGPFTLPVAAFAGGLVTTLLVYRLASA
EGRTSVATMLLAGIAVNALAGAGTGLLTFAATDAQLRSITFWSLGSLGGATWEALAGVAPPLLAAIVLLPTLARPLNAFL
LGEAEAVHLGVDIERVKAAAIVLAALAVGAAVSISGIIGFVGLAVPHLLRFWSGPDHRHLLIDASLLGAALLIAADWLCR
TVVAPAELPIGILTAALGAPFFLWLLLRERSQGWG

Sequences:

>Translated_355_residues
MSKAGFLPAKGTGRALRVAAPRLGLVGLLVALVLFAVGNGAVAIAPTQVAAILAGQIGVALPWAFEPQQEAVLLAVRLPR
VLLGALVGAALATAGAAMQGLFRNPLADPGLIGVSSGAALAAVGAIVLGTGSLAGPFTLPVAAFAGGLVTTLLVYRLASA
EGRTSVATMLLAGIAVNALAGAGTGLLTFAATDAQLRSITFWSLGSLGGATWEALAGVAPPLLAAIVLLPTLARPLNAFL
LGEAEAVHLGVDIERVKAAAIVLAALAVGAAVSISGIIGFVGLAVPHLLRFWSGPDHRHLLIDASLLGAALLIAADWLCR
TVVAPAELPIGILTAALGAPFFLWLLLRERSQGWG
>Mature_354_residues
SKAGFLPAKGTGRALRVAAPRLGLVGLLVALVLFAVGNGAVAIAPTQVAAILAGQIGVALPWAFEPQQEAVLLAVRLPRV
LLGALVGAALATAGAAMQGLFRNPLADPGLIGVSSGAALAAVGAIVLGTGSLAGPFTLPVAAFAGGLVTTLLVYRLASAE
GRTSVATMLLAGIAVNALAGAGTGLLTFAATDAQLRSITFWSLGSLGGATWEALAGVAPPLLAAIVLLPTLARPLNAFLL
GEAEAVHLGVDIERVKAAAIVLAALAVGAAVSISGIIGFVGLAVPHLLRFWSGPDHRHLLIDASLLGAALLIAADWLCRT
VVAPAELPIGILTAALGAPFFLWLLLRERSQGWG

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=284, Percent_Identity=40.8450704225352, Blast_Score=171, Evalue=9e-44,
Organism=Escherichia coli, GI1790740, Length=291, Percent_Identity=40.5498281786942, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1790741, Length=281, Percent_Identity=38.4341637010676, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1786805, Length=287, Percent_Identity=39.7212543554007, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1786804, Length=320, Percent_Identity=33.125, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1786347, Length=286, Percent_Identity=34.2657342657343, Blast_Score=99, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 35481; Mature: 35349

Theoretical pI: Translated: 10.56; Mature: 10.56

Prosite motif: PS00318 HMG_COA_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAGFLPAKGTGRALRVAAPRLGLVGLLVALVLFAVGNGAVAIAPTQVAAILAGQIGVA
CCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHCEE
LPWAFEPQQEAVLLAVRLPRVLLGALVGAALATAGAAMQGLFRNPLADPGLIGVSSGAAL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHH
AAVGAIVLGTGSLAGPFTLPVAAFAGGLVTTLLVYRLASAEGRTSVATMLLAGIAVNALA
HHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
GAGTGLLTFAATDAQLRSITFWSLGSLGGATWEALAGVAPPLLAAIVLLPTLARPLNAFL
CCCCCEEEEEECCHHHHEEEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LGEAEAVHLGVDIERVKAAAIVLAALAVGAAVSISGIIGFVGLAVPHLLRFWSGPDHRHL
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
LIDASLLGAALLIAADWLCRTVVAPAELPIGILTAALGAPFFLWLLLRERSQGWG
EEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKAGFLPAKGTGRALRVAAPRLGLVGLLVALVLFAVGNGAVAIAPTQVAAILAGQIGVA
CCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHCEE
LPWAFEPQQEAVLLAVRLPRVLLGALVGAALATAGAAMQGLFRNPLADPGLIGVSSGAAL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHH
AAVGAIVLGTGSLAGPFTLPVAAFAGGLVTTLLVYRLASAEGRTSVATMLLAGIAVNALA
HHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
GAGTGLLTFAATDAQLRSITFWSLGSLGGATWEALAGVAPPLLAAIVLLPTLARPLNAFL
CCCCCEEEEEECCHHHHEEEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LGEAEAVHLGVDIERVKAAAIVLAALAVGAAVSISGIIGFVGLAVPHLLRFWSGPDHRHL
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
LIDASLLGAALLIAADWLCRTVVAPAELPIGILTAALGAPFFLWLLLRERSQGWG
EEEHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]